The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Cognitive Function, Gait Speed Decline, and Comorbidities: The Health, Aging and Body Composition Study
Open accessAbstract
BACKGROUND: Emerging evidence indicates an association between cognitive function and physical performance in late life. This study examines the relationship between cognitive function and subsequent gait speed decline among high-functioning older adults. METHODS: Measures of global cognitive function (Modified Mini Mental State Examination [3MS]) and executive control function (ECF) (a clock drawing task [CLOX 1] and the 15-item Executive Interview [EXIT 15]) were obtained in the Health, Aging, and Body Composition Study in 1999-2000. Gait-speed (meters/second) was assessed over 20 meters at usual pace. Using a mixed model, we assessed the relationship between baseline cognitive function and gait-speed change over 3 years. RESULTS: Two thousand, three hundred forty-nine older adults (mean age 75.6 +/- 2.9 years) completed the assessments. After adjustment for baseline gait speed, a 1-standard-deviation (SD) lower performance on each cognitive test was associated with greater gait-speed decline over 3 years: 0.016 m/s for the 3MS (SD = 8.1), 0.009 m/s for CLOX 1 (SD = 2.4), and 0.012 m/s for EXIT 15 (SD = 4.1) (p <.0005 for all). After adjustment for comorbidities, the effect size was attenuated for 3MS and CLOX 1, and the association for EXIT 15 was no longer significant. Depression score was most strongly associated with the EXIT 15 effect reduction. CONCLUSION: Global and executive cognitive functions predict declines in gait speed. The association of ECF with gait speed decline is attenuated by comorbid conditions, particularly depression. Elucidation of the mechanisms underlying these associations may point to new pathways for the treatment of physical decline associated with diminished cognitive function.
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Cites
Screening for Depression in Well Older Adults: Evaluation of a Short Form of the CES-D
Andresen, E. M., Malmgren, J. A., Carter, W. B., & Patrick, D. L. (1994) · American Journal of Preventive Medicine · doi:10.1016/s0749-3797(18)30622-6 · Cited by 5,403
Cesari, M., Kritchevsky, S. B., Penninx, B. W. H. J., Nicklas, B. J., Simonsick, E. M., Newman, A. B., Tylavsky, F. A., Brach, J. S., Satterfield, S., Bauer, D. C., et al. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53501.x · Cited by 1,192 · cited 1×
“This study has several strengths, including a large community-representative study population, longitudinal design, the examination of both global cognitive function and ECF, use of a well-established objective measure of lower extremity physical performance that predicts functional limitations (37,38), and availabili…”
Self-citationSeeman, T. E., Charpentier, P. A., Berkman, L. F., Tinetti, M. E., Guralnik, J. M., Albert, M., Blazer, D., & Rowe, J. W. (1994) · Journal of Gerontology · doi:10.1093/geronj/49.3.m97 · Cited by 522
The hierarchy of functional loss associated with cognitive decline in older persons
Njegovan, V., Man-Son-Hing, M., Mitchell, S. L., & Molnar, F. J. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.10.m638 · Cited by 359
Performance-based physical function and future dementia in older people
Wang, L., Larson, E. B., Bowen, J. D., & van Belle, G. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.10.1115 · Cited by 329
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Studenski, S. (2011) · JAMA · doi:10.1001/jama.2010.1923 · Cited by 4,558
FedHealth: A Federated Transfer Learning Framework for Wearable Healthcare
Chen, Y., Qin, X., Wang, J., Yu, C., & Gao, W. (2020) · IEEE Intelligent Systems · doi:10.1109/mis.2020.2988604 · Cited by 1,005
Evidence for the Domains Supporting the Construct of Intrinsic Capacity
Cesari, M., Araujo de Carvalho, I., Amuthavalli Thiyagarajan, J., Cooper, C., Martin, F. C., Reginster, J.-Y., Vellas, B., & Beard, J. R. (2018) · The Journals of Gerontology: Series A · doi:10.1093/gerona/gly011 · Cited by 745
Self-citationObesity and mobility disability in the older adult
Vincent, H. K., Vincent, K. R., & Lamb, K. M. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00703.x · Cited by 382
Physical Activity and Cognitive Vitality
Prakash, R. S., Voss, M. W., Erickson, K. I., & Kramer, A. F. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010814-015249 · Cited by 376
Metadata
- Authors
- Atkinson, H. H., Rosano, C., Simonsick, E. M., Williamson, J. D., Davis, C., Ambrosius, W. T., Rapp, S. R., Cesari, M., Newman, A. B., Harris, T. B., Rubin, S. M., Yaffe, K., Satterfield, S., & Kritchevsky, S. B.
- Venue
- The Journals of Gerontology: Series A
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-08-01
- Volume
- 62
- Issue
- 8
- Pages
- 844-850
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2121239834
- Cited by
- 406
- References
- 5
- FWCI
- 44.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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