Mitochondrial dysfunction and lipotoxicity

Global Prevalence of Diabetes

Wild, S., Roglic, G., Green, A., Sicree, R., & King, H. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1047 · Cited by 15,297 · see citing works

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197 · see citing works

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093 · see citing works

Cellular mechanisms of insulin resistance

Shulman, G. I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10583 · Cited by 2,714 · see citing works

Reactive oxygen species have a causal role in multiple forms of insulin resistance

Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525 · see citing works

Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes

Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321 · see citing works

Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193 · see citing works

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107 · see citing works

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of <i>PGC1</i> and <i>NRF1</i>

Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032913100 · Cited by 1,952 · see citing works

High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria

Korshunov, S. S., Skulachev, V. P., & Starkov, A. A. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01159-9 · Cited by 1,727 · see citing works

Banting Lecture 2001

McGarry, J. D. (2002) · Diabetes · doi:10.2337/diabetes.51.1.7 · Cited by 1,435 · see citing works

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

Anderson, E. J., Lustig, M. E., Boyle, K. E., Woodlief, T. L., Kane, D. A., Lin, C.-T., Price, J. W., Kang, L., Rabinovitch, P. S., Szeto, H. H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37048 · Cited by 1,253 · see citing works

Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes

Goodpaster, B. H. (2001) · Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.86.12.5755 · Cited by 1,194 · see citing works

Fuel selection in human skeletal muscle in insulin resistance: a reexamination.

Kelley, D. E., & Mandarino, L. J. (2000) · Diabetes · doi:10.2337/diabetes.49.5.677 · Cited by 1,017 · see citing works

Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.

Perseghin, G., Scifo, P., De Cobelli, F., Pagliato, E., Battezzati, A., Arcelloni, C., Vanzulli, A., Testolin, G., Pozza, G., Del Maschio, A., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.8.1600 · Cited by 877 · see citing works

Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice

Bonnard, C., Durand, A., Peyrol, S., Chanseaume, E., Chauvin, M.-A., Morio, B., Vidal, H., & Rieusset, J. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32601 · Cited by 819 · see citing works

Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects.

Jacob, S., Machann, J., Rett, K., Brechtel, K., Volk, A., Renn, W., Maerker, E., Matthaei, S., Schick, F., Claussen, C. D., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.5.1113 · Cited by 643 · see citing works

A High-Fat Diet Coordinately Downregulates Genes Required for Mitochondrial Oxidative Phosphorylation in Skeletal Muscle

Sparks, L. M., Xie, H., Koza, R. A., Mynatt, R., Hulver, M. W., Bray, G. A., & Smith, S. R. (2005) · Diabetes · doi:10.2337/diabetes.54.7.1926 · Cited by 629 · see citing works

Effects of Acute Changes of Plasma Free Fatty Acids on Intramyocellular Fat Content and Insulin Resistance in Healthy Subjects

Boden, G., Lebed, B., Schatz, M., Homko, C., & Lemieux, S. (2001) · Diabetes · doi:10.2337/diabetes.50.7.1612 · Cited by 597 · see citing works

A signalling role for 4‐hydroxy‐2‐nonenal in regulation of mitochondrial uncoupling

Echtay, K. S., Esteves, T. C., Pakay, J. L., Jekabsons, M. B., Lambert, A. J., Portero‐Otín, M., Pamplona, R., Vidal‐Puig, A. J., Wang, S., Roebuck, S. J., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg412 · Cited by 597 · see citing works

Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes

Mogensen, M., Sahlin, K., Fernström, M., Glintborg, D., Vind, B. F., Beck-Nielsen, H., & Højlund, K. (2007) · Diabetes · doi:10.2337/db06-0981 · Cited by 573 · see citing works

High-fat diets cause insulin resistance despite an increase in muscle mitochondria

Hancock, C. R., Han, D.-H., Chen, M., Terada, S., Yasuda, T., Wright, D. C., & Holloszy, J. O. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802057105 · Cited by 538 · see citing works

Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in Muscle

Turner, N., Bruce, C. R., Beale, S. M., Hoehn, K. L., So, T., Rolph, M. S., & Cooney, G. J. (2007) · Diabetes · doi:10.2337/db07-0093 · Cited by 520 · see citing works

Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle

Boushel, R., Gnaiger, E., Schjerling, P., Skovbro, M., Kraunsøe, R., & Dela, F. (2007) · Diabetologia · doi:10.1007/s00125-007-0594-3 · Cited by 519 · see citing works

A linear model of muscle respiration explains monoexponential phosphocreatine changes

Meyer, R. A. (1988) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1988.254.4.c548 · Cited by 514 · see citing works

Oxidative Capacity, Lipotoxicity, and Mitochondrial Damage in Type 2 Diabetes

Schrauwen, P., & Hesselink, M. K. C. (2004) · Diabetes · doi:10.2337/diabetes.53.6.1412 · Cited by 408 · see citing works

Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes

Pospisilik, J. A., Knauf, C., Joza, N., Benit, P., Orthofer, M., Cani, P. D., Ebersberger, I., Nakashima, T., Sarao, R., Neely, G., et al. (2007) · Cell · doi:10.1016/j.cell.2007.08.047 · Cited by 404 · see citing works

Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients

Phielix, E., Schrauwen-Hinderling, V. B., Mensink, M., Lenaers, E., Meex, R., Hoeks, J., Kooi, M. E., Moonen-Kornips, E., Sels, J.-P., Hesselink, M. K. C., et al. (2008) · Diabetes · doi:10.2337/db08-0391 · Cited by 359 · see citing works

Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans.

Millet, L., Vidal, H., Andréelli, F., Larrouy, D., Riou, J. P., Ricquier, D., Laville, M., & Langin, D. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119811 · Cited by 351 · see citing works

Elevated Free Fatty Acids Induce Uncoupling Protein 3 Expression in Muscle: A Potential Explanation for the Effect of Fasting

Weigle, D. S., Selfridge, L. E., Schwartz, M. W., Seeley, R. J., Cummings, D. E., Havel, P. J., Kuijper, J. L., & BeltrandelRio, H. (1998) · Diabetes · doi:10.2337/diab.47.2.298 · Cited by 325 · see citing works

Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α: modulation by p38 MAPK

Fan, M., Rhee, J., St-Pierre, J., Handschin, C., Puigserver, P., Lin, J., Jäeger, S., Erdjument-Bromage, H., Tempst, P., & Spiegelman, B. M. (2004) · Genes &amp; Development · doi:10.1101/gad.1152204 · Cited by 309 · see citing works

Uncoupling activity of long-chian fatty acids

Borst, P., Loos, J. A., Christ, E., & Slater, E. C. (1962) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(62)90232-9 · Cited by 308 · see citing works

Role of UCP homologues in skeletal muscles and brown adipose tissue: mediators of thermogenesis or regulators of lipids as fuel substrate?

Samec, S., Seydoux, J., & Dulloo, A. G. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.9.715 · Cited by 305 · see citing works

Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects

Schrauwen-Hinderling, V. B., Kooi, M. E., Hesselink, M. K. C., Jeneson, J. A. L., Backes, W. H., van Echteld, C. J. A., van Engelshoven, J. M. A., Mensink, M., & Schrauwen, P. (2007) · Diabetologia · doi:10.1007/s00125-006-0475-1 · Cited by 304 · see citing works

Quantitative interpretation of bioenergetic data from 31P and 1H magnetic resonance spectroscopic studies of skeletal muscle: an analytical review.

Kemp, G. J., & Radda, G. K. (1994) · PubMed · Cited by 274 · see citing works

A potential link between muscle peroxisome proliferator- activated receptor-α signaling and obesity-related diabetes

Finck, B. N., Bernal-Mizrachi, C., Han, D. H., Coleman, T., Sambandam, N., LaRiviere, L. L., Holloszy, J. O., Semenkovich, C. F., & Kelly, D. P. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.01.006 · Cited by 270 · see citing works

Lipid Infusion Decreases the Expression of Nuclear Encoded Mitochondrial Genes and Increases the Expression of Extracellular Matrix Genes in Human Skeletal Muscle

Richardson, D. K., Kashyap, S., Bajaj, M., Cusi, K., Mandarino, S. J., Finlayson, J., DeFronzo, R. A., Jenkinson, C. P., & Mandarino, L. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m408985200 · Cited by 259 · see citing works

Muscle Mitochondrial ATP Synthesis and Glucose Transport/Phosphorylation in Type 2 Diabetes

Szendroedi, J., Schmid, A. I., Chmelik, M., Toth, C., Brehm, A., Krssak, M., Nowotny, P., Wolzt, M., Waldhausl, W., & Roden, M. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040154 · Cited by 243 · see citing works

Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle

Brehm, A., Krssak, M., Schmid, A. I., Nowotny, P., Waldhäusl, W., & Roden, M. (2006) · Diabetes · doi:10.2337/diabetes.55.01.06.db05-1286 · Cited by 239 · see citing works

A function for novel uncoupling proteins: antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet

Goglia, F., & Skulachev, V. P. (2003) · The FASEB Journal · doi:10.1096/fj.03-0159hyp · Cited by 229 · see citing works

Mild mitochondrial uncoupling impacts cellular aging in human muscles in vivo

Amara, C. E., Shankland, E. G., Jubrias, S. A., Marcinek, D. J., Kushmerick, M. J., & Conley, K. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610131104 · Cited by 223 · see citing works

Intramyocellular Lipid Content in Human Skeletal Muscle

Schrauwen‐Hinderling, V. B., Hesselink, M. K. C., Schrauwen, P., & Kooi, M. E. (2006) · Obesity · doi:10.1038/oby.2006.47 · Cited by 202 · see citing works

Markers of mitochondrial biogenesis and metabolism are lower in overweight and obese insulin-resistant subjects.

Heilbronn, L. K., Gan, S. K., Turner, N., Campbell, L. V., & Chisholm, D. J. (2007) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2006-2210 · Cited by 184 · see citing works

Skeletal muscle “mitochondrial deficiency” does not mediate insulin resistance

Holloszy, J. O. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26717c · Cited by 175 · see citing works

Changes in fat oxidation in response to a high-fat diet

Schrauwen, P., van Marken Lichtenbelt, W., Saris, W., & Westerterp, K. (1997) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.2.276 · Cited by 168 · see citing works

Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?

Russell, A. P., Gastaldi, G., Bobbioni-Harsch, E., Arboit, P., Gobelet, C., Dériaz, O., Golay, A., Witztum, J. L., & Giacobino, J.-P. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00875-5 · Cited by 166 · see citing works

Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1α and PPARβ/δ gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus

Mensink, M., Hesselink, M. K. C., Russell, A. P., Schaart, G., Sels, J.-P., & Schrauwen, P. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803567 · Cited by 160 · see citing works

Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance

Wredenberg, A., Freyer, C., Sandström, M. E., Katz, A., Wibom, R., Westerblad, H., & Larsson, N.-G. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.09.029 · Cited by 141 · see citing works

Interorgan signaling between adipose tissue metabolism and skeletal muscle uncoupling protein homologs: is there a role for circulating free fatty acids?

Samec, S., Seydoux, J., & Dulloo, A. G. (1998) · Diabetes · doi:10.2337/diabetes.47.11.1693 · Cited by 136 · see citing works

Early or advanced stage type 2 diabetes is not accompanied by in vivo skeletal muscle mitochondrial dysfunction.

De Feyter, H. M., van den Broek, N. M. A., Praet, S. F. E., Nicolay, K., van Loon, L. J. C., & Prompers, J. J. (2008) · European Journal of Endocrinology · doi:10.1530/eje-07-0756 · Cited by 116 · see citing works

Intramyocellular Lipid Content and Molecular Adaptations in Response to a 1‐Week High‐Fat Diet

Schrauwen‐Hinderling, V. B., Kooi, M. E., Hesselink, M. K. C., Moonen‐Kornips, E., Schaart, G., Mustard, K. J., Hardie, D. G., Saris, W. H. M., Nicolay, K., & Schrauwen, P. (2005) · Obesity Research · doi:10.1038/oby.2005.259 · Cited by 112 · see citing works

Uncoupling protein 3 content is decreased in skeletal muscle of patients with type 2 diabetes

Schrauwen, P., Hesselink, M. K. C., Blaak, E. E., Borghouts, L. B., Schaart, G., Saris, W. H. M., & Keizer, H. A. (2001) · Diabetes · doi:10.2337/diabetes.50.12.2870 · Cited by 112 · see citing works

Putative function and physiological relevance of the mitochondrial uncoupling protein-3: Involvement in fatty acid metabolism?

Schrauwen, P., Joris Hoeks, J., & Hesselink, M. K. C. (2005) · Progress in Lipid Research · doi:10.1016/j.plipres.2005.11.001 · Cited by 97 · see citing works

The effect of UCP3 overexpression on mitochondrial ROS production in skeletal muscle of young versus aged mice

Nabben, M., Joris Hoeks, J., Briedé, J. J., Glatz, J. F. C., Moonen‐Kornips, E., Hesselink, M. K. C., & Schrauwen, P. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.11.016 · Cited by 84 · see citing works

Effect of β 1 - and β 2 -adrenergic stimulation on energy expenditure, substrate oxidation, and UCP3 expression in humans

Joris Hoeks, J., van Baak, M. A., Hesselink, M. K. C., Hul, G. B. J., Vidal, H., Saris, W. H. M., & Schrauwen, P. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00175.2003 · Cited by 84 · see citing works

Skeletal muscle UCP2 and UCP3 expression in trained and untrained male subjects

Schrauwen, P., Troost, F. J., Xia, J., Ravussin, É., & Saris, W. H. M. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0801026 · Cited by 82 · see citing works

Increased uncoupling protein 3 content does not affect mitochondrial function in human skeletal muscle in vivo

Hesselink, M. K. C., Greenhaff, P. L., Constantin-Teodosiu, D., Hultman, E., Saris, W. H. M., Nieuwlaat, R., Schaart, G., Kornips, E., & Schrauwen, P. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16653 · Cited by 82 · see citing works

Peroxisome proliferator-activated receptor-γ coactivator-1 and insulin resistance: acute effect of fatty acids

Hoeks, J., Hesselink, M. K. C., Russell, A. P., Mensink, M., Saris, W. H. M., Mensink, R. P., & Schrauwen, P. (2006) · Diabetologia · doi:10.1007/s00125-006-0369-2 · Cited by 74 · see citing works

Reduced Skeletal Muscle Uncoupling Protein-3 Content in Prediabetic Subjects and Type 2 Diabetic Patients: Restoration by Rosiglitazone Treatment

Schrauwen, P., Mensink, M., Schaart, G., Moonen‐Kornips, E., Sels, J.-P. J. E., Blaak, E. E., Russell, A. P., & Hesselink, M. K. C. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1572 · Cited by 70 · see citing works

Elevated free fatty acids induce uncoupling protein 3 expression in muscle: a potential explanation for the effect of fasting

Weigle, D. S., Selfridge, L. E., Schwartz, M. W., et al. (1998) · Diabetes · doi:10.2337/diabetes.47.2.298 · Cited by 65 · see citing works

Mitochondrial function, content and ROS production in rat skeletal muscle: effect of high-fat feeding

Hoeks, J., Briedé, J. J., de Vogel, J., Schaart, G., Nabben, M., Moonen-Kornips, E., Hesselink, M. K. C., & Schrauwen, P. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.01.013 · Cited by 63 · see citing works

UCP3 Protein Regulation in Human Skeletal Muscle Fibre Types I, IIa and IIx is Dependent on Exercise Intensity

Russell, A. P., Somm, E., Praz, M., Crettenand, A., Hartley, O., Melotti, A., Giacobino, J., Muzzin, P., Gobelet, C., & Dériaz, O. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.040162 · Cited by 56 · see citing works

Interactions of acyl carnitines with model membranes

Ho, J., Duclos, R. I., & Hamilton, J. A. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200137-jlr200 · Cited by 56 · see citing works

Etomoxir‐induced increase in UCP3 supports a role of uncoupling protein 3 as a mitochondrial fatty acid anion exporter

Schrauwen, P., Schrauwen‐Hinderling, V. B., Hesselink, M. K. C., Schaart, G., Moonen‐Kornips, E., Saris, W. H. M., Westerterp‐Plantenga, M. S., & Langhans, W. (2002) · The FASEB Journal · doi:10.1096/fj.02-0275fje · Cited by 53 · see citing works

Diet-induced modulation of mitochondrial activity in rat muscle

Didier, L., Yerby, B., Deacon, R. W., & Gao, J. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00263.2007 · Cited by 48 · see citing works

Chronological Approach of Diet‐induced Alterations in Muscle Mitochondrial Functions in Rats

Chanséaume, E., Tardy, A.-L., Salles, J., Giraudet, C., Rousset, P., Tissandier, A., Boirie‌, Y., & Morio, B. (2007) · Obesity · doi:10.1038/oby.2007.511 · Cited by 45 · see citing works

Decreased Uncoupling Protein Expression and Intramyocytic Triglyceride Depletion in Formerly Obese Subjects

Mingrone, G., Rosa, G., Greco, A. V., Manco, M., Véga, N., Hesselink, M. K. C., Castagneto, M., Schrauwen, P., & Vidal, H. (2003) · Obesity Research · doi:10.1038/oby.2003.91 · Cited by 38 · see citing works

Increased uncoupling protein 3 content does not affect mitochondrial function in human skeletal muscle in vivo

Hesselink, M. K. C., Greenhaff, P. L., Constantin-Teodosiu, D., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200316653 · Cited by 28 · see citing works

The effect of high‐fat feeding on intramuscular lipid and lipid peroxidation levels in UCP3‐ablated mice

Joris Hoeks, J., Hesselink, M. K. C., Sluiter, W. J., Schaart, G., Willems, J., Morrisson, A., Clapham, J. C., Saris, W. H. M., & Schrauwen, P. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.01.059 · Cited by 26 · see citing works

Mitochondrial and metabolic dysfunction in ageing and age-related diseases

Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990 · see citing works

Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease

Smith, R. L., Soeters, M. R., Wüst, R. C. I., & Houtkooper, R. H. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00211 · Cited by 787 · see citing works

Pathological aspects of lipid peroxidation

Nègre‐Salvayre, A., Augè, N., Ayala, V., Başağa, H., Boada, J., Brenke, R., Chapple, S. J., Cohen, G., Fehér, J., Grune, T., et al. (2010) · Free Radical Research · doi:10.3109/10715762.2010.498478 · Cited by 451 · see citing works

Ectopic fat and insulin resistance: pathophysiology and effect of diet and lifestyle interventions.

Snel, M., Jonker, J. T., Schoones, J., Lamb, H., de Roos, A., Pijl, H., Smit, J. W. A., Meinders, A. E., & Jazet, I. M. (2012) · International Journal of Endocrinology · doi:10.1155/2012/983814 · Cited by 368 · see citing works

High-Fat Diet Causes Lipotoxicity Responses in Cumulus–Oocyte Complexes and Decreased Fertilization Rates

Wu, L., Dunning, K. R., Yang, X., Russell, D. L., Lane, M., Norman, R. J., & Robker, R. L. (2010) · Endocrinology · doi:10.1210/en.2010-0551 · Cited by 357 · see citing works

Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet

Sergi, D., Naumovski, N., Heilbronn, L. K., Abeywardena, M., O’Callaghan, N., Lionetti, L., & Luscombe-Marsh, N. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00532 · Cited by 347 · see citing works

Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function

Martins, A. R., Nachbar, R. T., Gorjão, R., Vinolo, M. A. R., Festuccia, W. T., Lambertucci, R. H., Cury‐Boaventura, M. F., Silveira, L. R., Curi, R., & Hirabara, S. M. (2012) · Lipids in Health and Disease · doi:10.1186/1476-511x-11-30 · Cited by 288 · see citing works

Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress

Yuzefovych, L., Wilson, G., & Rachek, L. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00238.2010 · Cited by 280 · see citing works

Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophy

Abel, E. D., & Doenst, T. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr015 · Cited by 263 · see citing works

Mitochondrial and cellular mechanisms for managing lipid excess

Aon, M. A., Bhatt, N., & Cortassa, S. C. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00282 · Cited by 253 · see citing works

Food as medicine: targeting the uraemic phenotype in chronic kidney disease

Mafra, D., Borges, N. A., Lindholm, B., Shiels, P. G., Evenepoel, P., & Stenvinkel, P. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-020-00345-8 · Cited by 238 · see citing works

Mitochondrial Dysfunction and Lipid Accumulation in the Human Diaphragm during Mechanical Ventilation

Picard, M. A., Jung, B., Liang, F., Azuelos, I., Hussain, S. N. A., Goldberg, P., Godin, R., Danialou, G., Chaturvedi, R. K., Rygiel, K. A., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201206-0982oc · Cited by 220 · see citing works

Exercise and nutrition strategies to counteract sarcopenic obesity

Trouwborst, I., Verreijen, A., Memelink, R., Massanet, P., Boirie, Y., Weijs, P., & Tieland, M. (2018) · Nutrients · doi:10.3390/nu10050605 · Cited by 210 · see citing works

Increasing Fatty Acid Oxidation Prevents High-Fat Diet–Induced Cardiomyopathy Through Regulating Parkin-Mediated Mitophagy

Shao, D., Kolwicz, S. C., Wang, P., Roe, N. D., Villet, O. M., Nishi, K., Hsu, Y. A., Flint, G. V., Caudal, A., Wang, W., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.043319 · Cited by 217 · see citing works

Interorgan Metabolic Crosstalk in Human Insulin Resistance

Gancheva, S., Jeleník, T., Álvarez-Hernández, E., & Roden, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00015.2017 · Cited by 192 · see citing works

Antimicrobial peptaibols from Trichoderma pseudokoningii induce programmed cell death in plant fungal pathogens

Shi, M., Chen, L., Wang, X., Zhang, T., Zhao, P., Song, X., Sun, C., Chen, X., Zhou, B., & Zhang, Y. (2011) · Microbiology · doi:10.1099/mic.0.052670-0 · Cited by 185 · see citing works

Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death

Lee, E. A., Angka, L., Rota, S.-G., Hanlon, T., Mitchell, A. S., Hurren, R., Wang, X. M., Gronda, M., Boyacı, E., Bojko, B., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2676 · Cited by 179 · see citing works

Caloric restriction and the aging process: a critique

Sohal, R. S., & Forster, M. J. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.015 · Cited by 178 · see citing works

Lower extremity muscle strength is reduced in people with type 2 diabetes, with and without polyneuropathy, and is associated with impaired mobility and reduced quality of life

IJzerman, T. H., Schaper, N. C., Melai, T., Meijer, K., Willems, P. J. B., & Savelberg, H. H. C. M. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2011.10.026 · Cited by 177 · see citing works

Chronic disease risk among adults with cerebral palsy: the role of premature sarcopoenia, obesity and sedentary behaviour

Peterson, M. D., Gordon, P. M., & Hurvitz, E. A. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01052.x · Cited by 176 · see citing works

The Role of microRNAs in Mitochondria: Small Players Acting Wide

Duarte, F. V., Palmeira, C. M., & Rolo, A. P. (2014) · Genes · doi:10.3390/genes5040865 · Cited by 151 · see citing works

Evidence for a Direct Effect of the NAD+ Precursor Acipimox on Muscle Mitochondrial Function in Humans

van de Weijer, T., Phielix, E., Bilet, L., Williams, E. G., Ropelle, E. R., Bierwagen, A., Livingstone, R., Nowotny, P., Sparks, L. M., Paglialunga, S., et al. (2015) · Diabetes · doi:10.2337/db14-0667 · Cited by 139 · see citing works

Macrophages, Low-Grade Inflammation, Insulin Resistance and Hyperinsulinemia: A Mutual Ambiguous Relationship in the Development of Metabolic Diseases

Püschel, G. P., Klauder, J., & Henkel, J. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11154358 · Cited by 145 · see citing works

Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria?

de Cavanagh, E. M. V., Inserra, F., & Ferder, L. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq285 · Cited by 136 · see citing works

A high‐fat diet impairs mitochondrial biogenesis, mitochondrial dynamics, and the respiratory chain complex in rat myocardial tissues

Chen, D., Li, X., Zhang, L., Zhu, M., & Gao, L. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27068 · Cited by 125 · see citing works

Leucine Modulates Mitochondrial Biogenesis and SIRT1-AMPK Signaling in C2C12 Myotubes

Liang, C., Curry, B. J., Brown, P. L., & Zemel, M. B. (2014) · Journal of Nutrition and Metabolism · doi:10.1155/2014/239750 · Cited by 125 · see citing works

Parturition dysfunction in obesity: time to target the pathobiology

Carlson, N. S., Hernandez, T. L., & Hurt, K. J. (2015) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-015-0129-6 · Cited by 123 · see citing works

MicroRNA 375 Mediates Palmitate-Induced Enteric Neuronal Damage and High-Fat Diet-Induced Delayed Intestinal Transit in Mice

Nezami, B. G., Mwangi, S. M., Lee, J. E., Jeppsson, S., Anitha, M., Yarandi, S., Farris, A. B., & Srinivasan, S. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.10.053 · Cited by 121 · see citing works

Disrupted circadian oscillations in type 2 diabetes are linked to altered rhythmic mitochondrial metabolism in skeletal muscle

Gabriel, B. M., Altıntaş, A., Smith, J. A. B., Puig, L. S., Zhang, X., Basse, A. L., Laker, R. C., Gao, H., Liu, Z., Dollet, L., et al. (2021) · Science Advances · doi:10.1126/sciadv.abi9654 · Cited by 118 · see citing works

Metabolomics – the complementary field in systems biology: a review on obesity and type 2 diabetes

Bakar, M. H. A., Sarmidi, M. R., Cheng, K., Khan, A. A., Suan, C. L., Huri, H. Z., & Yaakob, H. (2015) · Molecular BioSystems · doi:10.1039/c5mb00158g · Cited by 117 · see citing works

Lipid Replacement Therapy: A natural medicine approach to replacing damaged lipids in cellular membranes and organelles and restoring function

Nicolson, G. L., & Ash, M. E. (2013) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2013.11.010 · Cited by 113 · see citing works

Ectopic Fat Accumulation in Distinct Insulin Resistant Phenotypes; Targets for Personalized Nutritional Interventions

Trouwborst, I., Bowser, S. M., Goossens, G. H., & Blaak, E. E. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00077 · Cited by 115 · see citing works

Lipotoxicity-polarised macrophage-derived exosomes regulate mitochondrial fitness through Miro1-mediated mitophagy inhibition and contribute to type 2 diabetes development in mice

Li, J., Li, X., Chan, L., Hu, R., Zheng, T., Li, H., & Yang, S. (2023) · Diabetologia · doi:10.1007/s00125-023-05992-7 · Cited by 108 · see citing works

Obesity-exposed oocytes accumulate and transmit damaged mitochondria due to an inability to activate mitophagy

Boudoures, A. L., Saben, J. L., Drury, A. M., Scheaffer, S. M., Modi, Z. N., Zhang, W., & Moley, K. H. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.04.005 · Cited by 103 · see citing works

Cold tolerance of UCP1-ablated mice: A skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects

Shabalina, I. G., Joris Hoeks, J., Kramarova, T. V., Schrauwen, P., Cannon, B., & Nedergaard, J. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.02.033 · Cited by 101 · see citing works

Effects of exposure to BDE-99 on oxidative status of liver and kidney in adult rats

Albina, M. L., Alonso, V., Linares, V., Bellés, M., Sirvent, J. J., Domingo, J. L., & Sánchez, D. J. (2010) · Toxicology · doi:10.1016/j.tox.2010.03.006 · Cited by 97 · see citing works

Mitochondrial dysfunction in patients with primary congenital insulin resistance

Sleigh, A., Raymond‐Barker, P., Thackray, K., Porter, D. A., Hatunic, M., Vottero, A., Burren, C. P., Mitchell, C., McIntyre, M., Brage, S., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46405 · Cited by 95 · see citing works

Clozapine-Induced Mitochondria Alterations and Inflammation in Brain and Insulin-Responsive Cells

Contreras-Shannon, V., Heart, D. L., Paredes, R. M., Navaira, E., Catano, G., Maffi, S. K., & Walss‐Bass, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059012 · Cited by 96 · see citing works

MicroRNA-106b induces mitochondrial dysfunction and insulin resistance in C2C12 myotubes by targeting mitofusin-2

Zhang, Y., Yang, L., Yuan-fu, G., Fan, Z., Cai, X., Liu, M., Guo, X., Gao, C., & Xia, Z. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.08.004 · Cited by 94 · see citing works

Mitochondrial dysfunction as a central event for mechanisms underlying insulin resistance: The roles of long chain fatty acids

Hafizi Abu Bakar, M., Kian Kai, C., Wan Hassan, W. N., Sarmidi, M. R., Yaakob, H., & Zaman Huri, H. (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2601 · Cited by 91 · see citing works

Relationships between Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes Mellitus

van de Weijer, T., Sparks, L. M., Phielix, E., Meex, R. C., van Herpen, N. A., Hesselink, M. K. C., Schrauwen, P., & Schrauwen-Hinderling, V. B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0051648 · Cited by 87 · see citing works

The impact of diet upon mitochondrial physiology (Review)

Kyriazis, I. D., Vassi, E., Alvanou, M. V., Angelakis, C., Skaperda, Z., Tekos, F., Garikipati, V. N. S., Spandidos, D. A., & Kouretas, D. (2022) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2022.5191 · Cited by 91 · see citing works

Exercise Training Promotes Cardiac Hydrogen Sulfide Biosynthesis and Mitigates Pyroptosis to Prevent High-Fat Diet-Induced Diabetic Cardiomyopathy

Kar, S., Shahshahan, H. R., Hackfort, B. T., Yadav, S. K., Yadav, R., Kambis, T. N., Lefer, D. J., & Mishra, P. K. (2019) · Antioxidants · doi:10.3390/antiox8120638 · Cited by 85 · see citing works

Sex differences in the effect of high-fat diet feeding on rat white adipose tissue mitochondrial function and insulin sensitivity

Amengual-Cladera, E., Lladó, I., Gianotti, M., & Proenza, A. M. (2012) · Metabolism · doi:10.1016/j.metabol.2011.12.016 · Cited by 84 · see citing works

Myricanol modulates skeletal muscle–adipose tissue crosstalk to alleviate high‐fat diet‐induced obesity and insulin resistance

Shen, S., Liao, Q., Zhang, T., Pan, R., & Lin, L. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14802 · Cited by 86 · see citing works

The Emerging Role of MitomiRs in the Pathophysiology of Human Disease

Duarte, F. V., Palmeira, C. M., & Rolo, A. P. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-22671-2_8 · Cited by 81 · see citing works

The Renin-Angiotensin System in the Pathophysiology of Type 2 Diabetes

Goossens, G. H. (2012) · Obesity Facts · doi:10.1159/000342776 · Cited by 80 · see citing works

The Physiological Regulation of Skeletal Muscle Fatty Acid Supply and Oxidation During Moderate-Intensity Exercise

van Hall, G. (2015) · Sports Medicine · doi:10.1007/s40279-015-0394-8 · Cited by 77 · see citing works

Assessment of lower extremity muscle mass, muscle strength, and exercise therapy in elderly patients with diabetes mellitus

Nomura, T., Kawae, T., Kataoka, H., & Ikeda, Y. (2018) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-018-0710-7 · Cited by 78 · see citing works

Cardiomyocyte lipids impair β-adrenergic receptor function via PKC activation

Drosatos, K., Bharadwaj, K. G., Lymperopoulos, A., Ikeda, S., Khan, R. S., Hu, Y., Agarwal, R., Yu, S., Jiang, H., Steinberg, S. F., et al. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00569.2010 · Cited by 77 · see citing works

Effects of Adding Exercise to a 16-Week Very Low-Calorie Diet in Obese, Insulin-Dependent Type 2 Diabetes Mellitus Patients

Snel, M., Gastaldelli, A., Ouwens, D. M., Hesselink, M. K. C., Schaart, G., Buzzigoli, E., Frölich, M., Romijn, J. A., Pijl, H., Meinders, A. E., et al. (2012) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2011-3178 · Cited by 74 · see citing works

Evogliptin, a DPP-4 inhibitor, prevents diabetic cardiomyopathy by alleviating cardiac lipotoxicity in db/db mice

Kha, P. T., Nguyen, T., Yi, J. M., Kim, G. S., Yun, H. R., Kim, H. K., & Won, J. C. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-00958-6 · Cited by 74 · see citing works

Synergistic interaction of fatty acids and oxysterols impairs mitochondrial function and limits liver adaptation during nafld progression

Bellanti, F., Villani, R., Tamborra, R., Blonda, M., Iannelli, G., di Bello, G., Facciorusso, A., Poli, G., Iuliano, L., Avolio, C., et al. (2017) · Redox Biology · doi:10.1016/j.redox.2017.11.016 · Cited by 70 · see citing works

Protective Mechanisms of Mitochondria and Heart Function in Diabetes

Aon, M. A., Tocchetti, C. G., Bhatt, N., Paolocci, N., & Cortassa, S. C. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6123 · Cited by 70 · see citing works

Skeletal intramyocellular lipid metabolism and insulin resistance

Li, Y., Xu, S.-M., Zhang, X.-L., Yi, Z., & Cichello, S. (2015) · Biophysics Reports · doi:10.1007/s41048-015-0013-0 · Cited by 61 · see citing works

Membrane Lipid Replacement for chronic illnesses, aging and cancer using oral glycerolphospholipid formulations with fructooligosaccharides to restore phospholipid function in cellular membranes, organelles, cells and tissues

Nicolson, G. L., & Ash, M. E. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.04.013 · Cited by 71 · see citing works

Mitochondrial Dysfunction in Kidney Disease and Uremic Sarcopenia

Takemura, K., Nishi, H., & Inagi, R. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.565023 · Cited by 67 · see citing works

Mitochondrial Dysfunction and Lipid Homeostasis

Vamecq, J., Dessein, A., Fontaine, M., Briand, G., Porchet, N., Latruffe, N., Andreoletti, P., & Cherkaoui‐Malki, M. (2012) · Current Drug Metabolism · doi:10.2174/138920012803762792 · Cited by 68 · see citing works

Proton magnetic resonance spectroscopy reveals increased hepatic lipid content after a single high-fat meal with no additional modulation by added protein

Lindeboom, L., Nabuurs, C. I. H. C., Hesselink, M. K. C., Wildberger, J. E., Schrauwen, P., & Schrauwen‐Hinderling, V. B. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.094730 · Cited by 67 · see citing works

Myosteatosis: Diagnosis, pathophysiology and consequences in metabolic dysfunction-associated steatotic liver disease

Hénin, G., Loumaye, A., Leclercq, I. A., & Lanthier, N. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100963 · Cited by 70 · see citing works

Apolipoprotein O is mitochondrial and promotes lipotoxicity in heart

Turkieh, A., Caubère, C., Barutaut, M., Desmoulin, F., Harmancey, R., Galinier, M., Berry, M., Dambrin, C., Polidori, C., Casteilla, L., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74668 · Cited by 61 · see citing works

Breast cancer-associated skeletal muscle mitochondrial dysfunction and lipid accumulation is reversed by PPARG

Wilson, H. E., Stanton, D. A., Rellick, S. L., Geldenhuys, W. J., & Pistilli, E. E. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00264.2020 · Cited by 61 · see citing works

Optimization of lipid extraction and analytical protocols for UHPLC-ESI-HRMS-based lipidomic analysis of adherent mammalian cancer cells

Zhang, H., Gao, Y., Sun, J., Fan, S., Yao, X., Ran, X., Zheng, C., Huang, M., & Bi, H. (2017) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-017-0483-7 · Cited by 60 · see citing works

Genetic and cellular modifiers of oxidative stress: What can we learn from fatty acid oxidation defects?

Olsen, R. K. J., Cornelius, N., & Gregersen, N. (2013) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2013.10.007 · Cited by 58 · see citing works

The impact of bed rest on human skeletal muscle metabolism

Eggelbusch, M., Charlton, B. T., Bosutti, A., Ganse, B., Giakoumaki, I., Grootemaat, A. E., Hendrickse, P. W., Jaspers, Y. R. J., Kemp, S., Kerkhoff, T. J., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101372 · Cited by 57 · see citing works

Overexpression of Vesicle-associated Membrane Protein (VAMP) 3, but Not VAMP2, Protects Glucose Transporter (GLUT) 4 Protein Translocation in an in Vitro Model of Cardiac Insulin Resistance

Schwenk, R. W., Angın, Y., Steinbusch, L. K. M., Dirkx, E., Hoebers, N., Coumans, W. A., Bonen, A., Broers, J. L. V., van Eys, G. J. J. M., Glatz, J. F. C., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.363630 · Cited by 57 · see citing works

Strength training improves muscle aerobic capacity and glucose tolerance in elderly

Frank, P., Andersson, E. A., Pontén, M., Ekblom, B. T., Ekblom, M., & Sahlin, K. (2015) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12537 · Cited by 55 · see citing works

Acute Administration of Grape Seed Proanthocyanidin Extract Modulates Energetic Metabolism in Skeletal Muscle and BAT Mitochondria

Reguera, D. P., Díaz, S., Quesada, H., Fernández‐Iglesias, A., Mulero, M., Arola‐Arnal, A., Salvadó, M. J., Bladé, C., & Arola, L. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf200322x · Cited by 55 · see citing works

Impaired skeletal muscle mitochondrial function in morbidly obese patients is normalized one year after bariatric surgery

Vijgen, G. H. E. J., Bouvy, N. D., Joris Hoeks, J., Wijers, S. L. J., Schrauwen, P., & Lichtenbelt, W. D. V. M. (2013) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2013.03.009 · Cited by 55 · see citing works

Immuno-regenerative biomaterials for in situ cardiovascular tissue engineering – Do patient characteristics warrant precision engineering?

de Kort, B. J., Koch, S. E., Wissing, T. B., Krebber, M. M., Bouten, C. V. C., & Smits, A. I. P. M. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113960 · Cited by 58 · see citing works

Trimetazidine prevents palmitate-induced mitochondrial fission and dysfunction in cultured cardiomyocytes

Kuzmicic, J., Parra, V., Verdejo, H., López‐Crisosto, C., Chiong, M., Garcı́a, L., Jensen, M. D., Bernlohr, D., Castro, P., & Lavandero, S. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.07.022 · Cited by 53 · see citing works

Aloin Protects Skin Fibroblasts from Heat Stress-Induced Oxidative Stress Damage by Regulating the Oxidative Defense System

Liu, F.-W., Liu, F.-C., Wang, Y., Tsai, H., & Yu, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143528 · Cited by 53 · see citing works

Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and lipotoxicity in humans

Gemmink, A., Bosma, M., Kuijpers, H., Hoeks, J., Schaart, G., van Zandvoort, M., Schrauwen, P., & Hesselink, M. (2016) · Diabetologia · doi:10.1007/s00125-016-3865-z · Cited by 54 · see citing works

An Energy-Independent Pro-longevity Function of Triacylglycerol in Yeast

Handee, W., Li, X., Hall, K. W., Deng, X., Li, P., Christoph Benning, A., Williams, B. L., & Kuo, M. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005878 · Cited by 52 · see citing works

Circulating cell‐free mitochondrial deoxyribonucleic acid is increased in coronary heart disease patients with diabetes mellitus

Liu, J., Zou, Y., Tang, Y., Xi, M., Xie, L., Zhang, Q., & Gong, J. (2015) · Journal of Diabetes Investigation · doi:10.1111/jdi.12366 · Cited by 50 · see citing works

Antioxidant Effects of Statins in the Management of Cardiometabolic Disorders

Lim, S. K., & Barter, P. J. (2014) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.24398 · Cited by 50 · see citing works

Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity

Park, J. S., Lee, D. H., Lee, Y. S., Oh, E., Bae, K., Oh, K., Kim, H.-M., & Bae, S. H. (2019) · Autophagy · doi:10.1080/15548627.2019.1598751 · Cited by 51 · see citing works

Central fat and peripheral muscle: partners in crime in chronic obstructive pulmonary disease.

van den Borst, B., Gosker, H., & Schols, A. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201208-1441oe · Cited by 50 · see citing works

Insulin resistance in critical illness

Dhar, A. V., & Castillo, L. (2011) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e3283464b3e · Cited by 49 · see citing works

Tetramethylpyrazine protects palmitate-induced oxidative damage and mitochondrial dysfunction in C2C12 myotubes

Gao, X., Zhao, X., Zhu, Y., Li, X.-M., Xu, Q., Lin, H., & Wang, M. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.02.025 · Cited by 49 · see citing works

Soybean Oil-Derived Poly-Unsaturated Fatty Acids Enhance Liver Damage in NAFLD Induced by Dietary Cholesterol

Henkel, J., Alfine, E., Saín, J., Jöhrens, K., Weber, D., Castro, J. P., König, J., Stuhlmann, C., Vahrenbrink, M., Jonas, W., et al. (2018) · Nutrients · doi:10.3390/nu10091326 · Cited by 49 · see citing works

Predictors of Cardiometabolic Risk Among Adults With Cerebral Palsy

Peterson, M. D., Haapala, H. J., & Hurvitz, E. A. (2012) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2011.12.024 · Cited by 48 · see citing works

Protein tyrosine phosphatase 1B inhibition ameliorates palmitate-induced mitochondrial dysfunction and apoptosis in skeletal muscle cells

Taheripak, G., Bakhtiyari, S., Rajabibazl, M., Pasalar, P., & Meshkani, R. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.09.019 · Cited by 48 · see citing works

Squalene is lipotoxic to yeast cells defective in lipid droplet biogenesis

Valachovič, M., Garaiová, M., Holič, R., & Hapala, I. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.12.050 · Cited by 48 · see citing works

Cardiac transcriptome profiling of diabetic Akita mice using microarray and next generation sequencing

Kesherwani, V., Shahshahan, H. R., & Mishra, P. K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182828 · Cited by 48 · see citing works

Hexanoic, Octanoic and Decanoic Acids Promote Basal and Insulin-Induced Phosphorylation of the Akt-mTOR Axis and a Balanced Lipid Metabolism in the HepG2 Hepatoma Cell Line

Rial, S. A., Ravaut, G., Malaret, T., Bergeron, K., & Mounier, C. (2018) · Molecules · doi:10.3390/molecules23092315 · Cited by 49 · see citing works

Mitochondrial Function and Insulin Resistance during Aging – A Mini-Review

Phielix, E., Szendroedi, J., & Roden, M. (2011) · Gerontology · doi:10.1159/000317691 · Cited by 47 · see citing works

Decreased peripheral blood mitochondrial DNA content is related to HbA1c, fasting plasma glucose level and age of onset in Type 2 diabetes mellitus

Xu, F., Zhou, X. M., Shen, F., Pang, R. W. C., & Liu, S. M. (2011) · Diabetic Medicine · doi:10.1111/j.1464-5491.2011.03565.x · Cited by 47 · see citing works

Barth syndrome: cardiolipin, cellular pathophysiology, management, and novel therapeutic targets

Zegallai, H. M., & Hatch, G. M. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-020-04021-0 · Cited by 48 · see citing works

The dynamic interplay between cardiac mitochondrial health and myocardial structural remodeling in metabolic heart disease, aging, and heart failure

Werbner, B., Tavakoli‐Rouzbehani, O. M., Fatahian, A. N., & Boudina, S. (2023) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2022.42 · Cited by 44 · see citing works

The Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related Glucolipotoxicity

Moreto, F., de Oliveira, E. P., Manda, R. M., & Burini, R. C. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/505368 · Cited by 46 · see citing works

Rosmarinic Acid Mediates Mitochondrial Biogenesis in Insulin Resistant Skeletal Muscle Through Activation of AMPK

Jayanthy, G., Devi, V. R., Ilango, K., & Subramanian, S. P. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25869 · Cited by 47 · see citing works

Theaflavins Improve Insulin Sensitivity through Regulating Mitochondrial Biosynthesis in Palmitic Acid-Induced HepG2 Cells

Tong, T., Ren, N., Wu, J., Wu, J., Liu, X., Kang, H., Li, P., Kim, E., Wu, Y., He, P., et al. (2018) · Molecules · doi:10.3390/molecules23123382 · Cited by 46 · see citing works

A mitochondrial-targeted ubiquinone modulates muscle lipid profile and improves mitochondrial respiration in obesogenic diet-fed rats

Coudray, C., Fouret, G., Lambert, K., Ferreri, C., Rieusset, J., Błachnio-Zabielska, A. U., Lecomte, J., Elle, R. E., Badia, É., Murphy, M. P., et al. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114515005528 · Cited by 44 · see citing works

Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence

Zhang, H., Wang, Y., Guan, L., Chen, Y., Chen, P., Sun, J., Gonzalez, F. J., Huang, M., & Bi, H. (2020) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2020.04.004 · Cited by 42 · see citing works

Dynamic monitoring of carnitine and acetylcarnitine in the trimethylamine signal after exercise in human skeletal muscle by 7T1H‐MRS

Ren, J., Gilchrist, S. C., Haller, R. G., Sherry, A. D., & Malloy, C. R. (2012) · Magnetic Resonance in Medicine · doi:10.1002/mrm.24249 · Cited by 41 · see citing works

The Complex Interplay between Imbalanced Mitochondrial Dynamics and Metabolic Disorders in Type 2 Diabetes

Huynh, T. V., Rethi, L., Rethi, L., Chen, C., Chen, Y., & Kao, Y. (2023) · Cells · doi:10.3390/cells12091223 · Cited by 40 · see citing works

Targeting PPARβ/δ for the treatment of type 2 diabetes mellitus

Salvadó, L., Serrano, L., Barroso, E., Palomer, X., & Vázquez‐Carrera, M. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2012.658370 · Cited by 42 · see citing works

Clozapine Treatment Causes Oxidation of Proteins Involved in Energy Metabolism in Lymphoblastoid Cells: A Possible Mechanism for Antipsychotic- Induced Metabolic Alterations

Baig, M. R., Navaira, E., Escamilla, M., Raventós, H., & Walss‐Bass, C. (2010) · Journal of Psychiatric Practice · doi:10.1097/01.pra.0000388627.36781.6a · Cited by 41 · see citing works

Long-term high-fat-diet feeding induces skeletal muscle mitochondrial biogenesis in rats in a sex-dependent and muscle-type specific manner

Gómez‐Pérez, Y., Capllonch-Amer, G., Gianotti, M., Lladó, I., & Proenza, A. M. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-15 · Cited by 39 · see citing works

Is skeletal muscle mitochondrial dysfunction a cause or an indirect consequence of insulin resistance in humans?

Dumas, J., Simard, G., Flamment, M., Ducluzeau, P., & Ritz, P. (2009) · Diabetes & Metabolism · doi:10.1016/j.diabet.2009.02.002 · Cited by 55 · see citing works

Lipotoxicity and Mitochondrial Dysfunction in Type 2 Diabetes

Hesselink, M. K. C., Mensink, M., & Schrauwen, P. (2007) · Immunology Endocrine & Metabolic Agents - Medicinal Chemistry · doi:10.2174/187152207779802509 · Cited by 7 · see citing works

The relationship between muscle mitochondrial nutritional overloading and insulin resistance

Jeon, J., Moon, J. S., Won, K. C., & Lee, I. K. (2017) · Journal of Yeungnam Medical Science · doi:10.12701/yujm.2017.34.1.19

The complex interplay between oxinflammation, mitochondrial dysfunction and lipotoxicity: Focus on their role in the pathogenesis of skeletal muscle insulin resistance and modulation by dietary fatty acids

Passaro, A., Sanz, J. M., Naumovski, N., & Sergi, D. (2024) · Advances in Redox Research · doi:10.1016/j.arres.2024.100100 · Cited by 17 · see citing works

The role of mitochondrial function in skeletal muscle insulin resistance

Zhang, K., & Du, J. (2011) · Intern J Endocrinol Metab · doi:10.3760/cma.j.issn.1673-4157.2011.05.010