Maternal Fish Consumption in Pregnancy Is Associated with a Bifidobacterium-Dominant Microbiome Profile in Infants
Open accessAbstract
National guidelines suggest that pregnant women consume 2–3 servings of fish weekly and often focus exclusively on limiting mercury exposure. We examined if meeting this recommendation in the third trimester of pregnancy was associated with differences in infant fecal microbiota composition and diversity. We used multinomial regression to analyze data from 114 infant–mother dyads. Applying 16S rRNA gene sequencing, we identified 3 infant fecal microbiota profiles: Bifidobacterium dominant, Enterobacter dominant, and Escherichia dominant. We found that 20% of mothers met the recommended fish consumption, and those infants whose mothers met the recommendation were more likely to have a Bifidobacterium-dominant profile than an Escherichia-dominant profile (RR ratio: 4.61; 95% CI: 1.40, 15.15; P = 0.01). In multivariable models, the significant association persisted (P < 0.05). Our findings support the need to expand recommendations focusing on the beneficial effects of fish consumption on the infant fecal microbiota profile.
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Pregnant women who meet the recommended fish consumption of 2-3 times a week are more likely to have a dominant Bifidobacterium profile than a dominant Escherichia profile.
“pregnant women who meet the recommended fish consumption (2–3 times a week) are more likely to have a dominant Bifidobacterium profile than a dominant Escherichia profile [13].”
From Novel Insights on Intake of Fish and Prevention of Sarcopenia: All Reasons for an Adequate Consumption (2020) · cites this paper as [13]
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- Authors
- Simione, M., Harshman, S. G., Castro, I., Linnemann, R., Roche, B., Ajami, N. J., Petrosino, J. F., Raspini, B., Portale, S., Camargo, Jr., Taveras, E. M., Hasegawa, K., & Fiechtner, L.
- Affiliations
- Massachusetts General Hospital (US)
- Emory University (US)
- Baylor College of Medicine (US)
- University of Pavia (IT)
- Harvard University (US)
- Corresponding author
- Harshman, Stephanie G.
- ORCID
- Venue
- Current Developments in Nutrition
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 4
- Issue
- 1
- Pages
- nzz133
- ISSN
- 2475-2991 (ISSN-L)
- PMC
- PMC6923185
- OpenAlex
- W2995147755
- Cited by
- 13
- References
- 34
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2022: 1 · 2021: 3 · 2020: 3 · 2018: 1
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Current Developments in Nutrition (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- NIH (K24DK105989, P30DK040561, UG3/UH3 OD023253, U01 AI-087881, R01 AI134940, R01 AI137091)
- Agency for Healthcare Research and Quality (K12HS022986)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (1K23HD090222-01A1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- maternal fish consumption, pregnancy, infant gut microbiota, Bifidobacterium, fecal microbiota composition, microbiome diversity, third trimester, mercury exposure, dietary recommendations
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