Physical Exercise: A Novel Tool to Protect Mitochondrial Health
Open accessAbstract
Mitochondrial dysfunction is a crucial contributor to heart diseases. Alterations in energetic metabolism affect crucial homeostatic processes, such asATP production, the generation of reactive oxygen species, and the release of pro-apoptotic factors, associated with metabolic abnormalities. In response to energetic deficiency, the cardiomyocytes activate the Mitochondrial Quality Control (MQC), a critical process in maintaining mitochondrial health. This process is compromised in cardiovascular diseases depending on the pathology’s severity and represents, therefore, a potential therapeutic target. Several potential targeting molecules within this process have been identified in the last years, and therapeutic strategies have been proposed to ameliorate mitochondria monitoring and function. In this context, physical exercise is considered a non-pharmacological strategy to protect mitochondrial health. Physical exercise regulates MQC allowing the repair/elimination of damaged mitochondria and synthesizing new ones, thus recovering the metabolic state. In this review, we will deal with the effect of physical exercise on cardiac mitochondrial function tracing its ability to modulate specific steps in MQC both in physiologic and pathologic conditions.
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Regular physical activity or exercise training enhances mitochondrial homeostasis in individuals with sarcopenia and regulates mitophagy, mitochondrial biogenesis, mitochondrial dynamics, and mitochondrial redox biology.
“Engaging in regular physical activity or exercise training, which proves beneficial for enhancing mitochondrial homeostasis in individuals with sarcopenia, significantly regulates mitophagy, mitochondrial biogenesis, mitochondrial dynamics, and mitochondrial redox biology [9,10,11].”
From Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis (2025) · cites this paper as [10]
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SomaModules: A Pathway Enrichment Approach Tailored to SomaScan Data
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Association analysis of mitochondrial DNA heteroplasmic variants: Methods and application
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Dementia and Cognitive Decline: A HEALM Approach
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A mito-centric view on muscle aging and function
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Early Mobilization in the Intensive Care Unit: To Rest or to Test?
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Caring While Moving: Case Studies on Physical Activity and Dementia Caregiver Well-Being
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ATPase Inhibitory Factor 1—A Novel Marker of Cellular Fitness and Exercise Capacity?
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Environmental Influences on Genetic Aging Processes: Experimental Evidence from Model Systems
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Impact of exercise-induced DNA damage repair on age-related muscle weakness and sarcopenia
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Physical Therapist Management of Cardiovascular Diseases
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Strategic targeting of mitochondria in ischemic heart disease: mechanisms and emerging therapies
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Exerkines in diabetic retinopathy: from mechanisms to therapeutic prospects
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Is the muscle post-ACL injury ready to rebuild or is it limited by mitochondrial dysfunction?
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Exercise prevents fatal stress-induced myocardial injury in obese mice
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Parkinson's and physical activity: the what, why and how
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Aging: Generation of oxidative stress
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Mitochondrial defects in sporadic inclusion body myositis—causes and consequences
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Feretzakis, G., Sakagianni, A., Paxinou, E., & Verykios, V. S. (2024) · International Conference on Information, Intelligence, Systems & Applications (IISA) · doi:10.1109/iisa62523.2024.10786641
Ionic and Molecular Regulation of Mitochondrial Bioenergetics
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- Authors
- Sorriento, D., Di Vaia, E., & Iaccarino, G.
- Affiliations
- Federico II University Hospital (IT)
- Corresponding author
- Iaccarino, Guido
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2021-04-27
- Volume
- 12
- Pages
- 660068-660068
- ISSN
- 1664-042X (ISSN-L)
- PMC
- PMC8110831
- OpenAlex
- W3158316719
- Cited by
- 118
- References
- 168
- Citations by year
- 2026: 14 · 2025: 35 · 2024: 24 · 2023: 27 · 2022: 15 · 2021: 3
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Physiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- physical activity, mitochondrial quality control, mitochondrial dysfunction, cardiomyocytes, heart disease, reactive oxygen species, apoptosis, ATP production, energy metabolism, non-pharmacological treatment, mitochondrial biogenesis
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