Cellular and subcellular sites for noradrenergic action in the monkey dorsolateral prefrontal cortex as revealed by the immunocytochemical localization of noradrenergic receptors and axons
Abstract
A series of electron microscopic immunocytochemical studies was performed to analyze subcellular sites for noradrenergic modulation in monkey prefrontal cortex. One out of 12 noradrenergic varicosities, identified by dopamine beta-hydroxylase immunocytochemistry within single ultrathin sections, forms morphologically identifiable junctions with small dendrites and spines. Accordingly, alpha2-adrenergic receptors, almost all of which are of the A-subtype, that occur in spines are localized discretely over postsynaptic membranes. alpha2-Adrenergic receptors are also found at sites along axons, dendritic shafts and astrocytic processes lacking morphologically identifiable synaptic junctions, suggesting that these receptors are activated by volume transmission. In particular, axonal alpha2-adrenergic receptors occur mostly at pre-terminal regions, suggesting that axo-axonic interactions may mediate reduction of neurotransmitter release at sites other than axo-spinous junctions by closing voltage-dependent calcium channels. These results indicate that noradrenergic modulation of prefrontal cortex involves synaptic interactions at spines of pyramidal neurons and nonsynaptic volume transmission to glia, dendritic shafts and axons.
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Among α2-receptors, the α2A subtype is the most prevalent in the PFC and is found both presynaptically on noradrenergic terminals and postsynaptically on the dendritic spines of PFC pyramidal cells that receive network inputs.
“Among the α2-receptors, the α2A subtype is the most prevalent in the PFC and is found both presynaptically on noradrenergic terminals and postsynaptically on the dendritic spines of PFC pyramidal cells that receive network inputs (Aoki et al., 1998; Wang et al., 2007).”
From Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders (2011) · cites this paper as Aoki et al., 1998
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- Authors
- Aoki, C.
- Affiliations
- New York University (US)
- Corresponding author
- Aoki, C
- ORCID
- Aoki, C
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-04-01
- Volume
- 8
- Issue
- 3
- Pages
- 269-277
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2122625420
- Cited by
- 138
- References
- 3
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 7 · 2016: 7 · 2015: 6 · 2014: 5 · 2013: 5 · 2012: 11
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- Funders
- York University
- National Institutes of Health
- National Eye Institute (EY08055)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- noradrenergic modulation, dorsolateral prefrontal cortex, alpha2-adrenoceptors, dopamine beta-hydroxylase, dendritic spines, volume transmission, postsynaptic receptors, monkeys
- MeSH terms
- Animals, Axons, Dopamine beta-Hydroxylase, Immunohistochemistry, Macaca fascicularis, Norepinephrine, Receptors, Adrenergic, Subcellular Fractions, Microscopy, Immunoelectron, Prefrontal Cortex, Receptors, Adrenergic, alpha-2
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