The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Determination of Inorganic Nitrate in Serum and Urine by a Kinetic Cadmium-Reduction Method
Abstract
Nitrate in serum and urine was assayed by a modification of the cadmium-reduction method; the nitrite produced was determined by diazotization of sulfanilamide and coupling to naphthylethylene diamine. After samples were deproteinized with Somogyi reagent, the nitrate was reduced by Cu-coated Cd in glycine buffer at pH 9.7 (2.5 to 3 g of Cd granules for a 4-mL reaction mixture). The reduction followed pseudo-first-order reaction kinetics, a convenient time interval for assay being 75 to 90 min. Maximum reduction (85%) occurred at about 2 h. Detection limits in urine or serum were 2 to 250 µmol/L. This method does not require the reaction to go to completion, does not require expensive reagents or equipment, and can assay several samples simultaneously. Repeated assays of two serum pools gave CVs of 9.0% and 4.7% for nitrate concentrations of 31.4 and 80.2 µmol/L, nitrate was 1704.0 ± 1294 (SD) µmol/L (n = 21) in untimed normal urine, 81.8 ± 50.1 µmol/L in serum of 38 renal dialysis patients, and 51.2 ± 26.4 µmol/L in serum of 38 controls.
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Cites
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
Green, L. C., Wagner, D. A., Glogowski, J., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90118-x · Cited by 12,077
Serum kreatininbestimmung ohne enteiweissen
Bartels, H., Böhmer, M., & Heierli, C. (1972) · Clinica Chimica Acta · doi:10.1016/0009-8981(72)90432-9 · Cited by 804
Iyengar, R., Stuehr, D. J., & Marletta, M. A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.18.6369 · Cited by 662
Automatic methods for determining nitrate and nitrite in water and soil extracts
Henriksen, A., & Selmer-Olsen, A. R. (1970) · The Analyst · doi:10.1039/an9709500514 · Cited by 587
Nitrate Synthesis in the Germfree and Conventional Rat
Green, L. C., Tannenbaum, S. R., & Goldman, P. (1981) · Science · doi:10.1126/science.6451927 · Cited by 557
A METHOD FOR THE PREPARATION OF BLOOD FILTRATES FOR THE DETERMINATION OF SUGAR
Somogyi, M. (1930) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)78933-7 · Cited by 530
Wolff, I. A., & Wasserman, A. E. (1972) · Science · doi:10.1126/science.177.4043.15 · Cited by 451
Determination of nitrate and nitrite
Donald, D. J. (1957) · Methods in enzymology on CD-ROM/Methods in enzymology · Cited by 330
Nitrite and nitrate are formed by endogenous synthesis in the human intestine
Tannenbaum, S. R., Fett, D., Young, V. R., Land, P. D., & Bruce, W. R. (1978) · Science · doi:10.1126/science.663630 · Cited by 284
Wagner, D. A., Young, V. R., & Tannenbaum, S. R. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.14.4518 · Cited by 205
Cited by
Antioxidant enzyme activities and oxidative stress in affective disorders
Erkan Ozcan, M., Gulec, M., Ozerol, E., Polat, R., & Akyol, O. (2004) · International Clinical Psychopharmacology · doi:10.1097/00004850-200403000-00006 · Cited by 368
Adachi, T., Tanaka, H., Nonomura, S., Hara, H., Kondo, S.-I., & Hori, M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.11.014 · Cited by 334
Herken, H., Gurel, A., Selek, S., Armutcu, F., Ozen, M. E., Bulut, M., Kap, O., Yumru, M., Savas, H. A., & Akyol, O. (2007) · Archives of Medical Research · doi:10.1016/j.arcmed.2006.10.005 · Cited by 322
Akyol, Ö., Herken, H., Uz, E., Fadıllıoǧlu, E., Ünal, S., Söǧüt, S., Özyurt, H., & Savaş, H. A. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(02)00220-8 · Cited by 278
The course of nitric oxide and superoxide dismutase during treatment of bipolar depressive episode
Selek, S., Savas, H. A., Gergerlioglu, H. S., Bulbul, F., Uz, E., & Yumru, M. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.08.006 · Cited by 172
Metadata
- Authors
- Cortas, N. K., & Wakid, N. W.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-08-01
- Volume
- 36
- Issue
- 8
- Pages
- 1440-1443
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2148071155
- Cited by
- 894
- References
- 27
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Determination of Inorganic Nitrate in Serum and Urine by a Kinetic Cadmium-Reduction Method. https://app.cochat.ai/papers/10.1093/clinchem/36.8.1440
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- Cortas, N. K., & Wakid, N. W. (1990). Determination of Inorganic Nitrate in Serum and Urine by a Kinetic Cadmium-Reduction Method. Clinical Chemistry. https://doi.org/10.1093/clinchem/36.8.1440
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
