Cited by 202Atrial Fibrillation Management and OutcomesCardiac Arrhythmias and TreatmentsCardiac pacing and defibrillation studies

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Early and comprehensive management of atrial fibrillation: executive summary of the proceedings from the 2nd AFNET-EHRA consensus conference ‘research perspectives in AF’

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Kirchhof, Paulus, Bax, Jeroen, Blomstrom-Lundquist, Carina, Calkins, Hugh, Camm, A. John, Cappato, Ricardo, Cosio, Francisco, Crijns, Harry, Diener, Hans-Christian, Goette, Andreas, Israel, Carsten W., Kuck, Karl-Heinz, Lip, Gregory Y.H., Nattel, Stanley, Page, Richard L., Ravens, Ursula, Schotten, Ulrich, Steinbeck, Gerhard, Vardas, Panos, Waldo, Albert, Wegscheider, Karl, Willems, Stephan, Breithardt, Günter·2009·European Heart Journal

DOI 10.1093/eurheartj/ehp235

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Abstract

Atrial fibrillation (AF) causes important mortality and morbidity on a population-level. So far, we do not have the means to prevent AF or AF-related complications adequately. Therefore, over 70 experts on atrial fibrillation convened for the 2nd AFNET/EHRA consensus conference to suggest directions for research to improve management of AF patients (Supplementary Data). The group defined three main areas in need for research in AF: 1. better understanding of the mechanisms of AF; 2. Improving rhythm control monitoring and management; and 3. comprehensive cardiovascular risk management in AF patients. The group put forward the hypothesis that successful therapy of AF and its associated complications will require comprehensive therapy. This applies e.g. to the “old” debate of “rate versus rhythm control”, since rhythm control is generally added to underlying (continued) rate control therapy, but also to the emerging debate of “antiarrhythmic drugs versus catheter ablation”, of which both may be needed in most patients to maintain sinus rhythm, but also to therapy of conditions that predispose to AF and contribute to cardiovascular complications such as stroke, cognitive decline, heart failure, and acute coronary syndromes. We call for research initiatives aiming at a better understanding of the different causes of AF and its complications, and at development and validation of mechanism-based therapies. The future of AF therapy may require a combination of management of underlying and concomitant conditions, early and comprehensive rhythm control therapy, adequate control of ventricular rate and cardiac function, and continuous therapy to prevent AF-associated complications (e.g. antithrombotic therapy). The reasons for these suggestions are detailed in this paper.

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Authors: Kirchhof, P., Bax, J., Blomstrom-Lundquist, C., Calkins, H., Camm, A. J., Cappato, R., Cosio, F., Crijns, H., Diener, H.-C., Goette, A., Israel, C. W., Kuck, K.-H., Lip, G. Y. H., Nattel, S., Page, R. L., Ravens, U., Schotten, U., Steinbeck, G., Vardas, P., Waldo, A., Wegscheider, K., Willems, S., & Breithardt, G.
Affiliations: University of Münster (DE)
Leiden University (NL)
Uppsala University (SE)
Johns Hopkins University (US)
St George's, University of London (GB)
Policlinico S. Matteo 6 Department of Cardiology , , Pavia ,
Hospital Telleras 7 , Madrid ,
Maastricht University (NL)
University of Duisburg-Essen (DE)
Otto-von-Guericke-Universität Magdeburg (DE)
Goethe University Frankfurt (DE)
General Hospital St Georg 12 Department of Cardiology , , Hamburg ,
University of Birmingham (GB)
Montreal Heart Institute (CA)
University of Washington (US)
Technische Universität Dresden (DE)
Ludwig-Maximilians-Universität München (DE)
University of Crete (GR)
Case Western Reserve University (US)
Universität Hamburg (DE)
Corresponding author: Kirchhof, Paulus
ORCID: Kirchhof, Paulus
Bax, Jeroen
Calkins, Hugh
Camm, A. John
Crijns, Harry
Goette, Andreas
Israel, Carsten W.
Lip, Gregory Y.H.
Nattel, Stanley
Page, Richard L.
Ravens, Ursula
Schotten, Ulrich
Steinbeck, Gerhard
Vardas, Panos
Wegscheider, Karl
Willems, Stephan
Breithardt, Günter
Venue: European Heart Journal
Publisher: Oxford University Press (OUP)
Published: 2009-06-17
Volume: 30
Issue: 24
Pages: 2969-2980
ISSN: 0195-668X (ISSN-L)
1522-9645
DOI: 10.1093/eurheartj/ehp235
OpenAlex: W1970627024
Cited by: 202
References: 140
Citations by year: 2026: 4 · 2025: 5 · 2024: 2 · 2023: 7 · 2022: 12 · 2021: 14 · 2020: 8 · 2019: 6 · 2018: 8 · 2017: 10 · 2016: 14 · 2015: 13 · 2014: 16 · 2013: 16 · 2012: 23
FWCI: 14.45
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: European Heart Journal (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders: Kompetenznetz Vorhofflimmern
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Keywords: atrial fibrillation, atrial fibrillation management, rhythm control, rate control, antiarrhythmic drugs, catheter ablation, cardiovascular risk management, stroke prevention, antithrombotic therapy, heart failure, cognitive decline, acute coronary syndrome, mechanism-based therapy, atrial fibrillation mechanisms
MeSH terms: Anti-Arrhythmia Agents, Atrial Fibrillation, Fibrinolytic Agents, Humans, Patient Compliance, Risk Factors, Risk Management, Catheter Ablation, Stroke

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Early and comprehensive management of atrial fibrillation: executive summary of the proceedings from the 2nd AFNET-EHRA consensus conference ‘research perspectives in AF’

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