Cited by 170Antibiotic Use and ResistancePharmaceutical Economics and PolicyAntibiotic Resistance in Bacteria

Antibiotic effectiveness: Balancing conservation against innovation

Laxminarayan, Ramanan·2014·Science

Abstract

Antibiotic effectiveness is a natural societal resource that is diminished by antibiotic use. As with other such assets, keeping it available requires both conservation and innovation. Conservation encompasses making the best use of current antibiotic effectiveness by reducing demand through vaccination, infection control, diagnostics, public education, incentives for clinicians to prescribe fewer antibiotics, and restrictions on access to newer, last-resort antibiotics. Innovation includes improving the efficacy of current drugs and replenishing effectiveness by developing new drugs. In this paper, I assess the relative benefits and costs of these two approaches to maintaining our ability to treat infections.

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Crossref · 10.1126/science.1254163

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31 of 31 references verified0 citation errors · 0 not checkable

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  • Improving sanitation, expanding vaccine use, and strengthening hospital infection control are effective tools for reducing the need for antibiotic therapies.

    “improving sanitation, expanding the use of vaccines, and strengthening hospital infection control have proven extremely effective tools in reducing the needs for antibiotic therapies.”

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Authors
Laxminarayan, R.
Affiliations
Center for Disease Dynamics, Economics & Policy (US)
Corresponding author
Laxminarayan, Ramanan
Venue
Science
Published
2014-09-12
Volume
345
Issue
6202
Pages
1299-1301
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2004486295
Cited by
170
References
31
Citations by year
2026: 3 · 2025: 9 · 2024: 7 · 2023: 10 · 2022: 19 · 2021: 12 · 2020: 27 · 2019: 19 · 2018: 14 · 2017: 21 · 2016: 15 · 2015: 10 · 2014: 4
FWCI
14.15
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
  • Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Pharmaceutical Economics and Policy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
Keywords
antibiotic effectiveness, antibiotic resistance, new antibiotic development, demand reduction, vaccination, infection control, antimicrobial diagnostics, prescribing incentives
MeSH terms
Animals, Animal Husbandry, Anti-Bacterial Agents, Communicable Disease Control, Communicable Diseases, Humans, Vaccination, Drug Resistance, Bacterial, Livestock

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