Consolidation of Human Motor Cortical Neuroplasticity by D-Cycloserine
Open accessAbstract
D-Cycloserine (CYC), a partial N-methyl-D-aspartate (NMDA) agonist, has been shown to improve cognitive functions in humans. However, the neurophysiological basis of this effect is unclear so far. We studied the impact of this drug on long-lasting after-effects of transcranial direct current (tDCS)-generated motor cortical excitability shifts, as revealed by transcranial magnetic stimulation-elicited motor-evoked potentials. While anodal tDCS enhances motor cortical excitability, cathodal tDCS diminishes it. Both effects seem to be NMDA receptor dependent. D-CYC selectively potentiated the duration of motor cortical excitability enhancements induced by anodal tDCS. D-CYC alone did not modulate excitability. The potency of this drug to consolidate neuronal excitability enhancements, most probably by stabilizing the strengthening of NMDA receptors, which is a probable neurophysiological derivate of learning processes, makes it an interesting substance to improve cognitive functions.
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Studies using tDCS have shown that DCS modulates neuroplasticity through long-term potentiation via action on cortical NMDA receptors in humans.
“Studies using transcranial direct current stimulation (tDCS) have shown that DCS modulates neuroplasticity through long-term potentiation via action on cortical NMDA receptors in humans [168,169].”
From Pharmacotherapies Targeting GABA-Glutamate Neurotransmission for Treatment-Resistant Depression (2023) · cites this paper as [169]
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Perneger, T. V. (1998) · BMJ · doi:10.1136/bmj.316.7139.1236 · Cited by 5,900 · see citing works
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Self-citationDanysz, W., & Parsons, C. G. (2003) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.938 · Cited by 404 · see citing works
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Transcranial direct current stimulation: State of the art 2008
Nitsche, M. A., Cohen, L. G., Wassermann, E. M., Priori, A., Lang, N., Antal, A., Paulus, W., Hummel, F., Boggio, P. S., Fregni, F., et al. (2008) · Brain Stimulation · doi:10.1016/j.brs.2008.06.004 · Cited by 3,057 · see citing works
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Pharmacotherapies Targeting GABA-Glutamate Neurotransmission for Treatment-Resistant Depression
Vecera, C. M., C. Courtes, A., Jones, G., Soares, J. C., & Machado-Vieira, R. (2023) · Pharmaceuticals · doi:10.3390/ph16111572 · Cited by 48 · see citing works
“Studies using transcranial direct current stimulation (tDCS) have shown that DCS modulates neuroplasticity through long-term potentiation via action on cortical NMDA receptors in humans [168,169].”
BackgroundJongkees, B. J., Sellaro, R., Beste, C., Nitsche, M. A., Kühn, S., & Colzato, L. S. (2017) · Cortex · doi:10.1016/j.cortex.2017.02.014 · Cited by 21 · see citing works
Self-citationRetractedNeurochemical mechanisms underlying serotonergic modulation of neuroplasticity in humans
Melo, L., Beaupain, M. C., Ghanavati, E., Kuo, M.-F., & Nitsche, M. A. (2024) · Brain Stimulation · doi:10.1016/j.brs.2024.04.001 · Cited by 15 · see citing works
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- Authors
- Nitsche, M. A., Jaussi, W., Liebetanz, D., Lang, N., Tergau, F., & Paulus, W.
- Affiliations
- University of Göttingen (DE)
- Corresponding author
- Nitsche, Michael A
- Venue
- Neuropsychopharmacology
- Published
- 2004-06-16
- Volume
- 29
- Issue
- 8
- Pages
- 1573-1578
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W2083601314
- Cited by
- 385
- References
- 3
- Citations by year
- 2026: 2 · 2025: 15 · 2024: 22 · 2023: 19 · 2022: 14 · 2021: 26 · 2020: 17 · 2019: 18 · 2018: 24 · 2017: 28 · 2016: 28 · 2015: 28 · 2014: 25 · 2013: 15 · 2012: 26
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- GRO (submittedVersion, cc-by)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- D-cycloserine, NMDA receptor, motor cortex excitability, transcranial direct current stimulation, motor evoked potentials, cognitive enhancement, anodal tDCS, cathodal tDCS
- MeSH terms
- Adult, Antimetabolites, Cycloserine, Efferent Pathways, Electric Stimulation, Humans, Male, Motor Cortex, Neuronal Plasticity, Synapses, Receptors, N-Methyl-D-Aspartate, Evoked Potentials, Motor
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