Mitochondrial Uncoupling: A Key Contributor to Reduced Cardiac Efficiency in Diabetes
Abstract
Cardiovascular disease is the primary cause of death in individuals with obesity and diabetes. However, the underlying mechanisms for cardiac dysfunction are partially understood. Studies have suggested that altered cardiac metabolism may play a role. The diabetic heart is characterized by increased fatty acid oxidation, increased myocardial oxygen consumption, and reduced cardiac efficiency. Here, we review possible mechanisms for reduced cardiac efficiency in obesity and diabetes by focusing on the potential role of mitochondrial uncoupling.
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A commonly described feature of most animal models of obesity is increased accumulation of intramyocellular triglycerides in the heart.
“A commonly described feature of most animal models of obesity is increased accumulation of intramyocellular triglycerides in the heart. This has been reported in the hearts of genetic models such as ob/ob and db/db mice (29, 31, 34, 53), Zucker or fa/fa rats (394), and following high-fat feeding (346).”
From Cardiac remodeling in obesity (2008) · cites this paper as [29]
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- Authors
- Boudina, S., & Abel, E. D.
- Affiliations
- University of Utah (US)
- Venue
- Physiology
- Publisher
- American Physiological Society
- Published
- 2006-08
- Volume
- 21
- Issue
- 4
- Pages
- 250-258
- ISSN
- 0886-1714 (ISSN-L)
- 1548-9213
- 1548-9221
- OpenAlex
- W2109123226
- Cited by
- 199
- References
- 115
- Citations by year
- 2026: 6 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 11 · 2019: 6 · 2018: 14 · 2017: 8 · 2016: 7 · 2015: 16 · 2014: 17 · 2013: 16 · 2012: 10
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL073167, U01-HL70525, R01-HL-73167, R01HL070070, U01HL070525)
- National Institute of Diabetes and Digestive and Kidney Diseases (R21DK073590)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Keywords
- mitochondrial uncoupling, cardiac efficiency, diabetes mellitus, obesity, cardiac dysfunction, myocardial metabolism, fatty acid oxidation, myocardial oxygen consumption, cardiovascular disease
- MeSH terms
- Uncoupling Protein 1, Mitochondrial ADP, ATP Translocases, Animals, Carrier Proteins, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Fatty Acids, Heart, Humans, Ion Channels, Membrane Proteins, Mitochondria, Heart, Myocardium, Obesity, Oxygen Consumption, Mitochondrial Proteins, Mice
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