Prefrontal and monoaminergic contributions to stop-signal task performance in rats

Bari, A.; Mar, A. C.; Theobald, D. E.; Elands, S. A.; Oganya, K. C. N. A.; Eagle, D. M.; Robbins, T. W.

doi:10.1523/jneurosci.1543-11.2011

Cited by 188Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorAttention Deficit Hyperactivity Disorder

Prefrontal and monoaminergic contributions to stop-signal task performance in rats

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Bari, A., Mar, A. C., Theobald, D. E., Elands, S. A., Oganya, K. C. N. A., Eagle, D. M., Robbins, T. W.·2011·Journal of Neuroscience

DOI 10.1523/jneurosci.1543-11.2011PMC PMC3145112

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Abstract

Defining the neural and neurochemical substrates of response inhibition is of crucial importance for the study and treatment of pathologies characterized by impulsivity such as attention-deficit/hyperactivity disorder and addiction. The stop-signal task (SST) is one of the most popular paradigms used to study the speed and efficacy of inhibitory processes in humans and other animals. Here we investigated the effect of temporarily inactivating different prefrontal subregions in the rat by means of muscimol microinfusions on SST performance. We found that dorsomedial prefrontal cortical areas are important for inhibiting an already initiated response. We also investigated the possible neural substrates of the selective noradrenaline reuptake inhibitor atomoxetine via its local microinfusion into different subregions of the rat prefrontal cortex. Our results show that both orbitofrontal and dorsal prelimbic cortices mediate the beneficial effects of atomoxetine on SST performance. To assess the neurochemical specificity of these effects, we infused the α2-adrenergic agonist guanfacine and the D(1)/D(2) antagonist α-flupenthixol in dorsal prelimbic cortex to interfere with noradrenergic and dopaminergic neurotransmission, respectively. Guanfacine, which modulates noradrenergic neurotransmission, selectively impaired stopping, whereas blocking dopaminergic receptors by α-flupenthixol infusion prolonged go reaction time only, confirming the important role of noradrenergic neurotransmission in response inhibition. These results show that, similar to humans, distinct networks play important roles during SST performance in the rat and that they are differentially modulated by noradrenergic and dopaminergic neurotransmission. This study advances our understanding of the neuroanatomical and neurochemical determinants of impulsivity, which are relevant for a range of psychiatric disorders.

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Guanfacine reduces ascending norepinephrine release.
“Conversely, guanfacine, an agonist of α2-adrenergic autoreceptors, which reduces ascending norepinephrine release, worsens response inhibition in rats (Bari et al 2009, Bari et al 2011)”
From Prefrontal cortex executive processes affected by stress in health and disease (2018) · cites this paper as Bari et al 2011
Blocking either D1 or D2 in the mPFC or OFC had no effect on the 5-CRSTT or SST.
“blocking either D1 or D2 in the mPFC or OFC had no effect on the 5-CRSTT (Granon et al 2000, Winstanley et al 2010), or the SST (Bari et al 2011, Bari & Robbins 2013b)”
From Prefrontal cortex executive processes affected by stress in health and disease (2018) · cites this paper as Bari et al 2011
Guanfacine worsens response inhibition in rats.
“Conversely, guanfacine, an agonist of α2-adrenergic autoreceptors, which reduces ascending norepinephrine release, worsens response inhibition in rats (Bari et al 2009, Bari et al 2011)”
From Prefrontal cortex executive processes affected by stress in health and disease (2018) · cites this paper as Bari et al 2011

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The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Statistical Methods for Psychology.
Gudgeon, A. C., & Howell, D. C. (1994) · Journal of the Royal Statistical Society Series D (The Statistician) · doi:10.2307/2348956 · Cited by 8,277 · see citing works
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,501 · see citing works
An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance
Aston-Jones, G., & Cohen, J. D. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135709 · Cited by 4,472 · see citing works
Inhibition and the right inferior frontal cortex
Aron, A. R., Robbins, T. W., & Poldrack, R. A. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.02.010 · Cited by 3,197 · see citing works
Self-citation
The locus coeruleus–noradrenergic system: modulation of behavioral state and state-dependent cognitive processes
Berridge, C. W., & Waterhouse, B. D. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00143-7 · Cited by 2,529 · see citing works
Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat
Hoover, W. B., & Vertes, R. P. (2007) · Brain Structure and Function · doi:10.1007/s00429-007-0150-4 · Cited by 1,365 · see citing works
Prefrontal cortex in the rat: Projections to subcortical autonomic, motor, and limbic centers
Gabbott, P. L. A., Warner, T. A., Jays, P. R. L., Salway, P., & Busby, S. J. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20738 · Cited by 1,227 · see citing works
Atomoxetine Increases Extracellular Levels of Norepinephrine and Dopamine in Prefrontal Cortex of Rat A Potential Mechanism for Efficacy in Attention Deficit/Hyperactivity Disorder
Bymaster, F. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00346-9 · Cited by 1,123 · see citing works
Triangulating a cognitive control network using diffusion-weighted magnetic resonance imaging (MRI) and functional MRI
Aron, A. R., Behrens, T. E., Smith, S., Frank, M. J., & Poldrack, R. A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0519-07.2007 · Cited by 982 · see citing works
On the ability to inhibit thought and action: A users' guide to the stop signal paradigm
Logan, G. D. (1994) · UvA-DARE (University of Amsterdam) · Cited by 964 · see citing works
The Neuropsychopharmacology of Fronto-Executive Function: Monoaminergic Modulation
Robbins, T. W., & Arnsten, A. F. T. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135535 · Cited by 957 · see citing works
Self-citation
The medial prefrontal cortex in the rat: evidence for a dorso-ventral distinction based upon functional and anatomical characteristics
Heidbreder, C. A., & Groenewegen, H. J. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.09.003 · Cited by 882 · see citing works
Interactions among the medial prefrontal cortex, hippocampus and midline thalamus in emotional and cognitive processing in the rat
Vertes, R. P. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.06.027 · Cited by 811 · see citing works
Network reset: a simplified overarching theory of locus coeruleus noradrenaline function
Bouret, S., & Sara, S. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.09.002 · Cited by 806 · see citing works
Functional Neuroanatomy of the Noradrenergic Locus Coeruleus: Its Roles in the Regulation of Arousal and Autonomic Function Part I: Principles of Functional Organisation
Samuels, E., & Szabadi, E. (2008) · Current Neuropharmacology · doi:10.2174/157015908785777229 · Cited by 766 · see citing works
The role of locus coeruleus in the regulation of cognitive performance
Usher, M., Cohen, J. D., Servan-Schreiber, D., Rajkowski, J., & Aston-Jones, G. (1999) · Science · doi:10.1126/science.283.5401.549 · Cited by 715 · see citing works
Horse-race model simulations of the stop-signal procedure
Band, G. P. H., van der Molen, M. W., & Logan, G. D. (2003) · Acta Psychologica · doi:10.1016/s0001-6918(02)00079-3 · Cited by 687 · see citing works
Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines
Morón, J. A., Brockington, A., Wise, R. A., Rocha, B. A., & Hope, B. T. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00389.2002 · Cited by 681 · see citing works
α2A-Adrenoceptors Strengthen Working Memory Networks by Inhibiting cAMP-HCN Channel Signaling in Prefrontal Cortex
Wang, M., Ramos, B. P., Paspalas, C. D., Shu, Y., Simen, A., Duque, A., Vijayraghavan, S., Brennan, A., Dudley, A., Nou, E., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.015 · Cited by 672 · see citing works
Adaptive gain and the role of the locus coeruleus–norepinephrine system in optimal performance
Aston‐Jones, G., & Cohen, J. D. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20723 · Cited by 630 · see citing works
Inhibitory control and psychopathology: A meta-analysis of studies using the stop signal task
LIPSZYC, J., & SCHACHAR, R. (2010) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617710000895 · Cited by 627 · see citing works
The dopamine transporter: immunochemical characterization and localization in brain
Ciliax, B. J., Heilman, C. J., Demchyshyn, L. L., Pristupa, Z. B., Ince, E., Hersch, S. M., Niznik, H. B., & Levey, A. I. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-01714.1995 · Cited by 589 · see citing works
Neurochemical Modulation of Response Inhibition and Probabilistic Learning in Humans
Chamberlain, S. R., Müller, U., Blackwell, A. D., Clark, L., Robbins, T. W., & Sahakian, B. J. (2006) · Science · doi:10.1126/science.1121218 · Cited by 573 · see citing works
Self-citation
Afferent projections to the rat locus coeruleus as determined by a retrograde tracing technique
Cedarbaum, J. M., & Aghajanian, G. K. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901780102 · Cited by 549 · see citing works
The neuropsychopharmacology of action inhibition: cross-species translation of the stop-signal and go/no-go tasks
Eagle, D. M., Bari, A., & Robbins, T. W. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1127-6 · Cited by 548 · see citing works
Self-citation
Executive "Brake Failure" following Deactivation of Human Frontal Lobe
Chambers, C. D., Bellgrove, M. A., Stokes, M. G., Henderson, T. R., Garavan, H., Robertson, I. H., Morris, A. P., & Mattingley, J. B. (2006) · Journal of Cognitive Neuroscience · doi:10.1162/089892906775990606 · Cited by 544 · see citing works
Executive “Brake Failure” following Deactivation of Human Frontal Lobe
Chambers, C. D., Bellgrove, M. A., Stokes, M. G., Henderson, T. R., Garavan, H., Robertson, I. H., Morris, A. P., & Mattingley, J. B. (2006) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2006.18.3.444 · Cited by 544 · see citing works
The neuropharmacology of impulsive behaviour.
Pattij, T., & Vanderschuren, L. (2008) · TIPS - Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.01.002 · Cited by 480 · see citing works
Extrathalamic Modulation of Cortical Function
Foote, S. L., & Morrison, J. (1987) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.10.030187.000435 · Cited by 480 · see citing works
Functional Connectivity Delineates Distinct Roles of the Inferior Frontal Cortex and Presupplementary Motor Area in Stop Signal Inhibition
Duann, J., Ide, J. S., Luo, X., & Li, C. R. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1300-09.2009 · Cited by 476 · see citing works
Hippocampal Inactivation Disrupts Contextual Retrieval of Fear Memory after Extinction
Corcoran, K. A., & Maren, S. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01720.2001 · Cited by 455 · see citing works
Stop-Signal Reaction-Time Task Performance: Role of Prefrontal Cortex and Subthalamic Nucleus
Eagle, D. M., Baunez, C., Hutcheson, D. M., Lehmann, O., Shah, A. P., & Robbins, T. W. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm044 · Cited by 404 · see citing works
Self-citation
Catecholamine influences on prefrontal cortical function: Relevance to treatment of attention deficit/hyperactivity disorder and related disorders
Arnsten, A. F. T., & Pliszka, S. R. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.01.020 · Cited by 383 · see citing works
Similar effects of the selective noradrenaline reuptake inhibitor atomoxetine on three distinct forms of impulsivity in the rat
Robinson, E. S. J., Eagle, D. M., Mar, A. C., Bari, A., Banerjee, G., Jiang, X., Dalley, J. W., & Robbins, T. W. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301487 · Cited by 359 · see citing works
Self-citation
Afferent projections to the rat locus coeruleus demonstrated by retrograde and anterograde tracing with cholera-toxin B subunit and Phaseolus vulgaris leucoagglutinin
Luppi, P., Aston‐Jones, G., Akaoka, H., Chouvet, G., & Jouvet, M. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00481-j · Cited by 344 · see citing works
Addiction, compulsive drug seeking, and the role of frontostriatal mechanisms in regulating inhibitory control
Feil, J., Sheppard, D., Fitzgerald, P. B., Yücel, M., Lubman, D. I., & Bradshaw, J. L. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.03.001 · Cited by 342 · see citing works
Selective prefrontal cortical projections to the region of the locus coeruleus and raphe nuclei in the rhesus monkey
Arnsten, A. F. T., & Goldman-Rakic, P. S. (1984) · Brain Research · doi:10.1016/0006-8993(84)90351-2 · Cited by 333 · see citing works
Noradrenergic modulation of cognitive function in rat medial prefrontal cortex as measured by attentional set shifting capability
Bluhm, M. D. L., & Morilak, D. A. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.09.031 · Cited by 325 · see citing works
On the Role of the Striatum in Response Inhibition
Zandbelt, B. B., & Vink, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013848 · Cited by 322 · see citing works
Potent excitatory influence of prefrontal cortex activity on noradrenergic locus coeruleus neurons
Jodoj, E., Chiang, C., & Aston-Jones, G. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00372-2 · Cited by 321 · see citing works
Top-Down Control of Motor Cortex Ensembles by Dorsomedial Prefrontal Cortex
Narayanan, N. S., & Laubach, M. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.021 · Cited by 311 · see citing works
Cocaine Administered into the Medial Prefrontal Cortex Reinstates Cocaine-Seeking Behavior by Increasing AMPA Receptor-Mediated Glutamate Transmission in the Nucleus Accumbens
Park, W.-K., Bari, A., Jey, A. R., Anderson, S. M., Spealman, R. D., Rowlett, J. K., & Pierce, R. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02916.2002 · Cited by 310 · see citing works
Self-citation
Phasic norepinephrine: A neural interrupt signal for unexpected events
Dayan, P., & Yu, A. J. (2006) · Network Computation in Neural Systems · doi:10.1080/09548980601004024 · Cited by 302 · see citing works
Atomoxetine Modulates Right Inferior Frontal Activation During Inhibitory Control: A Pharmacological Functional Magnetic Resonance Imaging Study
Chamberlain, S. R., Hampshire, A., Müller, U., Rubia, K., del Campo, N., Craig, K. J., Regenthal, R., Suckling, J., Roiser, J. P., Grant, J. E., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.014 · Cited by 300 · see citing works
Self-citation
Effects of methylphenidate on inhibitory control in hyperactive children
Tannock, R., Schachar, R. J., Carr, R. P., Chajczyk, D., & Logan, G. D. (1989) · Research on Child and Adolescent Psychopathology · doi:10.1007/bf00916508 · Cited by 289 · see citing works
Atomoxetine improved response inhibition in adults with attention deficit/hyperactivity disorder
Chamberlain, S. R., del Campo, N., Dowson, J., Müller, U., Clark, L., Robbins, T. W., & Sahakian, B. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.003 · Cited by 288 · see citing works
Self-citation
Is there an inhibitory-response-control system in the rat? Evidence from anatomical and pharmacological studies of behavioral inhibition
Eagle, D. M., & Baunez, C. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.07.003 · Cited by 280 · see citing works
Self-citation
Inhibitory Control in Rats Performing a Stop-Signal Reaction-Time Task: Effects of Lesions of the Medial Striatum and d-Amphetamine.
Eagle, D. M., & Robbins, T. W. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.6.1302 · Cited by 252 · see citing works
Self-citation
ANOVA for the Behavioral Sciences Researcher
Cardinal, R. N., & Aitken, M. R. F. (2013) · Psychology Press eBooks · doi:10.4324/9780203763933 · Cited by 249 · see citing works
Pharmacological inactivation in the analysis of the central control of movement
Martin, J. H., & Ghez, C. P. (1999) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(98)00163-0 · Cited by 245 · see citing works
Methylphenidate and Atomoxetine Enhance Prefrontal Function Through α2-Adrenergic and Dopamine D1 Receptors
Gamo, N. J., Wang, M., & Arnsten, A. F. T. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.06.015 · Cited by 232 · see citing works
Locus coeruleus projections to cortex: Topography, morphology and collateralization
Loughlin, S. E., Foote, S. L., & Fallon, J. H. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90142-3 · Cited by 212 · see citing works
Local Influence of Endogenous Norepinephrine on Extracellular Dopamine in Rat Medial Prefrontal Cortex
Gresch, P. J., Sved, A. F., Zigmond, M. J., & Finlay, J. M. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65010111.x · Cited by 208 · see citing works
The advantages and limitations of permanent or reversible deactivation techniques in the assessment of neural function
Lomber, S. G. (1999) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(98)00160-5 · Cited by 206 · see citing works
The involvement of the orbitofrontal cortex in learning under changing task contingencies.
Kim, J., & Ragozzino, M. (2005) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.10.003 · Cited by 206 · see citing works
Activation of the noradrenergic system facilitates an attentional shift in the rat
Devauges, V., & Sara, S. J. (1990) · Behavioural Brain Research · doi:10.1016/0166-4328(90)90118-x · Cited by 202 · see citing works
Evidence for co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex
Devoto, P., Flore, G., Pani, L., & Gessa, G. L. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000904 · Cited by 196 · see citing works
Dissociable effects of noradrenaline, dopamine, and serotonin uptake blockade on stop task performance in rats
Bari, A., Eagle, D. M., Mar, A. C., Robinson, E. S. J., & Robbins, T. W. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1537-0 · Cited by 194 · see citing works
Self-citation
The orbital cortex in rats topographically projects to central parts of the caudate-putamen complex
Schilman, E. A., Uylings, H. B. M., Graaf, Y. G.-D., Joel, D., & Groenewegen, H. J. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2007.12.024 · Cited by 187 · see citing works
Differential effects of modafinil and methylphenidate on stop-signal reaction time task performance in the rat, and interactions with the dopamine receptor antagonist cis-flupenthixol
Eagle, D. M., Tufft, M. R. A., Goodchild, H. L., & Robbins, T. W. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0701-7 · Cited by 176 · see citing works
Self-citation
Contribution of Blockade of the Noradrenaline Carrier to the Increase of Extracellular Dopamine in the Rat Prefrontal Cortex by Amphetamine and Cocaine
Tanda, G., Pontieri, F. E., Frau, R., & Chiara, G. D. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01375.x · Cited by 169 · see citing works
Reversible inactivations of rat medial prefrontal cortex impair the ability to wait for a stimulus
Narayanan, N. S., Horst, N. K., & Laubach, M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.11.072 · Cited by 167 · see citing works
Contrasting roles for dopamine D1 and D2 receptor subtypes in the dorsomedial striatum but not the nucleus accumbens core during behavioral inhibition in the stop-signal task in rats
Eagle, D. M., Wong, J. C. K., Allan, M. E., Mar, A. C., Theobald, D. E., & Robbins, T. W. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6182-10.2011 · Cited by 145 · see citing works
Self-citation
Delineation of rat kidney α2A- and α2B-adrenoeeptors with [3H]RX821002 radiollgand binding: computer modelling reveals that guanfacine is an α2A-selective compound
Uhlén, S., & Wikberg, J. E. S. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90299-6 · Cited by 141 · see citing works
Cellular and subcellular sites for noradrenergic action in the monkey dorsolateral prefrontal cortex as revealed by the immunocytochemical localization of noradrenergic receptors and axons
Aoki, C. (1998) · Cerebral Cortex · doi:10.1093/cercor/8.3.269 · Cited by 138 · see citing works
Effects of methylphenidate, desipramine, and l-dopa on attention and inhibition in children with Attention Deficit Hyperactivity Disorder
Overtoom, C. C. E., Verbaten, M. N., Kemner, C., Kenemans, J. L., van Engeland, H., Buitelaar, J. K., van der Molen, M. W., van der Gugten, J., Westenberg, H. G. M., Maes, R. A. A., et al. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00097-4 · Cited by 138 · see citing works
Effects of dopamine depletion from the caudate-putamen and nucleus accumbens septi on the acquisition and performance of a conditional discrimination task
Robbins, T. W., Giardini, V., Jones, G. H., Reading, P., & Sahakian, B. J. (1990) · Behavioural Brain Research · doi:10.1016/0166-4328(90)90179-i · Cited by 137 · see citing works
Self-citation
Lesions of the medial prefrontal cortex or nucleus accumbens core do not impair inhibitory control in rats performing a stop-signal reaction time task
Eagle, D. M., & Robbins, T. W. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.09.022 · Cited by 129 · see citing works
Self-citation
Dorsomedial Prefrontal Cortex Contribution to Behavioral and Nucleus Accumbens Neuronal Responses to Incentive Cues
Ishikawa, A., Ambroggi, F., Nicola, S. M., & Fields, H. L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0253-08.2008 · Cited by 125 · see citing works
Pharmacological Enhancement of Memory and Executive Functioning in Laboratory Animals
Floresco, S., & Jentsch, J. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.158 · Cited by 120 · see citing works
α2‐Noradrenergic receptors activation enhances excitability and synaptic integration in rat prefrontal cortex pyramidal neurons via inhibition of HCN currents
Carr, D. B., Andrews, G. D., Glen, W. B., & Lavı́n, A. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.141671 · Cited by 119 · see citing works
Contributions of the amygdala and medial prefrontal cortex to incentive cue responding
Ishikawa, A., Ambroggi, F., Nicola, S. M., & Fields, H. L. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.06.037 · Cited by 110 · see citing works
Efficacy of atomoxetine in adult attention-Deficit/Hyperactivity Disorder: a drug-placebo response curve analysis
Faraone, S. V., Biederman, J., Spencer, T., Michelson, D., Adler, L., Reimherr, F., & Glatt, S. J. (2005) · Behavioral and Brain Functions · doi:10.1186/1744-9081-1-16 · Cited by 108 · see citing works
Cellular and subcellular localization of the dopamine transporter in rat cortex
Sesack, S. R., Hawrylak, V. A., Guido, M. A., & Levey, A. I. (1997) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60720-6 · Cited by 101 · see citing works
A Role for Medial Prefrontal Dopaminergic Innervation in Instrumental Conditioning
Naneix, F., Marchand, A. R., Scala, G. D., Pape, J., & Coutureau, É. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1234-09.2009 · Cited by 96 · see citing works
Selective depletion of cortical noradrenaline by anti-dopamine beta-hydroxylase-saporin impairs attentional function and enhances the effects of guanfacine in the rat
Milstein, J. A., Lehmann, O., Theobald, D. E. H., Dalley, J. W., & Robbins, T. W. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0594-x · Cited by 94 · see citing works
Self-citation
Beneficial effects of desipramine on cognitive function of chronically stressed rats are mediated by α1-adrenergic receptors in medial prefrontal cortex
Bondi, C. O., Jett, J. D., & Morilak, D. A. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.04.016 · Cited by 88 · see citing works
Excitotoxic lesions of the prelimbic‐infralimbic areas of the rodent prefrontal cortex disrupt motor preparatory processes
Risterucci, C., Terramorsi, D., Nieoullon, A. L., & Amalric, M. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02541.x · Cited by 87 · see citing works
Visual attention task performance in Wistar and Lister Hooded rats: response inhibition deficits after medial prefrontal cortex lesions
Broersen, L. M., & Uylings, H. B. M. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00312-7 · Cited by 85 · see citing works
Pharmacological actions of the antihypertensive agent N-amidino-2-(2,6-dichlorophenyl)acetamide hydrochloride (BS 100-141).
Scholtysik, G., Lauener, H., Eichenberger, E., Bürki, H. R., Salzmann, R., Müller‐Schweinitzer, E., & Waite, R. H. (1975) · PubMed · Cited by 80 · see citing works
In vivomicrodialysis of noradrenaline overflow: effects of α‐adrenoceptor agonists and antagonists measured by cumulative concentration‐response curves
van Veldhuizen, M. J. A., Feenstra, M. G. P., Heinsbroek, R. P. W., & Boer, G. J. (1993) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1993.tb13623.x · Cited by 80 · see citing works
Pharmacological Manipulation of Neuronal Ensemble Activity by Reverse Microdialysis in Freely Moving Rats: A Comparative Study of the Effects of Tetrodotoxin, Lidocaine, and Muscimol
van Duuren, E., Plasse, G., van der Blom, R., Joosten, R. N. J. M. A., Mulder, A. B., Pennartz, C. M. A., & Feenstra, M. G. P. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.124784 · Cited by 78 · see citing works
Lack of effects of guanfacine on executive and memory functions in healthy male volunteers
Müller, U., Clark, L., Lam, M. L., Moore, R. M., Murphy, C. L., Richmond, N. K., Sandhu, R. S., Wilkins, I. A., Menon, D. K., Sahakian, B. J., et al. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0078-4 · Cited by 73 · see citing works
Self-citation
Controlling stress: how the brain protects itself from depression
Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn0305-261 · Cited by 70 · see citing works
Self-citation
The effect of rat anterior cingulate inactivation on cognitive flexibility.
Ragozzino, M. E., & Rozman, S. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.4.698 · Cited by 63 · see citing works
Noradrenergic innervation patterns in three regions of medial cortex: An immunofluorescence characterization
Morrison, J. H., Ver, M. E. M., Grzanna, R., & Coyle, J. T. (1979) · Brain Research Bulletin · doi:10.1016/0361-9230(79)90022-4 · Cited by 62 · see citing works
Stimulation of α2-Adrenoceptors Suppresses Excitatory Synaptic Transmission in the Medial Prefrontal Cortex of Rat
Ji, X.-H., Ji, J.-Z., Zhang, H., & Li, B.-M. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301603 · Cited by 61 · see citing works
In vivo regulation of dopamine and noradrenaline release by α2A‐adrenoceptors in the mouse prefrontal cortex
Ihalainen, J. A., & Tanila, H. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02014.x · Cited by 61 · see citing works
Target-Specific Encoding of Response Inhibition: Increased Contribution of AMPA to NMDA Receptors at Excitatory Synapses in the Prefrontal Cortex
Hayton, S. J., Lovett-Barron, M., Dumont, É. C., & Olmstead, M. C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1550-10.2010 · Cited by 43 · see citing works
Atomoxetine produces changes in cortico-basal thalamic loop circuits: Assessed by phMRI BOLD contrast
Easton, N., Marshall, F. H., Fone, K. C. F., & Marsden, C. A. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.09.024 · Cited by 37 · see citing works
Contrasting effects of the imidazol(in)e α2‐adrenoceptor agonists, medetomidine, clonidine and UK 14,304 on extraneuronal levels of noradrenaline in the rat frontalcortex: evaluation usingin vivomicrodialysis and synaptosomal uptake studies
Dalley, J. W., & Stanford, S. C. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb14962.x · Cited by 36 · see citing works
Animal Models of ADHD
Bari, A., & Robbins, T. W. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_102 · Cited by 35 · see citing works
Self-citation
Selective responsiveness of medial prefrontal cortex neurons to the meaningful stimulus with a low probability of occurrence in rats
Jodo, E., Suzuki, Y., & Kayama, Y. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02386-0 · Cited by 32 · see citing works
Characteristics of 3H-cis-flupenthixol binding in rat striatum
Murrin, L. C. (1983) · Life Sciences · doi:10.1016/0024-3205(83)90289-8 · Cited by 32 · see citing works
Prefrontal dopamine is directly involved in the anxiogenic interoceptive cue of pentylenetetrazol but not in the interoceptive cue of chlordiazepoxide in the rat
Broersen, L. M., Abbate, F., Feenstra, M. G. P., de Bruin, J. P. C., Heinsbroek, R. P. W., & Olivier, B. (2000) · Psychopharmacology · doi:10.1007/s002130000390 · Cited by 29 · see citing works
Effects of Posttraining Treatments in the Posterior Cingulate Cortex on Short- and Long-Term Memory for Inhibitory Avoidance in Rats
de Souza, M. M., Souza, T. M. E., Vinadé, E. R., Rodrigues, C., Choi, H., Silva, T. L. D. E., Medina, J. H., & Izquierdo, I. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2001.4009 · Cited by 26 · see citing works
Extrathalamic Modulation Of Cortical Function
Foote, S. (1987) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.10.1.67 · Cited by 25 · see citing works
Differential attenuation of d-amphetamine-induced disruption of conditional discrimination performance by dopamine and serotonin antagonists
Dunn, M. J., & Killcross, S. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0488-y · Cited by 21 · see citing works
Comparison of Effects of Guanfacine and Clonidine on Blood Pressure, Heart Rate, Urinary Catecholamines, and Cyclic Nucleotides During and After Administration to Patients with Mild to Moderate Hypertension
Nami, R., Bianchini, C., Fiorella, G., Chierichetti, S. M., & Gennari, C. (1983) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-198307000-00006 · Cited by 16 · see citing works
Guanfacine and Other Centrally Acting Drugs in Antihypertensive Therapy; Pharmacological and Clinical Aspects
Saameli, K., Jerie, P., & Scholtysik, G. (1982) · Clinical and Experimental Hypertension · doi:10.3109/10641968209061586 · Cited by 14 · see citing works

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Inhibition and the right inferior frontal cortex: one decade on
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Self-citation
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Self-citation
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Self-citation
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Cognitive enhancement as a treatment for drug addictions
Sofuoglu, M., DeVito, E. E., Waters, A. J., & Carroll, K. M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.021 · Cited by 296 · see citing works
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Dissecting impulsivity and its relationships to drug addictions
Jentsch, J. D., Ashenhurst, J. R., Cervantes, M. C., Groman, S. M., James, A. S., & Pennington, Z. T. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12388 · Cited by 281 · see citing works
Differential roles of medial prefrontal subregions in the regulation of drug seeking
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Twenty-Five Lessons from Computational Neuromodulation
Dayan, P. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.027 · Cited by 190 · see citing works
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Self-citation
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Mueller, A., Hong, D. S., Shepard, S., & Moore, T. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.03.009 · Cited by 158 · see citing works
Neural mechanisms regulating different forms of risk-related decision-making: Insights from animal models
Orsini, C. A., Moorman, D. E., Young, J. W., Setlow, B., & Floresco, S. B. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.009 · Cited by 153 · see citing works
Rapid-response impulsivity: Definitions, measurement issues, and clinical implications.
Hamilton, K. R., Littlefield, A. K., Anastasio, N. C., Cunningham, K. A., Fink, L. H. L., Wing, V. C., Mathias, C. W., Lane, S. D., Schütz, C. G., Swann, A. C., et al. (2015) · Personality Disorders Theory Research and Treatment · doi:10.1037/per0000100 · Cited by 150 · see citing works
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Beste, C., Steenbergen, L., Sellaro, R., Grigoriadou, S., Zhang, R., Chmielewski, W. X., Stock, A., & Colzato, L. S. (2016) · Brain stimulation · doi:10.1016/j.brs.2016.07.004 · Cited by 140 · see citing works
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Self-citation
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Self-citation
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Self-citation
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Self-citation
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Pan, N., Wang, S., Zhao, Y., Lai, H., Qin, K., Li, J., Biswal, B. B., Sweeney, J. A., & Gong, Q. (2021) · Human Brain Mapping · doi:10.1002/hbm.25361 · Cited by 102 · see citing works
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Self-citation
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Self-citation
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Self-citation
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Self-citation
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Discriminative Inhibitory Control of Cocaine Seeking Involves the Prelimbic Prefrontal Cortex
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Self-citation
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Catecholamine receptors differentially mediate impulsive choice in the medial prefrontal and orbitofrontal cortex
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Prefrontal neuromodulation by nicotinic receptors for cognitive processes
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Prenatal nicotine exposure decreases the release of dopamine in the medial frontal cortex and induces atomoxetine-responsive neurobehavioral deficits in mice
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Neuro-Cognitive Effects of Acute Tyrosine Administration on Reactive and Proactive Response Inhibition in Healthy Older Adults
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Prefrontal D1 dopamine signaling is necessary for temporal expectation during reaction time performance
Parker, K. L., Alberico, S. L., Miller, A., & Narayanan, N. S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.09.057 · Cited by 46 · see citing works
Pharmacological inactivation of the prelimbic cortex emulates compulsive reward seeking in rats
Limpens, J. H. W., Damsteegt, R., Broekhoven, M. H., Voorn, P., & Vanderschuren, L. J. M. J. (2014) · Brain Research · doi:10.1016/j.brainres.2014.10.045 · Cited by 44 · see citing works
Prefrontal Cortical Connectivity Mediates Locus Coeruleus Noradrenergic Regulation of Inhibitory Control in Older Adults
Tomassini, A., Hezemans, F. H., Ye, R., Tsvetanov, K. A., Wolpe, N., & Rowe, J. B. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1361-21.2022 · Cited by 45 · see citing works
Noradrenergic α2A-receptor stimulation in the ventral hippocampus reduces impulsive decision-making
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Schevernels, H., van Bochove, M. E., Taeye, L. D., Bombeke, K., Vonck, K. E. J., Roost, D. V., Herdt, V. D., Santens, P., Raedt, R., & Boehler, C. N. (2016) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2016.09.014 · Cited by 45 · see citing works
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Donny, E. C., Taylor, T. G., LeSage, M. G., Levin, M., Buffalari, D. M., Joel, D., & Sved, A. F. (2012) · Nicotine & Tobacco Research · doi:10.1093/ntr/nts162 · Cited by 44 · see citing works
Role of medial prefrontal and orbitofrontal monoamine transporters and receptors in performance in an adjusting delay discounting procedure
Yates, J. R., Perry, J. L., Meyer, A. C., Gipson, C. D., Charnigo, R. J., & Bardo, M. T. (2014) · Brain Research · doi:10.1016/j.brainres.2014.06.004 · Cited by 42 · see citing works
Cortical dopamine release during a behavioral response inhibition task
Albrecht, D., Kareken, D. A., Christian, B. T., Džemidžić, M., & Yoder, K. K. (2014) · Synapse · doi:10.1002/syn.21736 · Cited by 41 · see citing works
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Humby, T., Eddy, J. B., Good, M. A., Reichelt, A. C., & Wilkinson, L. S. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.112 · Cited by 41 · see citing works
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Prenatal Nicotine Exposure Impairs Executive Control Signals in Medial Prefrontal Cortex
Bryden, D. W., Burton, A. C., Barnett, B. R., Cohen, V. J., Hearn, T. N., Jones, E. A. A., Kariyil, R., Kunin, A., Kwak, S. I., Lee, J., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.197 · Cited by 38 · see citing works
Alcohol Withdrawal Syndrome
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A novel continuous inhibitory-control task: variation in individual performance by young pheasants (Phasianus colchicus)
Meier, C., Pant, S. R., van Horik, J. O., Laker, P. R., Langley, E., Whiteside, M., Verbruggen, F., & Madden, J. R. (2017) · Animal Cognition · doi:10.1007/s10071-017-1120-8 · Cited by 35 · see citing works
Olfactory identification deficits and associated response inhibition in obsessive-compulsive disorder: On the scent of the orbitofronto–striatal model
Bersani, G., Quartini, A., Ratti, F., Pagliuca, G., & Gallo, A. (2013) · Psychiatry Research · doi:10.1016/j.psychres.2013.05.032 · Cited by 34 · see citing works
Adolescent methylphenidate treatment differentially alters adult impulsivity and hyperactivity in the Spontaneously Hypertensive Rat model of ADHD
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The beneficial effects of meditation: contribution of the anterior cingulate and locus coeruleus.
Craigmyle, N. A. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00731 · Cited by 32 · see citing works
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Gutman, A. L., Ewald, V. A. M., Cosme, C. V., Worth, W. R., & LaLumiere, R. T. (2016) · Addiction Biology · doi:10.1111/adb.12434 · Cited by 32 · see citing works
Dissecting Impulsivity: Brain Mechanisms and Neuropsychiatric Implications
Robbins, T. W., & Dalley, J. W. (2017) · Nebraska Symposium on Motivation/The Nebraska symposium on motivation · doi:10.1007/978-3-319-51721-6_7 · Cited by 30 · see citing works
Self-citation
Guanfacine enhances inhibitory control and attentional shifting in early abstinent cocaine-dependent individuals
Fox, H., Sofuoglu, M., & Sinha, R. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881114562464 · Cited by 30 · see citing works
The contribution of medial prefrontal cortical regions to conditioned inhibition.
Meyer, H. C., & Bucci, D. J. (2014) · Behavioral Neuroscience · doi:10.1037/bne0000023 · Cited by 30 · see citing works
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Tricklebank, M. D., Robbins, T. W., Simmons, C., & Wong, E. H. F. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05787-x · Cited by 30 · see citing works
Self-citation
Functional Coupling of the Locus Coeruleus Is Linked to Successful Cognitive Control
Grueschow, M., Kleim, B., & Ruff, C. C. (2022) · Brain Sciences · doi:10.3390/brainsci12030305 · Cited by 30 · see citing works
Proactive and reactive inhibitory control in rats
Mayse, J. D., Nelson, G. M., Park, P., Gallagher, M., & Lin, S. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00104 · Cited by 29 · see citing works
Effects of disrupting medial prefrontal cortex GABA transmission on decision-making in a rodent gambling task
Paine, T. A., O’Hara, A., Plaut, B., & Lowes, D. C. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3816-7 · Cited by 29 · see citing works
Pharmacological treatment of cognitive deficits in nondementing mental health disorders
Robbins, T. W. (2019) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2019.21.3/trobbins · Cited by 27 · see citing works
Self-citation
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Rinehart, L., & Spencer, S. M. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110066 · Cited by 27 · see citing works
MPTP-induced executive dysfunction is associated with altered prefrontal serotonergic function
Maiti, P., Gregg, L. C., & McDonald, M. P. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.09.014 · Cited by 26 · see citing works
Prefrontal regulation of behavioural control: Evidence from learning theory and translational approaches in rodents
Turner, K. M., & Parkes, S. L. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.07.010 · Cited by 25 · see citing works
Atomoxetine effects on attentional bias to drug-related cues in cocaine dependent individuals
Passamonti, L., Luijten, M., Ziauddeen, H., Coyle-Gilchrist, I. T. S., Rittman, T., Brain, S. A. E., Regenthal, R., Franken, I. H. A., Sahakian, B. J., Bullmore, E. T., et al. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4643-4 · Cited by 25 · see citing works
Self-citation
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Geisler, C. E., Décarie-Spain, L., Loh, M. K., Trumbauer, W., Gaisinsky, J., Klug, M. E., Pelletier, C., Davis, J. F., Schmidt, H. D., Roitman, M. F., et al. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.07.011 · Cited by 24 · see citing works
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SIROHI, S. K., & Walker, B. M. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13279 · Cited by 23 · see citing works
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Somkuwar, S. S., Kantak, K., & Dwoskin, L. (2015) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2015.02.002 · Cited by 20 · see citing works
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Farr, O. M., Hu, S., Matuskey, D., Zhang, S., Abdelghany, O., & Li, C. R. (2013) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0034465 · Cited by 23 · see citing works
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Zhuang, Q., Qiao, L., Xu, L., Yao, S., Chen, S., Zheng, X., Li, J., Fu, M., Li, K., Vatansever, D., et al. (2023) · Psychoradiology · doi:10.1093/psyrad/kkad016 · Cited by 21 · see citing works
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Randall, P. A., McElligott, Z. A., & Besheer, J. (2019) · Addiction Biology · doi:10.1111/adb.12782 · Cited by 22 · see citing works
Neurochemical substrates linked to impulsive and compulsive phenotypes in addiction: A preclinical perspective
Jones, J. A., Zühlsdorff, K., & Dalley, J. W. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15380 · Cited by 22 · see citing works
Dissociable effects of systemic and orbitofrontal administration of adrenoceptor antagonists on yohimbine-induced motor impulsivity
Adams, W. K., Barrus, M. M., Zeeb, F. D., Cocker, P. J., Benoit, J., & Winstanley, C. A. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.03.034 · Cited by 20 · see citing works
Frontal White Matter Damage Impairs Response Inhibition in Children Following Traumatic Brain Injury
Lipszyc, J., Levin, H., Hanten, G., Hunter, J., Dennis, M., & Schachar, R. (2014) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acu004 · Cited by 20 · see citing works
The 5-HT1A/1B-receptor agonist eltoprazine increases both catecholamine release in the prefrontal cortex and dopamine release in the nucleus accumbens and decreases motivation for reward and “waiting” impulsivity, but increases “stopping” impulsivity
Korte, S. M., Prins, J., van den Bergh, F. S., Oosting, R. S., Dupree, R., Korte-Bouws, G. A. H., Westphal, K. G. C., Olivier, B., Denys, D. A. J. P., Garland, A., et al. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.11.024 · Cited by 19 · see citing works
The ever-changing OFC landscape: What neural signals in OFC can tell us about inhibitory control.
Brockett, A. T., & Roesch, M. R. (2020) · Behavioral Neuroscience · doi:10.1037/bne0000412 · Cited by 20 · see citing works
Effective Use of Animal Models for Therapeutic Development in Psychiatric and Substance Use Disorders
Phillips, A. G., Geyer, M. A., & Robbins, T. W. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.01.014 · Cited by 19 · see citing works
Self-citation
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Stobernack, T., de Vries, S. P. W., Pereira, R. R., Pelsser, L. M. J., ter Braak, C. J. F., Aarts, E., van Baarlen, P., Kleerebezem, M., Frankena, K., & Hontelez, S. (2019) · BMJ Open · doi:10.1136/bmjopen-2019-029422 · Cited by 17 · see citing works
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Blaes, S. L., Shimp, K. G., Betzhold, S. M., Setlow, B., & Orsini, C. A. (2022) · Behavioral Neuroscience · doi:10.1037/bne0000509 · Cited by 17 · see citing works
Medial prefrontal cortex lesions disrupt prepotent action selection signals in dorsomedial striatum
Brockett, A. T., Tennyson, S. S., deBettencourt, C. A., Kallmyer, M., & Roesch, M. R. (2022) · Current Biology · doi:10.1016/j.cub.2022.06.025 · Cited by 17 · see citing works
Nucleus accumbens responses differentiate execution and restraint in reward-directed behavior
Roitman, J. D., & Loriaux, A. L. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00350.2013 · Cited by 16 · see citing works
Impulsivity, Risky Choice, and Impulse Control Disorders
Robbins, T. W., & Dalley, J. W. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-805308-9.00007-5 · Cited by 16 · see citing works
Self-citation
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Kennett, A., Heal, D. J., & Wonnacott, S. (2012) · Nicotine & Tobacco Research · doi:10.1093/ntr/nts128 · Cited by 15 · see citing works
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Zaehle, T., & Krauel, K. (2021) · Progress in brain research · doi:10.1016/bs.pbr.2021.03.001 · Cited by 17 · see citing works

Behavioural, neurochemical and neuroanatomical analysis of stop-signal task performance in rats
Bari, A. (2011) · OpenGrey (Institut de l'Information Scientifique et Technique)
Self-citation
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Bari, A., Eagle, D. M., Mar, A. C., Robinson, E. S. J., & Robbins, T. W. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1537-0 · Cited by 194 · see citing works
Self-citation
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Bari, A., & Robbins, T. W. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3141-6 · Cited by 105 · see citing works
Self-citation
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Self-citation
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Self-citation

Authors: Bari, A., Mar, A. C., Theobald, D. E., Elands, S. A., Oganya, K. C. N. A., Eagle, D. M., & Robbins, T. W.
Affiliations: University of Cambridge (GB)
Corresponding author: Bari, A.
ORCID: Bari, A.
Mar, A. C.
Eagle, D. M.
Robbins, T. W.
Venue: Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2011-06-22
Volume: 31
Issue: 25
Pages: 9254-9263
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.1543-11.2011
PMC: PMC3145112
OpenAlex: W2056110254
Cited by: 188
References: 100
Citations by year: 2026: 4 · 2025: 1 · 2024: 29 · 2023: 8 · 2022: 8 · 2021: 16 · 2020: 8 · 2019: 6 · 2018: 5 · 2017: 16 · 2016: 14 · 2015: 19 · 2014: 20 · 2013: 20 · 2012: 13
FWCI: 8.60
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Eli Lilly and Company
Wellcome Trust (089589/Z/09/Z, 089589, 093875)
University of Cambridge
Medical Research Council (G0001354, 089589/Z/09/Z)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Keywords: stop-signal task, response inhibition, prefrontal cortex, dorsomedial prefrontal cortex, orbitofrontal cortex, norepinephrine, dopamine, atomoxetine, guanfacine, alpha-flupenthixol, impulsivity, attention deficit hyperactivity disorder, addiction, muscimol inactivation, rats
MeSH terms: Animals, Impulsive Behavior, Male, Neural Inhibition, Psychomotor Performance, Biogenic Monoamines, Prefrontal Cortex, Rats

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Prefrontal and monoaminergic contributions to stop-signal task performance in rats

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