The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
PU.1 regulates both cytokine‐dependent proliferation and differentiation of granulocyte/macrophage progenitors
Open accessAbstract
PU.1 is a unique regulatory protein required for the generation of both the innate and the adaptive immune system. It functions exclusively in a cell-intrinsic manner to control the development of granulocytes, macrophages, and B and T lymphocytes. We demonstrate that mutation of the PU.1 gene causes a severe reduction in myeloid (granulocyte/macrophage) progenitors. PU.1 -/- myeloid progenitors can proliferate in vitro in response to the multilineage cytokines interleukin-3 (IL-3), IL-6 and stem cell factor but are unresponsive to the myeloid-specific cytokines granulocyte-macrophage colony-stimulating factor (GM-CSF), G-CSF and M-CSF. The failure of PU.1 -/- progenitors to respond to G-CSF is bypassed by transient signaling with IL-3. In the presence of IL-3 and G-CSF, PU.1 -/- progenitors can differentiate into granulocytic precursors containing myeloperoxidase-positive granules. Thus PU.1 is not essential for specification of granulocytic precursors, but is required for their further differentiation. The failure of PU.1 -/- progenitors to respond to M-CSF is due to lack of c-fms gene transcription. Transduction of c-fms into PU.1 -/- myeloid progenitors bypasses the block to M-CSF-dependent proliferation but does not induce detectable macrophage differentiation. Therefore, PU. 1 appears to be essential for specification of monocytic precursors. Importantly, retroviral transduction of PU.1 into mutant progenitors restores responsiveness to myeloid-specific cytokines and development of mature granulocytes and macrophages. Thus PU.1 controls myelopoiesis by regulating both proliferation and differentiation pathways.
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“These findings are consistent with prior work indicating PU.1 can constrain myelopoietic activity (DeKoter et al., 1998; Dakic et al., 2005)”
From PU.1 is required to restrain myelopoiesis during chronic inflammatory stress (2023) · cites this paper as DeKoter et al., 1998
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“We and others have previously shown that the myeloid ‘master regulator’ transcription factor PU.1 (DeKoter et al., 1998; Singh et al., 1999) is upregulated at the transcriptional and protein levels in HSC by chronic inflammatory signals such as the pro-inflammatory cytokine IL-1β (Algeciras-Schimnich et al., 2003; Pietras et al., 2016; Hernandez et al., 2020; Rabe et al., 2020; Chavez et al., 2021”
From PU.1 is required to restrain myelopoiesis during chronic inflammatory stress (2023) · cites this paper as DeKoter et al., 1998
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“Consistent with this, PU.1 is expressed at low levels in hematopoietic stem cells and is relatively more abundant during monocyte versus neutrophil differentiation (43).”
From PU.1, Interferon Regulatory Factor (IRF) 2, and the Interferon Consensus Sequence-binding Protein (ICSBP/IRF8) Cooperate to Activate NF1 Transcription in Differentiating Myeloid Cells (2007) · cites this paper as [43]
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Citations
Cites
Cytochemical Identification of Monocytes and Granulocytes
Yam, L. T., LI, C. Y., & Crosby, W. H. (1971) · American Journal of Clinical Pathology · doi:10.1093/ajcp/55.3.283 · Cited by 2,694
FACS-optimized mutants of the green fluorescent protein (GFP)
Cormack, B. P., Valdivia, R. H., & Falkow, S. (1996) · Gene · doi:10.1016/0378-1119(95)00685-0 · Cited by 2,621
Production of high-titer helper-free retroviruses by transient transfection.
Pear, W. S., Nolan, G. P., Scott, M. L., & Baltimore, D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8392 · Cited by 2,267
Kishimoto, T. (1989) · Blood · doi:10.1182/blood.v74.1.1.bloodjournal7411 · Cited by 2,068
Yoshida, H., Hayashi, S.-I., Kunisada, T., Ogawa, M., Nishikawa, S., Okamura, H., Sudo, T., Shultz, L. D., & Nishikawa, S.-I. (1990) · Nature · doi:10.1038/345442a0 · Cited by 1,789
Sherr, C. J., Rettenmier, C. W., Sacca, R. E., Roussel, M. F., Look, A. T., & Stanley, E. R. (1985) · Cell · doi:10.1016/s0092-8674(85)80047-7 · Cited by 1,539
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
Scott, E. W., Simon, M. C., Anastasi, J., & Singh, H. (1994) · Science · doi:10.1126/science.8079170 · Cited by 1,532
Self-citationInterleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
Taga, T., Hibi, M., Hirata, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T., & Kishimoto, T. (1989) · Cell · doi:10.1016/0092-8674(89)90438-8 · Cited by 1,396
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
Suzuki, H. I., Kurihara, Y., Takeya, M., Kamada, N., Kataoka, M., Jishage, K., Ueda, O., Sakaguchi, H., Higashi, T., Suzuki, T., et al. (1997) · Nature · doi:10.1038/386292a0 · Cited by 1,226
Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
McKercher, S. R., Torbett, B. E., Anderson, K. L., Henkel, G. W., Vestal, D. J., Baribault, H., Klemsz, M., Feeney, A. J., Wu, G. E., Paige, C. J., et al. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00949.x · Cited by 1,130
Thomson, A. W. (1994) · Cited by 1,114
Lieschke, G. J., Grail, D., HODGSON, G. S., Metcalf, D., Stanley, E. G., Cheers, C., Fowler, K., Basu, S., Zhan, Y., & Dunn, A. (1994) · Blood · doi:10.1182/blood.v84.6.1737.1737 · Cited by 956
The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene
Klemsz, M. J., McKercher, S. R., Celada, A., Van Beveren, C., & Maki, R. A. (1990) · Cell · doi:10.1016/0092-8674(90)90219-5 · Cited by 954
Identification of a ligand for the c-kit proto-oncogene
Williams, D. E., Eisenman, J., Baird, A. M., Rauch, C. T., Ness, K. V., March, C. J., Park, L. S., Martin, U., Mochizukl, D. Y., Boswell, H. S., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90297-r · Cited by 920
Stanley, E. G., Lieschke, G. J., Grail, D., Metcalf, D., HODGSON, G. S., Gall, J. A. M., Maher, D. W., Cebon, J. S., Sinickas, V., & Dunn, A. R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5592 · Cited by 880
Involvement of Granulocyte-Macrophage Colony-Stimulating Factor in Pulmonary Homeostasis
Dranoff, G., Crawford, A. D., Sadelain, M., Neugeboren, B. I., Rashid, A., Bronson, R. T., Dickersin, G. R., Bachurski, C. J., Mark, E. L., Whitsett, J. A., et al. (1994) · Science · doi:10.1126/science.8171324 · Cited by 877
Transcription Factors, Normal Myeloid Development, and Leukemia
Tenen, D. G., Hromas, R., Licht, J. D., & Zhang, D.-E. (1997) · Blood · doi:10.1182/blood.v90.2.489 · Cited by 735
Episomal Vectors Rapidly and Stably Produce High-Titer Recombinant Retrovirus
Kinsella, T. M., & Nolan, G. P. (1996) · Human Gene Therapy · doi:10.1089/hum.1996.7.12-1405 · Cited by 730
c-kit Ligand and Flt3 Ligand: Stem/Progenitor Cell Factors With Overlapping Yet Distinct Activities
Lyman, S. D., & Jacobsen, S. E. W. (1998) · Blood · doi:10.1182/blood.v91.4.1101 · Cited by 686
Versatile retroviral vectors for potential use in gene therapy.
Hawley, R. G., Lieu, F. H., Fong, A. Z. C., & Hawley, T. S. (1994) · PubMed · Cited by 652
Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites
Lantz, C. S., Boesiger, J., Song, C. H., Mach, N., Kobayashi, T., Mulligan, R. C., Nawa, Y., Dranoff, G., & Galli, S. J. (1998) · Nature · doi:10.1038/32190 · Cited by 573
The transcriptional control of hematopoiesis [see comments]
Shivdasani, R., & Orkin, S. (1996) · Blood · doi:10.1182/blood.v87.10.4025.bloodjournal87104025 · Cited by 560
Liu, F., Wu, H. Y., Wesselschmidt, R. L., Kornaga, T., & Link, D. C. (1996) · Immunity · doi:10.1016/s1074-7613(00)80504-x · Cited by 510
Steel locus defines new multipotent growth factor
Witte, O. N. (1990) · Cell · doi:10.1016/0092-8674(90)90280-r · Cited by 498
Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells
Hestdal, K., Ruscetti, F. W., Ihle, J. N., Jacobsen, S. E. W., Dubois, C. M., Kopp, W. C., Longo, D., & Keller, J. R. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.1.22 · Cited by 464
Spi-1 is a putative oncogene in virally induced murine erythroleukaemias
Moreau-Gachelin, F., Tavitian, A., & Tambourin, P. (1988) · Nature · doi:10.1038/331277a0 · Cited by 447
Zhang, D.-E., Hetherington, C. J., Chen, H.-M., & Tenen, D. G. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.1.373-381.1994 · Cited by 411
Colony-stimulating factor-1 receptor
Sherr, C. (1990) · Blood · doi:10.1182/blood.v75.1.1.bloodjournal7511 · Cited by 353 · cited 1×
“M-CSF acts through a single subunit receptor tyrosine kinase, also known as the proto-oncogene c-fms (Sherr et al., 1985; reviewed in Sherr, 1990).”
BackgroundExpression cloning of a receptor for murine granulocyte colony-stimulating factor
Fukunaga, R., Ishizaka-Ikeda, E., Seto, Y., & Nagata, S. (1990) · Cell · doi:10.1016/0092-8674(90)90814-u · Cited by 345
Structural Heterogeneity and Functional Domains of Murine Immunoglobulin G Fc Receptors
Ravetch, J. V., Luster, A. D., Weinshank, R. L., Kochan, J. P., Pavlovec, A., Portnoy, D. A., Hulmes, J. D., Pan, Y. E., & Unkeless, J. C. (1986) · Science · doi:10.1126/science.2946078 · Cited by 336
Smith, L., Hohaus, S., Gonzalez, D., Dziennis, S., & Tenen, D. (1996) · Blood · doi:10.1182/blood.v88.4.1234.bloodjournal8841234 · Cited by 332
Nishinakamura, R., Nakayama, N., Hirabayashi, Y., Inoue, T., Aud, D., McNeil, T., Azuma, S., Yoshida, S., Toyoda, Y., Aral, K.-I., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90046-2 · Cited by 309
The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter
Pahl, H. L., Scheibe, R. J., Zhang, D. E., Chen, H. M., Galson, D. L., Maki, R. A., & Tenen, D. G. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53496-7 · Cited by 301
Nuchprayoon, I., Meyers, S., Scott, L. M., Suzow, J., Hiebert, S., & Friedman, A. D. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.8.5558 · Cited by 296
Hohaus, S., Petrovick, M. S., Voso, M. T., Sun, Z., Zhang, D.-E., & Tenen, D. G. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.10.5830 · Cited by 284 · cited 1×
“…the promoters of genes encoding the myeloidspecific cytokine receptor subunits, granulocyte–macrophage colony-stimulating factor receptor α (GM-CSFRα) (Hohaus et al., 1995), c-Fms (Reddy et al., 1994; Zhang et al., 1994) and granulocyte colony-stimulating factor receptor (G-CSFR) (Smith et al.,…”
BackgroundScott, E. W., Fisher, R. C., Olson, M. C., Kehrli, E. W., Simon, M. C., & Singh, H. (1997) · Immunity · doi:10.1016/s1074-7613(00)80287-3 · Cited by 270
Self-citationBrass, A. L., Kehrli, E., Eisenbeis, C. F., Storb, U., & Singh, H. (1996) · Genes & Development · doi:10.1101/gad.10.18.2335 · Cited by 242 · cited 1×
“HA-tagged PU.1 cDNA (Brass et al., 1996) was blunt-end ligated into the HpaI site of MSCV-EGFP to produce MSCV-EGFP-PU.1. φNX-Eco retroviral packaging cells (Kinsella and Nolan, 1996) were maintained in complete Dulbecco’s modified Eagle’s medium (DMEM) containing 10% FBS. φNX-Eco cells at 80%…”
MethodSelf-citationNishinakamura, R., Miyajima, A., Mee, P., Tybulewicz, V., & Murray, R. (1996) · Blood · doi:10.1182/blood.v88.7.2458.bloodjournal8872458 · Cited by 233
[42] The macrophage colony-stimulating factor, CSF-1
Stanley, E. R. (1985) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(85)16044-1 · Cited by 225
Hematopoietic lineage- and stage-restricted expression of the ETS oncogene family member PU.1
Hromas, R., Orazi, A., Neiman, R., Maki, R., Van Beveran, C., Moore, J., & Klemsz, M. (1993) · Blood · doi:10.1182/blood.v82.10.2998.2998 · Cited by 216
CYTOKINE RECEPTOR SIGNAL TRANSDUCTION AND THE CONTROL OF HEMATOPOIETIC CELL DEVELOPMENT
Watowich, S. S., Wu, H., Socolovsky, M., Klingmüller, U., Constantinescu, S. N., & Lodish, H. F. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.91 · Cited by 200
Olson, M. C., Scott, E. W., Hack, A. A., Su, G. H., Tenen, D. G., Singh, H., & Simon, M. C. (1995) · Immunity · doi:10.1016/1074-7613(95)90060-8 · Cited by 191
Self-citationGorman, D. M., Itoh, N., Kitamura, T., Schreurs, J., Yonehara, S., Yahara, I., Arai, K., & Miyajima, A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.14.5459 · Cited by 182
Expression and regulation of myeloid-specific genes in normal and leukemic myeloid cells
Lübbert, M., Herrmann, F., & Koeffler, H. (1991) · Blood · doi:10.1182/blood.v77.5.909.909 · Cited by 172
Liu, F.-L., Poursine-Laurent, J., Wu, H.-Y., & Link, D. C. (1997) · Blood · doi:10.1182/blood.v90.7.2583.2583_2583_2590 · Cited by 162
Pytela, R. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb02953.x · Cited by 160
Liu, F., Poursine‐Laurent, J., Wu, H. Y., & Link, D. C. (1997) · Blood · doi:10.1182/blood.v90.7.2583 · Cited by 150
Metcalf, D., Burgess, A. W., Johnson, G. R., Nicola, N. A., Nice, E. C., DeLamarter, J. F., Thatcher, D. R., & Mermod, J. (1986) · Journal of Cellular Physiology · doi:10.1002/jcp.1041280311 · Cited by 140
Luskey, B., Rosenblatt, M., Zsebo, K. M., & Williams, D. E. (1992) · Blood · doi:10.1182/blood.v80.2.396.396 · Cited by 136
Reddy, M. A., Yang, B. S., Yue, X., Barnett, C. J., Ross, I. L., Sweet, M. J., Hume, D. A., & Ostrowski, M. C. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.6.2309 · Cited by 123
Spi-1/PU.1: an oncogene of the Ets family
Moreau-Gachelin, F. (1994) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(94)90011-6 · Cited by 110
Park, L. S., Martin, U., Sorensen, R., Luhr, S., Morrissey, P., Cosman, D. J., & Larsen, A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4295 · Cited by 109
Bourette, R. P., Myles, G. M., Choi, J., & Rohrschneider, L. R. (1997) · The EMBO Journal · doi:10.1093/emboj/16.19.5880 · Cited by 102
Feinman, R., Qiu, W. Q., Pearse, R. N., Nikolajczyk, B. S., Sen, R., Sheffery, M., & Ravetch, J. V. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06696.x · Cited by 88
Eichbaum, Q. G., Iyer, R., Raveh, D. P., Mathieu, C., & Ezekowitz, R. A. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.6.1985 · Cited by 86
Moulton, K. S., Semple, K., Wu, H., & Glass, C. K. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.7.4408 · Cited by 86
Molecular cloning and expression of the mouse high affinity Fc receptor for IgG.
Sears, D. W., Osman, N., Tate, B., McKenzie, I. F. C., & Hogarth, P. M. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.1.371 · Cited by 84
Perez, C., Coeffier, E., Moreau-Gachelin, F., Wietzerbin, J., & Benech, P. D. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.8.5023 · Cited by 84
Singh, H. (1996) · Current Opinion in Immunology · doi:10.1016/s0952-7915(96)80053-7 · Cited by 81
Self-citationBodine, D., Orlic, D., Birkett, N., Seidel, N., & Zsebo, K. M. (1992) · Blood · doi:10.1182/blood.v79.4.913.913 · Cited by 80
(1990) · Trends in Genetics · doi:10.1016/0168-9525(90)90199-g · Cited by 73
Bodine, D., Orlic, D., Birkett, N., et al. (1992) · Blood · doi:10.1182/blood.v79.4.913.bloodjournal794913 · Cited by 57
The mouse Fc receptor for IgG (Ly-17) : molecular cloning and specificity
Hogarth, P. M., Hibbs, M. L., Bonadonna, L., Scott, B., Witort, E. J., Pietersz, G. A., & McKenzie, I. F. C. (1987) · Immunogenetics · doi:10.1007/bf00365906 · Cited by 46
tie2, a putative protein tyrosine kinase from a new class of cell surface receptor.
Runting, A., Stacker, S. A., & Wilks, A. F. (1993) · PubMed · Cited by 44
Beck‐Engeser, G., Stocking, C., Just, U., Albritton, L. M., Dexter, T. M., Spooncer, E., & Ostertag, W. (1991) · Human Gene Therapy · doi:10.1089/hum.1991.2.1-61 · Cited by 40
Miura, N., Okada, S., Zsebo, K. M., Miura, Y., & Suda, T. (1993) · PubMed · Cited by 38
Transformation of murine fibroblasts by a retrovirus encoding the murine c-fms proto-oncogene.
Rohrschneider, L. R., Rothwell, V. M., & Nicola, N. A. (1989) · PubMed · Cited by 34
Kaufmann, Y., Tseng, E., & Springer, T. A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.1.369 · Cited by 33
Hematopoietic lineage- and stage-restricted expression of the ETS oncogene family member PU.1
Hromas, R., Orazi, A., Neiman, R., et al. (1993) · Blood · doi:10.1182/blood.v82.10.2998.bloodjournal82102998 · Cited by 29
Transcriptional Control of Hematopoiesis
Robb, L. G., Elefanty, A. G., & Begley, C. G. (1999) · Elsevier eBooks · doi:10.1016/b978-012624960-6/50003-0 · Cited by 27
Suda, T., Suda, J., Kajigaya, S., Nagata, S., Asano, S., Saito, M., & Miura, Y. (1987) · PubMed · Cited by 26
CSF‐Deficient Mice — What Have They Taught Us?
Lieschke, G. J. (2007) · Novartis Foundation symposium · doi:10.1002/9780470515280.ch5 · Cited by 25
Granulocyte Colony-Stimulating Factor Receptor and its Related Receptors
Nagata, S., & Fljkunaga, R. (1993) · Growth Factors · doi:10.3109/08977199309046930 · Cited by 19
The granulocyte-macrophage regulators: reappraisal by gene inactivation.
Metcalf, D. (1995) · PubMed · Cited by 15
Larsen, A. (1991) · Cytokine · doi:10.1016/1043-4666(91)90473-q · Cited by 12
Expression and regulation of myeloid-specific genes in normal and leukemic myeloid cells
Lubbert, M., Herrmann, F., & Koeffler, H. (1991) · Blood · doi:10.1182/blood.v77.5.909.bloodjournal775909 · Cited by 11
Luskey, B., Rosenblatt, M., Zsebo, K., et al. (1992) · Blood · doi:10.1182/blood.v80.2.396.bloodjournal802396 · Cited by 7
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Auffray, C., Sieweke, M. H., & Geissmann, F. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132557 · Cited by 1,745
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Metadata
- Authors
- DeKoter, R. P., Walsh, J. C., & Singh, H.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of Chicago (US)
- Corresponding author
- Singh, Harinder
- Venue
- The EMBO Journal
- Published
- 1998-08-03
- Volume
- 17
- Issue
- 15
- Pages
- 4456-4468
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC1170777
- OpenAlex
- W2081654176
- Cited by
- 296
- References
- 77
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 9 · 2018: 4 · 2017: 6 · 2016: 12 · 2015: 11 · 2014: 10 · 2013: 13 · 2012: 6
- FWCI
- 7.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The EMBO Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- University of Toronto
- National Institutes of Health
- National Heart, Lung, and Blood Institute (T32HL007237)
- National Institute of General Medical Sciences (T32GM007151)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- PU.1, ETS transcription factors, myeloid progenitor cells, granulocytic differentiation, macrophage differentiation, myelopoiesis, cytokine responsiveness, interleukin-3, granulocyte colony-stimulating factor, macrophage colony-stimulating factor, c-fms, granulocytic precursors, retroviral transduction
- MeSH terms
- Proto-Oncogene Protein Spi-1, Animals, Cell Differentiation, Cell Division, Colony-Forming Units Assay, Female, Gene Expression Regulation, Granulocytes, Hematopoietic Stem Cells, Interleukin-3, Macrophages, Male, Mutation, Proto-Oncogene Proteins, Retroviridae, Transduction, Genetic, Trans-Activators, Interleukin-6, Macrophage Colony-Stimulating Factor, Granulocyte-Macrophage Colony-Stimulating Factor, Granulocyte Colony-Stimulating Factor, Cytokines, Genes, fms, Mice, Knockout, Stem Cell Factor, Mice
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