The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
RETRACTED AND REPLACED: microRNA involvement in human cancer
Open accessAbstract
When, ∼20 years ago, investigators first determined that components of the genome considered nonfunctional had, in fact, gene regulatory capacity, they probably had no idea of their potential in controlling cell fate and were forced to revise and somehow reorganize their view of the molecular biology. Indeed, it is currently well documented how a class of small non-coding RNAs, microRNAs, are conserved among the species, expressed in different tissues and cell types and involved in almost every biological process, including cell cycle, growth, apoptosis, differentiation and stress response, exerting a finely tuned regulation of gene expression by targeting multiple molecules. As a consequence of the widespread range of processes they are able to influence, it is not surprising that miRNA deregulation is a hallmark of several pathological conditions, including cancer. Indeed, the aberrant expression of these tiny molecules in human tumors is not just a casual association, but they can exert a causal role, as oncogenes or tumor suppressors, in different steps of the tumorigenic process, from initiation and development to progression toward the acquisition of a metastatic phenotype. An increasing body of evidence has indeed proved the importance of miRNAs in cancer, suggesting their possible use as diagnostic, prognostic and predictive biomarkers and leading to exploit miRNA-based anticancer therapies, either alone or in combination with current targeted therapies, with the goal to improve disease response and increase cure rates. Here, we review our current knowledge about miRNA involvement in cancer.
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A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
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Self-citationMicroRNA Gene Expression Deregulation in Human Breast Cancer
Iorio, M. V., Ferracin, M., Liu, C.-G., Veronese, A., Spizzo, R., Sabbioni, S., Magri, E., Pedriali, M., Fabbri, M., Campiglio, M., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1783 · Cited by 4,053
Self-citationA microRNA component of the p53 tumour suppressor network
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Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
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Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
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Extensive modulation of a set of microRNAs in primary glioblastoma
Ciafrè, S. A., Galardi, S., Mangiola, A., Ferracin, M., Liu, C.-G., Sabatino, G., Negrini, M., Maira, G., Croce, C. M., & Farace, M. G. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.07.030 · Cited by 1,096
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Cited by
IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis
Rokavec, M., Öner, M. G., Li, H., Jackstadt, R., Jiang, L., Lodygin, D., Kaller, M., Horst, D., Ziegler, P. K., Schwitalla, S., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci73531 · Cited by 753
Small non-coding RNA and cancer
Romano, G., Veneziano, D., Acunzo, M., & Croce, C. M. (2017) · Carcinogenesis · doi:10.1093/carcin/bgx026 · Cited by 423
Self-citationInterplay between miRNAs and human diseases
Paul, P., Chakraborty, A., Sarkar, D., Langthasa, M., Rahman, M., Bari, M., Singha, R. S., Malakar, A. K., & Chakraborty, S. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.25854 · Cited by 420
MicroRNA-31 Promotes Skin Wound Healing by Enhancing Keratinocyte Proliferation and Migration
Li, D., Li, X. I., Wang, A., Meisgen, F., Pivarcsi, A., Sonkoly, E., Ståhle, M., & Landén, N. X. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.48 · Cited by 167
Xu, K., Zhan, Y., Yuan, Z., Qiu, Y., Wang, H., Fan, G., Wang, J., Li, W., Cao, Y., Shen, X., et al. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.05.017 · Cited by 160
Metadata
- Authors
- Iorio, M. V., & Croce, C. M.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-04-03
- Volume
- 33
- Issue
- 6
- Pages
- 1126-1133
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W2144149602
- Cited by
- 569
- References
- 13
- FWCI
- 20.27
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- bronze
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