Resource allocation in utero and health in later life
Abstract
The way that a fetus obtains and allocates nutritional resources has profound consequences for its life-long health. Under the new developmental model for the origins of chronic disease, the causes to be identified are linked to normal variations in the processes of feto-placental development, that are associated with differences in the supply of nutrients to the baby. These differences programme the function of a few key systems that are linked to chronic disease, including the immune system, anti-oxidant defences, inflammation, and the number and quality of stem cells. There is not a separate cause for each different disease. Which chronic disease originates during development may depend more on timing than on qualitative differences in experience.
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There are interactions between the current nutritional environment of the mother and her past nutritional history, as indicated by BMI and body composition, in determining placental phenotype.
“There are also interactions between the current nutritional environment of the mother and her past nutritional history, as indicated by her body mass index (BMI) and body composition, in determining placental phenotype (29,521,527,556).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [29]
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- Authors
- Barker, D. J. P., Lampl, M., Roseboom, T., & Winder, N.
- Affiliations
- Oregon Health & Science University (US)
- Emory University (US)
- Amsterdam UMC Location University of Amsterdam (NL)
- MRC Lifecourse Epidemiology Unit (GB)
- Corresponding author
- Barker, D.J.P.
- Venue
- Placenta
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 33
- Pages
- e30-e34
- ISSN
- 0143-4004 (ISSN-L)
- OpenAlex
- W2088947122
- Cited by
- 81
- References
- 42
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 8 · 2019: 7 · 2018: 8 · 2017: 9 · 2016: 9 · 2015: 7 · 2014: 9 · 2013: 6 · 2012: 2
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Placenta (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- fetal programming, placental development, fetal nutrition, immune system development, antioxidant defense, inflammation, stem cells, developmental timing, later-life health
- MeSH terms
- Birth Weight, Chronic Disease, Ethnicity, Female, Humans, Male, Maternal-Fetal Exchange, Organ Size, Placenta, Pregnancy, Prenatal Exposure Delayed Effects, Sex Factors, Prenatal Nutritional Physiological Phenomena, Fetal Development
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