The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Boosting Focally-Induced Brain Plasticity by Dopamine
Abstract
Dopamine (DA) simultaneously produces both excitation and inhibition in the human cortex. In order to shed light on the functional significance of these seemingly opposing effects, we administered the DA precursor levodopa (L-dopa) to healthy subjects in conjunction with 2 neuroplasticity-inducing motor cortex stimulation protocols. Transcranial direct current stimulation (tDCS) induces cortical excitability enhancement by anodal and depression by cathodal brain polarization, which is not restricted to specific subgroups of synapses. In contrast, paired associative stimulation (PAS) induces focal excitability enhancements of somatosensory and motor cortical neuronal synaptic connections. Here, we show that administering L-dopa turns the unspecific excitability enhancement caused by anodal tDCS into inhibition and prolongs the cathodal tDCS-induced excitability diminution. Conversely, it stabilizes the PAS-induced synapse-specific excitability increase. Most importantly, it prolongs all of these aftereffects by a factor of about 20. Hereby, DA focuses synapse-specific excitability-enhancing neuroplasticity in human cortical networks.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Ketamine arrests pathologic bursting in the lateral habenula and rebalances prefrontal microcircuits, producing fast antidepressant effects that nevertheless require stabilization to curb relapse [76,364].”
From Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery (2026) · cites this paper as [364]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans
Nitsche, M. A., & Paulus, W. (2001) · Neurology · doi:10.1212/wnl.57.10.1899 · Cited by 2,617
Self-citationCORTICAL PLASTICITY: From Synapses to Maps
Buonomano, D. V., & Merzenich, M. M. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.149 · Cited by 2,083
The principal features and mechanisms of dopamine modulation in the prefrontal cortex
Seamans, J. K., & Yang, C. R. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.006 · Cited by 1,592
Nitsche, M. A., Fricke, K., Henschke, U., Schlitterlau, A., Liebetanz, D., Lang, N., Henning, S. J., Tergau, F., & Paulus, W. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049916 · Cited by 1,587
Self-citationInduction of plasticity in the human motor cortex by paired associative stimulation
Stefan, K. (2000) · Brain · doi:10.1093/brain/123.3.572 · Cited by 1,484
Learning-Induced LTP in Neocortex
Rioult-Pedotti, M.-S., Friedman, D. J., & Donoghue, J. P. (2000) · Science · doi:10.1126/science.290.5491.533 · Cited by 1,014
INTRACELLULAR ACTIVITIES AND EVOKED POTENTIAL CHANGES DURING POLARIZATION OF MOTOR CORTEX.
Purpura, D., & McMurtry, J. G. (1965) · Journal of Neurophysiology · doi:10.1152/jn.1965.28.1.166 · Cited by 875
Level of action of cathodal DC polarisation induced inhibition of the human motor cortex
Nitsche, M. A., Nitsche, M. S., Klein, C. C., Tergau, F., Rothwell, J. C., & Paulus, W. (2003) · Clinical Neurophysiology · doi:10.1016/s1388-2457(02)00412-1 · Cited by 751
Self-citationStefan, K., Kunesch, E., Benecke, R., Cohen, L. G., & Claßen, J. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.023317 · Cited by 643
A temporally asymmetric Hebbian rule governing plasticity in the human motor cortex.
Wolters, A., Sandbrink, F., Schlottmann, A., Kunesch, E., Stefan, K., Cohen, L., Benecke, R., & Classen, J. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00900.2002 · Cited by 633
Extrathalamic Modulation Of Cortical Function
Foote, S. L., & Morrison, J. (1987) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.10.030187.000435 · Cited by 489
Effects of bromocriptine on human subjects depend on working memory capacity
Kimberg, D. Y., DʼEsposito, M., & Farah, M. J. (1997) · Neuroreport · doi:10.1097/00001756-199711100-00032 · Cited by 413
Gurden, H., Takita, M., & Jay, T. M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-22-j0003.2000 · Cited by 366
Nitsche, M. A., Lampe, C., Antal, A., Liebetanz, D., Lang, N., Tergau, F., & Paulus, W. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04676.x · Cited by 359
Self-citationUnder the curve: Critical issues for elucidating D1 receptor function in working memory
Williams, G. V., & Castner, S. A. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.09.028 · Cited by 326
D1- Versus D2-Receptor Modulation of Visuospatial Working Memory in Humans
Müller, U., von Cramon, D. Y., & Pollmann, S. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02720.1998 · Cited by 326
Facilitation of Working Memory in Humans by a D2 Dopamine Receptor Agonist
Luciana, M. M., Depue, R. A., Arbisi, P. A., & Leon, A. S. (1992) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1992.4.1.58 · Cited by 273
Levodopa: Faster and better word learning in normal humans
Knecht, S., Breitenstein, C., Bushuven, S., Wailke, S., Kamping, S., Flöel, A., Zwitserlood, P., & Ringelstein, E. B. (2004) · Annals of Neurology · doi:10.1002/ana.20125 · Cited by 252
Mehta, M. A., Swainson, R., Ogilvie, A. D., Sahakian, B., & Robbins, T. W. (2001) · Psychopharmacology · doi:10.1007/s002130100851 · Cited by 235
Floresco, S., & Phillips, A. G. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.4.934 · Cited by 231
A Neurocomputational Theory of the Dopaminergic Modulation of Working Memory Functions
Durstewitz, D., Kelc, M., & Güntürkün, O. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-07-02807.1999 · Cited by 229
Mehta, M. A., Sahakian, B. J., McKenna, P. J., & Robbins, T. W. (1999) · Psychopharmacology · doi:10.1007/s002130051102 · Cited by 223
Altered plasticity of the human motor cortex in Parkinson's disease
Ueki, Y., Mima, T., Kotb, M. A., Sawada, H., Saiki, H., Ikeda, A., Begum, T., Reza, F., Nagamine, T., & Fukuyama, H. (2005) · Annals of Neurology · doi:10.1002/ana.20692 · Cited by 215
The two sides of associative plasticity in writer's cramp
Weise, D. (2006) · Brain · doi:10.1093/brain/awl221 · Cited by 198
Dopamine facilitates long-term depression of glutamatergic transmission in rat prefrontal cortex
Otani, S., Blond, O., Desce, J. M., & Crépel, F. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00677-5 · Cited by 196
Dopaminergic influences on formation of a motor memory
Flöel, A., Breitenstein, C., Hummel, F. C., Celnik, P. A., Gingert, C., Sawaki, L. A., Knecht, S., & Cohen, L. G. (2005) · Annals of Neurology · doi:10.1002/ana.20536 · Cited by 187
Role of Dopamine in Learning and Memory
Kulisevsky, J. (2000) · Drugs & Aging · doi:10.2165/00002512-200016050-00006 · Cited by 183
Dopaminergic Modulation of Working Memory for Spatial but Not Object Cues in Normal Humans
Luciana, M. M., & Collins, P. F. (1997) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1997.9.3.330 · Cited by 172
Sawaguchi, T., Matsumura, M., & Kubota, K. (1990) · Journal of Neurophysiology · doi:10.1152/jn.1990.63.6.1385 · Cited by 169
Plasticity of the hippocampal-prefrontal cortex synapses
Jay, T. M., Burette, F., & Laroche, S. (1996) · Journal of Physiology-Paris · doi:10.1016/s0928-4257(97)87920-x · Cited by 113
Catecholamines in the Central Nervous System
Grace, A. A., Gerfen, C. R., & Aston‐Jones, G. (1997) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60836-4 · Cited by 69
A Model of Prefrontal Cortex Dopaminergic Modulation during the Delayed Alternation Task
Dreher, J., Guigon, E., & Burnod, Y. (2002) · Journal of Cognitive Neuroscience · doi:10.1162/089892902760191081 · Cited by 45
The modulatory effects of dopamine D1 and D2 receptor function on object working memory in humans
Bartholomeusz, C. F., Box, G., Rooy, C. V., & Nathan, P. J. (2003) · Journal of Psychopharmacology · doi:10.1177/0269881103017001688 · Cited by 32
Flagged first, then by citations
Research works printed but not linked: 2
- 1998, Advances in pharmacology, 42, 655
- 2000, Journal of Neuroscience, 20106, 1
Cited by
Sorted by citations
Transcranial direct current stimulation: State of the art 2008
Nitsche, M. A., Cohen, L. G., Wassermann, E. M., Priori, A., Lang, N., Antal, A., Paulus, W., Hummel, F., Boggio, P. S., Fregni, F., et al. (2008) · Brain Stimulation · doi:10.1016/j.brs.2008.06.004 · Cited by 3,057
Self-citationPhysiological basis of transcranial direct current stimulation
Stagg, C. J., & Nitsche, M. A. (2011) · The Neuroscientist · doi:10.1177/1073858410386614 · Cited by 1,719
Self-citationBrunoni, A. R., Nitsche, M. A., Bolognini, N., Bikson, M., Wagner, T., Merabet, L., Edwards, D. J., Valero-Cabre, A., Rotenberg, A., Pascual-Leone, A., et al. (2012) · Brain stimulation · doi:10.1016/j.brs.2011.03.002 · Cited by 1,445
Self-citationBatsikadze, G., Moliadze, V., Paulus, W., Kuo, M. ‐., & Nitsche, M. A. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.249730 · Cited by 1,017
Self-citationMusical Training as a Framework for Brain Plasticity: Behavior, Function, and Structure
Herholz, S. C., & Zatorre, R. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.10.011 · Cited by 976
Metadata
- Authors
- Kuo, M.-F., Paulus, W., & Nitsche, M. A.
- Affiliations
- University of Göttingen (DE)
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-06-24
- Volume
- 18
- Issue
- 3
- Pages
- 648-651
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2170170290
- Cited by
- 269
- References
- 33
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 12 · 2023: 9 · 2022: 13 · 2021: 15 · 2020: 6 · 2019: 17 · 2018: 11 · 2017: 19 · 2016: 13 · 2015: 22 · 2014: 23 · 2013: 12 · 2012: 19
- FWCI
- 10.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Keywords
- dopamine, levodopa, neuroplasticity, transcranial direct current stimulation, paired associative stimulation, motor cortex excitability, synaptic plasticity, anodal tDCS, cathodal tDCS, aftereffects, human cortex
- MeSH terms
- Adult, Dopamine, Female, Humans, Male, Motor Cortex, Neural Inhibition, Neuronal Plasticity, Evoked Potentials, Motor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
