Cited by 23SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesCOVID-19 Clinical Research Studies

Relating In Vitro Neutralization Level and Protection in the CVnCoV (CUREVAC) Trial

Open access
Cromer, Deborah, Reynaldi, Arnold, Steain, Megan, Triccas, James A, Davenport, Miles P, Khoury, David S·2022·Clinical Infectious Diseases

Published version of a preprint

Abstract

The vaccine candidate CVnCoV (CUREVAC) showed surprisingly low efficacy in a recent phase 3 trial compared with other messenger RNA (mRNA) vaccines. Here we show that the low efficacy follows from the dose used and the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and is predicted by the neutralizing antibody response induced by the vaccine.

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Crossref · 10.1093/cid/ciac075

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  • Neutralizing antibodies are one of the key parameters correlating with the observed protective efficacy of the first-generation SARS-CoV-2 mRNA vaccine CVnCoV and a licensed COVID-19 mRNA vaccine.

    “Neutralizing antibodies in the sera of the participants will be assessed since they have been identified as one of the key parameters correlating with the observed protective efficacy of the first generation SARS-CoV-2 mRNA vaccine CVnCoV27, and a licensed COVID-19 mRNA vaccine28.”

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2 of the 13 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Walsh, E.E., et al. Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates. New England Journal of Medicine 383, 2439-2450 (2020).

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Authors
Cromer, D., Reynaldi, A., Steain, M., Triccas, J. A., Davenport, M. P., & Khoury, D. S.
Affiliations
  • UNSW Sydney (AU)
  • The University of Sydney (AU)
Corresponding author
Khoury, David S
Venue
Clinical Infectious Diseases
Published
2022-02-01
Volume
75
Issue
1
Pages
e878-e879
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
OpenAlex
W4210340210
Cited by
23
References
13
Citations by year
2025: 2 · 2024: 1 · 2023: 11 · 2022: 7 · 2021: 2
FWCI
2.57
Type
journal article
Language
en
Open access
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • medRxiv (acceptedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • The Sydney eScholarship Repository (The University of Sydney) (submittedVersion)
  • UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by)
Funders
  • Australian Government Medical Research Future Fund (GNT2002073, MRF2005544, MRF2005760, MRF2007221)
  • NHMRC (GNT1149990)
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Keywords
SARS-CoV-2, COVID-19 vaccines, mRNA vaccines, vaccine efficacy, neutralizing antibodies, vaccine dose, SARS-CoV-2 variants, BNT162b2
MeSH terms
COVID-19, SARS-CoV-2, COVID-19 Vaccines, Antibodies, Viral, Humans, Viral Vaccines, Antibodies, Neutralizing

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