Relating In Vitro Neutralization Level and Protection in the CVnCoV (CUREVAC) Trial
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Abstract
The vaccine candidate CVnCoV (CUREVAC) showed surprisingly low efficacy in a recent phase 3 trial compared with other messenger RNA (mRNA) vaccines. Here we show that the low efficacy follows from the dose used and the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and is predicted by the neutralizing antibody response induced by the vaccine.
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Neutralizing antibodies are one of the key parameters correlating with the observed protective efficacy of the first-generation SARS-CoV-2 mRNA vaccine CVnCoV and a licensed COVID-19 mRNA vaccine.
“Neutralizing antibodies in the sera of the participants will be assessed since they have been identified as one of the key parameters correlating with the observed protective efficacy of the first generation SARS-CoV-2 mRNA vaccine CVnCoV27, and a licensed COVID-19 mRNA vaccine28.”
From Efficacy of an unmodified bivalent mRNA vaccine against SARS-CoV-2 variants in female small animal models (2023) · cites this paper as [27]
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- Authors
- Cromer, D., Reynaldi, A., Steain, M., Triccas, J. A., Davenport, M. P., & Khoury, D. S.
- Affiliations
- UNSW Sydney (AU)
- The University of Sydney (AU)
- Corresponding author
- Khoury, David S
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2022-02-01
- Volume
- 75
- Issue
- 1
- Pages
- e878-e879
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- PMC
- PMC9383389
- OpenAlex
- W4210340210
- Cited by
- 23
- References
- 13
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 11 · 2022: 7 · 2021: 2
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Clinical Infectious Diseases (publishedVersion)
- medRxiv (acceptedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The Sydney eScholarship Repository (The University of Sydney) (submittedVersion)
- UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by)
- Funders
- Australian Government Medical Research Future Fund (GNT2002073, MRF2005544, MRF2005760, MRF2007221)
- NHMRC (GNT1149990)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- SARS-CoV-2, COVID-19 vaccines, mRNA vaccines, vaccine efficacy, neutralizing antibodies, vaccine dose, SARS-CoV-2 variants, BNT162b2
- MeSH terms
- COVID-19, SARS-CoV-2, COVID-19 Vaccines, Antibodies, Viral, Humans, Viral Vaccines, Antibodies, Neutralizing
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