The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Differentiating Heavy from Light Drinkers by Neural Responses to Visual Alcohol Cues and Other Motivational Stimuli
Open accessAbstract
The course to alcohol dependence often starts with a preclinical period of heavy drinking. The present article reports functional magnetic resonance imaging data showing that even this pattern of alcohol consumption is associated with maladaptive neural responses to alcohol and other stimuli. When participants were confronted with visual cues related to alcohol, heavy drinkers showed amplified blood oxygen level-dependent signal responses in specific emotional areas (insular cortex) and in parts of the brain's reward circuitry (ventral striatum). This neuronal amplification was not present in light drinkers. Crucially, at the same time heavy drinkers showed reduced responses in frontal areas to pictures related to higher order life goals and in the cingulate cortex to appetitive food stimuli, suggesting that they have difficulty finding alternative, socially desirable goals. Using discriminant function analysis, we demonstrate that the combination of alcohol-related overactivation and underactivation to alternative goals allows heavy and light drinkers to be differentiated with a high degree of precision. Our findings highlight the diagnostic value of functional brain mapping of cue reactivity. Imaging measures may help to identify addictive dispositions in preclinical stages and to clarify the mechanisms that underlie the development and maintenance of alcohol dependence.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Heavy alcohol drinkers had an increased BOLD fMRI signal in response to alcohol cues in the insula (it was significant in the left insula and a trend in the right) and the ventral striatum compared to light drinkers.”
From The Insula: A Brain Stimulation Target for the Treatment of Addiction (2019) · cites this paper as Ihssen et al., 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Measuring emotion: The self-assessment manikin and the semantic differential
Bradley, M. M., & Lang, P. J. (1994) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/0005-7916(94)90063-9 · Cited by 9,538
Rizzolatti, G., & Craighero, L. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144230 · Cited by 7,433
(2005) · CTIT technical reports series · Cited by 5,307
Forman, S. D., Cohen, J. D., Fitzgerald, M., Eddy, W. F., Mintun, M. A., & Noll, D. C. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910330508 · Cited by 3,202
Cattaneo, L., & Rizzolatti, G. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.41 · Cited by 3,137
Grasping the intentions of others with one's own mirror neuron system
Iacoboni, M., Molnar-Szakacs, I., Gallese, V., Buccino, G., Mazziotta, J. C., & Rizzolatti, G. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030079 · Cited by 2,044 · cited 1×
“of action but also to process ‘‘action intentions/goals’’ (Iacoboni et al. 2005).”
Logothetis, N. K., & Wandell, B. A. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.082602.092845 · Cited by 1,568
A motivational model of alcohol use.
Cox, W. M., & Klinger, E. (1988) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.97.2.168 · Cited by 1,477
A motivational model of alcohol use.
Cox, W. M., & Klinger, E. (1988) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.97.2.168 · Cited by 1,114
Self-citationNeural correlates of conscious self-regulation of emotion
Beauregard, M., Lévesque, J., & Bourgouin, P. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-j0001.2001 · Cited by 1,033
Research works printed but not linked: 4
- 2007, 44, 364
- Heinz, 2004, American Journal of Psychiatry, 161, 1783, 10.1176/appi.ajp.161.10.1783 · DOI · Paper page
- 2003, 39, 1053
- 1999, 37, 989
Cited by
Sorted by citations
Schacht, J. P., Anton, R. F., & Myrick, H. (2013) · Addiction Biology · doi:10.1111/j.1369-1600.2012.00464.x · Cited by 583
Jasinska, A. J., Stein, E. A., Kaiser, J., Naumer, M. J., & Yalachkov, Y. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.10.013 · Cited by 513
Identifying Neurobiological Phenotypes Associated with Alcohol Use Disorder Severity
Claus, E. D., Ewing, S. W. F., Filbey, F. M., Sabbineni, A., & Hutchison, K. E. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.99 · Cited by 251
Lawrence, N. S., Hinton, E. C., Parkinson, J. A., & Lawrence, A. D. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.06.070 · Cited by 242
Goal Commitments and the content of thoughts and dreams: basic principles
Klinger, E. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00415 · Cited by 210
Metadata
- Authors
- Ihssen, N., Cox, W. M., Wiggett, A., Fadardi, J. S., & Linden, D. E. J.
- Affiliations
- Bangor University (GB)
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-11-02
- Volume
- 21
- Issue
- 6
- Pages
- 1408-1415
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2118964880
- Cited by
- 157
- References
- 33
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 3 · 2021: 8 · 2020: 51 · 2019: 9 · 2018: 4 · 2017: 12 · 2016: 10 · 2015: 10 · 2014: 10 · 2013: 9 · 2012: 11
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- Durham Research Online (Durham University) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- heavy drinking, alcoholism, alcohol cue reactivity, insula, ventral striatum, reward systems, frontal cortex, cingulate cortex, food cues, goal-directed behavior
- MeSH terms
- Adult, Alcohol Drinking, Alcohols, Analysis of Variance, Brain, Brain Mapping, Cues, Emotions, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Motivation, Oxygen, Photic Stimulation, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
