The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
J-curve revisited: an analysis of blood pressure and cardiovascular events in the Treating to New Targets (TNT) Trial
Abstract
AIM: In patients with coronary artery disease (CAD), a J-curve relationship has been reported between blood pressure (BP) and future cardiovascular events. However, this is controversial. The purpose of the study was to determine the relationship between on-treatment BP and cardiovascular outcomes in patients with CAD. METHODS AND RESULTS: We evaluated 10 001 patients with CAD and a low-density lipoprotein (LDL) cholesterol level <130 mg/dL, randomized to atorvastatin 80 vs. 10 mg, enrolled in the TNT trial. The post-baseline, time-dependent BPs [systolic blood pressure (SBP) and diastolic blood pressure (DBP)] were categorized into 10 mmHg increments. The primary outcome was a composite of death from coronary disease, non-fatal myocardial infarction (MI), resuscitated cardiac arrest, and fatal or non-fatal stroke. Among the 10 001 patients, 982 (9.82%) experienced a primary outcome at 4.9 years (median) of follow-up. The relationship between SBP or DBP and primary outcome followed a J-curve with increased event rates above and below the reference BP range, both unadjusted and adjusted (for baseline covariates, treatment effect, and LDL levels). A time-dependent, non-linear, multivariate Cox proportional hazard model identified a nadir of 146.3/81.4 mmHg where the event rate was lowest. A similar non-linear relationship with a higher risk of events at lower pressures was found for most of the secondary outcomes of all-cause mortality, cardiovascular mortality, non-fatal MI, or angina. However, for the outcome of stroke, lower was better for SBP. CONCLUSION: In patients with CAD, a low BP (<110-120/<60-70 mmHg) portends an increased risk of future cardiovascular events (except stroke).
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Hansson, L., Zanchetti, A., Carruthers, S. G., Dahlöf, B., Elmfeldt, D., Julius, S., Ménard, J., Rahn, K. H., Wedel, H., & Westerling, S. (1998) · The Lancet · doi:10.1016/s0140-6736(98)04311-6 · Cited by 5,728
Effects of intensive blood-pressure control in type 2 diabetes mellitus
(2010) · New England Journal of Medicine · doi:10.1056/nejmoa1001286 · Cited by 3,598
Intensive Lipid Lowering with Atorvastatin in Patients with Stable Coronary Disease
LaRosa, J. C., Grundy, S. M., Waters, D. D., Shear, C., Barter, P., Fruchart, J.-C., Gotto, A. M., Greten, H., Kastelein, J. J. P., Shepherd, J., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050461 · Cited by 3,489
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Mancia, G., Kreutz, R., Brunström, M., Burnier, M., Grassi, G., Januszewicz, A., Muiesan, M. L., Tsioufis, K., Agabiti-Rosei, E., Algharably, E. A. E., et al. (2023) · Journal of Hypertension · doi:10.1097/hjh.0000000000003480 · Cited by 3,473
Cheung, A. K., Chang, T. I., Cushman, W. C., Furth, S. L., Hou, F. F., Ix, J. H., Knoll, G. A., Muntner, P., Pecoits-Filho, R., Sarnak, M. J., et al. (2021) · Kidney International · doi:10.1016/j.kint.2020.11.003 · Cited by 1,452
Vidal-Petiot, E., Ford, I., Greenlaw, N., Ferrari, R., Fox, K. M., Tardif, J.-C., Tendera, M., Tavazzi, L., Bhatt, D. L., & Steg, P. G. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31326-5 · Cited by 470
Sim, J. J., Bhandari, S. K., Shi, J., Reynolds, K., Calhoun, D. A., Kalantar-Zadeh, K., & Jacobsen, S. J. (2015) · Kidney International · doi:10.1038/ki.2015.142 · Cited by 238
Vasopressin: a novel target for the prevention and retardation of kidney disease?
Bankir, L., Bouby, N., & Ritz, E. (2013) · Nature Reviews Nephrology · doi:10.1038/nrneph.2013.22 · Cited by 214
Blood Pressure and Mortality in U.S. Veterans With Chronic Kidney Disease: A Cohort Study
Kovesdy, C. P., Bleyer, A. J., Molnar, M. Z., Ma, J. Z., Sim, J. J., Cushman, W. C., Quarles, L. D., & Kalantar-Zadeh, K. (2013) · Annals of Internal Medicine · doi:10.7326/0003-4819-159-4-201308200-00004 · Cited by 213
Ried, K., & Fakler, P. (2014) · Integrated Blood Pressure Control · doi:10.2147/ibpc.s51434 · Cited by 198
Sussman, J. B., Kerr, E. A., Saini, S. D., Holleman, R. G., Klamerus, M. L., Min, L. C., Vijan, S., & Hofer, T. P. (2015) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2015.5110 · Cited by 160
Blood pressure targets for hypertension in people with diabetes mellitus
Arguedas, J. A., Leiva, V., & Wright, J. M. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008277.pub2 · Cited by 151
(2022) · PubMed Central · doi:10.6515/acs.202205_38(3).20220321a · Cited by 117
Bangalore, S., Fayyad, R., Laskey, R., DeMicco, D. A., Deedwania, P., Kostis, J. B., & Messerli, F. H. (2014) · The American Journal of Medicine · doi:10.1016/j.amjmed.2013.07.038 · Cited by 93
Self-citationIlkun, O. L., Greene, T., Cheung, A. K., Whelton, P. K., Wei, G., Boucher, R. E., Ambrosius, W., Chertow, G. M., & Beddhu, S. (2020) · Diabetes Care · doi:10.2337/dc19-2047 · Cited by 46
White, W. B., Jalil, F., Cushman, W. C., Bakris, G. L., Bergenstal, R., Heller, S. R., Liu, Y., Mehta, C., Zannad, F., & Cannon, C. P. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.009114 · Cited by 22
Metadata
- Authors
- Bangalore, S., Messerli, F. H., Wun, C.-C., Zuckerman, A. L., DeMicco, D., Kostis, J. B., LaRosa, J. C., & for the Treating to New Targets Steering Committee and Investigators
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-09-16
- Volume
- 31
- Issue
- 23
- Pages
- 2897-2908
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2116363103
- Cited by
- 367
- References
- 3
- FWCI
- 18.80
- Type
- journal article
- Language
- en
- Open access
- closed
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