Cardiac computed tomography and myocardial perfusion scintigraphy for risk stratification in asymptomatic individuals without known cardiovascular disease: a position statement of the Working Group on Nuclear Cardiology and Cardiac CT of the European Society of Cardiology

Perrone-Filardi, Pasquale; Achenbach, Stephan; Möhlenkamp, Stefan; Reiner, Zeljko; Sambuceti, Gianmario; Schuijf, Joanne D.; Van der Wall, Ernst; Kaufmann, Philip A.; Knuuti, Juhani; Schroeder, Stephen; Zellweger, Michael J.

doi:10.1093/eurheartj/ehq235

Cited by 149Cardiac Imaging and DiagnosticsHealth Promotion and Cardiovascular PreventionCardiovascular Effects of Exercise

Cardiac computed tomography and myocardial perfusion scintigraphy for risk stratification in asymptomatic individuals without known cardiovascular disease: a position statement of the Working Group on Nuclear Cardiology and Cardiac CT of the European Society of Cardiology

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Perrone-Filardi, Pasquale, Achenbach, Stephan, Möhlenkamp, Stefan, Reiner, Zeljko, Sambuceti, Gianmario, Schuijf, Joanne D., Van der Wall, Ernst, Kaufmann, Philip A. +3 more·2011·European Heart Journal

DOI 10.1093/eurheartj/ehq235

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Abstract

Cardiovascular events remain one of the most frequent causes of mortality and morbidity worldwide. The majority of cardiac events occur in individuals without known coronary artery disease (CAD) and in low- to intermediate-risk subjects. Thus, the development of improved preventive strategies may substantially benefit from the identification, among apparently intermediate-risk subjects, of those who have a high probability for developing future cardiac events. Cardiac computed tomography and myocardial perfusion scintigraphy (MPS) by single photon emission computed tomography may play a role in this setting. In fact, absence of coronary calcium in cardiac computed tomography and inducible ischaemia in MPS are associated with a very low rate of major cardiac events in the next 3–5 years. Based on current evidence, the evaluation of coronary calcium in primary prevention subjects should be considered in patients classified as intermediate-risk based on traditional risk factors, since high calcium scores identify subjects at high-risk who may benefit from aggressive secondary prevention strategies. In addition, calcium scoring should be considered for asymptomatic type 2 diabetic patients without known CAD to select those in whom further functional testing by MPS or other stress imaging techniques may be considered to identify patients with significant inducible ischaemia. From available data, the use of MPS as first line testing modality for risk stratification is not recommended in any category of primary prevention subjects with the possible exception of first-degree relatives of patients with premature CAD in whom MPS may be considered. However, the Working Group recognizes that neither the use of computed tomography for calcium imaging nor of MPS have been proven to significantly improve clinical outcomes of primary prevention subjects in prospective controlled studies. This information would be crucial to adequately define the role of imaging approaches in cardiovascular preventive strategies.

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Carotid or femoral plaque burden assessed by ultrasound is predictive of cardiovascular events, comparable to coronary artery calcium.
“Assessment of carotid or femoral plaque burden with ultrasound has also been demonstrated to be predictive of CV events, comparable to CAC [20-23]”
From 2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk (2019) · cites this paper as [23]

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Yach, D., Hawkes, C., Gould, C. L., & Hofman, K. J. (2004) · JAMA · doi:10.1001/jama.291.21.2616 · Cited by 1,369 · see citing works
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Rose, G. (1981) · BMJ · doi:10.1136/bmj.282.6279.1847 · Cited by 1,302 · see citing works
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Block, G. A., Raggi, P., Bellasi, A., Kooienga, L. A., & Spiegel, D. M. (2007) · Kidney International · doi:10.1038/sj.ki.5002059 · Cited by 794 · see citing works
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Wackers, F. J. T., Young, L. H., Inzucchi, S. E., Chyun, D. A., Davey, J. A., Barrett, E. J., Taillefer, R., Wittlin, S. D., Heller, G. V., Filipchuk, N., et al. (2004) · Diabetes Care · doi:10.2337/diacare.27.8.1954 · Cited by 791 · see citing works
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Graham, I. M. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.08.024 · Cited by 715 · see citing works
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Callister, T. Q., Raggi, P., Cooil, B., Lippolis, N. J., & Russo, D. J. (1998) · New England Journal of Medicine · doi:10.1056/nejm199812313392703 · Cited by 681 · see citing works
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Sarwar, A., Shaw, L. J., Shapiro, M. D., Blankstein, R., Hoffman, U., Cury, R. C., Abbara, S., Brady, T. J., Budoff, M. J., Blumenthal, R. S., et al. (2009) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2008.12.031 · Cited by 677 · see citing works
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Shaw, L. J., & Iskandrian, A. E. (2004) · Journal of Nuclear Cardiology · doi:10.1016/j.nuclcard.2003.12.004 · Cited by 661 · see citing works
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Taylor, A. J., Bindeman, J., Feuerstein, I. M., Cao, F., Brazaitis, M. P., & O’Malley, P. G. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.05.049 · Cited by 629 · see citing works
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Kronmal, R. A., McClelland, R. L., Detrano, R., Shea, S., Lima, J. A., Cushman, M., Bild, D. E., & Burke, G. L. (2007) · Circulation · doi:10.1161/circulationaha.106.674143 · Cited by 560 · see citing works
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Melander, O. (2009) · JAMA · doi:10.1001/jama.2009.943 · Cited by 552 · see citing works
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Schuijf, J. D., Wijns, W. C., Jukema, J. W., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.05.080 · Cited by 479 · see citing works
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Cooney, M. T., Dudina, A. L., & Graham, I. M. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.07.020 · Cited by 436 · see citing works
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Hoff, J. A., Chomka, E. V., Krainik, A. J., Daviglus, M. L., Rich, S., & Kondos, G. T. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)01548-x · Cited by 425 · see citing works
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Ambrose, J. A., Winters, S. L., Arora, R. R., Haft, J. I., Goldstein, J. E., Rentrop, K. P., Gorlin, R., & Fuster, V. (1985) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(85)80207-2 · Cited by 400 · see citing works
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Anand, D. V., Lim, E., Hopkins, D., Corder, R., Shaw, L. J., Sharp, P., Lipkin, D., & Lahiri, A. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi808 · Cited by 392 · see citing works
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Achenbach, S. S., Ropers, D., Pohle, K., Leber, A. W., Thilo, C., Knez, A., Menéndez, T., Maeffert, R., Kusus, M., Regenfus, M., et al. (2002) · Circulation · doi:10.1161/01.cir.0000027567.49283.ff · Cited by 337 · see citing works
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Choi, E., Choi, S. I., Rivera, J. J., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.02.086 · Cited by 326 · see citing works
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McCollough, C. H., Ulzheimer, S., Halliburton, S. S., Shanneik, K., White, R. D., & Kalender, W. A. (2007) · Radiology · doi:10.1148/radiol.2432050808 · Cited by 321 · see citing works
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Müller‐Nordhorn, J., Binting, S., Roll, S., & Willich, S. N. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm604 · Cited by 296 · see citing works
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Ünal, B., Critchley, J., & Capewell, S. (2005) · BMJ · doi:10.1136/bmj.38561.633345.8f · Cited by 292 · see citing works
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Kramer, M. C. A., Rittersma, S. Z. H., de Winter, R. J., Ladich, E. R., Fowler, D. R., Liang, Y.-H., Kutys, R., Carter‐Monroe, N., Kolodgie, F. D., van der Wal, A. C., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.09.007 · Cited by 270 · see citing works
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Raggi, P., Góngora, M. C., Gopal, A., Callister, T. Q., Budoff, M. J., & Shaw, L. J. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.04.004 · Cited by 266 · see citing works
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Fleg, J. L., Gerstenblith, G., Zonderman, A. B., Becker, L. C., Weisfeldt, M. L., Costa, P. T., & Lakatta, E. G. (1990) · Circulation · doi:10.1161/01.cir.81.2.428 · Cited by 265 · see citing works
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Chang, S. M., Nabi, F., Xu, J., Peterson, L. E., Achari, A., Pratt, C. M., & Mahmarian, J. J. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.05.071 · Cited by 262 · see citing works
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Bax, J. J., Young, L. H., Frye, R. L., Bonow, R. O., Steinberg, H. O., & Barrett, E. J. (2007) · Diabetes Care · doi:10.2337/dc07-9927 · Cited by 251 · see citing works
Identifying high-risk asymptomatic diabetic patients who are candidates for screening stress single-photon emission computed tomography imaging
Rajagopalan, N., Miller, T. D., Hodge, D. O., Frye, R. L., & Gibbons, R. J. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.06.078 · Cited by 237 · see citing works
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Kim, K. P., Einstein, A. J., & de González, A. B. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.162 · Cited by 236 · see citing works
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Zellweger, M. J. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.02.013 · Cited by 197 · see citing works
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Mehta, D., Curwin, J. H., Gomes, J. A., & Fuster, V. (1997) · Circulation · doi:10.1161/01.cir.96.9.3215 · Cited by 188 · see citing works
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Houslay, E. S., Cowell, S. J., Prescott, R. J., Reid, J. H., Burton, J., Northridge, D. B., Boon, N. A., & Newby, D. E. (2006) · Heart · doi:10.1136/hrt.2005.080929 · Cited by 182 · see citing works
Cross-sectional association of kidney function with valvular and annular calcification: the Framingham heart study.
Fox, C., Larson, M., Vasan, R., Guo, C.-Y., Parise, H., Levy, D., Leip, E., O'Donnell, C., D'Agostino, R., & Benjamin, E. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005060627 · Cited by 181 · see citing works
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Nasir, K., Michos, E. D., Rumberger, J. A., Braunstein, J. B., Post, W. S., Budoff, M. J., & Blumenthal, R. S. (2004) · Circulation · doi:10.1161/01.cir.0000144464.11080.14 · Cited by 172 · see citing works
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Lorenzo, A. D., Lima, R. S. L., de Siqueira-Filho, A. G., & Pantoja, M. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02702-9 · Cited by 165 · see citing works
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BURKE, A. P., Virmani, R., Galis, Z. S., Haudenschild, C. C., & Muller, J. E. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00359-0 · Cited by 159 · see citing works
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van Werkhoven, J. M., Schuijf, J. D., Gaemperli, O., Jukema, J. W., Kroft, L. J. M., Boersma, E. H., Pazhenkottil, A. P., Valenta, I., Pundziūtė, G., Roos, A., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp272 · Cited by 159 · see citing works
Self-citation
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Sorajja, P., Chareonthaitawee, P., Rajagopalan, N., Miller, T. D., Frye, R. L., Hodge, D. O., & Gibbons, R. J. (2005) · Circulation · doi:10.1161/circulationaha.104.525022 · Cited by 146 · see citing works
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Snell‐Bergeon, J. K., Hokanson, J. E., Jensen, L. E., et al. (2003) · Diabetes Care · doi:10.2337/diacare.26.10.2923 · Cited by 139 · see citing works
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Rozanski, A., Gransar, H., Wong, N. D., Shaw, L. J., Miranda-Peats, R., Polk, D. M., Hayes, S. W., Friedman, J. D., & Berman, D. S. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.12.035 · Cited by 139 · see citing works
Coronary artery calcium as a measure of biologic age
Shaw, L. J., Raggi, P., Berman, D. S., & Callister, T. Q. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.10.010 · Cited by 130 · see citing works
Progression of Subclinical Coronary Atherosclerosis: Does Obesity Make a Difference?
Cassidy, A. E., Bielak, L. F., Zhou, Y., Sheedy, P. F., Turner, S. T., Breen, J. F., Araoz, P. A., Kullo, I. J., Lin, X., & Peyser, P. A. (2005) · Circulation · doi:10.1161/01.cir.0000161820.40494.5d · Cited by 114 · see citing works
Coronary Calcium Coverage Score: Determination, Correlates, and Predictive Accuracy in the Multi-Ethnic Study of Atherosclerosis
Brown, E. R., Kronmal, R. A., Bluemke, D. A., Guerci, A. D., Carr, J. J., Goldin, J. G., & Detrano, R. (2008) · Radiology · doi:10.1148/radiol.2473071469 · Cited by 107 · see citing works
Usefulness of Electron Beam Tomography in Adolescents and Young Adults With Heterozygous Familial Hypercholesterolemia
Gidding, S. S., Bookstein, L. C., & Chomka, E. V. (1998) · Circulation · doi:10.1161/01.cir.98.23.2580 · Cited by 102 · see citing works
Coronary artery calcium screening: current status and recommendations from the European Society of Cardiac Radiology and North American Society for Cardiovascular Imaging
Oudkerk, M., Stillman, A. E., Halliburton, S. S., Kalender, W. A., Möhlenkamp, S., McCollough, C. H., Vliegenthart, R., Shaw, L. J., Stanford, W. L., Taylor, A. J., et al. (2008) · European Radiology · doi:10.1007/s00330-008-1095-6 · Cited by 101 · see citing works
Self-citation
Coronary Artery Calcium, Carotid Artery Wall Thickness, and Cardiovascular Disease Outcomes in Adults 70 to 99 Years Old
Newman, A. B., Naydeck, B. L., Ives, D. G., Boudreau, R. M., Sutton-Tyrrell, K., O’Leary, D. H., & Kuller, L. H. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.07.075 · Cited by 98 · see citing works
Methods and Limitations of Assessing New Noninvasive Tests
Hachamovitch, R., & Carli, M. F. D. (2008) · Circulation · doi:10.1161/circulationaha.107.714006 · Cited by 91 · see citing works
Threshold, incidence, and predictors of prognostically high-risk silent ischemia in asymptomatic patients without prior diagnosis of coronary artery disease
Zellweger, M. J., Hachamovitch, R., Kang, X., Hayes, S. W., Friedman, J. D., Germano, G., & Berman, D. S. (2009) · Journal of Nuclear Cardiology · doi:10.1007/s12350-008-9016-2 · Cited by 89 · see citing works
Self-citation
Exercise Thallium Tomography Predicts Future Clinically Manifest Coronary Heart Disease in a High-Risk Asymptomatic Population
Blumenthal, R. S., Becker, D. M., Moy, T. F., Coresh, J., Wilder, L. B., & Becker, L. C. (1996) · Circulation · doi:10.1161/01.cir.93.5.915 · Cited by 88 · see citing works
Annual Progression of Coronary Calcification in Trials of Preventive Therapies
McCullough, P. A. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.382 · Cited by 79 · see citing works
Should Coronary Calcium Screening Be Used in Cardiovascular Prevention Strategies?
Bonow, R. O. (2009) · New England Journal of Medicine · doi:10.1056/nejmcp0902177 · Cited by 71 · see citing works
Detection of occult coronary artery disease in asymptomatic individuals with diabetes mellitus using non-invasive cardiac angiography
Rivera, J. J., Nasir, K., Choi, E., Yoon, Y. E., Chun, E. J., Choi, S., Choi, D., Brancati, F. L., Blumenthal, R. S., & Chang, H. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.07.030 · Cited by 64 · see citing works
Multislice Computed Tomography in an Asymptomatic High-Risk Population
Romeo, F., Leo, R., Clementi, F., et al. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.08.029 · Cited by 54 · see citing works
Screening of asymptomatic patients with type 2 diabetes mellitus for silent coronary artery disease: Combined use of stress myocardial perfusion imaging and coronary calcium scoring
Scholte, A. J. H. A., Bax, J. J., & Wackers, F. J. T. (2006) · Journal of Nuclear Cardiology · doi:10.1016/j.nuclcard.2005.11.002 · Cited by 46 · see citing works
Comparison of Coronary Calcium and Stress Myocardial Perfusion Imaging in Apparently Healthy Siblings of Individuals With Premature Coronary Artery Disease
Blumenthal, R. S., Becker, D. M., Yanek, L. R., et al. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.08.048 · Cited by 43 · see citing works
Detection of silent coronary artery disease in adolescents and young adults with familial hypercholesterolemia by single-photon emission computed tomography thallium-201 scanning
Mouratidis, B., Vaughan-Neil, E. F., Gilday, D. L., et al. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90038-z · Cited by 42 · see citing works
Prognostic Significance of Silent Coronary Artery Disease in Type 2 Diabetes
Zellweger, M. J. (2006) · Herz · doi:10.1007/s00059-006-2790-1 · Cited by 39 · see citing works
Self-citation
Prognostic role of myocardial single photon emission computed tomography in the elderly
Filardi, P. P., Costanzo, P., Dellegrottaglie, S., Gargiulo, P., Ruggiero, D., Savarese, G., Parente, A., D’Amore, C., Cuocolo, A., & Massimo Chiariello, A. (2009) · Journal of Nuclear Cardiology · doi:10.1007/s12350-009-9182-x · Cited by 28 · see citing works
Stress single photon emission computed tomography for detection of coronary artery disease and risk stratification of asymptomatic patients at moderate risk
Khandaker, M. H., Miller, T. D., Chareonthaitawee, P., Askew, J. W., Hodge, D. O., & Gibbons, R. J. (2009) · Journal of Nuclear Cardiology · doi:10.1007/s12350-009-9085-x · Cited by 27 · see citing works
Relation of Aortic Valve and Coronary Artery Calcium in Patients With Chronic Kidney Disease to the Stage and Etiology of the Renal Disease
Piers, L. H., Touw, H. R. W., Gansevoort, R. T., Franssen, C. F. M., Oudkerk, M., Zijlstra, F., & Tio, R. A. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.01.396 · Cited by 22 · see citing works
The site of acute myocardial infarction is related to the coronary territory of transient defects on prior myocardial perfusion imaging
Galvin, J. M., & Brown, K. A. (1996) · Journal of Nuclear Cardiology · doi:10.1016/s1071-3581(96)90071-9 · Cited by 14 · see citing works
Witnessing ischemia or proofing coronary atherosclerosis: two different windows on the same or on different pathways precipitating cardiovascular events?
Sambuceti, G., Marini, C., Morbelli, S. D., Paoli, G., Derchi, M. E., & Pomposelli, E. (2009) · Journal of Nuclear Cardiology · doi:10.1007/s12350-009-9074-0 · Cited by 4 · see citing works
Self-citation
Error in Trial Registration Number in: Effect of a Pharmacist on Adverse Drug Events and Medication Errors in Outpatients With Cardiovascular Disease
(2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.143 · Cited by 1 · see citing works

Flagged first, then by citations

Research works printed but not linked: 5

Hoff JA, Chomka EV, Krainik AJ, Daviglus M, Rich S, Kondos GT. Age and gender distribution of coronary artery calcium detected by electron beam tomography. Am J Cardiol 2001;87:1335 -1339.
Erbel R, Mo ¨hlenkamp S, Lehmann N, Schmermund A, Roggenbuck U, Moebus S, Nico Dragano N, Ka ¨lsch H, Hoffmann B, Stang A, Broecker-Preuss M, Gro ¨nemeyer D, Seibel R, Mann K, Jo ¨ckeet KH. Net reclassification improvement is particularly high when coronary artery calcium scoring is focused on intermedi- ate risk subjects: The Heinz Nixdorf Recall Study. Circulation 2009;120:S425.
American Diabetes Association. Standard of medical care in diabetes-2007. Diabetes Care 2007;30:S1-S41.
Houslay ES, Cowell SJ, Prescott RJ, Reid J, Burton J, Northridge DB, Boon NA, Newby DE, on behalf of Scottish Aortic Stenosis, Lipid Lowering Therapy. Impact on regression (SALTIRE) trial Investigators. Heart 2006;92:1207 -1212.
Hendel RC, Patel MR, Kramer CM, Poon M, Hendel RC, Carr JC, Gerstad NA, Gillam LD, Hodgson JM, Kim RJ, Kramer CM, Lesser JR, Martin ET, Messer JV, Redberg RF, Rubin GD, Rumsfeld JS, Taylor AJ, Weigold WG, Woodard PK, Brindis RG, Hendel RC, Douglas PS, Peterson ED, Wolk MJ, Allen JM, Patel MR. ACCF/ACR/SCCT/SCMR/ASNC/NASCI/SCAI/SIR 2006 appropriate- ness criteria for cardiac computed tomography and cardiac magnetic resonance imaging: a report of the American College of Cardiology Foundation Quality Stra- tegic Directions Committee Appropriateness Criteria Working Group, American College of Radiology, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, American Society of Nuclear Cardiology, North American Society for Cardiac Imaging, Society for Cardiovascular Angio- graphy and Interventions, and Society of Interventional Radiology. J Am Coll Cardiol 2006;48:1475 -1497.

Sorted by citations

European Guidelines on cardiovascular disease prevention in clinical practice (version 2012)
Authors/Task Force Members:, Perk, J., De Backer, G., Gohlke, H., Graham, I., Reiner, Ž., Verschuren, M., Albus, C., Benlian, P., Boysen, G., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs092 · Cited by 8,490 · see citing works
Self-citation
2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk
Mach, F., Baigent, C., Catapano, A. L., Koskinas, K. C., Casula, M., Badimon, L., Chapman, M. J., De Backer, G. G., Delgado, V., Ference, B. A., et al. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.08.014 · Cited by 4,854 · see citing works
Benefits of Statins in Elderly Subjects Without Established Cardiovascular Disease
Savarese, G., Gotto, A. M., Paolillo, S., D'Amore, C., Losco, T., Musella, F., Scala, O., Marciano, C., Ruggiero, D., Marsico, F., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.07.069 · Cited by 219 · see citing works
Impact of early evidence of atherosclerotic changes on early treatment in children with familial hypercholesterolemia
Reiner, Ž. (2014) · Circulation Research · doi:10.1161/circresaha.113.302952 · Cited by 26 · see citing works
Self-citation
Usefulness of magnetocardiography to detect coronary artery disease and cardiac allograft vasculopathy
Wu, Y.-W., Lee, C.-M., Liu, Y.-B., Wang, S.-S., Huang, H.-C., Tseng, W.-K., Jui, H.-Y., Wang, S.-Y., Horng, H.-E., Yang, H.-C., et al. (2013) · Circulation Journal · doi:10.1253/circj.cj-12-1170 · Cited by 18 · see citing works

Myocardial perfusion imaging for the detection of coronary artery disease in patients with known or suspected disease
Machecourt, J. (2002) · European Heart Journal Supplements · doi:10.1016/s1520-765x(02)90039-8 · Cited by 5 · see citing works
Detection of coronary artery disease with perfusion stress echocardiography using a novel ultrasound imaging agent: two Phase 3 international trials in comparison with radionuclide perfusion imaging
Senior, R., Monaghan, M. J., MAIN, M., Zamorano, J. L., Tiemann, K., Agati, L., Weissman, N. J., Klein, A. L., Marwick, T. H., Ahmad, M., et al. (2009) · European Journal of Echocardiography · doi:10.1093/ejechocard/jen321 · Cited by 76 · see citing works
Development of Radiolabeled Compounds for Myocardial Perfusion Imaging
Lin, X., Zhang, J., Wang, X., et al. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799315876 · Cited by 8 · see citing works
Myocardial Perfusion by Coronary Computed Tomography in the Evaluation of Myocardial Ischemia: Simultaneous Stress Protocol with SPECT
Ker, W. D. S., das Neves, D. G., Magalhães, T. A., dos Santos, A. A. S. M. D., Mesquita, C. T., & Nacif, M. S. (2019) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20190201 · Cited by 2 · see citing works
Diagnostic performance of myocardial perfusion single-photon emission computed tomography with attenuation correction
Płachcińska, A., Włodarczyk, M., Kovacević-Kuśmierek, K., et al. (2015) · Kardiologia Polska · doi:10.5603/kp.a2015.0100 · Cited by 5 · see citing works

Authors: Perrone-Filardi, P., Achenbach, S., Möhlenkamp, S., Reiner, Z., Sambuceti, G., Schuijf, J. D., Van der Wall, E., Kaufmann, P. A., Knuuti, J., Schroeder, S., & Zellweger, M. J.
Affiliations: Federico II University of Naples 1 Department of Internal Medicine, Cardiovascular Sciences and Immunology , , Via Pansini, 5, 80131, Napoli ,
Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
West German Heart and Vascular Center Essen (DE)
University Hospital Centre Zagreb 4 Department of Internal Medicine , ,
University of Genoa (IT)
Leiden University (NL)
Leiden University Medical Centre 6 Department of Cardiology , , Leiden ,
University Hospital Zurich 7 Cardiovascular Centre, Nuclear Cardiology, Cardiac Imaging , ,
University of Turku (FI)
Klinik am Eichert 9 Department of Cardiology , , Goeppingen ,
University Hospital of Basel (CH)
ORCID: Achenbach, Stephan
Sambuceti, Gianmario
Schuijf, Joanne D.
Knuuti, Juhani
Zellweger, Michael J.
Venue: European Heart Journal
Publisher: Oxford University Press (OUP)
Published: 2010-07-14
Volume: 32
Issue: 16
Pages: 1986-1993
ISSN: 0195-668X (ISSN-L)
1522-9645
DOI: 10.1093/eurheartj/ehq235
OpenAlex: W2110141547
Cited by: 149
References: 90
Citations by year: 2026: 4 · 2025: 1 · 2024: 5 · 2023: 8 · 2022: 7 · 2021: 3 · 2020: 4 · 2019: 6 · 2018: 1 · 2017: 4 · 2016: 6 · 2015: 16 · 2014: 24 · 2013: 20 · 2012: 18
FWCI: 15.06
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: European Heart Journal (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
reroDoc Digital Library (submittedVersion)
Universitätsbibliographie, Universität Duisburg-Essen (submittedVersion)
CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
Zurich Open Repository and Archive (University of Zurich)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
Keywords: risk stratification, asymptomatic individuals, primary prevention, coronary artery disease, cardiac CT, myocardial perfusion scintigraphy, coronary artery calcium score, type 2 diabetes, cardiovascular events, secondary prevention
MeSH terms: Age Factors, Calcinosis, Coronary Artery Disease, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Humans, Hyperlipoproteinemia Type II, Kidney Diseases, Pedigree, Prognosis, Tomography, X-Ray Computed, Disease Progression, Risk Assessment, Early Diagnosis, Myocardial Perfusion Imaging

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Cardiac computed tomography and myocardial perfusion scintigraphy for risk stratification in asymptomatic individuals without known cardiovascular disease: a position statement of the Working Group on Nuclear Cardiology and Cardiac CT of the European Society of Cardiology

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