The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Intermediate Neuronal Progenitors (Basal Progenitors) Produce Pyramidal–Projection Neurons for All Layers of Cerebral Cortex
Open accessAbstract
The developing cerebral cortex contains apical and basal types of neurogenic progenitor cells. Here, we investigated the cellular properties and neurogenic output of basal progenitors, also called intermediate neuronal progenitors (INPs). We found that basal mitoses expressing transcription factor Tbr2 (an INP marker) were present throughout corticogenesis, from embryonic day 10.5 through birth. Postnatally, Tbr2(+) progenitors were present in the dentate gyrus, subventricular zone (SVZ), and posterior periventricle (pPV). Two morphological subtypes of INPs were distinguished in the embryonic cortex, "short radial" in the ventricular zone (VZ) and multipolar in the SVZ, probably corresponding to molecularly defined INP subtypes. Unexpectedly, many short radial INPs appeared to contact the apical (ventricular) surface and some divided there. Time-lapse video microscopy suggested that apical INP divisions produced daughter INPs. Analysis of neurogenic divisions (Tis21-green fluorescent protein [GFP](+)) indicated that INPs may produce the majority of projection neurons for preplate, deep, and superficial layers. Conversely, proliferative INP divisions (Tis21-GFP(-)) increased from early to middle corticogenesis, concomitant with SVZ growth. Our findings support the hypothesis that regulated amplification of INPs may be an important factor controlling the balance of neurogenesis among different cortical layers.
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Citations
Cites
Specification of Cerebral Cortical Areas
Rakic, P. (1988) · Science · doi:10.1126/science.3291116 · Cited by 3,127 · cited 1×
“Previous studies suggested that Pax6, Ngn2, and Tbr2 are part of a transcription factor cascade (Pax6 / Ngn2 / Tbr2 / Tbr1) that is central to the gene expression program for glutamatergic neurogenesis (reviewed in Hevner 2006; Hevner et al. 2006).”
BackgroundNoctor, S. C., Martínez-Cerdeño, V., Ivic, L., & Kriegstein, A. R. (2004) · Nature Neuroscience · doi:10.1038/nn1172 · Cited by 2,229
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Self-citationA gene expression atlas of the central nervous system based on bacterial artificial chromosomes
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Self-citationDevelopment of the human cerebral cortex: Boulder Committee revisited
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Tbr1 regulates differentiation of the preplate and layer 6
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Self-citationRole of Intermediate Progenitor Cells in Cerebral Cortex Development
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Cited by
Development and Evolution of the Human Neocortex
Lui, J. H., Hansen, D. V., & Kriegstein, A. R. (2011) · Cell · doi:10.1016/j.cell.2011.06.030 · Cited by 1,342
Neurogenic radial glia in the outer subventricular zone of human neocortex
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Molecular logic of neocortical projection neuron specification, development and diversity
Greig, L. C., Woodworth, M. B., Galazo, M. J., Padmanabhan, H., & Macklis, J. D. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3586 · Cited by 863
OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling
Fietz, S. A., Kelava, I., Vogt, J., Wilsch-Bräuninger, M., Stenzel, D., Fish, J. L., Corbeil, D., Riehn, A., Distler, W., Nitsch, R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2553 · Cited by 830
Self-citationA single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex
Zhong, S., Zhang, S., Fan, X., Wu, Q., Yan, L., Dong, J., Zhang, H., Li, L., Sun, L., Pan, N., et al. (2018) · Nature · doi:10.1038/nature25980 · Cited by 689
Metadata
- Authors
- Kowalczyk, T., Pontious, A., Englund, C., Daza, R. A. M., Bedogni, F., Hodge, R., Attardo, A., Bell, C., Huttner, W. B., & Hevner, R. F.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-01-23
- Volume
- 19
- Issue
- 10
- Pages
- 2439-2450
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2101147969
- Cited by
- 409
- References
- 13
- FWCI
- 9.02
- Type
- journal article
- Language
- en
- Open access
- green
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- Kowalczyk, T., Pontious, A., Englund, C., Daza, R. A. M., Bedogni, F., Hodge, R., Attardo, A., Bell, C., Huttner, W. B., & Hevner, R. F. (2009). Intermediate Neuronal Progenitors (Basal Progenitors) Produce Pyramidal–Projection Neurons for All Layers of Cerebral Cortex. Cerebral Cortex. https://doi.org/10.1093/cercor/bhn260
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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