The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
The Impact of Vaccination on Coronavirus Disease 2019 (COVID-19) Outbreaks in the United States
Open accessAbstract
Background: Global vaccine development efforts have been accelerated in response to the devastating coronavirus disease 2019 (COVID-19) pandemic. We evaluated the impact of a 2-dose COVID-19 vaccination campaign on reducing incidence, hospitalizations, and deaths in the United States. Methods: We developed an agent-based model of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission and parameterized it with US demographics and age-specific COVID-19 outcomes. Healthcare workers and high-risk individuals were prioritized for vaccination, whereas children under 18 years of age were not vaccinated. We considered a vaccine efficacy of 95% against disease following 2 doses administered 21 days apart achieving 40% vaccine coverage of the overall population within 284 days. We varied vaccine efficacy against infection and specified 10% preexisting population immunity for the base-case scenario. The model was calibrated to an effective reproduction number of 1.2, accounting for current nonpharmaceutical interventions in the United States. Results: Vaccination reduced the overall attack rate to 4.6% (95% credible interval [CrI]: 4.3%–5.0%) from 9.0% (95% CrI: 8.4%–9.4%) without vaccination, over 300 days. The highest relative reduction (54%–62%) was observed among individuals aged 65 and older. Vaccination markedly reduced adverse outcomes, with non-intensive care unit (ICU) hospitalizations, ICU hospitalizations, and deaths decreasing by 63.5% (95% CrI: 60.3%–66.7%), 65.6% (95% CrI: 62.2%–68.6%), and 69.3% (95% CrI: 65.5%–73.1%), respectively, across the same period. Conclusions: Our results indicate that vaccination can have a substantial impact on mitigating COVID-19 outbreaks, even with limited protection against infection. However, continued compliance with nonpharmaceutical interventions is essential to achieve this impact.
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Estimating the effects of non-pharmaceutical interventions on COVID-19 in Europe
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Social Contacts and Mixing Patterns Relevant to the Spread of Infectious Diseases
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Evaluation of Waning of SARS-CoV-2 Vaccine–Induced Immunity: A Systematic Review and Meta-analysis
Menegale, F., Manica, M., Zardini, A., Guzzetta, G., Marziano, V., d'Andrea, V., Trentini, F., Ajelli, M., Poletti, P., & Merler, S. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.10650 · Cited by 280
Lee, B. E. C., Ling, M., Boyd, L., Olsson, C., & Sheen, J. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.03.012 · Cited by 120
Characterizing the spatiotemporal heterogeneity of the COVID-19 vaccination landscape
Tiu, A., Susswein, Z., Merritt, A., & Bansal, S. (2021) · doi:10.1101/2021.10.04.21263345 · Cited by 37
Waning of SARS-CoV-2 vaccine-induced immunity: A systematic review and secondary data analysis
Menegale, F., Manica, M., Zardini, A., Guzzetta, G., Marziano, V., d’Andrea, V., Trentini, F., Ajelli, M., Poletti, P., & Merler, S. (2022) · doi:10.1101/2022.07.04.22277225 · Cited by 1
Metadata
- Authors
- Moghadas, S. M., Vilches, T. N., Zhang, K., Wells, C. R., Shoukat, A., Singer, B. H., Meyers, L. A., Neuzil, K. M., Langley, J. M., Fitzpatrick, M. C., & Galvani, A. P.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2021-01-30
- Volume
- 73
- Issue
- 12
- Pages
- 2257-2264
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W3128361403
- Cited by
- 678
- References
- 39
- FWCI
- 56.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Moghadas, S. M., Vilches, T. N., Zhang, K., Wells, C. R., Shoukat, A., Singer, B. H., Meyers, L. A., Neuzil, K. M., Langley, J. M., Fitzpatrick, M. C., & Galvani, A. P. (2021). The Impact of Vaccination on Coronavirus Disease 2019 (COVID-19) Outbreaks in the United States. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciab079
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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