Cited by 379Hereditary Neurological DisordersAmyotrophic Lateral Sclerosis ResearchMicrotubule and mitosis dynamics

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Kinesin Mutations Cause Motor Neuron Disease Phenotypes by Disrupting Fast Axonal Transport in Drosophila

Hurd, Daryl D, Saxton, William M·1996·Genetics

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Abstract

Previous work has shown that mutation of the gene that encodes the microtubule motor subunit kinesin heavy chain (Khc) in Drosophila inhibits neuronal sodium channel activity, action potentials and neurotransmitter secretion. These physiological defects cause progressive distal paralysis in larvae. To identify the cellular defects that cause these phenotypes, larval nerves were studied by light and electron microscopy. The axons of Khc mutants develop dramatic focal swellings along their lengths. The swellings are packed with fast axonal transport cargoes including vesicles, synaptic membrane proteins, mitochondria and prelysosomal organelles, but not with slow axonal transport cargoes such as cytoskeletal elements. Khc mutations also impair the development of larval motor axon terminals, causing dystrophic morphology and marked reductions in synaptic bouton numbers. These observations suggest that as the concentration of maternally provided wild-type KHC decreases, axonal organelles transported by kinesin periodically stall. This causes organelle jams that disrupt retrograde as well as anterograde fast axonal transport, leading to defective action potentials, dystrophic terminals, reduced transmitter secretion and progressive distal paralysis. These phenotypes parallel the pathologies of some vertebrate motor neuron diseases, including some forms of amyotrophic lateral sclerosis (ALS), and suggest that impaired fast axonal transport is a key element in those diseases.

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Antibodies to horseradish peroxidase as specific neuronal markers in Drosophila and in grasshopper embryos.
Jan, L. Y., & Jan, Y. N. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.8.2700 · Cited by 759
Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin
Hata, Y., Slaughter, C., & Südhof, T. (1993) · Nature · doi:10.1038/366347a0 · Cited by 751
The neuron-specific kinesin superfamily protein KIF1A is a uniqye monomeric motor for anterograde axonal transport of synaptic vesicle precursors
Okada, Y., Yamazaki, H., Sekine‐Aizawa, Y., & Hirokawa, N. (1995) · Cell · doi:10.1016/0092-8674(95)90538-3 · Cited by 679
Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans
Hall, D. H., & Hedgecock, E. M. (1991) · Cell · doi:10.1016/0092-8674(91)90391-b · Cited by 564
Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease
Xu, Z. (1993) · Cell · doi:10.1016/0092-8674(93)90157-l · Cited by 543
Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis
Collard, J.-F., Côté, F., & Julien, J. (1995) · Nature · doi:10.1038/375061a0 · Cited by 462
Differential ultrastructure of synaptic terminals on ventral longitudinal abdominal muscles in Drosophila larvae
Atwood, H. L., Govind, C. K., & Wu, C. (1993) · Journal of Neurobiology · doi:10.1002/neu.480240803 · Cited by 399
A mutant neurofilament subunit causes massive, selective motor neuron death: Implications for the pathogenesis of human motor neuron disease
Lee, M. K., Marszalek, J. R., & Cleveland, D. W. (1994) · Neuron · doi:10.1016/0896-6273(94)90263-1 · Cited by 365
Amyotrophic lateral sclerosis: Recent insights from genetics and transgenic mice
Brown, R. H. (1995) · Cell · doi:10.1016/0092-8674(95)90346-1 · Cited by 352
Polarity orientation of axonal microtubules.
Heidemann, S. R., Landers, J. M., & Hamborg, M. A. (1981) · The Journal of Cell Biology · doi:10.1083/jcb.91.3.661 · Cited by 349

Show all 41 references

Research works printed but not linked: 5

DLJBRE~JII., R. R., and J. Y I ~, 1994 Ankyrin and P-spectrin accumulate independently of a-spectrin in Drosophila. Proc. Natl. Acad. Sci.
IAMBF.RI, E. H., and P. J. DYCK, 1993 Compound action potentials of sural nerve in vitro in peripheral neuropathy, pp. 672-685 in I'priphrral Ahropathy, edited by P. J. DYCK, P. K. THOMAS, J. W. GRIFFIN. P. A. L , o w and,J. F. PoDr:sI.o. W. B. Saunders, Philadel- phia.
HIROKAWA, N., R. %TO-YOSHITAKE, N. KOBAYASHI, K. K. PFISTER, G. s. LINDSIXY, D. L., and G. G. ZIMM, 1992 The Genolnc of Drosophila melanogarter. Academic Press, San Diego.
OCHS, s., and W. s. BRIMIIOIN, 1993 Axonal transport, pp. 331-360 in Peri>herd Neuropathy, edited by P. J. DYCK, P. K. THOMAS, J. W. GKIFFIN, P. A. LOW and J. F. PODUSIX). W. B. Saunders, Philadel- phia.
ROWAND, L. P., 1994 Natural history and clinical features of amyo- trophic lateral sclerosis, pp. 507-522 in A;rurorlegpnrrativeDisf~asps, edited by D. B. CNX.E. W. B. Saunders Co., Philadelphia.

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Authors: Hurd, D. D., & Saxton, W. M.
Affiliations: Indiana University Bloomington (US)
Corresponding author: Saxton, William M
Venue: Genetics
Publisher: Oxford University Press (OUP)
Published: 1996-11-01
Volume: 144
Issue: 3
Pages: 1075-1085
ISSN: 0016-6731 (ISSN-L)
1943-2631
DOI: 10.1093/genetics/144.3.1075
OpenAlex: W1877780738
Cited by: 379
References: 41
Citations by year: 2026: 1 · 2025: 8 · 2024: 9 · 2023: 14 · 2022: 8 · 2021: 10 · 2020: 8 · 2019: 7 · 2018: 11 · 2017: 16 · 2016: 11 · 2015: 14 · 2014: 18 · 2013: 18 · 2012: 22
FWCI: 3.52
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
National Institutes of Health (5t32gm007227-21)
National Institute of General Medical Sciences (T32GM-07227, R01GM046295, GM-46295)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Keywords: kinesin heavy chain, motor neuron disease, fast axonal transport, retrograde transport, anterograde transport, axonal swellings, organelle transport, synaptic boutons, neurotransmitter release, amyotrophic lateral sclerosis, Drosophila
MeSH terms: Animals, Axons, Biological Transport, Calcium-Binding Proteins, Drosophila, Female, Male, Membrane Glycoproteins, Membrane Proteins, Nerve Tissue Proteins, Paralysis, Phenotype, Rabbits, Organelles, Cell Adhesion Molecules, Neuronal, Mutagenesis, Motor Neuron Disease, Kinesins, Presynaptic Terminals, Animals, Genetically Modified, Qa-SNARE Proteins, Synaptotagmins, HSP40 Heat-Shock Proteins, Mice

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Kinesin Mutations Cause Motor Neuron Disease Phenotypes by Disrupting Fast Axonal Transport in Drosophila

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