Cited by 199Mitochondrial Function and PathologyCardiovascular Function and Risk FactorsCardiac Ischemia and Reperfusion

Mitochondrial Uncoupling: A Key Contributor to Reduced Cardiac Efficiency in Diabetes

Boudina, Sihem, Abel, E. Dale·2006·Physiology

Abstract

Cardiovascular disease is the primary cause of death in individuals with obesity and diabetes. However, the underlying mechanisms for cardiac dysfunction are partially understood. Studies have suggested that altered cardiac metabolism may play a role. The diabetic heart is characterized by increased fatty acid oxidation, increased myocardial oxygen consumption, and reduced cardiac efficiency. Here, we review possible mechanisms for reduced cardiac efficiency in obesity and diabetes by focusing on the potential role of mitochondrial uncoupling.

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Crossref · 10.1152/physiol.00008.2006

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115 of 115 references verified0 citation errors · 0 not checkable

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  • A commonly described feature of most animal models of obesity is increased accumulation of intramyocellular triglycerides in the heart.

    “A commonly described feature of most animal models of obesity is increased accumulation of intramyocellular triglycerides in the heart. This has been reported in the hearts of genetic models such as ob/ob and db/db mice (29, 31, 34, 53), Zucker or fa/fa rats (394), and following high-fat feeding (346).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [29]

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Authors
Boudina, S., & Abel, E. D.
Affiliations
University of Utah (US)
Venue
Physiology
Published
2006-08
Volume
21
Issue
4
Pages
250-258
ISSN
  • 0886-1714 (ISSN-L)
  • 1548-9213
  • 1548-9221
OpenAlex
W2109123226
Cited by
199
References
115
Citations by year
2026: 6 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 11 · 2019: 6 · 2018: 14 · 2017: 8 · 2016: 7 · 2015: 16 · 2014: 17 · 2013: 16 · 2012: 10
FWCI
0.98
Type
journal article
Language
en
Open access
closed
Locations
  • Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Heart, Lung, and Blood Institute (R01HL073167, U01-HL70525, R01-HL-73167, R01HL070070, U01HL070525)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R21DK073590)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
Keywords
mitochondrial uncoupling, cardiac efficiency, diabetes mellitus, obesity, cardiac dysfunction, myocardial metabolism, fatty acid oxidation, myocardial oxygen consumption, cardiovascular disease
MeSH terms
Uncoupling Protein 1, Mitochondrial ADP, ATP Translocases, Animals, Carrier Proteins, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Fatty Acids, Heart, Humans, Ion Channels, Membrane Proteins, Mitochondria, Heart, Myocardium, Obesity, Oxygen Consumption, Mitochondrial Proteins, Mice

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