Cited by 111Diabetes Management and ResearchNeurological and metabolic disordersDiabetes Treatment and Management

Mini-review: Impact of recurrent hypoglycemia on cognitive and brain function

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McNay, Ewan C., Cotero, Victoria E.·2010·Physiology & Behavior

Abstract

Recurrent hypoglycemia (RH), the most common side-effect of intensive insulin therapy for diabetes, is well established to diminish counter-regulatory responses to further hypoglycemia. However, despite significant patient concern, the impact of RH on cognitive and neural function remains controversial. Here we review the data from both human studies and recent animal studies regarding the impact of RH on cognitive, metabolic, and neural processes. Overall, RH appears to cause brain adaptations which may enhance cognitive performance and fuel supply when euglycemic but which pose significant threats during future hypoglycemic episodes.

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Crossref · 10.1016/j.physbeh.2010.01.004

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  1. [23]Strachan MWJ Deary IJ Ewing FME Frier BM Recovery of cognitive function and mood after severe hypoglycemia in adults with insulin-treated diabetes Diabetes Care 2000 23 305 312 10868856
  2. [34]Jacob RJ Dziura J Blumberg M Morgen JP Sherwin RS Effects of recurrent hypoglycemia on brainstem function in diabetic BB rats: protective adaptation during acute hypoglycemia Diabetes 1999 48 141 5 9892235
  3. [36]Strachan M Deary I Ewing F Frier B Recovery of Cognitive Function and Mood After Severe Hypoglycemia in Adults With Insulin-Treated Diabetes Diabetes Care 2000 23 305 312 10868856
  4. [69]Tkacs N Pan Y Raghupathi R Dunn-Meynell A Levin B Cortical Fluoro-Jade staining and blunted adrenomedullary response to hypoglycemia after noncoma hypoglycemia in rats Cerebral Blood Flow and Metabolism 2005 25 1645 1655 15902194
  5. [72]Yamada KA Rensing N Izumi Y de Erausquin GA Gazit V Dorsey DA Herrera DG Repetitive hypoglycemia in young rats impairs hippocampal long-term potentiation Pediatric research 2004 55 372 379 14681492

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Authors
McNay, E. C., & Cotero, V. E.
Affiliations
University at Albany, State University of New York (US)
Corresponding author
McNay, Ewan C.
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
2010-06
Volume
100
Issue
3
Pages
234-238
ISSN
0031-9384 (ISSN-L)
OpenAlex
W2071350148
Cited by
111
References
70
Citations by year
2026: 5 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 3 · 2020: 5 · 2019: 11 · 2018: 13 · 2017: 7 · 2016: 7 · 2015: 7 · 2014: 3 · 2013: 8 · 2012: 8
FWCI
1.36
Type
journal article
Language
en
Open access
Locations
  • Physiology & Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK077106)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Neurological and metabolic disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
recurrent hypoglycemia, cognitive function, brain function, counterregulatory response, intensive insulin therapy, diabetes mellitus, brain adaptation, hypoglycemic episodes
MeSH terms
Blood Glucose, Brain, Cognition, Diabetes Mellitus, Humans, Hypoglycemia, Insulin

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