Mini-review: Impact of recurrent hypoglycemia on cognitive and brain function
Open accessAbstract
Recurrent hypoglycemia (RH), the most common side-effect of intensive insulin therapy for diabetes, is well established to diminish counter-regulatory responses to further hypoglycemia. However, despite significant patient concern, the impact of RH on cognitive and neural function remains controversial. Here we review the data from both human studies and recent animal studies regarding the impact of RH on cognitive, metabolic, and neural processes. Overall, RH appears to cause brain adaptations which may enhance cognitive performance and fuel supply when euglycemic but which pose significant threats during future hypoglycemic episodes.
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- Authors
- McNay, E. C., & Cotero, V. E.
- Affiliations
- University at Albany, State University of New York (US)
- Corresponding author
- McNay, Ewan C.
- ORCID
- McNay, Ewan C.
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 100
- Issue
- 3
- Pages
- 234-238
- ISSN
- 0031-9384 (ISSN-L)
- PMC
- PMC2860007
- OpenAlex
- W2071350148
- Cited by
- 111
- References
- 70
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 3 · 2020: 5 · 2019: 11 · 2018: 13 · 2017: 7 · 2016: 7 · 2015: 7 · 2014: 3 · 2013: 8 · 2012: 8
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK077106)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Neurological and metabolic disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- recurrent hypoglycemia, cognitive function, brain function, counterregulatory response, intensive insulin therapy, diabetes mellitus, brain adaptation, hypoglycemic episodes
- MeSH terms
- Blood Glucose, Brain, Cognition, Diabetes Mellitus, Humans, Hypoglycemia, Insulin
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