Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 1,167

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2

Open access
Stott, F. J.·1998·The EMBO Journal
DOI 10.1093/emboj/17.17.5001
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1093/emboj/17.17.5001

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 24 references

Research works printed but not linked: 74

  1. Arap W, Knudsen E, Sewell DA, Sidransky D, Wang JYJ, Huang H‐JS and Cavanee WK (1997) Functional analysis of wild‐type and malignant glioma derived CDKN2Aβ alleles: evidence for an RB‐independent growth suppressive pathway. Oncogene, 15, 2013–2020. · DOI
  2. Barak Y, Juven T, Haffner R and Oren M (1993) mdm2 expression is induced by wild type p53 activity. EMBO J, 12, 461–468. · DOI · Paper page
  3. Bates S and Vousden KH (1996) p53 in signaling checkpoint arrest or apoptosis. Curr Opin Genet Dev, 6, 12–18. · DOI · Paper page
  4. Bates S, Bonetta L, MacAllan D, Parry D, Holder A, Dickson C and Peters G (1994a) CDK6 (PLSTIRE) and CDK4 (PSK‐J3) are a distinct subset of the cyclin‐dependent kinases that associate with cyclin D1. Oncogene, 9, 71–79.
  5. Bates S, Parry D, Bonetta L, Vousden K, Dickson C and Peters G (1994b) Absence of cyclin D/cdk complexes in cells lacking functional retinoblastoma protein. Oncogene, 9, 1633–1640.
  6. Bates S, Ryan KM, Phillips AC and Vousden KH (1998) Cell cycle arrest and DNA endoreduplication following p21WAF1/CIP1 expression. Oncogene, in press. · DOI · Paper page
  7. Cairns P (1994) Rates of p16 (MTS1) mutations in primary tumors with 9p loss. Science, 265, 415–416. · DOI · Paper page
  8. Cayrol C, Knibiehler M and Ducommun B (1998) p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53‐deficient cells. Oncogene, 16, 311–320. · DOI · Paper page
  9. Chen J, Marechal V and Levine AJ (1993) Mapping of the p53 and mdm‐2 interaction domains. Mol Cell Biol, 13, 4107–4114.
  10. Chen J, Lin J and Levine AJ (1995) Regulation of transcription functions of the p53 tumor suppressor by the mdm‐2 oncogene. Mol Med, 1, 142–152. · DOI · Paper page
  11. Cross SM, Sanchez CA, Morgan CA, Schimke MK, Ramel S, Idzerda RL, Raskind WH and Reid BJ (1995) A p53‐dependent mouse spindle checkpoint. Science, 267, 1353–1356. · DOI · Paper page
  12. Della Valle V, Duro D, Bernard O and Larsen C‐J (1997) The human protein p19ARF is not detected in hemopoietic human cell lines that abundantly express the alternative β transcript of the p16INK4a/MTS1 gene. Oncogene, 15, 2475–2481. · DOI
  13. Diller L (1990) p53 functions as a cell cycle control point in osteosarcoma. Mol Cell Biol, 10, 5772–5781.
  14. Duro D, Bernard O, Della Valle V, Berger R and Larsen C‐J (1995) A new type of p16INK4/MTS1 gene transcript expressed in B‐cell malignancies. Oncogene, 11, 21–29.
  15. El‐Deiry WS (1993) WAF1, a potential mediator of p53 tumor suppression. Cell, 75, 817–825. · DOI · Paper page
  16. Elenbaas B, Dobbelstein M, Roth J, Shenk T and Levine AJ (1996) The MDM2 oncoprotein binds specifically to RNA through its RING finger domain. Mol Med, 2, 439–451. · DOI · Paper page
  17. Fukasawa K, Choi T, Kuriyama R, Rulong S and Vande Woude GF (1996) Abnormal centrosome amplification in the absence of p53. Science, 271, 1744–1747. · DOI · Paper page
  18. Guan K‐L, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, Matera AG and Xiong Y (1994) Growth suppression by p18, a p16INK4/MTS1 and p14INK4/MTS2‐related CDK6 inhibitor, correlates with wild‐type pRb function. Genes Dev, 8, 2939–2952. · DOI · Paper page
  19. Hainaut P, Soussi T, Shomer B, Hollstein M, Greenblatt M, Hovig E, Harris CC and Montesano R (1997) Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects. Nucleic Acids Res, 25, 151–157. · DOI · Paper page
  20. Hara E, Tsurui H, Shinozaki A, Nakada S and Oda K (1991) Cooperative effect of antisense‐Rb and antisense‐p53 oligomers on the extension of life span of human diploid fibroblasts, TIG‐1. Biochem Biophys Res Commun, 179, 528–534. · DOI · Paper page
  21. Hara E, Smith R, Parry D, Tahara H, Stone S and Peters G (1996) Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence. Mol Cell Biol, 16, 859–867. · DOI · Paper page
  22. Harper JW (1995) Inhibition of cyclin‐dependent kinases by p21. Mol Biol Cell, 6, 387–400. · DOI · Paper page
  23. Harvey DM and Levine AJ (1991) p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts. Genes Dev, 5, 2375–2385. · DOI · Paper page
  24. Harvey M (1993) In vitro growth characteristics of embryo fibroblasts isolated from p53‐deficient mice. Oncogene, 8, 2457–2467.
  25. Horowitz JM, Park S‐H, Bogenmann E, Cheng J‐G, Yandell DW, Kaye FJ, Minna JD, Dryja TP and Weinberg RA (1990) Frequent inactivation of the retinoblastoma anti‐oncogene is restricted to a subset of human tumor cells. Proc Natl Acad Sci USA, 87, 2775–2779. · DOI · Paper page
  26. Jiang P, Stone S, Wagner R, Wang S, Dayananth P, Kozak CA, Wold B and Kamb A (1995) Comparative analysis of Homo sapiens and Mus musculus cyclin‐dependent kinase (CDK) inhibitor genes P16 (MTS1) and P15 (MTS2). J Mol Evol, 41, 795–802. · DOI
  27. Larsen C‐J (1996) p16INK4a: a gene with a dual capacity to encode unrelated proteins that inhibit cell cycle progression. Oncogene, 12, 2041–2044.
  28. Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell, 88, 323–331. · DOI · Paper page
  29. Li Y, Jenkins CW, Nichols MA and Xiong Y (1994a) Cell cycle expression and p53 regulation of the cyclin‐dependent kinase inhibitor p21. Oncogene, 9, 2261–2268.
  30. Li Y, Nichols MA, Shay JW and Xiong Y (1994b) Transcriptional repression of the D‐type cyclin‐dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb. Cancer Res, 54, 6078–6082.
  31. Liggett WHJ, Sewell DA, Rocco J, Ahrendt SA, Koch W and Sidransky D (1996) p16 and p16β are potent growth suppressors of head and neck squamous carcinoma cells in vitro. Cancer Res, 56, 4119–4123.
  32. Linardopoulos S, Street AJ, Quelle DE, Parry D, Peters G, Sherr CJ and Balmain A (1995) Deletion and altered regulation of p16INK4a and p15INK4b in undifferentiated mouse skin tumors. Cancer Res, 55, 5168–5172.
  33. Lloyd AC, Obermuller F, Staddon S, Barth CF, McMahon M and Land H (1997) Cooperating oncogenes converge to regulate cyclin/cdk complexes. Genes Dev, 11, 663–677. · DOI · Paper page
  34. Loughran O, Malliri A, Owens D, Gallimore PH, Stanley MA, Ozanne B, Frame MC and Parkinson EK (1996) Association of CDKN2A/p16INK4A with human head and neck keratinocyte replicative senescence: relationship of dysfunction to immortality and neoplasia. Oncogene, 13, 561–568.
  35. Lukas J, Petersen BO, Bartek J and Helin K (1996) Deregulated expression of E2F family members induces S‐phase entry and overcomes p16INK4A‐mediated growth suppression. Mol. Cell. Biol, 16, 1047–1057.
  36. Mann DJ and Jones NC (1996) E2F‐1 but not E2F‐4 can overcome p16‐induced G1 cell cycle arrest. Curr Biol, 6, 474–483. · DOI
  37. Mao L, Merlo A, Bedi G, Shapiro GI, Edwards CD, Rollins BJ and Sidransky D (1995) A novel p16INK4A transcript. Cancer Res, 55, 2995–2997.
  38. Marston NJ, Crook T and Vousden KH (1994) Interaction of p53 with MDM2 is independent of E6 and does not mediate wild type transformation suppressor function. Oncogene, 9, 2707–2716.
  39. Medema R, Herrera RE, Lam F and Weinberg RA (1995) Growth suppression by p16INK4 requires functional retinoblastoma protein. Proc Natl Acad Sci USA, 92, 6289–6293. · DOI · Paper page
  40. Morgenstern JP and Land H (1990) Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper‐free packaging cell line. Nucleic Acids Res, 18, 3587–3596. · DOI · Paper page
  41. Niculescu AB,III, Chen X, Smeets M, Hengst L, Prives C and Reed SI (1998) Effects of p21Cip1/Waf1 at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol Cell Biol, 18, 629–643. · DOI · Paper page
  42. Noble JR, Rogan EM, Neumann AA, Maclean K, Bryan TM and Reddel RR (1996) Association of extended in vitro proliferative potential with loss of p16INK4 expression. Oncogene, 13, 1259–1268.
  43. Nobori T, Miura K, Wu DJ, Lois A, Takabayashi K and Carson DA (1994) Deletions of the cyclin‐dependent kinase‐4 inhibitor gene in multiple human cancers. Nature, 368, 753–756. · DOI · Paper page
  44. Okamoto A (1994) Mutations and altered expression of p16INK4 in human cancer. Proc Natl Acad Sci USA, 91, 11045–11049. · DOI · Paper page
  45. Oliner JD, Pietenpol JA, Thiagalingam S, Gyuris J, Kinzler KW and Vogelstein B (1993) Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature, 362, 857–860. · DOI · Paper page
  46. Palmero I, McConnell B, Parry D, Brookes S, Hara E, Bates S, Jat P and Peters G (1997) Accumulation of p16INK4a in mouse fibroblasts as a function of replicative senescence and not of retinoblastoma gene status. Oncogene, 15, 495–503. · DOI
  47. Parry D, Bates S, Mann DJ and Peters G (1995) Lack of cyclin D–Cdk complexes in Rb‐negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product. EMBO J, 14, 503–511. · DOI · Paper page
  48. Pear WS, Nolan GP, Scott ML and Baltimore D (1993) Production of high‐titer helper‐free retroviruses by transient transfection. Proc Natl Acad Sci USA, 90, 8392–8396. · DOI · Paper page
  49. Quelle DE (1995a) Cloning and characterization of murine p16INK4a and p15INK4b genes. Oncogene, 11, 635–645.
  50. Quelle DE, Zindy F, Ashmun RA and Sherr CJ (1995b) Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell, 83, 993–1000. · DOI · Paper page
  51. Quelle DE, Cheng M, Ashmun RA and Sherr CJ (1997) Cancer‐associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF. Proc Natl Acad Sci USA, 94, 669–673. · DOI · Paper page
  52. Reznikoff CA, Yeager TR, Belair CA, Savelieva E, Puthenveettil JA and Stadler WM (1996) Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6, but not E7, transformed human uroepithelial cells. Cancer Res, 56, 2886–2890.
  53. Rittling SR and Denhardt DT (1992) p53 mutations in spontaneously immortalized 3T12 but not 3T3 mouse embryo cells. Oncogene, 7, 935–943.
  54. Rogan EM (1995) Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li–Fraumeni syndrome fibroblasts. Mol Cell Biol, 15, 4745–4753. · DOI
  55. Ruas M and Peters G (1998) The p16INK4a tumor suppressor and its relatives. Biochim Biophys Acta, in press. · DOI · Paper page
  56. Scheffner M, Werness B, Huibregtse JM, Levine AJ and Howley PM (1990) The E6 oncoprotein encoded by human papilloma virus types 16 and 18 promotes the degradation of p53. Cell, 63, 1129–1136. · DOI · Paper page
  57. Serrano M, Lee H‐W, Chin L, Cordon‐Cardo C, Beach D and DePinho RA (1996) Role of the INK4a locus in tumor suppression and cell mortality. Cell, 85, 27–37. · DOI · Paper page
  58. Sewing A, Wiseman B, Lloyd AC and Land H (1997) High‐intensity Raf signal causes cell cycle arrest mediated by p21CIP1. Mol. Cell. Biol, 17, 5588–5597.
  59. Shay JW and Wright WE (1989) Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T‐antigen. Exp Cell Res, 184, 109–118. · DOI · Paper page
  60. Shay JW, Wright WE and Werbin H (1991b) Defining the molecular mechanisms of human cell immortalization. Biochim Biophys Acta, 1072, 1–7.
  61. Sherr CJ and Roberts JM (1995) Inhibitors of mammalian G1 cyclin‐dependent kinases. Genes Dev, 9, 1149–1163. · DOI · Paper page
  62. Sidransky D (1996) Two tracks but one race? Curr Biol, 6, 523–525. · DOI
  63. Spruck CH,III, Gonzales‐Zulueta M, Shibata A, Simoneau AR, Lin M‐F, Gonzales F, Tsai YC and Jones PA (1994) p16 gene in uncultured tumours. Nature, 370, 183–184. · DOI · Paper page
  64. Stewart N, Hicks GG, Paraskevas F and Mowat M (1995) Evidence for a second cell cycle block at G2/M by p53. Oncogene, 10, 109–115.
  65. Stone S, Dayanath P, Jiang P, Weaver‐Feldhaus JM, Tavtigian SV, Cannon‐Albright L and Kamb A (1995a) Genomic structure, expression and mutational analysis of the P15 (MTS2) gene. Oncogene, 11, 987–991.
  66. Stone S, Jiang P, Dayanath P, Tavtigian SV, Katcher H, Parry D, Peters G and Kamb A (1995b) Complex structure and regulation of the P16 (MTS1) locus. Cancer Res, 55, 2988–2994.
  67. Swafford DS, Middleton SK, Palmisano WA, Nikula KJ, Tesfaigzi J, Baylin SB, Herman JG and Belinsky SA (1997) Frequent aberrant methylation of p16INK4a in primary rat lung tumors. Mol Cell Biol, 17, 1366–1374. · DOI
  68. Tahara H, Sato E, Noda A and Ide T (1995) Increase in expression level of p21sdi1/cip1/waf1 with increasing division age in both normal and SV40‐transformed human fibroblasts. Oncogene, 10, 835–840.
  69. Tsukuda T (1993) Enhanced proliferative potential in culture of cells from p53‐deficient mice. Oncogene, 8, 3313–3322.
  70. van den Heuvel S and Harlow E (1993) Distinct roles for cyclin‐dependent kinases in cell cycle control. Science, 262, 2050–2054. · DOI · Paper page
  71. Wong H and Riabowol K (1996) Differential CDK‐inhibitor gene expression in aging human diploid fibroblasts. Exp Gerontol, 31, 311–325. · DOI
  72. Woods D, Parry D, Cherwinsky H, Bosch E, Lees E and McMahon M (1997) Raf‐induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol Cell Biol, 17, 5598–5611. · DOI · Paper page
  73. Wright WE, Pereira Smith OM and Shay JW (1989) Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts. Mol Cell Biol, 9, 3088–3092.
  74. Wu X, Bayle JH, Olson D and Levine AJ (1993) The p53–mdm‐2 autoregulatory feedback loop. Genes Dev, 7, 1126–1132. · DOI · Paper page

Cited by

See all 1,167

Metadata

Authors
Stott, F. J.
Venue
The EMBO Journal
Publisher
Springer Science and Business Media LLC
Published
1998-09-01
Volume
17
Issue
17
Pages
5001-5014
ISSN
  • 0261-4189 (ISSN-L)
  • 1460-2075
DOI
10.1093/emboj/17.17.5001
OpenAlex
W2136422121
Cited by
1,167
References
24
FWCI
34.04
Type
journal article
Language
en
Open access
green
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2. https://app.cochat.ai/papers/10.1093/emboj/17.17.5001
The paper
Stott, F. J. (1998). The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2. The EMBO Journal. https://doi.org/10.1093/emboj/17.17.5001

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.