Functional neuroimaging studies of alcohol cue reactivity: A quantitative meta-analysis and systematic review
Open accessAbstract
A comprehensive understanding of the neurobiology of alcohol cue reactivity is critical in identifying the neuropathology of alcohol use disorders (AUD) and developing treatments that may attenuate alcohol craving and reduce relapse risk. Functional neuroimaging studies have identified many brain areas in which alcohol cues elicit activation. However, extant studies have included relatively small numbers of cases, with AUD of varying severity, and have employed many different cue paradigms. We used activation likelihood estimation, a quantitative, coordinate-based meta-analytic method, to analyze the brain areas activated by alcohol-related cues across studies, and to examine whether these areas were differentially activated between cases and controls. Secondarily, we reviewed correlations between behavioral measures and cue-elicited activation, as well as treatment effects on such activation. Data analyzed were from 28 studies of 679 cases and 174 controls. Among cases, alcohol cues elicited robust activation of limbic and prefrontal regions, including ventral striatum, anterior cingulate and ventromedial prefrontal cortex. As compared to controls, cases demonstrated greater activation of parietal and temporal regions, including posterior cingulate, precuneus and superior temporal gyrus. Cue-elicited activation of ventral striatum was most frequently correlated with behavioral measures and most frequently reduced by treatment, but these results were often derived from region-of-interest analyses that interrogated only limbic regions. These findings support long-standing theories of mesolimbic involvement in alcohol cue processing, but suggest that cue-elicited activation of other brain areas may more clearly differentiate cases from controls. Prevention and treatment for AUD should consider interventions that may reduce cue-elicited activation of these areas.
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Neuroimaging studies consistently demonstrate that exposure to alcohol cues increases activation in the NAc and striatum, which is correlated with subjective alcohol craving.
“Neuroimaging studies consistently demonstrate that exposure to alcohol cues increases activation in the NAc and striatum, which is correlated with subjective alcohol craving”
From A Narrative Review of Current and Emerging Trends in the Treatment of Alcohol Use Disorder (2024) · cites this paper as [113]
The Discussion reports robust alcohol-cue activation in the ventral striatum, including a cluster encompassing the nucleus accumbens. The Results report correlations between ventral-striatal activation and in vivo craving in 3 of 5 relevant studies. The claim overstates the consistency of that correlation and does not distinguish the ventral striatum from the nucleus accumbens specifically; the Discussion also cautions that many correlations came from region-of-interest analyses. (LLM, conf=0.86)
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- Authors
- Schacht, J. P., Anton, R. F., & Myrick, H.
- Affiliations
- Medical University of South Carolina (US)
- Corresponding author
- Schacht, Joseph P.
- Venue
- Addiction Biology
- Publisher
- Wiley
- Published
- 2012-05-10
- Volume
- 18
- Issue
- 1
- Pages
- 121-133
- ISSN
- 1355-6215 (ISSN-L)
- 1369-1600
- PMC
- PMC3419322
- OpenAlex
- W1551563638
- Cited by
- 583
- References
- 85
- Citations by year
- 2026: 18 · 2025: 33 · 2024: 108 · 2023: 40 · 2022: 45 · 2021: 43 · 2020: 42 · 2019: 52 · 2018: 33 · 2017: 33 · 2016: 39 · 2015: 43 · 2014: 33 · 2013: 18 · 2012: 3
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Addiction Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA017633, K05AA017435, P50AA010761, T32AA007474)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- alcohol cue reactivity, alcoholism, alcohol craving, relapse risk, ventral striatum, mesolimbic system, anterior cingulate cortex, ventromedial prefrontal cortex, posterior cingulate cortex, precuneus, superior temporal gyrus, alcohol prevention
- MeSH terms
- Ethanol, Basal Ganglia, Brain, Cues, Data Interpretation, Statistical, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Tomography, Emission-Computed, Single-Photon, Case-Control Studies, Behavior, Addictive, Prefrontal Cortex, Alcohol-Related Disorders, Positron-Emission Tomography, Functional Neuroimaging
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