The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index; 14 of the 53 sources its claims cite were checked for support.
Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women
Open accessAbstract
AIMS: Carnitine and choline are major nutrient precursors for gut microbiota-dependent generation of the atherogenic metabolite, trimethylamine N-oxide (TMAO). We performed randomized-controlled dietary intervention studies to explore the impact of chronic dietary patterns on TMAO levels, metabolism and renal excretion. METHODS AND RESULTS: Volunteers (N = 113) were enrolled in a randomized 2-arm (high- or low-saturated fat) crossover design study. Within each arm, three 4-week isocaloric diets (with washout period between each) were evaluated (all meals prepared in metabolic kitchen with 25% calories from protein) to examine the effects of red meat, white meat, or non-meat protein on TMAO metabolism. Trimethylamine N-oxide and other trimethylamine (TMA) related metabolites were quantified at the end of each diet period. A random subset (N = 13) of subjects also participated in heavy isotope tracer studies. Chronic red meat, but not white meat or non-meat ingestion, increased plasma and urine TMAO (each >two-fold; P < 0.0001). Red meat ingestion also significantly reduced fractional renal excretion of TMAO (P < 0.05), but conversely, increased fractional renal excretion of carnitine, and two alternative gut microbiota-generated metabolites of carnitine, γ-butyrobetaine, and crotonobetaine (P < 0.05). Oral isotope challenge revealed red meat or white meat (vs. non-meat) increased TMA and TMAO production from carnitine (P < 0.05 each) but not choline. Dietary-saturated fat failed to impact TMAO or its metabolites. CONCLUSION: Chronic dietary red meat increases systemic TMAO levels through: (i) enhanced dietary precursors; (ii) increased microbial TMA/TMAO production from carnitine, but not choline; and (iii) reduced renal TMAO excretion. Discontinuation of dietary red meat reduces plasma TMAO within 4 weeks.
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Claims the paper makes
32 Own result · 19 Not checked yet · 8 Own interpretation · 6 Own method · 3 Partly supported · 1 Supported · 1 Supported so far · accuracy not yet measured
Every source the paper cites for this claim was checked and supports it.
In the paper
“Thus, decreasing systemic levels of TMAO has become a rational potential therapeutic strategy for decreasing risks for the development and progression of atherosclerotic heart disease.8,[13][14][15]”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Introduction
What the sources say
- Supportedcites [8] Wang, 2015, Non-lethal inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis, Cell source
The Introduction describes TMAO-lowering interventions as being of interest for their potential therapeutic benefit. The Discussion presents inhibition of the TMA-to-TMAO pathway as a potential approach to preventing or treating atherosclerosis. These passages support the claim as a therapeutic rationale, not as an established reduction in human risk; page numbers are unavailable in the supplied copy. (LLM, conf=0.92)
- Supportedcites [13] Roberts, 2018, Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential, Nat Med source
The Introduction reports that lowering plasma TMAO in atherosclerosis-prone mice coincided with attenuated atherosclerotic lesion development, and describes growing interest in targeting TMAO generation to treat cardiovascular disease. The Discussion likewise identifies TMAO suppression as a potential approach for people at risk of cardiovascular disease. These passages support the claim as a potential strategy, not an established clinical benefit. (LLM, conf=0.88)
- Supportedcites [14] Brown, 2018, Microbial modulation of cardiovascular disease, Nat Rev Microbiol source
In “The gut microbe-derived metabolite TMAO,” the review calls TMAO a promising drug target and discusses TMAO-lowering therapeutic strategies for atherosclerotic coronary heart disease. It cautions that further work is needed to determine which patients would benefit, consistent with the claim’s description of the strategy as potential rather than proven. (LLM, conf=0.90)
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
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In the paper
“Interestingly, in small cross-sectional observational studies, plasma levels of TMAO were modestly increased in omnivores relative to vegans/vegetarians, and in recent clinical challenge studies, TMA and TMAO generation from oral carnitine was observed to be substantially reduced in vegans/vegetarians.3,19”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Introduction
What the sources say
- Partly supportedcites [3] Koeth, 2013, Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis, Nat Med sourceExperimental — accuracy not yet measured
The Results section, “Vegans and vegetarians produce less TMAO from L-carnitine” (page unavailable), reports markedly reduced TMAO production after an oral carnitine challenge in long-term vegans/vegetarians. It does not report a corresponding reduction in TMA generation in those human participants; the passages reporting TMA measurements concern mice. (LLM, conf=0.85)
- Supportedcites [19] Koeth, 2018, L-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans, J Clin Invest source
The clinical challenge results report minimal TMAO production from oral carnitine in vegans/vegetarians at baseline, while omnivores readily produced it. The paper also reports greater microbial conversion to TMA in omnivores. Supplementation increased TMAO production in some vegans/vegetarians, but the Discussion says their production capacity remained lower overall. Page numbers were not supplied in the passages. (LLM, conf=0.93)
plaindirect- Asserted: passes — The authors put it forward as true.
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- Based: passes — The paper gives a reason why it holds.
- Partly supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In contrast, the fractional renal excretion of carnitine, c-butyrobetaine, and crotonobetaine increased significantly (P < 0.0001, P < 0.0001, and P = 0.0007, respectively) on the red meat diet in comparison to the non-meat diet (Figure 5D-F).”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Chronic dietary exposure to red meat diet differentially impacts fractional renal excretion of trimethylamine N-oxide vs. carnitine and its metabolites
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Interestingly, very modest but statistically significant reductions were noted in plasma betaine and urine choline concentrations following chronic consumption of the red meat diet compared with the non-meat or white meat diets (Figures 2A and 3).”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Results
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Two additional carnitine related metabolites generated by gut microbiota, c-butyrobetaine, and crotonobetaine, 16,19 both showed significant increases in both plasma (P < 0.0001 and P = 0.004, respectively) and urine (P < 0.0001 each) concentrations following 4 weeks of the red meat diet, though the relative magnitude of the increase was smaller than that for TMAO (Figures 2A and 3).”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Results
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Two additional carnitine related metabolites generated by gut microbiota, c-butyrobetaine, and crotonobetaine, 16,19 both showed significant increases in both plasma (P < 0.0001 and P = 0.004, respectively) and urine (P < 0.0001 each) concentrations following 4 weeks of the red meat diet, though the relative magnitude of the increase was smaller than that for TMAO (Figures 2A and 3).”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Results
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Notably, plasma levels of TMAO were most strongly correlated to choline and carnitine (and choline and carnitine with one another), particularly following 4 weeks of the red meat and white meat diets.”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Results
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Thus, increased level of dietary-saturated fat had no effect on plasma concentrations of TMAO.”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Results
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“Further, we too had performed unpublished untargeted metabolomics analyses and identified symmetric dimethylarginine (SDMA) as being highly correlated with renal function (r > 0.80; P < 0.0001) in both men and women alike (data not shown), and alternative published studies have similarly suggested SDMA serves as an excellent endogenous marker of renal function. 25”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Chronic dietary exposure to red meat diet differentially impacts fractional renal excretion of trimethylamine N-oxide vs. carnitine and its metabolites
What the sources say
- Not checked yetcites [25] Kielstein, 2006, Symmetric dimethylarginine (SDMA) as endogenous marker of renal function–a meta-analysis, Nephrol Dial Transplant source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“For example, the 24 h urine d3-TMA and d3-TMAO recovered following ingestion of d3-carnitine was significantly (several-fold) higher in subjects following either the red meat or white meat diets compared to the non-meat diet (Figure 7A and B).”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Chronic dietary exposure to red meat diet differentially impacts fractional renal excretion of trimethylamine N-oxide vs. carnitine and its metabolites
plaindirectn = 13- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- It may state two separate claims as one. 27
- Probably not a substantial claim. 10
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“Notably, a clinical prognostic value of TMAO has been supported by multiple meta-analyses reaffirming that elevated circulating TMAO levels are associated with both CVD and mortality risks across multiple cohorts and continents.[10][11][12]”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Introduction
What the sources say
- Not checked yetcites [10] Schiattarella, 2017, Gut microbe-generated metabolite trimethylamine-N-oxide as cardiovascular risk biomarker: a systematic review and dose-response meta-analysis, Eur Heart J source
- Supportedcites [11] Qi, 2018, Circulating trimethylamine N-oxide and the risk of cardiovascular diseases: a systematic review and meta-analysis of 11 prospective cohort studies, J Cell Mol Med source
The Discussion reports that a meta-analysis of 11 prospective cohorts found higher baseline TMAO associated with increased cardiovascular-event and all-cause mortality risks. The Results (Study characteristics) place those cohorts in North America, Europe and New Zealand. The paper describes this as potential prognostic power, while cautioning that further studies are needed to establish prognostic efficacy. (LLM, conf=0.88)
- Supportedcites [12] Heianza, 2017, Gut microbiota metabolites and risk of major adverse cardiovascular disease events and death: a systematic review and meta-analysis of prospective studies, J Am Heart Assoc source
The Discussion reports that high circulating TMAO was associated with increased risks of major adverse cardiovascular events and all-cause death in a meta-analysis of prospective studies. The Strengths and Limitations section says participants came mainly from Europe and the United States, supporting the claim’s cross-continent scope. The paper cautions that its results may not apply to other racial or ethnic groups. (LLM, conf=0.92)
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Beyond choline and carnitine, potential nutrient precursors for TMA production have been reported, including the carnitine related metabolites c-butyrobetaine and crotonobetaine, and the choline oxidation product betaine.1,16,19”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Introduction
What the sources say
- Partly supportedcites [1] Wang, 2011, Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease, Nature sourceExperimental — accuracy not yet measured
The Results section ('Identification of dietary phosphatidylcholine metabolites as markers for increased CVD risk'; page unavailable) states that intestinal microbes can produce TMA from betaine and identifies betaine as a choline metabolite. Our copy does not identify γ-butyrobetaine or crotonobetaine as TMA precursors, so it supports only the betaine portion of the cited sentence. (LLM, conf=0.87)
- Supportedcites [16] Koeth, 2014, γ-butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO, Cell Metab source
The Results section on yeaW/X reports TMA production from γ-butyrobetaine and betaine. The Discussion identifies trans crotonobetaine as a possible route to TMA, while emphasizing that its contribution in vivo is likely modest. These findings support the claim’s cautious description of all three as potential precursors. (LLM, conf=0.88)
- Partly supportedcites [19] Koeth, 2018, L-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans, J Clin Invest sourceExperimental — accuracy not yet measured
The Discussion reports that γ-butyrobetaine (γBB) is converted to TMA, and the Figure 7 caption places crotonobetaine in the l-carnitine-to-γBB pathway. These passages support the carnitine-related portion of the claim, but our copy does not identify betaine as a TMA precursor or describe it as a choline oxidation product. No page number is available in the indexed passages. (LLM, conf=0.86)
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Partly supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Some of these TMA containing compounds can participate in TMA/TMAO formation in a gut microbiota-dependent manner, and also be generated by gut microbiota metabolism of L-carnitine.1,3,16,19”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Introduction
What the sources say
- Partly supportedcites [1] Wang, 2011, Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease, Nature sourceExperimental — accuracy not yet measured
The Results section on TMAO formation from dietary phosphatidylcholine reports an obligate role for gut microbiota and the pathway PC → choline → TMA → TMAO. The Discussion also describes gut-flora-dependent TMA formation from trimethylamine-containing species. Our copy does not support the additional claim that these compounds are generated by gut microbiota metabolism of L-carnitine (searched: L-carnitine, carnitine). No page numbers are provided in the indexed passages. (LLM, conf=0.88)
- Partly supportedcites [3] Koeth, 2013, Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis, Nat Med sourceExperimental — accuracy not yet measured
The Results section, “TMAO production from dietary L-carnitine is inducible” (page unavailable), shows that gut microbiota are required to produce TMA and TMAO from L-carnitine in mice. The cited passages do not establish that other TMA-containing compounds are both generated from L-carnitine and subsequently participate in TMA/TMAO formation. (LLM, conf=0.82)
- Supportedcites [16] Koeth, 2014, γ-butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO, Cell Metab source
The Results section identifies γ-butyrobetaine (γBB) as a gut-microbial product of L-carnitine and an intermediate subsequently converted to TMA and TMAO. The Discussion likewise describes the L-carnitine → γBB → TMA pathway, followed by host conversion of TMA to TMAO. (LLM, conf=0.92)
- Supportedcites [19] Koeth, 2018, L-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans, J Clin Invest source
The Discussion states that γ-butyrobetaine (γBB) is produced by gut microbiota-dependent metabolism of ingested l-carnitine in humans and is an intermediate in TMAO formation. It also describes the microbial conversion of γBB to TMA, supporting both parts of the attributed claim. (LLM, conf=0.94)
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
- Partly supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“First, compared to the other metabolites, the fractional excretion of TMAO was found to be both higher, and to demonstrate a remarkably broader range of values extending from nearly zero to over 700%, with a sizable proportion of subjects (almost half) showing >100%, particularly following the white meat and non-meat diet interventions.”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Chronic dietary exposure to red meat diet differentially impacts fractional renal excretion of trimethylamine N-oxide vs. carnitine and its metabolites
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Interestingly, examination of the carnitine content of the diets (Supplementary ma- terial online, Table S1) reveals the baseline diet had 2 Â the carnitine level (56 mg) of the non-meat (high-saturated fat) diet (22 mg).”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Results
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Similarly, no changes in plasma concentrations of other TMA containing compounds (choline, carnitine, cbutyrobetaine, and crotonobetaine; all P > 0.05, Figure 4B and D-F) were noted with high-vs.low-saturated fat except for a modest reduction in betaine levels with increased saturated fat (P < 0.05; Figure 4C).”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Results
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“We also noted that following the red meat diet, subjects showed a modest but significant (P = 0.006; Supplementary material online, Table S3) increase in serum creatinine (still within the normal range), while urine creatinine concentrations were increased (within normal range).”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Chronic dietary exposure to red meat diet differentially impacts fractional renal excretion of trimethylamine N-oxide vs. carnitine and its metabolites
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Notably, in contrast to creatinine, none of the surrogate indicators of renal function showed significant changes in plasma or urine levels based on diet, and all were highly correlated with creatinine (Supplementary material online, Tables S3 and S4).”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Chronic dietary exposure to red meat diet differentially impacts fractional renal excretion of trimethylamine N-oxide vs. carnitine and its metabolites
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In analyses examining the relationship between plasma and urine levels of TMAO, plasma TMAO levels were highly correlated with concurrently collected spot urine TMAO concentration (r = 0.41, P < 0.0001; N = 113) or urine TMAO/creatinine (r = 0.55, P < 0.0001; N = 113), and 24 h urine TMAO collections (r = 0.74, P < 0.001; N = 13).”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Results
plaincorrelationaln = 113 ·- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In contrast, no significant change in renal clearance of choline and only modest changes with betaine were observed among the three diets (Figure 5C).”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Chronic dietary exposure to red meat diet differentially impacts fractional renal excretion of trimethylamine N-oxide vs. carnitine and its metabolites
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“On average, plasma TMAO levels increased approximately three-fold (P < 0.0001) during the red meat diet, compared with the white meat . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .or non-meat diets, with some subjects showing over a 10-fold increase (Figure 2A).”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Results
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“this in- crease was substantially less than the 3.8-fold and 7.9-fold higher car- nitine content present in the red meat diet compared with the white meat and non-meat diets, respectively (Supplementary material on- line, Table S1).”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Discussion
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“While the total choline content of the red meat diet provided approximately 15% and 28% more compared with the average daily total choline content of the white meat and non-meat diets, respectively (Supplementary material online, Table S1)”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Discussion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“subjects experienced on average an absolute change in median TMAO level of 5.9 lM and 5.7 lM during the red meat diet arm (compared with non-meat and white meat diets, respectively)”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Discussion
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Trimethylamine N-oxide (TMAO) is a gut microbiota-generated metabolite with mechanistic links to the pathogenesis of atherosclerotic heart disease.[1][2][3][4][5]”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Introduction
What the sources say
- Not checked yetcites [1] Wang, 2011, Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease, Nature source
- Not checked yetcites [2] Tang, 2013, Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk, N Engl J Med source
- Not checked yetcites [3] Koeth, 2013, Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis, Nat Med source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Carnitine is enriched in red meat, 3 and higher total choline content is found in beef and other meats, liver, and egg yolks.17”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Introduction
What the sources say
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Based upon the many epidemiological and nutrition studies suggesting a positive association between red meat ingestion and CVD risks, [27][28][29][30][31][32][33] most dietary recommendations advise limiting red meat ingestion.26”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Discussion
What the sources say
- Not checked yetcites [26] Piepoli, 2016, 2016 European guidelines on cardiovascular disease prevention in clinical practice: the Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts). Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR), Eur Heart J source
- Not checked yetcites [27] Abete, 2014, Association between total, processed, red and white meat consumption and all-cause, CVD and IHD mortality: a meta-analysis of cohort studies, Br J Nutr source
- Not checked yetcites [28] O'Connor, 2017, Total red meat intake of >/=0.5 servings/d does not negatively influence cardiovascular disease risk factors: a systemically searched meta-analysis of randomized controlled trials, Am J Clin Nutr source
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Moreover, adherence to a red meat diet raises systemic TMAO levels by three different mechanisms: (i) enhanced nutrient density of dietary TMA precursors; (ii) increased microbial TMA/TMAO production from carnitine, but not choline; and (iii) reduced renal TMAO excretion.”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Discussion
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“This dietary intervention study had a randomized three-period crossover design.”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Trial participants and study designs
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Lastly, in contrast to TMAO, the fractional renal excretion of choline, betaine, carnitine, and c-butyrobetaine were significantly less than 100%, indicating that after filtering through the kidneys, most of these metabolites are reabsorbed, but less so following chronic dietary red meat exposure (Figure 5B-E).”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Chronic dietary exposure to red meat diet differentially impacts fractional renal excretion of trimethylamine N-oxide vs. carnitine and its metabolites
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Studies have also shown dose-dependent TMA/TMAO formation with egg ingestion.2,18”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Introduction
What the sources say
- Not checked yetcites [2] Tang, 2013, Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk, N Engl J Med source
- Not checked yetcites [18] Miller, 2014, Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study, Am J Clin Nutr source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“However, some recent meta-analyses suggest the association between red meat ingestion and adverse changes to traditional CVD risk factors is not as strong, 28 despite the relatively consistent association with hard endpoints like heart attack, stroke, mortality, and CVD development.[29][30][31][32][33]”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Discussion
What the sources say
- Not checked yetcites [28] O'Connor, 2017, Total red meat intake of >/=0.5 servings/d does not negatively influence cardiovascular disease risk factors: a systemically searched meta-analysis of randomized controlled trials, Am J Clin Nutr source
- Not checked yetcites [29] Schwingshackl, 2017, Food groups and risk of all-cause mortality: a systematic review and meta-analysis of prospective studies, Am J Clin Nutr source
- Not checked yetcites [30] Haring, 2017, Red meat consumption and cardiovascular target organ damage (from the Strong Heart Study), J Hypertens source
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“beyond quantity, the quality of diet composition (with respect to protein source, but not saturated fat content) impacts overall TMAO metabolism and excretion.”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Discussion
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Reduced urine TMAO levels were recently reported in an observational study among subjects following a Mediterranean diet in a post hoc cross-sectional analysis comparing omnivores vs. vegetarians or vegans 35 ; moreover, a trend towards reduced urinary TMAO levels was observed among subjects with increased reported compliance with the Mediterranean diet (based on the PREDIMED trial compliance tool”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Discussion
What the sources say
- Not checked yetcites [35] De Filippis, 2016, High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome, Gut source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Fractional excretion calculations utilized creatinine plasma and urine concentrations, which varied based on diet, though we also quantified three separate alternative metabolites identified to serve as surrogate markers of renal function, and observed qualitatively comparable results.”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Limitations
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“the increases in plasma TMAO observed with the red meat diet would correspond to an approximate 4.5% increase in relative risk of mortality compared with the non-meat diet, and a 4.3% difference in mortality compared with white meat diet.”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Discussion
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- The authors state this as an assumption: The changes in TMAO observed after one month of diet can be extrapolated to the mean follow-up of 4.3 years used in the meta-analysis.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“the present studies are the first to directly explore the relationship of dietary protein source to plasma TMAO levels with defined isocaloric randomized diets, and the time needed to reduce TMAO levels with dietary changes.”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Discussion
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The present studies thus suggest that a diet rich in red meat would be associated with heightened TMAO levels, and potential heightened thrombotic event risk.”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Discussion
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“numerous epidemiological studies show a dose-dependent heightened risk of thrombotic events, CVD, and mortality risks with red meat consumption.[29][30][31][32][33]”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Discussion
What the sources say
- Not checked yetcites [29][30][31][32][33]
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“The kidney is an important organ to maintain homoeostasis of plasma metabolites, 23 yet little is known about factors impacting renal excretion of TMAO or its related metabolites.”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Chronic dietary exposure to red meat diet differentially impacts fractional renal excretion of trimethylamine N-oxide vs. carnitine and its metabolites
What the sources say
- Not checked yetcites [23] Thurau, 1964, Autoregulation of renal blood flow and glomerular filtration rate, including data on tubular and peritubular capillary pressures and vessel wall tension, Circ Res
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Only two visits of blood and urine for each diet arm were collected, which may not reflect the total intra-individual variability in subjects.”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Limitations
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“The Mediterranean diet in the PREDIMED trial, which showed a 30% reduction in CVD risk, was characterized by avoidance of red meat as a protein source.36,37”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Discussion
What the sources say
- Not checked yetcites [36] Estruch, 2013, Primary prevention of cardiovascular disease with a Mediterranean diet, N Engl J Med source
- Not checked yetcites [37] Estruch, 2018, Primary prevention of cardiovascular disease with a Mediterranean diet supplemented with extra-virgin olive oil or nuts, N Engl J Med source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“TMAO has been shown to directly interact with platelets (human and murine), increasing their responsiveness, and promoting a prothrombotic phenotype.4,5”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Discussion
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Blood collection time after meal was not controlled, which may lead to fluctuation of plasma metabolite levels.”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Limitations
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
The paper relies on this without support.
Few studies have systematically explored the influence of chronic dietary patterns on TMA and TMAO production, metabolism, and renal excretion.
“Few studies have systematically explored the influence of chronic dietary patterns on TMA and TMAO production, metabolism, and renal excretion.”
The paper relies on this without support.
The direct contribution of TMAO to CVD pathogenesis in humans is unclear.
“the direct contribution of TMAO to CVD pathogenesis in humans is unclear, and the impact of dietary interventions on TMAO have not been extensively investigated.”
The paper relies on this without support.
The impact of dietary interventions on TMAO has not been extensively investigated.
“the direct contribution of TMAO to CVD pathogenesis in humans is unclear, and the impact of dietary interventions on TMAO have not been extensively investigated.”
The paper relies on this without support.
Little is known about factors impacting renal excretion of TMAO or its related metabolites.
“yet little is known about factors impacting renal excretion of TMAO or its related metabolites.”
The authors state this as an assumption.
The changes in TMAO observed after one month of diet can be extrapolated to the mean follow-up of 4.3 years used in the meta-analysis.
“assuming changes observed following 1 month of diet can be extended to the mean length of follow-up (4.3 year) in the meta-analysis”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“There are, however, safety concerns about augmenting dietary protein above the 0.8 g·kg−1·d−1 range, especially from animal sources, because of concerns of accelerating coronary artery disease and HF incidence, as well as the potential for accelerating CKD progression.123–125”
From Malnutrition and Cachexia in Inpatients With Acute Cardiac Conditions: A Scientific Statement From the American Heart Association (2026) · cites this paper as [124]
Experimental — accuracy not yet measuredIn the citing paper
“A randomized controlled trial found that chronic ingestion of red meat, but not white meat or non-meat, increased plasma and urine levels of TMAO.142”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [142]
In the citing paper
“In a recent human dietary intervention study examining protein source (red meat vs white meat vs non-meat), substantially higher levels of circulating TMAO were observed when subjects consumed a red meat diet (equivalent to 8oz of steak daily for 1 month)111.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [111]
In the citing paper
“In addition to having enhanced nutrient density of TMA(O) precursors (including carnitine), isotope tracer studies showed the red meat rich diet induced functional remodeling of the gut microbial community to enhance carnitine→→TMA transformation, but not choline→TMA generation111.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [111]
In the citing paper
“The TMAO pathway is an excellent example of this, given the nutrient precursors are more abundant in a Western diet, and diets rich in phosphatidylcholine and carnitine are associated with heightened levels of TMAO, whereas vegetarian or vegan diets have reduced nutrient precursors111, 118.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [111]
In the citing paper
“Notably, however, TMAO levels appear to be driven more so by the gut microbial community composition than by the dietary intervention, and significant variation in TMAO production among individuals on a given diet is observed14, 111.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [111]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Trial participants and study designs
“each separated by a 2-7 weeks washout period”
§ Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women > Limitations
“with 2-week wash-out diets between each intervention dietary period”
Citations
Cites
2 retracted
RETRACTED: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet
Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1200303 · Cited by 4,257
RetractedEstruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmc1806491 · Cited by 1,008
RetractedEuropean Guidelines on cardiovascular disease prevention in clinical practice (version 2012)
Authors/Task Force Members:, Perk, J., De Backer, G., Gohlke, H., Graham, I., Reiner, Ž., Verschuren, M., Albus, C., Benlian, P., Boysen, G., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs092 · Cited by 8,490
2016 European Guidelines on cardiovascular disease prevention in clinical practice
Piepoli, M. F., Hoes, A. W., Agewall, S., Albus, C., Brotons, C., Catapano, A. L., Cooney, M.-T., Corrà, U., Cosyns, B., Deaton, C., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw106 · Cited by 6,457
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597
Self-citationIntestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3145 · Cited by 4,386
Self-citationEstruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1800389 · Cited by 3,616
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
Tang, W. H. W., Wang, Z., Levison, B. S., Koeth, R. A., Britt, E. B., Fu, X., Wu, Y., & Hazen, S. L. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1109400 · Cited by 3,400 · cited 1×
“Studies have also shown dose-dependent TMA/TMAO formation with egg ingestion.(2,18) Beyond choline and carnitine, potential nutrient precursors for TMA production have been reported, including the carnitine related metabolites c-butyrobetaine and crotonobetaine, and the choline oxidation product betaine.”
BackgroundSelf-citationGut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk
Zhu, W., Gregory, J. C., Org, E., Buffa, J. A., Gupta, N., Wang, Z., Li, L., Fu, X., Wu, Y., Mehrabian, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.011 · Cited by 1,968
Self-citationDe Filippis, F., Pellegrini, N., Vannini, L., Jeffery, I. B., La Storia, A., Laghi, L., Serrazanetti, D. I., Di Cagno, R., Ferrocino, I., Lazzi, C., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309957 · Cited by 1,638
Cited by
Sorted by citations
Items 401–491 of 491
Mesas, A. E., Bizzozero‐Peroni, B., Martínez-Vizcaíno, V., Cabrera, M. A. S., Urbano, M. R., Martins, A. C., Aschner, M., & Paoliello, M. M. B. (2025) · Nutrition Research · doi:10.1016/j.nutres.2025.11.001 · Cited by 1
The Role of the Gut Microbiota in Vascular Physiology and Health
Neag, M. A., Moacă, L.-Ș., Deac, A. L., Măgureanu, D. C., Vulturar, D.-M., Todea, D. A., Gherman, D., Buzoianu, A. D., Gherman, C., & Militaru, F. C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262311553 · Cited by 3
Exploring the effect of gut flora on atrial fibrillation based on epidemiological history
Wang, C., Shen, M., Zhao, Y., Xu, Z., Huang, Y., & Xiang, H. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1655007 · Cited by 1
Ovalı, F., Vatansev, H., & Akyürek, F. (2026) · Genel Tıp Dergisi · doi:10.54005/geneltip.1549005 · Cited by 1
Khuc, T. H. H., Duc, T. Q., Di, K. N., Khoa, D. D., Huyen, N. T. H., & Anh, N. H. P. (2026) · Preventive Medicine · doi:10.1016/j.ypmed.2026.108551 · Cited by 3
Alvarado, S. J., Enciso, M. F. F., Amedei, A., & Aguirre‐García, M. M. (2026) · World Journal of Cardiology · doi:10.4330/wjc.v18.i3.116780 · Cited by 1
Wei, T., Gao, Y., Zhu, L., Zeng, C., Cai, R., Rao, F., Zhao, Y., Zhang, X., Yang, J., Sheng, Y., et al. (2026) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(26)61174-0 · Cited by 1
Yokoshiki, H., Watanabe, M., Mitsuhashi, T., et al. (2026) · Journal of Arrhythmia · doi:10.1002/joa3.70349 · Cited by 1
Heianza, Y., & Hu, F. B. (2026) · Journal of Diabetes · doi:10.1111/1753-0407.70234 · Cited by 2
da Cunha, R. S., Gregório, P. C., de Morais, A. C. C., Barreto, F. C., & Stinghen, A. E. M. (2026) · Toxins · doi:10.3390/toxins18070311 · Cited by 1
Noise, pollution, food, or medication: what really matters in primary prevention?
Lüscher, T. F. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz036 · Cited by 1
Etiopathogenesis of NAFLD: Diet, Gut, and NASH
Miele, L., Biolato, M., Conte, C., Mangiola, F., Liguori, A., Gasbarrini, A., & Grieco, A. (2020) · Springer eBooks · doi:10.1007/978-3-319-95828-6_5 · Cited by 2
Impact de la nutrition sur le microbiote intestinal dans la maladie rénale chronique
Koppe, L., & Soulage, C. O. (2022) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2022.07.005 · Cited by 2
“Aging Gut Microbiota and Colorectal Cancer Pathways Correlations”
Catanzaro, R., Sciuto, M., Fattahi, N., Saidpour, A., & Marotta, F. (2023) · Healthy ageing and longevity · doi:10.1007/978-3-031-14023-5_15 · Cited by 1
Multiomics: paving the path towards personalized prevention of hypertension
Latosińska, A., Siwy, J., & Mischak, H. (2024) · Journal of Hypertension · doi:10.1097/hjh.0000000000003722 · Cited by 1
张, 阳. (2024) · Traditional Chinese Medicine · doi:10.12677/tcm.2024.139361 · Cited by 1
Adhikari, A., DeJesus, S., Swe, N. C., et al. (2024) · American Heart Journal Plus Cardiology Research and Practice · doi:10.1016/j.ahjo.2024.100471 · Cited by 1
Zhu, X., Gayathri, R., Manasa, V. S., Abirami, K., Bhupathiraju, S. N., Anjana, R. M., Givens, D. I., Wijeyesekera, A., Sudha, V., Mohan, V., et al. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.04.018 · Cited by 1
Rodrigues, F. D. A. A. (2022) · Ciencia Latina Revista Científica Multidisciplinar · doi:10.37811/cl_rcm.v6i1.1732
They eat, what we eat, they digest, what we ingest: the microbiome and the vulnerable plaque
Lüscher, T. F. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa339 · Cited by 1
Golzarand, M., Mirmiran, P., & Azizi, F. (2021) · Research Square · doi:10.21203/rs.3.rs-639951/v1 · Cited by 1
Mei, Z., Chen, G., Wang, Z., Usyk, M., Yu, B., Baeza, Y. V., Humphrey, G. C., Benítez, R. A. S., Li, J., Williams-Nguyen, J. S., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-61643/v1 · Cited by 1
Self-citationBean, L. D., Wing, J. J., Harris, R. E., Smart, S., Raman, S. V., & Milks, M. W. (2022) · Research Square · doi:10.21203/rs.3.rs-1386907/v1 · Cited by 1
Lanng, S. K., Oxfeldt, M., Johansen, F. T., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2949302/v1 · Cited by 1
Lüscher, T. F. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz632
Cardiovascular issues in women: expanding diversity in medicine
Lüscher, T. F. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz878
Suplementacja karnityną - dwie strony medalu
Olek, R. A. (2021) · Kosmos · doi:10.36921/kos.2020_2706
Branched-chain amino acids and trimethylamine N-oxide as biomarkers of cardiometabolic outcomes
Flores-Guerrero, J. L. (2021) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.33612/diss.192215052
El compromiso de la negociación ante los conflictos societarios
Monforte, J. D. (2005) · Nuevas tendencias
A new era for theEuropean Heart Journal
(2021) · European Heart Journal · doi:10.1093/eurheartj/ehab655
Trimethylamine N-Oxide (TMAO) as a Biomarker
Gabbianelli, R., & Bordoni, L. (2022) · Biomarkers in disease · doi:10.1007/978-3-030-81304-8_2-1
Sharma, D., & Prashar, A. (2022) · American Heart Journal Plus Cardiology Research and Practice · doi:10.1016/j.ahjo.2022.100150 · Cited by 1
Preventing age‐related vascular dysfunction: the gut of the matter
Chavez, D. A., & Bohmke, N. J. (2022) · The Journal of Physiology · doi:10.1113/jp283910
Trimethylamine N-Oxide (TMAO) as a Biomarker
Gabbianelli, R., & Bordoni, L. (2022) · Biomarkers in disease · doi:10.1007/978-3-031-07389-2_2
Revisiting dietary effects on the gut microbiota and their implications in health and disease
Thakran, Y., Bali, V., Badhan, G., Kaur, J., & Kaur, J. (2022) · Microsphere · doi:10.59118/hugx5553
Abioye, A. I., Hughes, M. D., Sudfeld, C. R., Noor, R. A., Isanaka, S., Lukmanji, Z., Mugusi, F. M., & Fawzi, W. W. (2023) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000003221
The Emerging Role of Microbiome in Cardiovascular Diseases
Shehata, E., & Day-Walsh, P. E. (2023) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815165012123010008
Regulation of Trimethylamine N-oxide in Treatment of Cardiometabolic Diseases. Doctoral Thesis
Ozola, M. (2023) · doi:10.25143/prom-rsu_2023-16_dt · Cited by 1
Influence of the Gut Microbiome on Cardiovascular Health and Hypertension
Kumar, S., Choubey, A., Sharma, A., Jedhe, A., Pandey, K., Prakash, A., & Khan, A. U. (2023) · Springer eBooks · doi:10.1007/978-981-99-3126-2_15
Decisive Guidelines for Keeping the Heart Attacks on The Sidelines
Kaur, S., & Parle, M. (2023) · International Clinical and Medical Case Reports · doi:10.59657/2837-5998.brs.23.018
Sun, X., Wu, X., Wu, T., & Xie, X. (2024) · Research Square · doi:10.21203/rs.3.rs-3991146/v1
Reducing Cardiovascular Risk: The Potential of Plant-Based Meat Alternatives and Egg Substitutes
Spence, J. D. (2024) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2023.12.026 · Cited by 1
Phenol as a breath marker for hemodialysis of chronic kidney disease patientsPreprint
Eickel, I., Zygmunt, A.-C., Streit, F., et al. (2024) · medRxiv · doi:10.1101/2024.09.02.24310987
Dietary Meat, Plasma Metabolites, and Cardiovascular Disease Risk: A Multi-Cohort Study in SwedenPreprint
Arage, G., Dekkers, K. F., Rašo, L. M., Hammar, U., Ericson, U., Larsson, S. C., Engel, H., Baldanzi, G., Pertiwi, K., Sayols-Baixeras, S., et al. (2024) · medRxiv · doi:10.1101/2024.10.21.24315788
Plant-based diet and cardiovascular health
Reddy, K. R., & Basu‐Ray, I. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99645-7.00001-9
Healthful vs. Unhealthful Plant-Based Restaurant Meals
Williams, K. A., Sr., Horton, A. M., Baldridge, R. D., & Ikram, M. (2025) · Nutrients · doi:10.3390/nu17050742
Gut Microbe-Derived N -Acyl Serinol Lipids Shape Host Postprandial Metabolic HomeostasisPreprint
Dutta, S., Mahen, K. K., Massey, W. J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.11.648385
Self-citationPhenol as a breath marker for hemodialysis of chronic kidney disease patients
Eickel, I., Zygmunt, A.-C., Streit, F., et al. (2025) · Journal of Breath Research · doi:10.1088/1752-7163/add958
Mulders, L. V., Vanhaecke, L., Locquet, L., et al. (2025) · Journal of Zoo and Wildlife Medicine · doi:10.1638/2024-0094
How the Microbiome Drives Cardiovascular Disease
Ho, K. J., Vs, J., Abualhuda, A., & Wang, B. (2025) · Surgical Clinics of North America · doi:10.1016/j.suc.2025.07.001
Das Darmmikrobiom und dessen Einfluss auf das kardiovaskuläre Risiko
Roessler, J., & Haghikia, A. (2025) · Aktuelle Kardiologie · doi:10.1055/a-2606-7097
Wang, M., Peng, H., Yang, R., Yu, H., Hou, T., Wu, Y., Qin, X., Li, J., Chen, D., Hu, Y., et al. (2025) · British Journal Of Nutrition · doi:10.1017/s0007114525104224
Self-citationvan der Heijden, I., West, S., Monteyne, A. J., Coelho, M. D. F. R., Finnigan, T. J. A., Stephens, F. B., & Wall, B. T. (2025) · The Journal of Nutritional Physiology · doi:10.1016/j.jnphys.2025.100012
Maharana, K. C., Adsule, M., Rajkumar, M., Vishwas, G., & Singh, S. (2025) · Next research. · doi:10.1016/j.nexres.2025.101133
Faist, C., Tacke, E., Eierhoff, T., Oberhuber, A., & Hayen, H. (2025) · Journal of Chromatography A · doi:10.1016/j.chroma.2025.466636
Suchecka, N. A., Popławska, P., Obrycka, P., Frątczak, A., Tokarz, E., Soczyńska, J., & Woźniak, S. (2026) · Biomedicines · doi:10.3390/biomedicines14020287
Du, H., Xu, X., Lei, Q., Qian, C., Wang, Z., Yu, X., & Lei, Q. (2026) · BMC Cardiovascular Disorders · doi:10.1186/s12872-026-05715-x · Cited by 1
Self-citationPlant-Forward Diets Lower Circulating TMAO in Adults: A Systematic Review and Meta-AnalysisPreprint
Zupo, R., Castellana, F., Catino, F., Lampignano, L., Zheng, Y., Lip, G. Y. H., Mastrangelo, A., Ikram, M. A., Rodriguez‐Mateos, A., Menni, C., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-9382739/v1
Song, J., & Jian, F. (2026) · Journal of Functional Foods · doi:10.1016/j.jff.2026.107297
Duan, J., Li, X., & Li, F. (2026) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2026.117830
Self-citationZheng, X., Li, Y., Wang, P., Guo, Z., Liu, Y., Liu, Q., Wang, B., Wang, H., Zheng, L., Li, C., et al. (2026) · Clinical and Translational Medicine · doi:10.1002/ctm2.70674
Zhao, D., Cui, Y., & Hua, Z. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1783688
Microbial-derived mediators of the gut–brain axis: Implications for neurological disorders
Abady, M. M., Shawky, A. M., & Mohammed, D. M. (2026) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2026.110394
The gut–brain axis and trimethylamine N-oxide: an emergent biomarker in neurological diseases
Arangia, A., Paola, R. D., Cuzzocrea, S., Siracusa, R., D’Amico, R., & Impellizzeri, D. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.05.005 · Cited by 1
Li, W., Jiang, J., Zhou, J., Li, P., & Duan, X. (2026) · International Journal of General Medicine · doi:10.2147/ijgm.s594053
Ortíz‐Gutiérrez, S., Serralde-Zúñiga, A. E., González-Salazar, L. E., Estrada-Trujillo, M. G., Flores‐López, A., Hernández-Gómez, K. G., Pichardo‐Ontiveros, E., Díaz‐Villaseñor, A., Ávila-Nava, A., Vázquez-Manjarrez, N., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-53056-8
The influence of trimethylamine-n-oxide on the risk of cardiovascular disease progression
Khaуrullin, R. N., Rakhimova, R. M., & Хусаинов, И. Х. (2026) · Kazan medical journal · doi:10.17816/kmj642035
Medouni‐Haroune, L., Medouni‐Adrar, S., Messaoudene, L., Negrichi, S., Bouiche, C., Sahraoui-Remini, Y., Allam, A., Meghlaoui, Z., Mouhoubi, K., Abbou, A., et al. (2026) · Food & Function · doi:10.1039/d6fo00371k
Smółka, L., Strugała, M., Kursa, K., Blady, K., & Stanek, A. (2026) · Nutrients · doi:10.3390/nu18132056
Zhang, X., Luo, J., Zhang, X., Yang, F., Zhang, X., Yu, X., & Dong, L. (2026) · Biology · doi:10.3390/biology15131078
Maki, K. C., Dicklin, M. R., Kirkpatrick, C. F., & Palacios, O. M. (2026) · Nutrients · doi:10.3390/nu18132207
Xie, M.-M., Wang, Y.-L., Liu, J.-X., Li, X., LIU, F., Zheng, W.-R., Xing, W.-Y., Liu, B.-Q., Wu, L., Han, Y., et al. (2026) · European Journal of Nutrition · doi:10.1007/s00394-026-04058-9
Self-citationDiDonato, J. A., Weeks, T. L., Gupta, N., Mallela, D. P., Buffa, J. A., Wang, Z., Li, X. S., Anderson, J. T., Fu, X., Sangwan, N., et al. (2026) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000001171
Self-citationMetabolic regulation of the microbiome-dependent metabolites and cardiovascular function
Wang, Y., Shi, Y., Jin, L., & Ni, Y. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-34186-1.00023-2
Jiang, S., Bi, K., Zhou, Z., Li, L., & Xu, K. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.109595
Self-citationCVD Emerging Risk Factors: Gut Microbiota
Abais‐Battad, J. M. (2026) · Physiology in health and disease · doi:10.1007/978-3-032-26472-5_16
Luengo-Dilla, R., Ortega‐Hernández, A., González, M. Á., Gutiérrez-Corral, J., Modrego, J., Torrego-Ellacuría, M., Bentefrit, I. J., Rodríguez, S. D. L. T., García, J. G., Gil, M. S. F., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10445595/v1
Mohamedrashed, M., Chauhan, A., Svolos, V., Vasudevan, A., & Yao, C. K. (2026) · JGH Open · doi:10.1002/jgh3.70462
Gut dysbiosis and complement-mediated neuroinflammation in vascular dementia
Ünal, S. (2026) · Academia Neuroscience and Brain Research · doi:10.20935/acadneurosci8477
The Gut Microbiome as a Mechanistic Link Between the Planetary Health Diet and Healthy Aging
Jarecsny, T., Ceglédi, A., Csípő, T., Fazekas‐Pongor, V., Mózes, N., Csík, B., Zábó, V., Lipécz, Á., Nyáry, D., & Fekete, M. (2026) · Nutrients · doi:10.3390/nu18172864
Mohammadzadeh, M., Söğüt, M. Ü., Fazlzadeh, A., & Çelik, M. N. (2026) · Current Nutrition Reports · doi:10.1007/s13668-026-00795-9 · Cited by 1
Ionescu, R. F., & Creţoiu, S. M. (2026) · Cureus · doi:10.7759/cureus.115807
Yuan, D., He, S., Su, X.-N., Sun, Q., Wang, Y.-T., Li, M.-X., Wu, X., Xie, Y.-H., Zhang, Y., & Qin, Y.-L. (2026) · Folia Microbiologica · doi:10.1007/s12223-026-01583-2
Strizzi, C. T., Hernandez, L. N., Arefin, S., Cantaluppi, V., Pesce, F., Stenvinkel, P., & Kublickiene, K. R. (2026) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2026.107178
Marino, F., Savo, M. T., Cozac, D. A., Galzerano, D., Sabah, M. E., Cordoni, G., Tansella, D., Palmisano, M., Kholaif, N., Mohty, D., et al. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15197428
Yu, M., Sun, M.-Y., Yang, F., Yuan, Y.-F., Zhang, Y.-M., Ruan, C.-C., 季永, Libby, P., & Cheng, X. (2026) · 中国科学通报：英文版 · doi:10.1016/j.scib.2026.09.081
张俊艳, Chen, Y., Tao, S., Zhou, M., Li, C., 饶莉, He, Y., & Chen, Z. (2026) · Cardiovascular Toxicology · doi:10.1007/s12012-026-10189-6
Metadata
- Authors
- Wang, Z., Bergeron, N., Levison, B. S., Li, X. S., Chiu, S., Jia, X., Koeth, R. A., Li, L., Wu, Y., Tang, W. H. W., Krauss, R. M., & Hazen, S. L.
- Affiliations
- Cleveland Clinic (US)
- Touro University California (US)
- Department of Atherosclerosis Research, Children’s Hospital Oakland Research Institute, Martin Luther King Jr Way, Oakland, CA, USA
- Cleveland State University (US)
- Corresponding author
- Hazen, Stanley L
- ORCID
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-12-10
- Volume
- 40
- Issue
- 7
- Pages
- 583-594
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- PMC
- PMC6374688
- OpenAlex
- W2904124435
- Semantic Scholar
- e6c31002dc7272f769757169c410825c0b0308a3
- Cited by
- 496
- References
- 40
- Citations by year
- 2026: 62 · 2025: 70 · 2024: 62 · 2023: 59 · 2022: 72 · 2021: 73 · 2020: 68 · 2019: 28 · 2018: 1
- FWCI
- 15.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Heart Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Touro Scholar (Touro College) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (HL103866, R01 HL126827, R01 DK106000, RO1 HL106003, R01 HL130819)
- Leducq Foundation
- Clinical and Translational Science Unit
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Meat and Animal Product Quality
- Keywords
- trimethylamine N-oxide, red meat, white meat, L-carnitine, choline, gut microbiota, renal excretion, saturated fat, dietary protein, isotope tracers
- MeSH terms
- Red Meat, Adult, Aged, Animals, Diet, Dietary Proteins, Feeding Behavior, Female, Humans, Male, Methylamines, Middle Aged, Poultry, Reference Values, Cross-Over Studies, Young Adult, Renal Elimination
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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