Dysbiosis anticipating necrotizing enterocolitis in very premature infants

R: A Language and Environment for Statistical Computing

R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,706 · see citing works

QIIME allows analysis of high-throughput community sequencing data

Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works

Search and clustering orders of magnitude faster than BLAST

Edgar, R. C. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq461 · Cited by 20,617 · see citing works

SILVA: a comprehensive online resource for quality checked and aligned ribosomal RNA sequence data compatible with ARB

Pruesse, E., Quast, C., Knittel, K., Fuchs, B. M., Ludwig, W., Peplies, J., & Glöckner, F. O. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm864 · Cited by 6,682 · see citing works

Ribosomal Database Project: data and tools for high throughput rRNA analysis

Cole, J. R., Wang, Q., Fish, J. A., Chai, B., McGarrell, D. M., Sun, Y., Brown, C. T., Porras‐Alfaro, A., Kuske, C. R., & Tiedje, J. M. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1244 · Cited by 4,322 · see citing works

Neonatal Necrotizing Enterocolitis

BELL, M. J., Ternberg, J. L., Feigin, R. D., Keating, J., MARSHALL, R., Barton, L. L., & Brotherton, T. J. (1978) · Annals of Surgery · doi:10.1097/00000658-197801000-00001 · Cited by 3,582 · see citing works

Chimeric 16S rRNA sequence formation and detection in Sanger and 454-pyrosequenced PCR ampliconsPreprint

Haas, B. J., Gevers, D., Earl, A. M., Feldgarden, M., Ward, D. V., Giannoukos, G., Ciulla, D., Tabbaa, D., Highlander, S. K., Sodergren, E. J., et al. (2011) · Genome Research · doi:10.1101/gr.112730.110 · Cited by 3,451 · see citing works

Factors influencing the composition of the intestinal microbiota in early infancy

Penders, J., Thijs, C., Vink, C., Stelma, F. F., Snijders, B., Kummeling, I., van den Brandt, P. A., & Stobberingh, E. E. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2824 · Cited by 2,232 · see citing works

Necrotizing Enterocolitis

Neu, J., & Walker, W. A. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1005408 · Cited by 2,141 · see citing works

Removing Noise From Pyrosequenced Amplicons

Quince, C., Lanzén, A., Davenport, R. J., & Turnbaugh, P. J. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-38 · Cited by 1,584 · see citing works

The influence of sex, handedness, and washing on the diversity of hand surface bacteria

Fierer, N., Hamady, M., Lauber, C. L., & Knight, R. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807920105 · Cited by 1,100 · see citing works

Short term outcomes after extreme preterm birth in England: comparison of two birth cohorts in 1995 and 2006 (the EPICure studies)

Costeloe, K. L., Hennessy, E. M., Haider, S., Stacey, F., Marlow, N., & Draper, E. S. (2012) · BMJ · doi:10.1136/bmj.e7976 · Cited by 816 · see citing works

Neonatal Necrotizing Enterocolitis

Basler, R. S., & Jones, H. E. (1978) · New England Journal of Medicine · doi:10.1056/nejm197802022980519 · Cited by 722 · see citing works

Mortality of necrotizing enterocolitis expressed by birth weight categories

Fitzgibbons, S., Ching, Y., Yu, D. C., Carpenter, J., Kenny, M. J., Weldon, C. B., Lillehei, C. W., Valim, C., Horbar, J. D., & Jaksic, T. (2009) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2009.02.013 · Cited by 614 · see citing works

Prolonged Initial Empirical Antibiotic Treatment is Associated with Adverse Outcomes in Premature Infants

Kuppala, V. S., Meinzen‐Derr, J. K., Morrow, A. L., & Schibler, K. R. (2011) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2011.05.033 · Cited by 613 · see citing works

16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis

Wang, Y., Hoenig, J. D., Malin, K. J., Qamar, S., Petrof, E. O., Sun, J., Antonopoulos, D. A., Chang, E. B., & Claud, E. C. (2009) · The ISME Journal · doi:10.1038/ismej.2009.37 · Cited by 598 · see citing works

Patterned progression of bacterial populations in the premature infant gut

Rosa, P. S. L., Warner, B. B., Zhou, Y., Weinstock, G. M., Sodergren, E. J., Hall-Moore, C. M., Stevens, H. J., Bennett, W. E., Shaikh, N., Linneman, L. A., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409497111 · Cited by 573 · see citing works

Fecal Microbiota in Premature Infants Prior to Necrotizing Enterocolitis

Mai, V., Young, C., Ukhanova, M., Wang, X., Sun, Y., Casella, G., Theriaque, D. W., Li, N., Sharma, R. R., Hudak, M. L., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020647 · Cited by 503 · see citing works

Establishment and development of intestinal microbiota in preterm neonates

Arboleya, S., Binetti, A. G., Salazar, N., Fernández, N., Sánchez, G. S., Hernández‐Barranco, A. M., Margollés, A., Reyes‐Gavilán, C. G. D. L., & Gueimonde, M. (2011) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2011.01261.x · Cited by 439 · see citing works

Neonatal necrotizing enterocolitis: Pathogenesis, classification, and spectrum of illness

Kliegman, R. M., & Walsh, M. C. (1987) · Current Problems in Pediatrics · doi:10.1016/0045-9380(87)90031-4 · Cited by 418 · see citing works

Hypothesis: inappropriate colonization of the premature intestine can cause neonatal necrotizing enterocolitis

Claud, E. C., & Walker, W. A. (2001) · The FASEB Journal · doi:10.1096/fj.00-0833hyp · Cited by 415 · see citing works

Early Empiric Antibiotic Use in Preterm Infants Is Associated with Lower Bacterial Diversity and Higher Relative Abundance of Enterobacter

Greenwood, C., Morrow, A. L., Lagomarcino, A. J., Altaye, M., Taft, D. H., Yu, Z., Newburg, D. S., Ward, D. V., & Schibler, K. R. (2014) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2014.01.010 · Cited by 410 · see citing works

The Roles of Bacteria and TLR4 in Rat and Murine Models of Necrotizing Enterocolitis

Jilling, T., Simon, D., Lu, J. N., Meng, F. J., Li, D., Schy, R., Thomson, R. B., Soliman, A., Arditi, M., & Caplan, M. S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.5.3273 · Cited by 395 · see citing works

Beta2 toxin, a novel toxin produced by Clostridium perfringens

Gibert, M., Jolivet-Renaud, C., & Popoff, M. R. (1997) · Gene · doi:10.1016/s0378-1119(97)00493-9 · Cited by 295 · see citing works

Emerging trends in acquired neonatal intestinal disease: is it time to abandon Bell's criteria?

Gordon, P. V., Swanson, J. R., Attridge, J. T., & Clark, R. H. (2007) · Journal of Perinatology · doi:10.1038/sj.jp.7211782 · Cited by 201 · see citing works

Redefining the Role of Intestinal Microbes in the Pathogenesis of Necrotizing Enterocolitis

Morowitz, M. J., Poroyko, V. A., Caplan, M. S., Alverdy, J. C., & Liu, D. C. (2010) · PEDIATRICS · doi:10.1542/peds.2009-3149 · Cited by 197 · see citing works

Improved Detection of Bifidobacteria with Optimised 16S rRNA-Gene Based Pyrosequencing

Sim, K., Cox, M. J., Wopereis, H., Martı́n, R., Knol, J., Li, M., Cookson, W., Moffatt, M. F., & Kroll, J. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032543 · Cited by 196 · see citing works

Probiotic supplement reduces risk of necrotizing enterocolitis and mortality in preterm very low-birth-weight infants: an updated meta-analysis of 20 randomized, controlled trials

Wang, Q., Dong, J., & Zhu, Y. (2012) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2011.09.064 · Cited by 193 · see citing works

Intestinal Microbial Ecology and Environmental Factors Affecting Necrotizing Enterocolitis

Torrazza, R. J. M., Ukhanova, M., Wang, X., Sharma, R. R., Hudak, M. L., Neu, J., & Mai, V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083304 · Cited by 184 · see citing works

Association of beta2 toxin production with Clostridium perfringens type A human gastrointestinal disease isolates carrying a plasmid enterotoxin gene

Fisher, D. J., Miyamoto, K., Harrison, B. R., Akimoto, S., Sarker, M. R., & McClane, B. A. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04573.x · Cited by 175 · see citing works

Bacterial community structure and functional contributions to emergence of health or necrotizing enterocolitis in preterm infants

Claud, E. C., Keegan, K. P., Brulc, J. M., Lu, L., Bartels, D., Glass, E. M., Chang, E. B., Meyer, F., & Antonopoulos, D. A. (2013) · Microbiome · doi:10.1186/2049-2618-1-20 · Cited by 172 · see citing works

The phylogenetic position of Serratia, Buttiauxella and some other genera of the family Enterobacteriaceae

Spröer, C., Mendrock, U., Swiderski, J., Lang, E., & Stackebrandt, E. S. (1999) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/00207713-49-4-1433 · Cited by 154 · see citing works

Manual of operations

Khwāmthukyāk, K. L. (2003) · Medical Entomology and Zoology · Cited by 146 · see citing works

Necrotizing Enterocolitis – 150 Years of Fruitless Search for the Cause

Obladen, M. (2009) · Neonatology · doi:10.1159/000215590 · Cited by 142 · see citing works

Comparative efects of ischemia, bacteria, and substrate on the pathogenesis of intestinal necrosis

Musemeche, C. A., Kosloske, A. M., Bartow, S. A., & Umland, E. T. (1986) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(86)80228-7 · Cited by 92 · see citing works

Evidence for Clostridial Implication in Necrotizing Enterocolitis through Bacterial Fermentation in a Gnotobiotic Quail Model

Waligora‐Dupriet, A., Dugay, A., Auzeil, N., Huerre, M., & Butel, M. (2005) · Pediatric Research · doi:10.1203/01.pdr.0000180538.13142.84 · Cited by 90 · see citing works

Necrotizing enterocolitis of the neonate with Clostridium perfringens: diagnosis, clinical course, and role of alpha toxin

Dittmar, E., Beyer, P., Fischer, D., Schäfer, V., Schoepe, H., Bauer, K., & Schlößer, R. L. (2007) · European Journal of Pediatrics · doi:10.1007/s00431-007-0614-9 · Cited by 76 · see citing works

The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota

Milani, C., Duranti, S., Bottacini, F., Casey, E., Turroni, F., Mahony, J., Belzer, C., Delgado Palacio, S., Arboleya Montes, S., Mancabelli, L., et al. (2017) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00036-17 · Cited by 1,950 · see citing works

Intestinal dysbiosis in preterm infants preceding necrotizing enterocolitis: a systematic review and meta-analysis

Pammi, M., Cope, J., Tarr, P. I., Warner, B. B., Morrow, A. L., Mai, V., Gregory, K. E., Kroll, J. S., McMurtry, V., Ferris, M. J., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0248-8 · Cited by 708 · see citing works

Gut bacteria dysbiosis and necrotising enterocolitis in very low birthweight infants: a prospective case-control study

Warner, B. B., Deych, E., Zhou, Y., Hall-Moore, C. M., Weinstock, G. M., Sodergren, E. J., Shaikh, N., Hoffmann, J. A., Linneman, L. A., Hamvas, A., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00081-7 · Cited by 475 · see citing works

The microbiome and critical illness

Dickson, R. P. (2016) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00427-0 · Cited by 460 · see citing works

An update on the human and animal enteric pathogen Clostridium perfringens

Kiu, R., & Hall, L. J. (2018) · Emerging Microbes & Infections · doi:10.1038/s41426-018-0144-8 · Cited by 447 · see citing works

The Role of the Microbiome in the Developmental Origins of Health and Disease

Stiemsma, L. T., & Michels, K. B. (2018) · PEDIATRICS · doi:10.1542/peds.2017-2437 · Cited by 361 · see citing works

Clostridium butyricum : from beneficial to a new emerging pathogen

Cassir, N., Benamar, S., & Scola, B. L. (2015) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2015.10.014 · Cited by 234 · see citing works

Microbiota Supplementation with Bifidobacterium and Lactobacillus Modifies the Preterm Infant Gut Microbiota and Metabolome: An Observational Study

Alcon-Giner, C., Dalby, M. J., Caim, S., Ketskemety, J., Shaw, A., Sim, K., Lawson, M. A., Kiu, R., Leclaire, C., Chalklen, L., et al. (2020) · Cell Reports Medicine · doi:10.1016/j.xcrm.2020.100077 · Cited by 229 · see citing works

Human milk oligosaccharide DSLNT and gut microbiome in preterm infants predicts necrotising enterocolitis

Masi, A. C., Embleton, N. D., Lamb, C. A., Young, G. R., Granger, C. L., Najera, J. A., Smith, D. P., Hoffman, K. L., Petrosino, J. F., Bode, L., et al. (2020) · Gut · doi:10.1136/gutjnl-2020-322771 · Cited by 228 · see citing works

Intestinal microbiota in early life and its implications on childhood health

Zhuang, L., Chen, H., Zhang, S., Zhuang, J., Li, Q., & Feng, Z. (2019) · Genomics, Proteomics & Bioinformatics · doi:10.1016/j.gpb.2018.10.002 · Cited by 219 · see citing works

Temporal bacterial and metabolic development of the preterm gut reveals specific signatures in health and disease

Stewart, C. J., Embleton, N. D., Marrs, E. C. L., Smith, D. P., Nelson, A., Abdulkadi̇r, B., Skeath, T., Petrosino, J. F., Perry, J. D., Berrington, J. E., et al. (2016) · Microbiome · doi:10.1186/s40168-016-0216-8 · Cited by 208 · see citing works

Secretory IgA in the Coordination of Establishment and Maintenance of the Microbiota

Pabst, O., Cerovic, V., & Hornef, M. W. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.03.002 · Cited by 201 · see citing works

New Medical and Surgical Insights Into Neonatal Necrotizing Enterocolitis

Frost, B. L., Modi, B. P., Jaksic, T., & Caplan, M. S. (2016) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2016.2708 · Cited by 177 · see citing works

Antibiotic therapy in neonates and impact on gut microbiota and antibiotic resistance development: a systematic review

Fjalstad, J. W., Esaiassen, E., Juvet, L. K., van den Anker, J. N., & Klingenberg, C. (2017) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx426 · Cited by 175 · see citing works

Rapid MinION profiling of preterm microbiota and antimicrobial-resistant pathogens

Leggett, R. M., Alcon-Giner, C., Heavens, D., Caim, S., Brook, T. C., Kujawska, M., Martin, S., Peel, N., Acford-Palmer, H., Hoyles, L., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0626-z · Cited by 175 · see citing works

The infant gut microbiome as a microbial organ influencing host well-being

Turroni, F., Milani, C., Duranti, S., Lugli, G. A., Bernasconi, S., Margollés, A., Pierro, F. D., van Sinderen, D., & Ventura, M. (2020) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/s13052-020-0781-0 · Cited by 165 · see citing works

A Necrotizing Enterocolitis-Associated Gut Microbiota Is Present in the Meconium: Results of a Prospective Study

Heida, F. H., van Zoonen, A. G. J. F., Hulscher, J. B. F., Kiefte, B. J. C. T., Wessels, R., Kooi, E. M. W., Bos, A. F., Harmsen, H. J. M., & de Goffau, M. C. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw016 · Cited by 163 · see citing works

Bifidobacterium breve UCC2003 metabolises the human milk oligosaccharides lacto-N-tetraose and lacto-N-neo-tetraose through overlapping, yet distinct pathways

James, K., Motherway, M. O., Bottacini, F., & van Sinderen, D. (2016) · Scientific Reports · doi:10.1038/srep38560 · Cited by 153 · see citing works

<i>Clostridium butyricum</i>Strains and Dysbiosis Linked to Necrotizing Enterocolitis in Preterm Neonates

Cassir, N., Benamar, S., Khalil, J. B., Croce, O., Saint-Faust, M., Jacquot, A., Million, M., Azza, S., Armstrong, N., Henry, M., et al. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ468 · Cited by 151 · see citing works

The Microbiome and Metabolome of Preterm Infant Stool Are Personalized and Not Driven by Health Outcomes, Including Necrotizing Enterocolitis and Late-Onset Sepsis

Wandro, S., Osborne, S., Enriquez, C., Bixby, C., Arrieta, A. C., & Whiteson, K. (2018) · mSphere · doi:10.1128/msphere.00104-18 · Cited by 149 · see citing works

Clinical implications of preterm infant gut microbiome development

Healy, D., Ryan, C. A., Ross, R. P., Stanton, C., & Dempsey, E. M. (2021) · Nature Microbiology · doi:10.1038/s41564-021-01025-4 · Cited by 132 · see citing works

The Microbiota of the Extremely Preterm Infant

Underwood, M. A., & Sohn, K. (2017) · Clinics in Perinatology · doi:10.1016/j.clp.2017.01.005 · Cited by 123 · see citing works

Impact of early gut microbiota on immune and metabolic development and function

Wang, M., Monaco, M. H., & Donovan, S. M. (2016) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2016.04.004 · Cited by 115 · see citing works

Impact of Antibiotics on Necrotizing Enterocolitis and Antibiotic-Associated Diarrhea

Silverman, M. A., Konnikova, L., & Gerber, J. S. (2017) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2016.09.010 · Cited by 113 · see citing works

Probing Genomic Aspects of the Multi-Host Pathogen Clostridium perfringens Reveals Significant Pangenome Diversity, and a Diverse Array of Virulence Factors

Kiu, R., Caim, S., Alexander, S., Pachori, P., & Hall, L. J. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02485 · Cited by 104 · see citing works

Nutritional strategies and gut microbiota composition as risk factors for necrotizing enterocolitis in very-preterm infants

Rozé, J., Ancel, P., Lepage, P., Marchand‐Martin, L., Nabhani, Z. A., Delannoy, J., Picaud, J., Lapillonne, A., Aires, J., Durox, M., et al. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.152967 · Cited by 102 · see citing works

Late-onset bloodstream infection and perturbed maturation of the gastrointestinal microbiota in premature infants

Shaw, A. G., Sim, K., Randell, P., Cox, M. J., McClure, Z. E., Li, M.-S., Donaldson, H., Langford, P. R., Cookson, W. O. C. M., Moffatt, M. F., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132923 · Cited by 96 · see citing works

Dysbiosis in the intensive care unit: Microbiome science coming to the bedside

Kitsios, G. D., Morowitz, M. J., Dickson, R. P., Huffnagle, G. B., McVerry, B. J., & Morris, A. (2016) · Journal of Critical Care · doi:10.1016/j.jcrc.2016.09.029 · Cited by 91 · see citing works

Current Status of Necrotizing Enterocolitis

Knell, J., Han, S. M., Jaksic, T., & Modi, B. P. (2018) · Current Problems in Surgery · doi:10.1067/j.cpsurg.2018.11.005 · Cited by 92 · see citing works

A systematic review of the factors influencing microbial colonization of the preterm infant gut

Aguilar‐López, M., Dinsmoor, A. M., Ho, T. T. B., & Donovan, S. M. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1884514 · Cited by 91 · see citing works

Routine Use of Probiotics in Preterm Infants: Longitudinal Impact on the Microbiome and Metabolome

Abdulkadi̇r, B., Nelson, A., Skeath, T., Marrs, E. C. L., Perry, J. D., Cummings, S. P., Embleton, N. D., Berrington, J. E., & Stewart, C. J. (2016) · Neonatology · doi:10.1159/000442936 · Cited by 89 · see citing works

Latitude in sample handling and storage for infant faecal microbiota studies: the elephant in the room?

Shaw, A., Sim, K., Powell, E. A., Cornwell, E., Cramer, T. L. M., McClure, Z. E., Li, M., & Kroll, J. S. (2016) · Microbiome · doi:10.1186/s40168-016-0186-x · Cited by 83 · see citing works

The heart-gut axis: new target for atherosclerosis and congestive heart failure therapy

Forkosh, E., & Ilan, Y. (2019) · Open Heart · doi:10.1136/openhrt-2018-000993 · Cited by 82 · see citing works

Gut Microbiota and the Pathogenesis of Necrotizing Enterocolitis in Preterm Neonates

Cassir, N., Siméoni, U., & Scola, B. L. (2016) · Future Microbiology · doi:10.2217/fmb.15.136 · Cited by 74 · see citing works

The role of the preterm intestinal microbiome in sepsis and necrotising enterocolitis

Masi, A. C., & Stewart, C. J. (2019) · Early Human Development · doi:10.1016/j.earlhumdev.2019.104854 · Cited by 71 · see citing works

Particular genomic and virulence traits associated with preterm infant-derived toxigenic Clostridium perfringens strains

Kiu, R., Shaw, A., Sim, K., Acuna-Gonzalez, A., Price, C. A., Bedwell, H., Dreger, S. A., Fowler, W. J., Cornwell, E., Pickard, D., et al. (2023) · Nature Microbiology · doi:10.1038/s41564-023-01385-z · Cited by 70 · see citing works

Gut microbiota of preterm infants supplemented with probiotics: sub-study of the ProPrems trial

for the ProPrems Study Group, Plummer, E. L., Bulach, D., Murray, G. L., Jacobs, S. E., Tabrizi, S. N., & Garland, S. M. (2018) · BMC Microbiology · doi:10.1186/s12866-018-1326-1 · Cited by 70 · see citing works

Preterm infants harbour diverse Klebsiella populations, including atypical species that encode and produce an array of antimicrobial resistance- and virulence-associated factors

Chen, Y., Brook, T. C., Soe, C. Z., O’Neill, I. J., Alcon-Giner, C., Leelastwattanagul, O., Phillips, S., Caim, S., Clarke, P., Hall, L. J., et al. (2020) · Microbial Genomics · doi:10.1099/mgen.0.000377 · Cited by 69 · see citing works

Pathophysiology of Necrotizing Enterocolitis: An Update

Bazacliu, C., & Neu, J. (2018) · Current Pediatric Reviews · doi:10.2174/1573396314666181102123030 · Cited by 68 · see citing works

Impact of Probiotic B. infantis EVC001 Feeding in Premature Infants on the Gut Microbiome, Nosocomially Acquired Antibiotic Resistance, and Enteric Inflammation

Nguyen, M., Holdbrooks, H., Mishra, P. K., Abrantes, M. A., Eskew, S., Garma, M., Oca, C.-G., McGuckin, C., Hein, C. T., Mitchell, R. D., et al. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.618009 · Cited by 61 · see citing works

Does the maternal vaginal microbiota play a role in seeding the microbiota of neonatal gut and nose?

Sakwińska, O., Foata, F., Berger, B. W., Brüssow, H., Combremont, S., Mercenier, A., Dogra, S. K., Soh, S., Chan, J. K. Y., Heong, G. Y. S., et al. (2017) · Beneficial Microbes · doi:10.3920/bm2017.0064 · Cited by 62 · see citing works

Human Milk Microbiome—A Review of Scientific Reports

Dombrowska-Pali, A., Wiktorczyk-Kapischke, N., Chrustek, A., Olszewska-Słonina, D. M., Gospodarek-Komkowska, E., & Socha, M. W. (2024) · Nutrients · doi:10.3390/nu16101420 · Cited by 69 · see citing works

Necrotizing enterocolitis and preterm infant gut bacteria

Warner, B. B., & Tarr, P. I. (2016) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2016.06.001 · Cited by 62 · see citing works

Galleria mellonella Infection Model Identifies Both High and Low Lethality of Clostridium perfringens Toxigenic Strains and Their Response to Antimicrobials

Kay, S., Edwards, J., Brown, J., & DIXON, R. A. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01281 · Cited by 62 · see citing works

Intestinal dysbiosis and necrotizing enterocolitis: assessment for causality using Bradford Hill criteria

Fundora, J. B., Guha, P., Shores, D. R., Pammi, M., & Maheshwari, A. (2019) · Pediatric Research · doi:10.1038/s41390-019-0482-9 · Cited by 60 · see citing works

Microbiota-derived short chain fatty acids in pediatric health and diseases: from gut development to neuroprotection

Hsu, C., Khachatryan, L., Younis, N. K., Mustafa, M. A., Ahmad, N., Athab, Z. H., Валерьевна, П. А., Викторовна, К. Е., Mirzaei, R., & Karampoor, S. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1456793 · Cited by 68 · see citing works

Cytotoxin-producing Klebsiella oxytoca in the preterm gut and its association with necrotizing enterocolitis

Paveglio, S. A., Ledala, N., Rezaul, K., Lin, Q., Zhou, Y., Provatas, A. A., Bennett, E., Lindberg, T. P., Caimano, M. J., & Matson, A. P. (2020) · Emerging Microbes & Infections · doi:10.1080/22221751.2020.1773743 · Cited by 59 · see citing works

Exploring the Role of Gut Bacteria in Health and Disease in Preterm Neonates

Lee, J. K.-F., Tan, L. T., Ramadas, A., Mutalib, N. A., & Lee, L. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17196963 · Cited by 59 · see citing works

Evidence for persistent and shared bacterial strains against a background of largely unique gut colonization in hospitalized premature infants

Raveh-Sadka, T., Firek, B., Sharon, I., Baker, R. W., Brown, C. T., Thomas, B. C., Morowitz, M. J., & Banfield, J. F. (2016) · The ISME Journal · doi:10.1038/ismej.2016.83 · Cited by 56 · see citing works

Incidence of Clostridium perfringens and its toxin genes in the gut of children with autism spectrum disorder

Alshammari, M. K., AlKhulaifi, M. M., Al Farraj, D. A., Somily, A. M., & Albarrag, A. M. (2020) · Anaerobe · doi:10.1016/j.anaerobe.2019.102114 · Cited by 53 · see citing works

The Neurodevelopmental Perspective of Surgical Necrotizing Enterocolitis: The Role of the Gut-Brain Axis

Moschopoulos, C., Kratimenos, P., Koutroulis, I., Shah, B. V., Mowes, A., & Bhandari, V. (2018) · Mediators of Inflammation · doi:10.1155/2018/7456857 · Cited by 52 · see citing works

Clostridia and necrotizing enterocolitis in preterm neonates

Schönherr-Hellec, S., & Aires, J. (2019) · Anaerobe · doi:10.1016/j.anaerobe.2019.04.005 · Cited by 52 · see citing works

Preterm Infant-Associated Clostridium tertium, Clostridium cadaveris, and Clostridium paraputrificum Strains: Genomic and Evolutionary Insights

Kiu, R., Caim, S., Alcon-Giner, C., Bélteki, G., Clarke, P., Pickard, D., Gordon Dougan, B., & Hall, L. J. (2017) · Genome Biology and Evolution · doi:10.1093/gbe/evx210 · Cited by 49 · see citing works

High-Resolution Differentiation of Enteric Bacteria in Premature Infant Fecal Microbiomes Using a Novel rRNA Amplicon

Graf, J., Ledala, N., Caimano, M. J., Jackson, E., Gratalo, D., Fasulo, D., Driscoll, M. D., Coleman, S., & Matson, A. P. (2021) · mBio · doi:10.1128/mbio.03656-20 · Cited by 49 · see citing works

Preterm gut microbiota and metabolome following discharge from intensive care

Stewart, C. J., Skeath, T., Nelson, A., Fernstad, S. J., Marrs, E. C. L., Perry, J. D., Cummings, S. P., Berrington, J. E., & Embleton, N. D. (2015) · Scientific Reports · doi:10.1038/srep17141 · Cited by 48 · see citing works

Necrotizing enterocolitis: Bench to bedside approaches and advancing our understanding of disease pathogenesis

Singh, D. K., Miller, C. M., Orgel, K., Dave, M., Mackay, S., & Good, M. L. (2023) · Frontiers in Pediatrics · doi:10.3389/fped.2022.1107404 · Cited by 45 · see citing works

The Metabolome and the Gut Microbiota for the Prediction of Necrotizing Enterocolitis and Spontaneous Intestinal Perforation: A Systematic Review

Moschino, L., Verlato, G., Duci, M., Cavicchiolo, M. E., Guiducci, S., Stocchero, M., Giordano, G., Leon, F. F., & Baraldi, E. (2022) · Nutrients · doi:10.3390/nu14183859 · Cited by 41 · see citing works

Metabolomic signatures distinguish the impact of formula carbohydrates on disease outcome in a preterm piglet model of NEC

Call, L., Stoll, B., Oosterloo, B. C., Ajami, N. J., Sheikh, F., Wittke, A., Waworuntu, R. V., Berg, B. M., Petrosino, J. F., Olutoye, O. O., et al. (2018) · Microbiome · doi:10.1186/s40168-018-0498-0 · Cited by 41 · see citing works

Gut Sphingolipid Composition as a Prelude to Necrotizing Enterocolitis

Rusconi, B. A., Jiang, X., Sidhu, R., Ory, D. S., Warner, B. B., & Tarr, P. I. (2018) · Scientific Reports · doi:10.1038/s41598-018-28862-4 · Cited by 37 · see citing works

Bacterial Indole as a Multifunctional Regulator of Klebsiella oxytoca Complex Enterotoxicity

Ledala, N., Malik, M., Rezaul, K., Paveglio, S. A., Provatas, A. A., Kiel, A., Caimano, M. J., Zhou, Y., Lindgren, J., Krasulová, K., et al. (2022) · mBio · doi:10.1128/mbio.03752-21 · Cited by 37 · see citing works

Impact of early life antibiotic and probiotic treatment on gut microbiome and resistome of very-low-birth-weight preterm infants.

Kiu, R., Darby, E. M., Alcon-Giner, C., Acuna-Gonzalez, A., Camargo, A., Lamberte, L. E., Phillips, S., Sim, K., Shaw, A. G., Clarke, P., et al. (2025) · Nature communications · doi:10.1038/s41467-025-62584-2 · Cited by 36 · see citing works

Rapid profiling of the preterm infant gut microbiota using nanopore sequencing aids pathogen diagnosticsPreprint

Leggett, R. M., Alcon-Giner, C., Heavens, D., Caim, S., Brook, T. C., Kujawska, M., Martin, S., Hoyles, L., Clarke, P., Hall, L. J., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/180406 · Cited by 36 · see citing works

Development of the gut microbiota during early life in premature and term infants

Sim, K., Powell, E., Cornwell, E., Kroll, J. S., & Shaw, A. (2023) · Gut Pathogens · doi:10.1186/s13099-022-00529-6 · Cited by 35 · see citing works

Factors Influencing Neonatal Gut Microbiome and Health with a Focus on Necrotizing Enterocolitis

Beharry, K. D. A., Latkowska, M., Valencia, A. M., Allana, A., Soto, J., Cai, C. L., GOLOMBEK, S. G., Hand, I. L., & Aranda, J. V. (2023) · Microorganisms · doi:10.3390/microorganisms11102528 · Cited by 36 · see citing works

Colonization of Supplemented Bifidobacterium breve M-16V in Low Birth Weight Infants and Its Effects on Their Gut Microbiota Weeks Post-administration

Horigome, A., Hisata, K., Odamaki, T., Iwabuchi, N., Xiao, J., & Shimizu, T. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.610080 · Cited by 34 · see citing works

An update on biomarkers of necrotizing enterocolitis

Ng, P. C. (2018) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2018.07.006 · Cited by 33 · see citing works

Effect of a Short-Time Probiotic Supplementation on the Abundance of the Main Constituents of the Gut Microbiota of Term Newborns Delivered by Cesarean Section—A Randomized, Prospective, Controlled Clinical Trial

Hurkała, J., Lauterbach, R., Radziszewska, R., Strus, M., & Heczko, P. B. (2020) · Nutrients · doi:10.3390/nu12103128 · Cited by 33 · see citing works

Necrotizing Enterocolitis Pathophysiology

Kim, C. S., & Claud, E. C. (2018) · Clinics in Perinatology · doi:10.1016/j.clp.2018.10.003 · Cited by 32 · see citing works

The bacterial gut microbiome of probiotic-treated very-preterm infants: changes from admission to discharge

Westaway, J. A. F., Huerlimann, R., Kandasamy, Y., Miller, C., Norton, R. E., Staunton, K. M., Watson, D., & Rudd, D. (2021) · Pediatric Research · doi:10.1038/s41390-021-01738-6 · Cited by 32 · see citing works

Principles and Mechanism of MALDI-ToF-MS Analysis

Hosseini, S., & Martinez-Chapa, S. O. (2016) · SpringerBriefs in applied sciences and technology · doi:10.1007/978-981-10-2356-9_1 · Cited by 31 · see citing works

Clostridial Strain-Specific Characteristics Associated with Necrotizing Enterocolitis

Schönherr-Hellec, S., Klein, G., Delannoy, J., Ferraris, L., Rozé, J., Butel, M. J., & Aires, J. (2018) · Applied and Environmental Microbiology · doi:10.1128/aem.02428-17 · Cited by 31 · see citing works

Necrotizing enterocolitis and the gut-lung axis

Willis, K. A., & Ambalavanan, N. (2021) · Seminars in Perinatology · doi:10.1016/j.semperi.2021.151454 · Cited by 31 · see citing works

The protective effects of fecal microbiota transplantation in an experimental model of necrotizing enterocolitis

Prado, C., Michels, M., Ávila, P. R. M., Burger, H., Milioli, M. V. M., & Dal‐Pizzol, F. (2018) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2018.10.045 · Cited by 31 · see citing works

The Microbiome and Biomarkers for Necrotizing Enterocolitis: Are We Any Closer to Prediction?

Rusconi, B. A., Good, M. L., & Warner, B. B. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2017.05.075 · Cited by 30 · see citing works

Hypoxic/ischemic hits predispose to necrotizing enterocolitis in (near) term infants with congenital heart disease: a case control study

van der Heide, M., Mebius, M. J., Bos, A. F., Roofthooft, M. T. R., Berger, R. M. F., Hulscher, J. B. F., & Kooi, E. M. W. (2020) · BMC Pediatrics · doi:10.1186/s12887-020-02446-6 · Cited by 30 · see citing works

The potential of gut microbiota and fecal volatile organic compounds analysis as early diagnostic biomarker for necrotizing enterocolitis and sepsis in preterm infants

Berkhout, D. J. C., Niemarkt, H. J., de Boer, N. K. H., Benninga, M. A., & de Meij, T. G. J. (2018) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2018.1446826 · Cited by 30 · see citing works

Infant gut microbiota modulation by human milk disaccharides in humanized microbiome mice

Rubio‐del‐Campo, A., Gozalbo‐Rovira, R., Moya-Gonzálvez, E. M., Alberola, J., Rodríguez‐Díaz, J., & Yebra, M. J. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1914377 · Cited by 29 · see citing works

Premature neonatal gut microbial community patterns supporting an epithelial TLR-mediated pathway for necrotizing enterocolitis

Shaw, A., Sim, K., Rose, G., Wooldridge, D. J., Li, M.-S., Misra, R., Gharbia, S. E., & Kroll, J. S. (2021) · BMC Microbiology · doi:10.1186/s12866-021-02285-0 · Cited by 28 · see citing works

Human Breast Milk: The Key Role in the Maturation of Immune, Gastrointestinal and Central Nervous Systems: A Narrative Review

Dimitroglou, M., Iliodromiti, Z., Christou, E., Volaki, P., Petropoulou, C., Sokou, R., Boutsikou, Τ., & Iacovidou, N. M. (2022) · Diagnostics · doi:10.3390/diagnostics12092208 · Cited by 28 · see citing works

Short-term surgical outcomes of preterm infants with necrotizing enterocolitis

Sheng, Q., Lv, Z., Xu, W., Liu, J., Wu, Y., Shi, J., & Xi, Z. (2016) · Medicine · doi:10.1097/md.0000000000004379 · Cited by 27 · see citing works

Phylogenomic analysis of gastroenteritis-associated Clostridium perfringens in England and Wales over a 7-year period indicates distribution of clonal toxigenic strains in multiple outbreaks and extensive involvement of enterotoxin-encoding (CPE) plasmids

Kiu, R., Caim, S., Painset, A., Pickard, D., Swift, C., Gordon Dougan, B., Mather, A. E., Amar, C., & Hall, L. J. (2019) · Microbial Genomics · doi:10.1099/mgen.0.000297 · Cited by 27 · see citing works

Preterm infants with necrotising enterocolitis demonstrate an unbalanced gut microbiota

Itani, T. M., Moubareck, C. A., Melki, I., Rousseau, C., Mangin, I., Butel, M., & Karam‐Sarkis, D. (2017) · Acta Paediatrica · doi:10.1111/apa.14078 · Cited by 26 · see citing works

Increased incidence of necrotizing enterocolitis associated with routine administration of Infloran™ in extremely preterm infants

Escribano, E., Zozaya, C., Madero, R., Sánchez, L., van Goudoever, J. B., Rodríguez, J. M., & de Pipaón, M. S. (2018) · Beneficial Microbes · doi:10.3920/bm2017.0098 · Cited by 25 · see citing works

Distinct mucosal microbial communities in infants with surgical necrotizing enterocolitis correlate with age and antibiotic exposure

Romano-Keeler, J., Shilts, M. H., Tovchigrechko, A., Wang, C., Brucker, R. M., Moore, D. J., Fonnesbeck, C., Meng, S., Correa, H., Lovvorn, H. N., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0206366 · Cited by 25 · see citing works

Defining the Relationship of Gut Microbiota, Immunity, and Cognition in Early Life—A Narrative Review

Kartjito, M. S., Yosia, M., Wasito, E., Soloan, G., Agussalim, A. A. K., & Basrowi, R. W. (2023) · Nutrients · doi:10.3390/nu15122642 · Cited by 29 · see citing works

Bifidobacterium and Lactobacillus for preventing necrotizing enterocolitis in very-low-birth-weight preterm infants: a systematic review and meta-analysis

Jiao, X., Fu, M., Wang, Y., Xue, J., & Zhang, Y. (2019) · World Journal of Pediatrics · doi:10.1007/s12519-019-00297-5 · Cited by 24 · see citing works

The Assessment of Fecal Volatile Organic Compounds in Healthy Infants: Electronic Nose Device Predicts Patient Demographics and Microbial Enterotype

Hosfield, B. D., Pecoraro, A. R., Baxter, N. T., Hawkins, T., & Markel, T. A. (2020) · Journal of Surgical Research · doi:10.1016/j.jss.2020.05.010 · Cited by 24 · see citing works

Use of omic technologies in early life gastrointestinal health and disease: from bench to bedside

Beck, L. C., Granger, C. L., Masi, A. C., & Stewart, C. J. (2021) · Expert Review of Proteomics · doi:10.1080/14789450.2021.1922278 · Cited by 24 · see citing works

Streaming histogram sketching for rapid microbiome analytics

Rowe, W. P. M., Carrieri, A. P., Alcon-Giner, C., Caim, S., Shaw, A., Sim, K., Kroll, J. S., Hall, L. J., Pyzer‐Knapp, E. O., & Winn, M. (2019) · Microbiome · doi:10.1186/s40168-019-0653-2 · Cited by 23 · see citing works

High-resolution microbiome analysis reveals exclusionary Klebsiella species competition in preterm infants at risk for necrotizing enterocolitis

Coleman, S., Unterhauser, K., Rezaul, K., Ledala, N., Lesmes, S., Caimano, M. J., Zhou, Y., Jackson, E., Gratalo, D., Driscoll, M. D., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-34735-2 · Cited by 23 · see citing works

Developing a Laser Induced Liquid Beam Ion Desorption Spectral Database as Reference for Spaceborne Mass Spectrometers

Klenner, F., Umair, M., Walter, S. H. G., Khawaja, N., Hillier, J. K., Nölle, L., Zou, Z., Napoleoni, M., Sanderink, A., Zuschneid, W., et al. (2022) · Earth and Space Science · doi:10.1029/2022ea002313 · Cited by 22 · see citing works

Role of gut-brain axis in neurodevelopmental impairment of necrotizing enterocolitis

Wang, Y., Hang, C., Hu, J. X., Li, C., Zhan, C., Pan, J., & Yuan, T. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1059552 · Cited by 22 · see citing works

Neonatal necrotizing enterocolitis: Clostridium butyricum and Clostridium neonatale fermentation metabolism and enteropathogenicity

Ferraris, L., Balvay, A., Bellet, D., Delannoy, J., Maudet, C., Larcher, T., Rozé, J., Philippe, C., Meylheuc, T., Butel, M., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2172666 · Cited by 22 · see citing works

Updating on gut microbiota and its relationship with the occurrence of necrotizing enterocolitis

Hosny, M., Cassir, N., & Scola, B. L. (2017) · Human Microbiome Journal · doi:10.1016/j.humic.2016.09.002 · Cited by 20 · see citing works

A Multiscale Spatiotemporal Model Including a Switch from Aerobic to Anaerobic Metabolism Reproduces Succession in the Early Infant Gut Microbiota

Versluis, D. M., Schoemaker, R., Looijesteijn, E., Muysken, D., Jeurink, P. V., Paques, M., Geurts, J. M. W., & Merks, R. M. H. (2022) · mSystems · doi:10.1128/msystems.00446-22 · Cited by 20 · see citing works

Changes of gut microbiota and tricarboxylic acid metabolites may be helpful in early diagnosis of necrotizing enterocolitis: A pilot study

Du, T.-T., Liu, X., He, Y., Gao, X., Liu, Z., Wang, Z., & Li, L.-Q. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1119981 · Cited by 21 · see citing works

Gut Mucosal and Fecal Microbiota Profiling Combined to Intestinal Immune System in Neonates Affected by Intestinal Ischemic Injuries

Romani, L., CHIERICO, F. D., Chiriaco, M., Foligno, S., Reddel, S., Salvatori, G., Cifaldi, C., Faraci, S., Finocchi, A., Rossi, P., et al. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00059 · Cited by 21 · see citing works

Necrotizing Enterocolitis and Intestinal Microbiota: The Timing of Disease and Combined Effects of Multiple Species

Fu, X., Li, S., Jiang, Y., Hu, X., & Wu, H. M. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.657349 · Cited by 20 · see citing works

Prevalence and Genetic Diversity of Clostridium perfringens Isolates in Hospitalized Diarrheal Patients from Central China

Wang, B., Dong, W., Ma, L., Dong, Y.-H., Wang, S., Yuan, Y., Ma, Q., Xu, J., Yan, W., Nan, J., et al. (2021) · Infection and Drug Resistance · doi:10.2147/idr.s338593 · Cited by 20 · see citing works

Human Milk-Based or Bovine Milk-Based Fortifiers Differentially Impact the Development of the Gut Microbiota of Preterm Infants

Aguilar‐López, M., Wetzel, C., MacDonald, A., Ho, T. T. B., & Donovan, S. M. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.719096 · Cited by 20 · see citing works

Defining the gastrointestinal microbiota in premature neonates: Its development and relation to necrotizing enterocolitis

Sim, K. (2015) · doi:10.25560/31587 · Cited by 2 · see citing works

Low Microbial Diversity and Abnormal Microbial Succession Is Associated with Necrotizing Enterocolitis in Preterm Infants

Dobbler, P. T., Procianoy, R. S., Mai, V., Silveira, R. C., Corso, A., Rojas, B. S., & Roesch, L. F. W. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02243 · Cited by 100 · see citing works

Fecal Microbiota in Premature Infants Prior to Necrotizing Enterocolitis

Mai, V., Young, C., Ukhanova, M., Wang, X., Sun, Y., Casella, G., Theriaque, D. W., Li, N., Sharma, R. R., Hudak, M. L., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020647 · Cited by 503 · see citing works

Early intestinal colonization phenotypes predict necrotizing enterocolitis in preterm infants

Morrow, A. L., Lagomarcino, A. J., Schibler, K. R., Taft, D. H., Yu, Z., Wang, B., Gevers, D., Ward, D. V., Kennedy, M. A., Huttenhower, C., et al. (2013) · The FASEB Journal · doi:10.1096/fasebj.27.1_supplement.357.1

Early microbial and metabolomic signatures predict later onset of necrotizing enterocolitis in preterm infants

Morrow, A. L., Lagomarcino, A. J., Schibler, K. R., Taft, D. H., Yu, Z., Wang, B., Altaye, M., Wagner, M., Gevers, D., Ward, D. V., et al. (2013) · Microbiome · doi:10.1186/2049-2618-1-13 · Cited by 342 · see citing works