Cholinergic modulation of response gain in the primary visual cortex of the macaque
Abstract
ACh modulates neuronal activity throughout the cerebral cortex, including the primary visual cortex (V1). However, a number of issues regarding this modulation remain unknown, such as the effect and its function and the receptor subtypes involved. To address these issues, we combined extracellular single-unit recordings and microiontophoretic administration of ACh and measured V1 neuronal responses to drifting sinusoidal grating stimuli in anesthetized macaque monkeys. ACh was found to have mostly facilitatory effects on the visual responses, although some cases of suppressive effects were also seen. To assess the functional role of ACh, we further examined how ACh modulates the stimulus contrast-response function, finding that the response gain increased with the facilitatory effect. The response facilitation was completely or strongly blocked by atropine (At), a muscarinic ACh receptor (mAChR) antagonist, in almost all neurons (96% of cells), whereas any residual effect after At administration was fully removed by mecamylamine, a nicotinic AChR (nAChR) antagonist, suggesting a predominant role for mAChRs in this mechanism. Furthermore, we found no laminar distribution bias for the facilitatory modulation, although the relative contribution of mAChRs was smaller in layer 4C than in other layers. The suppressive effect was blocked completely by At. These results demonstrate that ACh plays an important role in visual information processing in V1 by controlling the response gain via mAChRs across all cortical layers and via nAChRs, mainly in layer 4C.
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Stimulation of nicotinic ACh receptors with nicotine in macaque V1 causes increases in firing rates and gain modulation of sensory-evoked activity in thalamo-recipient cortical layers and has various effects in other layers.
“Stimulation of nicotinic ACh receptors (nAChRs) with nicotine in macaque V1 causes increases in firing rates and gain modulation of sensory-evoked activity in the thalamo-recipient cortical layers and has various effects in other layers165,170,171”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [171]
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Intrinsic Control Mechanisms of Neuronal Network Dynamics
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Catecholaminergic neuromodulation and selective attention jointly shape perceptual decision makingPreprint
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Catecholaminergic neuromodulation and selective attention jointly shape perceptual decision-making
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is mediated by GABAergic inhibition Cholinergic suppression of visual responses in primate V1
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Catecholaminergic neuromodulation and selective attention jointly shape perceptual decision-makingPreprint
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Catecholaminergic neuromodulation and selective attention jointly shape perceptual decision-makingPreprint
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- Authors
- Soma, S., Shimegi, S., Osaki, H., & Sato, H.
- Affiliations
- Graduate Schools of 1Frontier Biosciences and
- The University of Osaka (JP)
- Corresponding author
- Shimegi, Satoshi
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 2012-01
- Volume
- 107
- Issue
- 1
- Pages
- 283-291
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W2039917259
- Cited by
- 75
- References
- 41
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 10 · 2022: 2 · 2021: 5 · 2020: 8 · 2019: 2 · 2018: 4 · 2017: 5 · 2016: 6 · 2015: 3 · 2014: 8 · 2013: 11 · 2012: 6
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (24500460, 21500369)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- acetylcholine, primary visual cortex, cholinergic modulation, muscarinic receptors, nicotinic acetylcholine receptors, response gain, contrast response function, atropine, mecamylamine, cortical laminar distribution, visual processing, macaque
- MeSH terms
- Acetylcholine, Animals, Macaca, Photic Stimulation, Receptors, Muscarinic, Visual Cortex, Visual Perception, Cholinergic Neurons
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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