The course of nitric oxide and superoxide dismutase during treatment of bipolar depressive episode
Abstract
Background and aims Studies have already pointed out a possible pathophysiological role of oxidative and antioxidative molecules in bipolar disorder. We aimed to evaluate the activity and levels of antioxidant superoxide dismutase (SOD), and oxidant nitric oxide (NO), in bipolar I depressive episode (BD-DE) patients in a prospective design.Method 30 BD-DE patients, diagnosed according to DSM IV, and 30 healthy volunteer controls were included. The serum levels of NO and SOD have been studied when admitted to hospital (1st) and on the 30th days. Clinical outcome was measured by Hamilton Depression Scale (HAM-D). The patients were allowed to have their treatments. One patient was dropped out due to insufficient sampling.Results As in the previous studies, NO 1st day levels were significantly higher in patients and SOD 1st day activity was significantly low (p<0.01). NO levels significantly decreased (p<0.01) and normalized, as SOD activity significantly increased but did not reach to the controls' levels (p<0.01) on the 30th day.Conclusion Despite normalized NO levels, persistent low SOD activity might point out an oxidative imbalance in BD-DE. Chronic low SOD activity may be associated with incapacity of coping with oxidative stress. This research connotes the probable oxidative imbalance in BD-DE and discusses that phenomenon within the continuum of the disease state.
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Additional reports indicated that lithium therapy in rats can increase the specific activity of SOD and GPX in the brain.
“Moreover, additional reports indicated that lithium therapy in rats can increase the specific activity of SOD and GPX in the brain [261].”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [261]
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- Authors
- Selek, S., Savas, H. A., Gergerlioglu, H. S., Bulbul, F., Uz, E., & Yumru, M.
- Affiliations
- Gaziantep University (TR)
- Süleyman Demirel Üniversitesi (TR)
- Corresponding author
- Savas, Haluk A.
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 107
- Issue
- 1-3
- Pages
- 89-94
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2096047662
- Cited by
- 172
- References
- 29
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 8 · 2021: 3 · 2020: 14 · 2019: 8 · 2018: 12 · 2017: 8 · 2016: 10 · 2015: 14 · 2014: 20 · 2013: 15 · 2012: 11
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- bipolar disorder, nitric oxide, superoxide dismutase, oxidative stress, antioxidant status, serum biomarkers, oxidative imbalance, treatment response
- MeSH terms
- Adult, Antidepressive Agents, Bipolar Disorder, Electroconvulsive Therapy, Female, Humans, Male, Nitric Oxide, Prospective Studies, Superoxide Dismutase, Antipsychotic Agents, Case-Control Studies, Free Radical Scavengers, Oxidants, Oxidative Stress
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