Cited by 132Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Age-Related Differences in Hippocampal Extracellular Fluid Glucose Concentration During Behavioral Testing and Following Systemic Glucose Administration

McNay, E. C., Gold, P. E.·2001·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Abstract

Recent evidence indicates that the level of glucose in the brain's extracellular fluid (ECF) is not constant, as traditionally thought, but fluctuates. We determined the effect of aging on hippocampal ECF glucose before, during, and after spatial memory testing. Fischer-344 rats (24 months old) showed a greater decrease in ECF glucose than 3-month-old rats (48% vs 12%); the decrease seen in 24-month-old rats persisted for much longer following testing. These changes were associated with an age-related deficit in spontaneous alternation performance. Following systemic glucose administration, the decrease in ECF glucose was reversed in both aged and young rats, and performance in aged versus young rats following glucose administration did not differ. These findings suggest that increased susceptibility to depletion of ECF glucose in aged rats may contribute to age-related deficits in learning and memory and that administration of glucose may enhance memory by providing additional glucose to the brain at times of increased cognitive demand.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1093/gerona/56.2.b66

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 2

  1. Craik FIM. Age differences in human memory. In: Klix F, Hagendorf H, eds. Human Memory and Cognitive Capabilities. Amsterdam, The Netherlands: Elsevier; 1977:409-422.
  2. Ragozzino ME, Pal SN, Unick KE, Stefani MR, Gold PE. Modulation of hippocampal acetylcholine release and of memory by intrahippo- campal glucose injections. J Neurosci. 1998;18:1595-1601.

Cited by

Sorted by citations

Authors
McNay, E. C., & Gold, P. E.
Affiliations
  • Yale University (US)
  • University of Illinois Urbana-Champaign (US)
Corresponding author
McNay, E. C.
Venue
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Published
2001-02-01
Volume
56
Issue
2
Pages
B66-B71
ISSN
  • 1079-5006 (ISSN-L)
  • 1758-535X
OpenAlex
W2137593311
Cited by
132
References
40
Citations by year
2026: 2 · 2025: 4 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 1 · 2020: 10 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 6 · 2014: 8 · 2013: 8 · 2012: 9
FWCI
3.67
Type
journal article
Language
en
Open access
closed
Locations
  • The Journals of Gerontology Series A (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Agriculture
  • Alzheimer's Association
  • Glenn Foundation for Medical Research
  • Yale University
  • University of Illinois at Urbana-Champaign
  • Raymond and Beverly Sackler Institute for Biological, Physical and Engineering Sciences, Yale University
  • National Institute on Aging (R01AG007648, AG 07648)
  • National Institute of Neurological Disorders and Stroke (NS-32914, R01NS032914)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
aging, spatial memory, spontaneous alternation, glucose administration, age-related memory decline, learning and memory, F344 rats
MeSH terms
Aging, Animals, Behavior, Animal, Extracellular Space, Glucose, Hippocampus, Male, Memory, Osmolar Concentration, Rats, Inbred F344, Space Perception, Microdialysis, Maze Learning, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review