Cited by 157Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Differentiating Heavy from Light Drinkers by Neural Responses to Visual Alcohol Cues and Other Motivational Stimuli

Open access

Ihssen, N., Cox, W. M., Wiggett, A., Fadardi, J. S., Linden, D. E. J.·2011·Cerebral Cortex

DOI 10.1093/cercor/bhq220

Open this paper in CoChat — free account Open PDF

Abstract

The course to alcohol dependence often starts with a preclinical period of heavy drinking. The present article reports functional magnetic resonance imaging data showing that even this pattern of alcohol consumption is associated with maladaptive neural responses to alcohol and other stimuli. When participants were confronted with visual cues related to alcohol, heavy drinkers showed amplified blood oxygen level-dependent signal responses in specific emotional areas (insular cortex) and in parts of the brain's reward circuitry (ventral striatum). This neuronal amplification was not present in light drinkers. Crucially, at the same time heavy drinkers showed reduced responses in frontal areas to pictures related to higher order life goals and in the cingulate cortex to appetitive food stimuli, suggesting that they have difficulty finding alternative, socially desirable goals. Using discriminant function analysis, we demonstrate that the combination of alcohol-related overactivation and underactivation to alternative goals allows heavy and light drinkers to be differentiated with a high degree of precision. Our findings highlight the diagnostic value of functional brain mapping of cue reactivity. Imaging measures may help to identify addictive dispositions in preclinical stages and to clarify the mechanisms that underlie the development and maintenance of alcohol dependence.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/cercor/bhq220

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Measuring emotion: The self-assessment manikin and the semantic differential
Bradley, M. M., & Lang, P. J. (1994) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/0005-7916(94)90063-9 · Cited by 9,538
THE MIRROR-NEURON SYSTEM
Rizzolatti, G., & Craighero, L. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144230 · Cited by 7,433
Untitled work
(2005) · CTIT technical reports series · Cited by 5,307
Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold
Forman, S. D., Cohen, J. D., Fitzgerald, M., Eddy, W. F., Mintun, M. A., & Noll, D. C. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910330508 · Cited by 3,202
The mirror neuron system
Cattaneo, L., & Rizzolatti, G. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.41 · Cited by 3,137
Grasping the intentions of others with one's own mirror neuron system
Iacoboni, M., Molnar-Szakacs, I., Gallese, V., Buccino, G., Mazziotta, J. C., & Rizzolatti, G. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030079 · Cited by 2,044 · cited 1×
“of action but also to process ‘‘action intentions/goals’’ (Iacoboni et al. 2005).”
Interpreting the BOLD Signal
Logothetis, N. K., & Wandell, B. A. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.082602.092845 · Cited by 1,568
A motivational model of alcohol use.
Cox, W. M., & Klinger, E. (1988) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.97.2.168 · Cited by 1,477
A motivational model of alcohol use.
Cox, W. M., & Klinger, E. (1988) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.97.2.168 · Cited by 1,114
Self-citation
Neural correlates of conscious self-regulation of emotion
Beauregard, M., Lévesque, J., & Bourgouin, P. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-j0001.2001 · Cited by 1,033

Show all 33 references

Research works printed but not linked: 4

2007, 44, 364
Heinz, 2004, American Journal of Psychiatry, 161, 1783, 10.1176/appi.ajp.161.10.1783 · DOI · Paper page
2003, 39, 1053
1999, 37, 989

Sorted by citations

Functional neuroimaging studies of alcohol cue reactivity: A quantitative meta-analysis and systematic review
Schacht, J. P., Anton, R. F., & Myrick, H. (2013) · Addiction Biology · doi:10.1111/j.1369-1600.2012.00464.x · Cited by 583
Factors modulating neural reactivity to drug cues in addiction: a survey of human neuroimaging studies
Jasinska, A. J., Stein, E. A., Kaiser, J., Naumer, M. J., & Yalachkov, Y. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.10.013 · Cited by 513
Identifying Neurobiological Phenotypes Associated with Alcohol Use Disorder Severity
Claus, E. D., Ewing, S. W. F., Filbey, F. M., Sabbineni, A., & Hutchison, K. E. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.99 · Cited by 251
Nucleus accumbens response to food cues predicts subsequent snack consumption in women and increased body mass index in those with reduced self-control
Lawrence, N. S., Hinton, E. C., Parkinson, J. A., & Lawrence, A. D. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.06.070 · Cited by 242
Goal Commitments and the content of thoughts and dreams: basic principles
Klinger, E. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00415 · Cited by 210
Reward processing in obesity, substance addiction and non‐substance addiction
García‐García, I., Horstmann, A., Jurado, M. Á., Garolera, M., Chaudhry, S. J., Margulies, D. S., Villringer, A., & Neumann, J. (2014) · Obesity Reviews · doi:10.1111/obr.12221 · Cited by 177
Striatal ups and downs: Their roles in vulnerability to addictions in humans
Leyton, M., & Vezina, P. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.01.018 · Cited by 165
Motivation and the Goal Theory of Current Concerns
Klinger, E., & Cox, W. M. (2011) · Wiley eBooks · doi:10.1002/9780470979952.ch1 · Cited by 165
Pathways to alcohol-induced brain impairment in young people: A review
Hermens, D. F., Lagopoulos, J., Tobias‐Webb, J., Regt, T. D., Dore, G., Juckes, L., Latt, N. C., & Hickie, I. B. (2012) · Cortex · doi:10.1016/j.cortex.2012.05.021 · Cited by 163
The Insula: A Brain Stimulation Target for the Treatment of Addiction
Ibrahim, C., Rubin-Kahana, D. S., Pushparaj, A., Musiol, M., Blumberger, D. M., Daskalakis, Z. J., Zangen, A., & Le Foll, B. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00720 · Cited by 133
Response Inhibition during Cue Reactivity in Problem Gamblers: An fMRI Study
van Holst, R. J., van Holstein, M., van den Brink, W., Veltman, D. J., & Goudriaan, A. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030909 · Cited by 139
Functional neuroimaging studies in addiction: Multisensory drug stimuli and neural cue reactivity
Yalachkov, Y., Kaiser, J., & Naumer, M. J. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.004 · Cited by 125
Functional magnetic resonance imaging ( fMRI) response to alcohol pictures predicts subsequent transition to heavy drinking in college students
Dager, A. D., Anderson, B. M., Rosen, R., Khadka, S., Sawyer, B. A., Jiantonio‐Kelly, R. E., Austad, C. S., Raskin, S. A., Tennen, H. A., Wood, R. M., et al. (2013) · Addiction · doi:10.1111/add.12437 · Cited by 101
Applying incentive sensitization models to behavioral addiction
Thomsen, K. R., Fjorback, L. O., Møller, A., & Lou, H. C. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.07.009 · Cited by 103
Neuroimaging in alcohol use disorder: From mouse to man
Fritz, M., Klawonn, A. M., & Zahr, N. M. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24423 · Cited by 89
Evidence for incentive salience sensitization as a pathway to alcohol use disorder
Cofresí, R. U., Bartholow, B. D., & Piasecki, T. M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.009 · Cited by 94
Neurofeedback training for alcohol dependence versus treatment as usual: study protocol for a randomized controlled trial
Cox, W. M., Subramanian, L., Linden, D. E. J., Lührs, M., McNamara, R. L., Playle, R., Hood, K., Watson, G. L., Whittaker, J. R., Sakhuja, R., et al. (2016) · Trials · doi:10.1186/s13063-016-1607-7 · Cited by 91
Alcohol craving in adolescents: bridging the laboratory and natural environment
Ramirez, J. J., & Miranda, R. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3372-6 · Cited by 77
Resting‐State Synchrony in Short‐Term Versus Long‐Term Abstinent Alcoholics
Camchong, J., Stenger, V. A., & Fein, G. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12037 · Cited by 79
“Wanting,” “liking,” and their relation to consciousness.
Anselme, P., & Robinson, M. J. F. (2015) · Journal of Experimental Psychology Animal Learning and Cognition · doi:10.1037/xan0000090 · Cited by 82
Is addiction a brain disease? A plea for agnosticism and heterogeneity
Pickard, H. (2021) · Psychopharmacology · doi:10.1007/s00213-021-06013-4 · Cited by 74
Vulnerability to alcohol‐related problems: a policy brief with implications for the regulation of alcohol marketing
Babor, T. F., Robaina, K., Noel, J. K., & Ritson, E. B. (2016) · Addiction · doi:10.1111/add.13626 · Cited by 66
The Cambridge Handbook of Substance and Behavioral Addictions
Sussman, S. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591 · Cited by 64
Individualized relapse prediction: Personality measures and striatal and insular activity during reward-processing robustly predict relapse
Gowin, J. L., Ball, T. M., Wittmann, M., Tapert, S. F., & Paulus, M. P. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.04.018 · Cited by 64
Perspectives on fronto-fugal circuitry from human imaging of alcohol use disorders
Zahr, N. M., Adolf Pfefferbaum, A., & Sullivan, E. V. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.018 · Cited by 67
Addictions Neuroclinical Assessment: A reverse translational approach
Kwako, L. E., Momenan, R., Grodin, E. N., Litten, R. Z., Koob, G. F., & Goldman, D. A. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.03.006 · Cited by 67
How Acute and Chronic Alcohol Consumption Affects Brain Networks: Insights from Multimodal Neuroimaging
Schulte, T., Oberlin, B. G., Kareken, D. A., Marinković, K., Müller‐Oehring, E. M., Meyerhoff, D. J., & Tapert, S. F. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2012.01831.x · Cited by 64
Adolescent heavy drinkers' amplified brain responses to alcohol cues decrease over one month of abstinence
Brumback, T., Squeglia, L. M., Jacobus, J., Pulido, C., Tapert, S. F., & Brown, S. A. (2015) · Addictive Behaviors · doi:10.1016/j.addbeh.2015.03.001 · Cited by 64
On Cue: Striatal Ups and Downs in Addictions
Leyton, M., & Vezina, P. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.04.036 · Cited by 53
Executive Control and Striatal Resting-State Network Interact with Risk Factors to Influence Treatment Outcomes in Alcohol-Use Disorder
Kohno, M., Dennis, L. E., McCready, H. D., & Hoffman, W. F. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00182 · Cited by 58
Real-time fMRI brain-computer interface: development of a “motivational feedback” subsystem for the regulation of visual cue reactivity
Sokunbi, M. O., Linden, D. E. J., Isabelle, H., Johnston, S. J., & Ihssen, N. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00392 · Cited by 52
Activation in inhibitory brain regions during food choice correlates with temptation strength and self-regulatory success in weight-concerned women
van der Laan, L. N., de Ridder, D. T. D., Viergever, M. A., & Smeets, P. A. M. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00308 · Cited by 49
Neural mechanisms of high‐risk decisions‐to‐drink in alcohol‐dependent women
Arcurio, L. R., Finn, P., & James, T. W. (2013) · Addiction Biology · doi:10.1111/adb.12121 · Cited by 50
Behavioral Economic Considerations of Novel Addictions and Nonaddictive Behavior: Research and Analytic Methods
Reed, D. D., Naudé, G. P., Gelino, B. W., & Amlung, M. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.011 · Cited by 48
The Prevention and Treatment of Gambling Disorders: Some Art, Some Science
Derevensky, J. L. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.024 · Cited by 45
Considering the Overlap and Nonoverlap of Compulsivity, Impulsivity, and Addiction
Blum, A. W., & Grant, J. E. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.038 · Cited by 44
Neurobiological Foundations of Behavioral Addictions
Vaccaro, A. G., & Potenza, M. N. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.016 · Cited by 45
Neurobiology of Substance Addictions
Christie, N. C., & Bechara, A. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.015 · Cited by 44
Sensitization of Incentive Salience and the Transition to Addiction
Warlow, S. M., Baumgartner, H. M., Freeland, C. M., Naffziger, E. E., Olney, J. J., Berridge, K. C., & Robinson, M. J. F. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.006 · Cited by 46
Mindfulness-Based Interventions Applied to Addiction Treatments
Kechter, A., & Black, D. S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.040 · Cited by 43
Multiple Memory Systems, Addiction, and Health Habits: New Routes for Translational Science
Stacy, A. W., Pike, J. R., & Lee, A. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.017 · Cited by 43
Tanning as an Addiction: The State of the Research and Implications for Intervention
Miller, K. A., & Mays, D. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.037 · Cited by 43
Food versus Eating Addictions
Schulte, E. M., Schiestl, E. T., & Gearhardt, A. N. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.035 · Cited by 43
Interoception and alcohol: Mechanisms, networks, and implications
Lovelock, D. F., Tyler, R. E., & Besheer, J. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108807 · Cited by 44
Modulation of sensitivity to alcohol by cortical and thalamic brain regions
Jaramillo, A. A., Randall, P. A., Frisbee, S., & Besheer, J. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13374 · Cited by 42
Behavioral Economics and Addictive Disorders
Jarmolowicz, D. P., & Schneider, T. D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.005 · Cited by 42
Prevention and Treatment of Compulsive Buying Disorder
Galimov, A., & Black, D. W. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.027 · Cited by 42
Precision Behavioral Management (PBM): A Novel Genetically Guided Therapy to Combat Reward Deficiency Syndrome (RDS) Relevant to the Opiate Crisis
Blum, K., Roy, A. K., Podesta, A., Modestino, E. J., Steinberg, B., Gondré-Lewis, M. C., Baron, D. A., Thanos, P. K., Lott, L., Badgaiyan, S., et al. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.031 · Cited by 42
Prevention and Treatment of “Food Addiction”
Davis, C., & Mason, A. E. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.023 · Cited by 42
Human Neurobiological Approaches to Hedonically Motivated Behaviors
Burger, K. S., Shearrer, G. E., & Sadler, J. R. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.009 · Cited by 42
Feedback Models for Gambling Control: The Use and Efficacy of Online Responsible Gambling Tools
Griffiths, M. D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.034 · Cited by 42
The motivational basis of cognitive determinants of addictive behaviors
Cox, W. M., Klinger, E., & Fadardi, J. S. (2015) · Addictive Behaviors · doi:10.1016/j.addbeh.2014.11.019 · Cited by 41
Self-citation
Alcohol-cue exposure effects on craving and attentional bias in underage college-student drinkers.
Ramirez, J. J., Monti, P. M., & Colwill, R. M. (2014) · Psychology of Addictive Behaviors · doi:10.1037/adb0000028 · Cited by 42
Mindful attention promotes control of brain network dynamics for self-regulation and discontinues the past from the present
Zhou, D., Kang, Y., Cosme, D., Jovanova, M., He, X., Mahadevan, A. S., Ahn, J., Stanoi, O. A., Brynildsen, J. K., Cooper, N., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2201074119 · Cited by 44
Alcohol use and interoception – A narrative review
Wiśniewski, P., Maurage, P., Jakubczyk, A., Trucco, E. M., Suszek, H., & Kopera, M. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110397 · Cited by 46
Binge drinking is associated with altered resting state functional connectivity of reward-salience and top down control networks
Arienzo, D., Happer, J. P., Molnar, S. M., Alderson‐Myers, A., & Marinković, K. (2019) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00107-6 · Cited by 39
A reward and incentive-sensitization perspective on compulsive use of social networking sites – Wanting but not liking predicts checking frequency and problematic use behavior
Ihssen, N., & Wadsley, M. G. (2020) · Addictive Behaviors · doi:10.1016/j.addbeh.2020.106808 · Cited by 42
Neuroplasticity in Human Alcoholism: Studies of Extended Abstinence with Potential Treatment Implications
Fein, G. (2015) · Alcohol research · doi:10.35946/arcr.v37.1.09 · Cited by 38
Impaired Processing of 3D Motion-Defined Faces in Mild Cognitive Impairment and Healthy Aging: An fMRI Study
Graewe, B., Lemos, R., Ferreira, C., Santana, I. J., Farivar, R., Weerd, P. D., & Castelo-Branco, M. S. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs246 · Cited by 36
Pattern classification of valence in depression
Habes, I., Krall, S. C., Johnston, S. J., Yuen, K. S. L., Healy, D., Goebel, R., Sorger, B., & Linden, D. E. J. (2013) · NeuroImage Clinical · doi:10.1016/j.nicl.2013.05.001 · Cited by 34
Reward System Activation in Response to Alcohol Advertisements Predicts College Drinking
Courtney, A. L., Rapuano, K. M., Sargent, J. D., Heatherton, T. F., & Kelley, W. M. (2017) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2018.79.29 · Cited by 35
The nucleus accumbens and alcoholism: a target for deep brain stimulation
Ho, A. L., Salib, A.-M. N., Pendharkar, A. V., Sussman, E. S., Giardino, W. J., & Halpern, C. H. (2018) · Neurosurgical FOCUS · doi:10.3171/2018.5.focus18157 · Cited by 34
Targeting the Salience Network: A Mini-Review on a Novel Neuromodulation Approach for Treating Alcohol Use Disorder
Padula, C. B., Tenekedjieva, L., McCalley, D. M., Al-Dasouqi, H., Hanlon, C. A., Williams, L. M., Kozel, F. A., Knutson, B. D., Durazzo, T. C., Yesavage, J. A., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.893833 · Cited by 36
How Do We ‘Learn' Addiction? Risk Factors and Mechanisms Getting Addicted to Alcohol
Hägele, C., Friedel, E., Kienast, T., & Kiefer, F. (2014) · Neuropsychobiology · doi:10.1159/000364825 · Cited by 33
Brain Network Allostasis after Chronic Alcohol Drinking Is Characterized by Functional Dedifferentiation and Narrowing
Pérez‐Ramírez, Ú., López‐Madrona, V. J., Pérez-Segura, A., Pallarés, V., Moreno, A., Ciccocioppo, R., Hyytiä, P., Sommer, W. H., Moratal, D., & Canals, S. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0389-21.2022 · Cited by 27
Review of Orbitofrontal Cortex in Alcohol Dependence: A Disrupted Cognitive Map?
Shields, C. N., & Gremel, C. M. (2020) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14441 · Cited by 26
The Impact of Acamprosate on Cue Reactivity in Alcohol Dependent Individuals
Langosch, J. M., Spiegelhalder, K., Jahnke, K., Feige, B., Regen, W., Kiemen, A., Hennig, J., & Olbrich, H. M. (2012) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318267b586 · Cited by 24
The Galician Beverage Picture Set (GBPS): A standardized database of alcohol and non-alcohol images
López‐Caneda, E., & Carbia, C. (2018) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2017.11.022 · Cited by 28
Reward Prediction Errors in Drug Addiction and Parkinson’s Disease: from Neurophysiology to Neuroimaging
García‐García, I., Zeighami, Y., & Dagher, A. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0755-9 · Cited by 28
Instrumental and Pavlovian Mechanisms in Alcohol Use Disorder
Doñamayor, N., Ebrahimi, C., Garbusow, M., Wedemeyer, F., Schlagenhauf, F., & Heinz, A. (2020) · Current Addiction Reports · doi:10.1007/s40429-020-00333-9 · Cited by 24
Craving and acute effects of alcohol in youths’ daily lives: Associations with alcohol use disorder severity.
Padovano, H. T., & Miranda, R. (2017) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000133 · Cited by 21
EEG coherence related to fMRI resting state synchrony in long-term abstinent alcoholics
Cardenas, V. A., Price, M., & Fein, G. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.11.008 · Cited by 21
Neural Evidence for Emotional Involvement in Pathological Alcohol Craving
Lee, E. M., Ku, J. H., Jung, Y., Lee, H., An, S. K., Kim, K. R., Yoon, K.-J., & Namkoong, K. (2012) · Alcohol and Alcoholism · doi:10.1093/alcalc/ags130 · Cited by 22
Neuroscience of attentional processes for addiction medicine
Fadardi, J. S., Cox, W. M., & Rahmani, A. (2015) · Progress in brain research · doi:10.1016/bs.pbr.2015.08.002 · Cited by 20
Sensory cue reactivity: Sensitization in alcohol use disorder and obesity
Agarwal, K., Manza, P., Leggio, L., Livinski, A. A., Volkow, N. D., & Joseph, P. V. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.014 · Cited by 19
Neurofeedback Training versus Treatment-as-Usual for Alcohol Dependence: Results of an Early-Phase Randomized Controlled Trial and Neuroimaging Correlates
Subramanian, L., Skottnik, L., Cox, W. M., Lührs, M., McNamara, R. L., Hood, K., Watson, G. L., Whittaker, J. R., Williams, A. N., Sakhuja, R., et al. (2021) · European Addiction Research · doi:10.1159/000513448 · Cited by 20
Pattern classification predicts individuals’ responses to affective stimuli
Yuen, K. S. L., Johnston, S. J., Martino, F. D., Sorger, B., Formisano, E., Linden, D. E. J., & Goebel, R. (2012) · Translational Neuroscience · doi:10.2478/s13380-012-0029-6 · Cited by 19
Maximizing the utility of a single site randomized controlled psychotherapy trial
Norman, S. B., Haller, M. M., Spadoni, A. D., Drummond, S. P. A., Risbrough, V. B., Hamblen, J. L., Trim, R. S., & Blanes, E. X. (2015) · Contemporary Clinical Trials · doi:10.1016/j.cct.2015.04.011 · Cited by 17
To drink or not to drink: Harmful drinking is associated with hyperactivation of reward areas rather than hypoactivation of control areas in men
Stuke, H., Gutwinski, S., Wiers, C. E., Schmidt, T. T., Gröpper, S., Parnack, J., Gawron, C. K., Attar, C. H., Spengler, S., Walter, H., et al. (2016) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.150203 · Cited by 19
Development of stimulus material for research in alcohol use disorders
Fey, W., Moggi, F., Rohde, K., Michel, C., Seitz, A., & Stein, M. (2016) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.1527 · Cited by 17
American Alcohol Photo Stimuli (AAPS): A standardized set of alcohol and matched non-alcohol images
Stauffer, C. S., Dobberteen, L., & Woolley, J. D. (2016) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2016.1253093 · Cited by 18
Free will in addictive behaviors: A matter of definition
Cox, W. M., Klinger, E., & Fadardi, J. S. (2017) · Addictive Behaviors Reports · doi:10.1016/j.abrep.2017.03.001 · Cited by 17
Model-Free Temporal-Difference Learning and Dopamine in Alcohol Dependence: Examining Concepts From Theory and Animals in Human Imaging
Huys, Q. J. M., Deserno, L., Obermayer, K., Schlagenhauf, F., & Heinz, A. (2016) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2016.06.005 · Cited by 18
Brain responses to anticipating and receiving beer: Comparing light, at‐risk, and dependent alcohol users
Groefsema, M. M., Engels, R. C. M. E., Voon, V., Schellekens, A., Luijten, M., & Sescousse, G. (2019) · Addiction Biology · doi:10.1111/adb.12766 · Cited by 12
Appetitive Needs and Addiction
Sussman, S. Y., & Pakdaman, S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.004 · Cited by 12
Purpose in life, Neural Alcohol Cue Reactivity, and Daily Alcohol Use in Social Drinkers.
Kang, Y., Cosme, D., Lydon-Staley, D., Ahn, J., Jovanova, M., Corbani, F., Lomax, S., Stanoi, O. A., Strecher, V., Mucha, P., et al. (2022) · Addiction · doi:10.1111/add.16012 · Cited by 13
Further support for association between GWAS variant for positive emotion and reward systems
Lancaster, T. M., Ihssen, N., Brindley, L. M., & Linden, D. E. J. (2017) · Translational Psychiatry · doi:10.1038/tp.2016.289 · Cited by 12
Alcohol Cue Processing in Co-Occurring Bipolar Disorder and Alcohol Use Disorder
Mellick, W. H., Tolliver, B. K., Brenner, H. M., Anton, R. F., & Prisciandaro, J. J. (2023) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2023.2726 · Cited by 11
Brain activation to cannabis- and alcohol-related words in alcohol use disorder
Müller‐Oehring, E. M., Berre, A. L., Serventi, M. R., Kalon, E., Haas, A. L., Padula, C. B., & Schulte, T. (2019) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2019.111005 · Cited by 12
Exploring Attentional Bias toward Alcohol Content: Insights from Eye-Movement Activity
Ghiţă, A., Hernández-Serrano, O., Moreno, M., Monràs, M., Gual, A., Maurage, P., Gacto‐Sánchez, M., Ferrer‐García, M., Porras-García, B., & Gutiérrez‐Maldonado, J. (2024) · European Addiction Research · doi:10.1159/000536252 · Cited by 10
Affective Perception: The Power Is in the Picture
Bradley, M. M., Sambuco, N., & Lang, P. J. (2021) · Springer eBooks · doi:10.1007/978-3-030-81465-6_3 · Cited by 10
Insula Dynorphin and Kappa Opioid Receptor Systems Regulate Alcohol Drinking in a Sex-Specific Manner in Mice
Pina, M. M., Pati, D., Neira, S., Taxier, L. R., Stanhope, C. M., Mahoney, A. A., D’Ambrosio, S., Kash, T. L., & Navarro, M. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0406-22.2023 · Cited by 10
Striatal ups or downs? Neural correlates of monetary reward anticipation, cue reactivity and their interaction in alcohol use disorder and gambling disorder
van Timmeren, T., van Holst, R. J., & Goudriaan, A. E. (2023) · Journal of Behavioral Addictions · doi:10.1556/2006.2023.00015 · Cited by 9
Conscious and unconscious brain responses to food and cocaine cues
Wiers, C. E., Zhao, J., Manza, P., Murani, K., Ramirez, V., Zehra, A., Freeman, C. R., Yuan, K., Wang, G., Demiral, Ş. B., et al. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00258-x · Cited by 9
Assessment on interoceptive awareness on alcohol use and gambling disorders reveals dissociable interoceptive abilities linked to external and internal dependencies: Practical use of Body Perception Questionnaire Very Short Form (BPQ‐VSF) in clinical settings
London, G., Hida, H., Kagaya, A., Yamawaki, S., & Machizawa, M. G. (2024) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12424 · Cited by 7
Online Gaming Behavior And Psychosocial Well-Being In Greek Adolescents
Pappa, E., Apergi, F.-S., Ventouratou, R., Janikian, M., & Beratis, I. (2015) · The European Journal of Social & Behavioural Sciences · doi:10.15405/ejsbs.180 · Cited by 8
The role of social stimuli content in neuroimaging studies investigating alcohol cue-reactivity
Groefsema, M. M., Engels, R. C. M. E., & Luijten, M. (2016) · Addictive Behaviors · doi:10.1016/j.addbeh.2016.02.033 · Cited by 10
Qualitative Approaches to the Study of Substance and Behavioral Addictions
Simpson, K. A., & Bluthenthal, R. N. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.013 · Cited by 10
Brain Activation Associated with Automatic Processing of Alcohol-Related Cues in Young Heavy Drinkers and Its Modulation by Alcohol Administration
Kreusch, F., Goffaux, V., Siep, N., Houben, K., Quertemont, É., & Wiers, R. W. H. J. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12835 · Cited by 8
Wege in die Abhängigkeit
Garbusow, M., Friedel, E., Sebold, M., Beck, A., Heinz, A., & Smolka, M. N. (2013) · SUCHT - Zeitschrift für Wissenschaft und Praxis / Journal of Addiction Research and Practice · doi:10.1024/0939-5911.a000254 · Cited by 7

Authors: Ihssen, N., Cox, W. M., Wiggett, A., Fadardi, J. S., & Linden, D. E. J.
Affiliations: Bangor University (GB)
ORCID: Ihssen, N.
Cox, W. M.
Fadardi, J. S.
Linden, D. E. J.
Venue: Cerebral Cortex
Publisher: Oxford University Press (OUP)
Published: 2010-11-02
Volume: 21
Issue: 6
Pages: 1408-1415
ISSN: 1047-3211 (ISSN-L)
1460-2199
DOI: 10.1093/cercor/bhq220
OpenAlex: W2118964880
Cited by: 157
References: 33
Citations by year: 2026: 2 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 3 · 2021: 8 · 2020: 51 · 2019: 9 · 2018: 4 · 2017: 12 · 2016: 10 · 2015: 10 · 2014: 10 · 2013: 9 · 2012: 11
FWCI: 5.35
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Cerebral Cortex (publishedVersion)
PubMed (publishedVersion)
Durham Research Online (Durham University) (submittedVersion, cc-by)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: heavy drinking, alcoholism, alcohol cue reactivity, insula, ventral striatum, reward systems, frontal cortex, cingulate cortex, food cues, goal-directed behavior
MeSH terms: Adult, Alcohol Drinking, Alcohols, Analysis of Variance, Brain, Brain Mapping, Cues, Emotions, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Motivation, Oxygen, Photic Stimulation, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Differentiating Heavy from Light Drinkers by Neural Responses to Visual Alcohol Cues and Other Motivational Stimuli

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks