Cited by 118Mitochondrial Function and PathologyAutophagy in Disease and TherapyCardiovascular and exercise physiology

Physical Exercise: A Novel Tool to Protect Mitochondrial Health

Open access
Sorriento, Daniela, Di Vaia, Eugenio, Iaccarino, Guido·2021·Frontiers in Physiology

Abstract

Mitochondrial dysfunction is a crucial contributor to heart diseases. Alterations in energetic metabolism affect crucial homeostatic processes, such asATP production, the generation of reactive oxygen species, and the release of pro-apoptotic factors, associated with metabolic abnormalities. In response to energetic deficiency, the cardiomyocytes activate the Mitochondrial Quality Control (MQC), a critical process in maintaining mitochondrial health. This process is compromised in cardiovascular diseases depending on the pathology’s severity and represents, therefore, a potential therapeutic target. Several potential targeting molecules within this process have been identified in the last years, and therapeutic strategies have been proposed to ameliorate mitochondria monitoring and function. In this context, physical exercise is considered a non-pharmacological strategy to protect mitochondrial health. Physical exercise regulates MQC allowing the repair/elimination of damaged mitochondria and synthesizing new ones, thus recovering the metabolic state. In this review, we will deal with the effect of physical exercise on cardiac mitochondrial function tracing its ability to modulate specific steps in MQC both in physiologic and pathologic conditions.

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Crossref · 10.3389/fphys.2021.660068

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  • Regular physical activity or exercise training enhances mitochondrial homeostasis in individuals with sarcopenia and regulates mitophagy, mitochondrial biogenesis, mitochondrial dynamics, and mitochondrial redox biology.

    “Engaging in regular physical activity or exercise training, which proves beneficial for enhancing mitochondrial homeostasis in individuals with sarcopenia, significantly regulates mitophagy, mitochondrial biogenesis, mitochondrial dynamics, and mitochondrial redox biology [9,10,11].”

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Authors
Sorriento, D., Di Vaia, E., & Iaccarino, G.
Affiliations
Federico II University Hospital (IT)
Corresponding author
Iaccarino, Guido
Venue
Frontiers in Physiology
Published
2021-04-27
Volume
12
Pages
660068-660068
ISSN
1664-042X (ISSN-L)
OpenAlex
W3158316719
Cited by
118
References
168
Citations by year
2026: 14 · 2025: 35 · 2024: 24 · 2023: 27 · 2022: 15 · 2021: 3
FWCI
1.81
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Physiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
physical activity, mitochondrial quality control, mitochondrial dysfunction, cardiomyocytes, heart disease, reactive oxygen species, apoptosis, ATP production, energy metabolism, non-pharmacological treatment, mitochondrial biogenesis

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