The Early Origins of Chronic Heart Failure: Impaired Placental Growth and Initiation of Insulin Resistance in Childhood
Open accessAbstract
Aims: Low birth weight and low placental weight predict later coronary heart disease and hypertension. This has led to the hypothesis that these diseases are initiated by foetal programming, the process by which foetal malnutrition leads to permanent changes in the body in ways that lead to chronic disease in later life. Here we examine the association between body and placental size at birth and later chronic heart failure. Methods and results: We identified 187 patients taking medications for chronic heart failure in a birth cohort of 13 345 people born in Helsinki, Finland during 1934–44. Chronic heart failure was associated with a small placental surface area. In people born with a placental area less than 225 cm2, the odds ratio for chronic heart failure was 1.7 (1.1–2.5), compared with people born with a placental area greater than 295 cm2. The risk of heart failure was further increased by rapid gain in body mass index after the age of 2 years, a path of growth known to be linked to insulin resistance in later life. In a simultaneous regression, low body mass index at 2 years and high body mass index at 11 years were each associated with chronic heart failure (P = 0.008 and 0.001, respectively). Conclusion: Chronic heart failure in adult life may be initiated by impaired placental growth which adversely affects cardiac development. People born with a vulnerable heart are more likely to develop chronic heart failure if they become insulin resistant.
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There was no relationship between chronic heart failure and placental weight.
“There was no relationship with placental weight.”
From Placental Origins of Chronic Disease (2016) · cites this paper as [27]
The relationships between placental surface area and chronic heart failure were strongest among women of below median stature.
“As with hypertension, the relationships were strongest among women of below median stature (Table 2), suggesting a link with the mother's own nutritional state during her fetal and childhood development.”
From Placental Origins of Chronic Disease (2016) · cites this paper as [27]
In the Helsinki Birth Cohort, chronic heart failure was associated with a small surface area of the delivered placenta, with an odds ratio of 1.7 (1.1-2.5) in men and women born with a placental area <225 cm2 compared with those with an area >295 cm2.
“Their disease was associated with a small surface area of the delivered placenta, and the odds ratio for chronic heart failure was 1.7 (1.1-2.5) in men and women born with a placental area <225 cm 2 compared those with an area >295 cm 2 (27).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [27]
People born with a vulnerable heart are more likely to develop chronic heart failure if they become insulin resistant.
“In addition, people born with a vulnerable heart are more likely to develop chronic heart failure if they become insulin resistant (27).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [27]
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Cites
ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult
Hunt, S. A. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.08.022 · Cited by 4,127 · see citing works
Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M. L., Konstam, M. A., MANCINI, D. M., Michl, K., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.192065 · Cited by 3,712 · see citing works
WEIGHT IN INFANCY AND DEATH FROM ISCHAEMIC HEART DISEASE
Barker, D. J. P., Osmond, C., Winter, P. D., Margetts, B., & Simmonds, S. J. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90710-1 · Cited by 3,574 · see citing works
Self-citationFetal origins of coronary heart disease
Barker, D. J. P. (1995) · BMJ · doi:10.1136/bmj.311.6998.171 · Cited by 3,570 · see citing works
Self-citationESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008
Dickstein, K., Authors Task Force Members, Solal, A. C., Filippatos, G. S., McMurray, J. J. V., Ponikowski, P. P., Poole-Wilson, P. A., Strömberg, A., van Veldhuisen, D. J., Atar, D., et al. (2008) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2008.08.005 · Cited by 3,515 · see citing works
Fetal and infant growth and impaired glucose tolerance at age 64
Hales, C. N., Barker, D. J., Clark, P. M., Cox, L. J., Fall, C., Osmond, C., & Winter, P. D. (1991) · BMJ · doi:10.1136/bmj.303.6809.1019 · Cited by 2,708 · see citing works
Self-citationAuthors Task Force Members, Dickstein, K., Solal, A. C., Filippatos, G., McMurray, J. J. V., Ponikowski, P. P., Poole-Wilson, P. A., Strömberg, A., van Veldhuisen, D. J., Atar, D., et al. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn309 · Cited by 2,688 · see citing works
Trajectories of growth among children who have coronary events as adults
Barker, D. J. P., Osmond, C., Forsén, T. J., Kajantie, E., & Eriksson, J. G. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa044160 · Cited by 1,517 · see citing works
Self-citationCalvert, H., Horwich, A., Newlands, E. S., Beǵent, R. H. J., Rustin, G. J. S., Kaye, S. B., Harris, A. L., Williams, C. J., & Slevin, M. L. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92709-2 · Cited by 1,183 · see citing works
Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976
Rich-Edwards, J. W., Stampfer, M. J., Manson, J. E., ROSNER, B. A., Hankinson, S. E., Colditz, G. A., Hennekens, C. H., & Willett, W. C. (1997) · BMJ · doi:10.1136/bmj.315.7105.396 · Cited by 814 · see citing works
Insulin Resistance and Risk of Congestive Heart Failure
Ingelsson, E., Sundström, J., Ärnlöv, J., Zethelius, B., & Lind, L. (2005) · JAMA · doi:10.1001/jama.294.3.334 · Cited by 569 · see citing works
The nutritional basis of the fetal origins of adult disease
Harding, J. E. (2001) · International Journal of Epidemiology · doi:10.1093/ije/30.1.15 · Cited by 561 · see citing works
Mother's weight in pregnancy and coronary heart disease in a cohort of finnish men: follow up study
Forsén, T., Eriksson, J. G., Tuomilehto, J. O., Teramo, K., Osmond, C., & Barker, D. J. P. (1997) · BMJ · doi:10.1136/bmj.315.7112.837 · Cited by 452 · see citing works
Self-citationInsulin-Resistant Cardiomyopathy
Witteles, R. M., & Fowler, M. B. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.10.021 · Cited by 349 · see citing works
Fetal cardiac output, distribution to the placenta and impact of placental compromise
Kiserud, T., Ebbing, C., Kessler, J., & Rasmussen, S. (2006) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.2832 · Cited by 275 · see citing works
The surface area of the placenta and hypertension in the offspring in later life
Barker, D. J. P., Thornburg, K. L., Osmond, C., Kajantie, E., & Eriksson, J. G. (2010) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082760db · Cited by 212 · see citing works
Self-citationChildhood Growth and Hypertension in Later Life
Eriksson, J. G., Forsén, T., Kajantie, E., Osmond, C., & Barker, D. J. P. (2007) · Hypertension · doi:10.1161/hypertensionaha.106.085597 · Cited by 204 · see citing works
Self-citationPlacental characteristics and birthweight
Salafia, C. M., Zhang, J., CHARLES, A. K., Bresnahan, M. A., Shrout, P. E., Sun, W., & Maas, E. M. (2008) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.2008.00935.x · Cited by 150 · see citing works
Mäkikallio, K., Vuolteenaho, O. J., Jouppila, P. I., & Rasanen, J. P. (2002) · Circulation · doi:10.1161/01.cir.0000015505.24187.fa · Cited by 149 · see citing works
Cleal, J. K., Poore, K. R., Boullin, J. P., Khan, O. A., Chau, R., Hambidge, O., Torrens, C., Newman, J. P., Poston, L., Noakes, D. E., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610373104 · Cited by 137 · see citing works
Right ventricular systolic pressure load alters myocyte maturation in fetal sheep
Barbera, A. F., Giraud, G. D., Reller, M. D., Maylie, J., Morton, M. J., & Thornburg, K. L. R. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.4.r1157 · Cited by 135 · see citing works
Self-citationPesonen, A., Räikkönen, K., Heinonen, K., Kajantie, E., Forsén, T., & Eriksson, J. G. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm254 · Cited by 118 · see citing works
Self-citationÄrnlöv, J., Lind, L., Zethelius, B., Andrén, B., Hales, C. N., Vessby, B. O., & Lithell, H. (2001) · American Heart Journal · doi:10.1067/mhj.2001.116957 · Cited by 107 · see citing works
Burkhardt, T., Schäffer, L., Schneider, C., Zimmermann, R., & Kurmanavičius, J. (2005) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2005.10.032 · Cited by 103 · see citing works
In preeclampsia, the placenta grows slowly along its minor axis
Kajantie, E., Thornburg, K. L. R., Eriksson, J. G., Osmond, C., & Barker, D. J. P. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082833ek · Cited by 100 · see citing works
Self-citationRelationship of maternal protein turnover and lean body mass during pregnancy and birth length
DUGGLEBY, S. L., & Jackson, A. A. (2001) · Clinical Science · doi:10.1042/cs1010065 · Cited by 93 · see citing works
Prenatal exposure to maternal undernutrition induces adult cardiac dysfunction
Cheema, K. K., Dent, M. R., Saini, H. K., et al. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041392 · Cited by 85 · see citing works
Rosso, P., & Kava, R. (1980) · Journal of Nutrition · doi:10.1093/jn/110.12.2350 · Cited by 82 · see citing works
Fernandez‐Twinn, D. S., Ekizoglou, S., Wayman, A., Petry, C. J., & Ozanne, S. E. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00608.2005 · Cited by 61 · see citing works
Heart failure in different occupational classes in Sweden
Schaufelberger, M., & Rosengren, A. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl435 · Cited by 44 · see citing works
Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M. L., Konstam, M. A., MANCINI, D. M., Michl, K., et al. (2005) · Cited by 37 · see citing works
Treatment of Advanced Heart Disease
(2006) · CRC Press eBooks · doi:10.3109/9781420020168 · Cited by 15 · see citing works
Device Therapy for Heart Failure
Fang, J. C.-T. (2006) · Fundamental and clinical cardiology · doi:10.3109/9781420020168.017 · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- [16]Anderson MC. Lessons in Midwifery for Nurses and Midwifes. London: A & C Black; 1930. [Google Scholar]
- [17]Hinselmann H. Biologie und Pathologie des Weibes. Berlin: Urban & Schwarzenberg; 1925. [Google Scholar]
- [21]Tanner JM. Fetus into Man. 2nd edn. Castlemead: Ware; 1989. [Google Scholar]
Cited by
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Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717 · see citing works
Self-citationPlacental programming of chronic diseases, cancer and lifespan: A review
Barker, D. J. P., & Thornburg, K. L. (2013) · Placenta · doi:10.1016/j.placenta.2013.07.063 · Cited by 276 · see citing works
Self-citationZijlmans, M. A. C., Riksen-Walraven, J. M., & de Weerth, C. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.02.015 · Cited by 221 · see citing works
The Programming Power of the Placenta
Sferruzzi-Perri, A. N., & Camm, E. J. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00033 · Cited by 223 · see citing works
Mother's body size and placental size predict coronary heart disease in men
Eriksson, J. G., Kajantie, E., Thornburg, K. L., Osmond, C., & Barker, D. J. P. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr147 · Cited by 125 · see citing works
Self-citationThe placental origins of sudden cardiac death
Barker, D. J., Larsen, G., Osmond, C., Thornburg, K. L., Kajantie, E., & Eriksson, J. G. (2012) · International Journal of Epidemiology · doi:10.1093/ije/dys116 · Cited by 93 · see citing works
Self-citationResource allocation in utero and health in later life
Barker, D. J. P., Lampl, M., Roseboom, T., & Winder, N. (2012) · Placenta · doi:10.1016/j.placenta.2012.06.009 · Cited by 81 · see citing works
Self-citationHow to Build a Healthy Heart from Scratch
Thornburg, K. L. R., & Challis, J. R. G. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-1031-1_18 · Cited by 10 · see citing works
Self-citation
- Authors
- Barker, D. J. P., Gelow, J., Thornburg, K., Osmond, C., Kajantie, E., & Eriksson, J. G.
- Affiliations
- Oregon Health & Science University (US)
- Southampton General Hospital (GB)
- Helsinki University Hospital (FI)
- University of Helsinki (FI)
- Corresponding author
- Barker, David J.P.
- Venue
- European Journal of Heart Failure
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-08-01
- Volume
- 12
- Issue
- 8
- Pages
- 819-825
- ISSN
- 1388-9842 (ISSN-L)
- 1879-0844
- PMC
- PMC5477852
- OpenAlex
- W2135396506
- Cited by
- 176
- References
- 33
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 6 · 2023: 9 · 2022: 5 · 2021: 8 · 2020: 10 · 2019: 8 · 2018: 11 · 2017: 10 · 2016: 18 · 2015: 14 · 2014: 13 · 2013: 17 · 2012: 22
- FWCI
- 15.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- European Journal of Heart Failure (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
- Funders
- British Heart Foundation
- National Institute on Aging (R01AG032339)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- chronic heart failure, placental development, placental surface area, fetal programming, insulin resistance, childhood body mass index, low birth weight, coronary artery disease, hypertension, heart development, birth cohort
- MeSH terms
- Age Factors, Aged, Child, Child, Preschool, Coronary Artery Disease, Diabetes Mellitus, Type 2, Employment, Female, Finland, Heart Failure, Humans, Infant, Infant, Low Birth Weight, Infant, Newborn, Insulin Resistance, Male, Mortality, Placentation, Pregnancy, Risk Factors, Social Class, Time Factors, Cohort Studies, Confidence Intervals, Odds Ratio, Disease Progression, Fetal Nutrition Disorders
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