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Is oxidative stress a therapeutic target in cardiovascular disease?
Abstract
An abnormal production of reactive oxygen species (ROS) and the subsequent decrease in vascular bioavailability of nitric oxide (NO) have long been proposed to be the common pathogenetic mechanism of the endothelial dysfunction, resulting from diverse cardiovascular risk factors such as hypercholesterolaemia, diabetes mellitus, chronic smoking, metabolic syndrome, and hypertension. Superoxide produced by the nicotinamide dinucleotide phosphate (NADPH) oxidase, mitochondrial sources, or the xanthine oxidase may react with NO, thereby resulting in excessive formation of peroxynitrite, a reactive nitrogen species that has been demonstrated to accelerate the atherosclerotic process by causing direct structural damage and by causing further ROS production. Despite this sound biological rationale and a number of pre-clinical and clinical lines of evidence, studies testing the effects of classical antioxidants such as vitamin C, vitamin E, or folic acid in combination with vitamin E have been disappointing. Rather, substances such as statins, angiotensin-converting enzyme inhibitors, or AT1-receptor blockers, which possess indirect antioxidant properties mediated by the stimulation of NO production and simultaneous inhibition of superoxide production (e.g. from the NADPH oxidase), have been shown to improve vascular function in pre-clinical and clinical studies and to reduce the incidence of cardiovascular events in patients with cardiovascular disease. Today, oxidative stress remains an attractive target for cardiovascular prevention and therapy. However, a deeper understanding of its source, and of its role in vascular pathology, is necessary before new trials are attempted.
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“Cardiovascular risk factors (e.g., hypercholesterolemia, diabetes mellitus) impair the synthesis and bioactivity of endothelium-derived NO (4, 5).”
From Dietary nitrate, nitric oxide, and restenosis (2011) · cites this paper as [5]
In the citing paper
“Their adverse effect on the NOS pathway is mediated by asymmetric dimethylarginine (ADMA; the endogenous antagonist of NO synthesis) and by the vascular generation of superoxide anion (O 2 -), which degrades NO to peroxynitrite anion (ONOO -) (4, 5).”
From Dietary nitrate, nitric oxide, and restenosis (2011) · cites this paper as [5]
Citations
Cites
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513
Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study
Hertog, M. G. L., Feskens, E. J. M., Kromhout, D., Hertog, M. G. L., Hollman, P. C. H., Hertog, M. G. L., & Katan, M. (1993) · The Lancet · doi:10.1016/0140-6736(93)92876-u · Cited by 4,336
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275
Garg, U. C., & Hassid, A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114081 · Cited by 2,154
Stephens, N. G., Parsons, A., Brown, M. J., Schofield, P. M., Kelly, F., Cheeseman, K., & Mitchinson, M. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90866-1 · Cited by 2,148
Heitzer, T., Schlinzig, T., Krohn, K., Meinertz, T., & Münzel, T. (2001) · Circulation · doi:10.1161/hc4601.099485 · Cited by 1,961
Self-citationHypercholesterolemia increases endothelial superoxide anion production.
Ohara, Y., Peterson, T. E., & Harrison, D. G. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116491 · Cited by 1,765
Pacher, P., Nivorozhkin, A., & Szabó, C. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.1.6 · Cited by 1,218
Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus
Hink, U., Li, H., Mollnau, H., Oelze, M., Matheis, E., Hartmann, M., Skatchkov, M. P., Thaiss, F., Stahl, R. A. K., Warnholtz, A., et al. (2001) · Circulation Research · doi:10.1161/01.res.88.2.e14 · Cited by 1,191
Self-citationHooper, L., Kroon, P. A., Rimm, E. B., Cohn, J. S., Harvey, I., Le Cornu, K. A., Ryder, J. J., Hall, W. L., & Cassidy, A. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.1.38 · Cited by 1,097
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Abdulle, A. E., Bourgonje, A. R., Kieneker, L. M., Koning, A. M., Gemert, S. L. B., Bulthuis, M. L. C., Dijkstra, G. D. H., Faber, K. N., Dullaart, R. P. F., Bakker, S. J. L., et al. (2020) · BMC Medicine · doi:10.1186/s12916-020-01587-w · Cited by 60
Daiber, A., Steven, S., Vujačić-Mirski, K., Kalinovic, S., Oelze, M. W., Lisa, F. D., & Münzel, T. F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103405 · Cited by 59
Self-citationMoreira, E. L. G., de Oliveira, J., Dutra, M. F., dos Santos, D. B., Goncalves, C. A., Goldfeder, E. M., Bem, A. F. D., Prediger, R. D., Aschner, M., & Farina, M. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfs252 · Cited by 58
Buys, E. S., Potter, L. R., Pasquale, L. R., & Ksander, B. R. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00038 · Cited by 58
Wang, G., Coleman, C. G., Chan, J., Faraco, G., Marques-Lopes, J., Milner, T. A., Guruju, M. R., Anrather, J., Davisson, R. L., Iadecola, C., et al. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00367.2012 · Cited by 58
Tousson, E., Elgharabawy, R. M., & El-Masry, T. A. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9434385 · Cited by 58
Potue, P., Wunpathe, C., Maneesai, P., Kukongviriyapan, U., Prachaney, P., & Pakdeechote, P. (2019) · Food & Function · doi:10.1039/c8fo02408a · Cited by 60
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Violi, F., Pignatelli, P., Pignata, C., Plebani, A., Rossi, P., Sanguigni, V., Carnevale, R., Soresina, A., Finocchi, A., Cirillo, E., et al. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300438 · Cited by 57
MicroRNAs Regulating Reactive Oxygen Species in Cardiovascular Diseases
Gong, Y.-Y., Luo, J., Wang, L., & Huang, Y. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7328 · Cited by 55
Steven, S., Frenis, K., Kalinovic, S., Kvandová, M., Oelze, M. W., Helmstädter, J., Hahad, O., Filippou, K. V., Kuś, K., Trevisan, C., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101515 · Cited by 53
Self-citationZhang, X., Lei, H., Liu, A., Zou, Y., Shen, F., & Su, D. (2011) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2011.00271.x · Cited by 52
Das, A. K., Gopalakrishnan, B., Voss, O. H., Doseff, A. I., & Villamena, F. A. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.04.021 · Cited by 52
Liu, L., Cheng, K., Ning, M., Li, H.-H., Wang, H., Li, F., Chen, S., Qu, F., & Guo, W. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.02.013 · Cited by 52
Wang, X., Yang, J., Ji, C., Zeng, X., Shi, G., Fisher, M., & Liu, C. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.09759 · Cited by 52
Bilirubin Nanoparticles Protect Against Cardiac Ischemia/Reperfusion Injury in Mice
Ai, W., Bae, S., Ke, Q., Su, S., Li, R., Chen, Y., Yoo, D., Lee, E., Jon, S., & Kang, P. M. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.021212 · Cited by 52
Ademosun, A. O., Oboh, G., Passamonti, S., Tramer, F., Žiberna, L., Boligon, A. A., & Athayde, M. L. (2015) · Food Science and Human Wellness · doi:10.1016/j.fshw.2015.05.002 · Cited by 53
Molecular mechanisms of lipid- and glucose-lowering activities of bergamot flavonoids
Janda, E., Lascala, A., Martino, C., Ragusa, S., Nucera, S., Walker, R., Gratteri, S., & Mollace, V. (2016) · PharmaNutrition · doi:10.1016/j.phanu.2016.05.001 · Cited by 51
The alterations of mitochondrial DNA in coronary heart disease
Hu, H., Lin, Y., Xu, X., Lin, S., Chen, X., & Wang, S. (2020) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2020.104412 · Cited by 52
Role of Oxidative DNA Damage and Repair in Atrial Fibrillation and Ischemic Heart Disease
Hu, L., Wang, Z., Carmone, C., Keijer, J., & Zhang, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083838 · Cited by 52
Bertin, R., Chen, Z., Marin, R., Donati, M., Feltrinelli, A., Montopoli, M., Zambon, S., Manzato, E., & Froldi, G. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.05.019 · Cited by 51
Stress in Obesity and Associated Metabolic and Cardiovascular Disorders
Holvoet, P. (2012) · Scientifica · doi:10.6064/2012/205027 · Cited by 53
Gawron-Skarbek, A., Chrzczanowicz, J., Kostka, J., Nowak, D., Drygas, W., Jegier, A., & Kostka, T. (2014) · BioMed Research International · doi:10.1155/2014/216964 · Cited by 49
Nugroho, A. E., Malik, A., & Pramono, S. (2013) · International Food Research Journal · Cited by 49
Increased inducible nitric oxide synthase (iNOS) expression in human myocardial infarction
Wilmes, V., Scheiper-Welling, S., Roehr, W., Nieß, C., Kippenberger, S., Steinhorst, K., Verhoff, M. A., & Kauferstein, S. (2019) · International Journal of Legal Medicine · doi:10.1007/s00414-019-02051-y · Cited by 49
Hahad, O., Wild, P. S., Prochaska, J. H., Schulz, A., Hermanns, I., Lackner, K. J., Pfeiffer, N., Schmidtmann, I. M., Beutel, M. E., Gori, T., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.012509 · Cited by 48
Self-citationOxidative stress, oxidative balance score, and hypertension among a racially diverse population
Annor, F. B., Goodman, M. G., Okosun, I. S., Wilmot, D., Il’yasova, D., Ndirangu, M., & Lakkur, S. (2015) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2015.05.014 · Cited by 49
Rajlic, S., Treede, H., Münzel, T. F., Daiber, A., & Duerr, G. D. (2023) · Cells · doi:10.3390/cells12040583 · Cited by 51
Self-citationNitrate therapy and nitrate tolerance in patients with coronary artery disease
Münzel, T. F., & Gori, T. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2012.12.008 · Cited by 49
Self-citationPietro, M. D., Filardo, S., Santis, F. D., & Sessa, R. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140715105 · Cited by 47
Takotsubo Syndrome: Translational Implications and Pathomechanisms
Fan, X., Yang, G., Kowitz, J., Akın, İ., Zhou, X., & El‐Battrawy, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23041951 · Cited by 47
Targeting SOD1 induces synthetic lethal killing inBLM- and CHEK2-deficient colorectal cancer cells
Sajesh, B. V., & McManus, K. J. (2015) · Oncotarget · doi:10.18632/oncotarget.4875 · Cited by 44
Obstructive sleep apnoea in acute coronary syndrome
Randerath, W. J., Bonsignore, M. R., & Herkenrath, S. D. (2019) · European Respiratory Review · doi:10.1183/16000617.0114-2018 · Cited by 49
Abbasi, A., Corpeleijn, E., Postmus, D., Gansevoort, R. T., de Jong, P. E., Gans, R. O. B., Struck, J., Schulte, J., Hillege, H. L., van der Harst, P., et al. (2012) · Journal of the American Heart Association · doi:10.1161/jaha.112.002956 · Cited by 47
Burgess, A., Vanella, L., Bellner, L., Gotlinger, K. H., Falck, J. R., Abraham, N. G., Schwartzman, M. L., & Kappas, A. (2012) · Cellular Physiology and Biochemistry · doi:10.1159/000337591 · Cited by 45
Glucose-regulated protein 78 is essential for cardiac myocyte survival
Wang, X., Bi, X., Zhang, G., Deng, Y., Luo, X., Xu, L., Scherer, P. E., Ferdous, A., Fu, G., Gillette, T. G., et al. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0109-4 · Cited by 45
Xu, Q., Xia, P., Li, X., Wang, W., Liu, Z., & Gao, X. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088243 · Cited by 43
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Butnariu, M., Fratantonio, D., Herrera‐Bravo, J., Sukreet, S., Martorell, M., Garsiya, E. R., Les, F., López, V., Kumar, M., Pentea, M., et al. (2023) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026623666230106144509 · Cited by 42
Role of nitrosative and oxidative stress in neuropathy in patients with type 2 diabetes mellitus
Al-Nimer, M. S. M., Al-Ani, F. S., & Ali, F. (2012) · Journal of Neurosciences in Rural Practice · doi:10.4103/0976-3147.91932 · Cited by 41
Li, K., Cui, Y., Zhang, H., Liu, X., Zhang, D., Wu, A., Li, J., & Tang, Y. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132402 · Cited by 42
DNA damage response signaling: A common link between cancer and cardiovascular diseases
Nikfarjam, S., & Singh, K. K. (2022) · Cancer Medicine · doi:10.1002/cam4.5274 · Cited by 45
Burgess, A., Vanella, L., Bellner, L., Schwartzman, M. L., & Abraham, N. G. (2011) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2011.10.002 · Cited by 41
Paulo, M., Costa, D. E. F. D. R., Bonaventura, D., Lunardi, C. N., & Bendhack, L. M. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200519114442 · Cited by 41
Takotsubo Syndrome: Impact of endothelial dysfunction and oxidative stress
Münzel, T. F., Templin, C., Cammann, V. L., & Hahad, O. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.03.033 · Cited by 43
Self-citationBiological effects of low-dose radiation: of harm and hormesis
Gori, T., & Münzel, T. F. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr288 · Cited by 41
Self-citationCovid‐19 and thymoquinone: Connecting the dots
Ahmad, A., Rehman, M. U., Ahmad, P., & Alkharfy, K. M. (2020) · Phytotherapy Research · doi:10.1002/ptr.6793 · Cited by 40
Bourgonje, A. R., Abdulle, A. E., Bourgonje, M. F., Binnenmars, S. H., Gordijn, S. J., Bulthuis, M. L. C., Gemert, S. L. B., Kieneker, L. M., Gansevoort, R. T., Bakker, S. J. L., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102211 · Cited by 40
Rimoldi, S. F., Sartori, C. S., Rexhaj, E., Bailey, D. M., de Marchi, S. F., McEneny, J., von Arx, R., Černý, D., Duplain, H., Germond, M., et al. (2014) · European Journal of Preventive Cardiology · doi:10.1177/2047487314535117 · Cited by 40
Epigenetics and Cardiovascular Disease in Diabetes
Pasquier, J., Hoarau-Véchot, J., Fakhro, K. A., Rafii, A., & Khalil, C. A. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0677-3 · Cited by 41
Wang, Y., Xie, C., Wang, P., Wang, X., Wang, C., Xun, X., Lin, C., Huang, Z., Cheng, Y., Li, L., et al. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.04.042 · Cited by 40
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Liang, Z., Chen, Y., Wang, Z., Wu, X., Deng, C., Wang, C., Yang, W., Tian, Y., Zhang, S., Lu, C., et al. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.12.007 · Cited by 39
Rodrigues-Díez, R. R., García‐Redondo, A. B., Orejudo, M., Rodrigues‐Díez, R., Briones, A. M., Bosch‐Panadero, E., Kéri, G., Pató, J., Ortíz, A., Salaíces, M., et al. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5500 · Cited by 39
Galougahi, K. K., Liu, C., Garcia, A., Gentile, C., Fry, N. A. S., Hamilton, E. J., Hawkins, C. L., & Figtree, G. A. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002824 · Cited by 41
Endothelial Function: A Short Guide for the Interventional Cardiologist
Gori, T. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123838 · Cited by 39
Self-citationVascular and Cardiac Oxidative Stress and Inflammation as Targets for Cardioprotection
Daiber, A., Steven, S., Euler, G., & Schulz, R. (2021) · Current Pharmaceutical Design · doi:10.2174/1381612827666210125155821 · Cited by 40
Antidiabetic, Antihyperlipidemic and Antioxidant Effects of the Flavonoids
Unnikrishnan, M. K., Veerapur, V. P., Nayak, Y., Mudgal, P. P., & Mathew, G. (2013) · Polyphenols in Human Health and Disease · doi:10.1016/b978-0-12-398456-2.00013-x · Cited by 43
Mao, C.-Y., Lu, H., Kong, N., Li, J., Liu, M., Yang, C., & Yang, P. (2014) · International Journal of Medical Sciences · doi:10.7150/ijms.9153 · Cited by 38
Alterations in oxidative stress biomarkers associated with mild hyperlipidemia and smoking
Miri, R., Saadati, H., Ardi, P., & Firuzi, O. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.12.031 · Cited by 40
Hyperglycemia-induced oxidative stress and epigenetic regulation of ET-1 gene in endothelial cells
Binjawhar, D. N., Alhazmi, A. T., Jawhar, W. N. B., Mohammedsaeed, W. M., & Safi, S. Z. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1167773 · Cited by 37
Polyphenols, Antioxidants and the Sympathetic Nervous System
Bruno, R. M., & Ghiadoni, L. (2018) · Current Pharmaceutical Design · doi:10.2174/1381612823666171114170642 · Cited by 37
Self-citationTian, C., Alomar, F. A., Moore, C. J., Shao, C. H., Kutty, S., Singh, J., & Bidasee, K. R. (2013) · Heart Failure Reviews · doi:10.1007/s10741-013-9384-9 · Cited by 36
Fiuza, B., Subelzú, N., Calcerrada, P., Straliotto, M. R., Piacenza, L., Cassina, A., da Rocha, J. B. T., Radí, R., Bem, A. F. D., & Peluffo, G. (2014) · Free Radical Research · doi:10.3109/10715762.2014.983096 · Cited by 36
Carrara, D., Bruno, R. M., Bacca, A., Taddei, S., Duranti, E., Ghiadoni, L., & Bernini, G. P. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000001072 · Cited by 37
Self-citationImpaired Vascular Redox Signaling in the Vascular Complications of Obesity and Diabetes Mellitus
Akoumianakis, I., & Antoniades, C. A. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7421 · Cited by 37
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Sunthonkun, P., Palajai, R., Somboon, P., Chua, L. S., Ungsurangsri, M., & Soontorngun, N. (2019) · Scientific Reports · doi:10.1038/s41598-019-54448-9 · Cited by 35
Meng, P., Yang, R., Jiang, F., Guo, J., Lu, X., Yang, T., & He, Q. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/1481236 · Cited by 35
Xie, Y., Li, Y., Chen, J., Ding, H., & Zhang, X. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1162662 · Cited by 36
Bencsik, P., Sasi, V., Kiss, K., Kupai, K., Kolossváry, M., Maurovich‐Horvat, P., Csont, T., Ungi, I., Merkely, B. P., & Ferdinandy, P. (2015) · European Journal of Clinical Investigation · doi:10.1111/eci.12458 · Cited by 34
Guzzardi, M. A., Iozzo, P., Salonen, M. K., Kajantie, E., & Eriksson, J. G. (2015) · Annals of Medicine · doi:10.3109/07853890.2015.1074718 · Cited by 33
Brown, K. E., Dhaun, N., Goddard, J. G., & Webb, D. J. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01774 · Cited by 33
Deletion of Phd2 in Myeloid Lineage Attenuates Hypertensive Cardiovascular Remodeling
Ikeda, J., Ichiki, T., Matsuura, H., Inoue, E., Kishimoto, J., Watanabe, A., Sankoda, C., Kitamoto, S., Tokunou, T., Takeda, K., et al. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000178 · Cited by 34
Solini, A., Rossi, C., Duranti, E., Taddei, S., Natali, A., & Virdis, A. (2015) · Vascular Pharmacology · doi:10.1016/j.vph.2015.10.002 · Cited by 33
Self-citationSkuratovskaia, D., Komar, A., Vulf, M. A., & Litvinova, L. S. (2020) · PeerJ · doi:10.7717/peerj.9741 · Cited by 37
Impact of air pollution on cardiovascular aging
Kuntić, M., Kuntić, I., Hahad, O., Lelieveld, J., Münzel, T. F., & Daiber, A. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111857 · Cited by 36
Self-citationRole of reactive oxygen species in myelodysplastic syndromes
Jing, Q., Zhou, C., Zhang, J., Zhang, P., Wu, Y., Zhou, J., Tong, X., Li, Y., Du, J., & Wang, Y. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00570-0 · Cited by 33
Antioxidants, endothelial dysfunction, and DCS: in vitro and in vivo study
Wang, Q., Mazur, A., Guerrero, F., Lambrechts, K., Buzzacott, P. L., Belhomme, M., & Théron, M. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00167.2015 · Cited by 32
Improving Antioxidant Activity of β-Lactoglobulin by Nature-Inspired Conjugation with Gentisic Acid
Li, H., Pan, Y., Yang, Z., Rao, J., & Chen, B. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b05304 · Cited by 32
Kalinovic, S., Oelze, M. W., Kröller‐Schön, S., Steven, S., Vujačić-Mirski, K., Kvandová, M., Schmal, I., Zuabi, A. A., Münzel, T. F., & Daiber, A. (2019) · Antioxidants · doi:10.3390/antiox8110514 · Cited by 31
Self-citationVessières, E., Guihot, A., Toutain, B., Maquigneau, M., Fassot, C., Loufrani, L., & Henrion, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068217 · Cited by 35
Dayoub, O., Andriantsitohaina, R., & Clere, N. (2014) · Cardiovascular & Hematological Agents in Medicinal Chemistry · doi:10.2174/1871525712666140309233048 · Cited by 32
Protective effects of ginsenoside Rg2 against H2O2-induced injury and apoptosis in H9c2 cells.
Fu, W., Sui, D., Yu, X., Gou, D., Zhou, Y., & Xu, H. (2015) · PubMed Central · Cited by 32
Pahua-Ramos, M. E., Garduño‐Siciliano, L., Dorantes‐Álvarez, L., Chamorro, G., Herrera-Martínez, J., Osorio-Esquivel, O., & Ortiz‐Moreno, A. (2013) · Plant Foods for Human Nutrition · doi:10.1007/s11130-013-0395-4 · Cited by 31
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Khan, A., Dawoud, H., & Maliñski, T. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s152822 · Cited by 30
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Sharawy, N., & Lehmann, C. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117821 · Cited by 30
Stamm, P., Oelze, M. W., Steven, S., Kröller‐Schön, S., Kvandová, M., Kalinovic, S., Jasztal, A., Kij, A., Kuntić, M., Jiménez, M. T. B., et al. (2021) · Nitric Oxide · doi:10.1016/j.niox.2021.06.001 · Cited by 29
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Katulanda, P., Ranasinghe, P. D., Jayawardena, R., Sheriff, R., & Matthews, D. R. (2014) · Diabetic Medicine · doi:10.1111/dme.12591 · Cited by 29
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Metadata
- Authors
- Münzel, T., Gori, T., Bruno, R. M., & Taddei, S.
- Affiliations
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- University of Pisa (IT)
- Corresponding author
- Münzel, Thomas
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-10-25
- Volume
- 31
- Issue
- 22
- Pages
- 2741-2748
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W1974850809
- Cited by
- 470
- References
- 54
- Citations by year
- 2026: 13 · 2025: 12 · 2024: 21 · 2023: 25 · 2022: 21 · 2021: 33 · 2020: 42 · 2019: 32 · 2018: 26 · 2017: 30 · 2016: 32 · 2015: 46 · 2014: 44 · 2013: 39 · 2012: 35
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- oxidative stress, reactive oxygen species, nitric oxide bioavailability, endothelial dysfunction, NADPH oxidase, superoxide, peroxynitrite, xanthine oxidase, mitochondrial superoxide, antioxidants, statins, ACE inhibitors, angiotensin receptor blockers, atherosclerosis, cardiovascular disease prevention, cardiovascular disease treatment
- MeSH terms
- Antioxidants, Arginine, Cardiovascular Diseases, Endothelium, Vascular, Humans, Mitochondria, Prognosis, Prospective Studies, Risk Factors, Vitamins, Xanthine Oxidase, Reactive Oxygen Species, Oxidative Stress, Nitric Oxide Synthase, NADPH Oxidases, Polyphenols
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