Caloric restriction improves health and survival of rhesus monkeys
Open accessAbstract
Caloric restriction (CR) without malnutrition extends lifespan and delays the onset of age-related disorders in most species but its impact in nonhuman primates has been controversial. In the late 1980s two parallel studies were initiated to determine the effect of CR in rhesus monkeys. The University of Wisconsin study reported a significant positive impact of CR on survival, but the National Institute on Aging study detected no significant survival effect. Here we present a direct comparison of longitudinal data from both studies including survival, bodyweight, food intake, fasting glucose levels and age-related morbidity. We describe differences in study design that could contribute to differences in outcomes, and we report species specificity in the impact of CR in terms of optimal onset and diet. Taken together these data confirm that health benefits of CR are conserved in monkeys and suggest that CR mechanisms are likely translatable to human health.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Calorie restriction has an established beneficial effect on health and life span in laboratory animal models from yeast to rhesus monkeys.
“It has an established beneficial effect on health and life span in laboratory animal models from yeast to rhesus monkeys [78,79].”
From Molecular Targets of 20-Hydroxyecdysone in Mammals, Mechanism of Action: Is It a Calorie Restriction Mimetic and Anti-Aging Compound? (2025) · cites this paper as [79]
The Abstract reports lifespan extension in yeast and other short-lived species and health benefits in rhesus monkeys. It also says monkey survival findings differed between the two studies. The Results (‘Impact of CR on survival’; page unavailable) state that neither monkey study reports longevity data, so an established lifespan benefit across the full range is stronger than this source supports. (LLM, conf=0.86)
Experimental — accuracy not yet measuredIn ad libitum-fed male monkeys, a higher-GL/high-sugar diet compared with a lower-GL/low-sugar diet increased adiposity without increasing total energy intake through age 20 y.
“In ad libitum–fed male monkeys, a higher-GL/high-sugar diet compared with a lower-GL/low-sugar diet increased adiposity without increasing total energy intake through age 20 y (111).”
From The carbohydrate-insulin model: A physiological perspective on the obesity pandemic (2021) · cites this paper as [111]
The same phenomenon of caloric restriction prolonging lifespan was found in primates.
“Some follow-up studies also found the same phenomenon in primates [168, 169].”
From Immunosenescence: a key player in cancer development (2020) · cites this paper as [168]
FOXO transcription factors are downstream effectors of the IIS pathway, are involved in cancer, and mediate many positive effects of caloric restriction on healthy aging.
“Among the downstream effectors of the IIS pathway are the FOXO family of transcription factors, which are also involved in cancer and mediate many of the positive effects of caloric restriction (CR) on healthy aging.211,212”
From Meta-hallmarks of aging and cancer (2023) · cites this paper as [211]
Caloric restriction without hunger- or disease-related malnutrition in animals and humans results in healthier aging through improved metabolic health, reduced obesity, and reduced risk of T2DM, cancer, and cardiovascular disease.
“CR without hunger- or disease-related malnutrition in animals and humans results in healthier aging through improved metabolic health, reduced obesity, and the risk of T2DM, cancer, and cardiovascular disease (236).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [236]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
Geroscience: Linking Aging to Chronic Disease
Kennedy, B. K., Berger, S. L., Brunet, A., Campisi, J., Cuervo, A. M., Epel, E. S., Franceschi, C., Lithgow, G. J., Morimoto, R. I., Pessin, J. E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.039 · Cited by 2,764 · see citing works
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, T. M., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W., et al. (2009) · Science · doi:10.1126/science.1173635 · Cited by 2,277 · see citing works
Self-citationThe retardation of aging and disease by dietary restriction
(1989) · Choice Reviews Online · doi:10.5860/choice.26-5101 · Cited by 1,477 · see citing works
Evolutionary and biomedical insights from the rhesus macaque genome.
Gibbs, R. A., Rogers, J., Katze, M. G., Bumgarner, R., Weinstock, G. M., Mardis, E. R., Remington, K. A., Strausberg, R. L., Venter, J. C., Wilson, R. K., et al. (2007) · Science · doi:10.1126/science.1139247 · Cited by 1,403 · see citing works
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
Mattison, J. A., Roth, G. S., Beasley, T. M., Tilmont, E. M., Handy, A. M., Herbert, R. L., Longo, D. L., Allison, D. B., Young, J. E., Bryant, M., et al. (2012) · Nature · doi:10.1038/nature11432 · Cited by 1,145 · see citing works
Self-citationWeindruch, R. H., Walford, R. L., Fligiel, S., & Guthrie, D. (1986) · Journal of Nutrition · doi:10.1093/jn/116.4.641 · Cited by 992 · see citing works
Self-citationHeilbronn, L. K., de Jonge, L., Frisard, M. I., DeLany, J. P., Larson-Meyer, D. E., Rood, J., Nguyen, T., Martin, C. K., Volaufova, J., Most, M. M., et al. (2006) · JAMA · doi:10.1001/jama.295.13.1539 · Cited by 969 · see citing works
Insulin resistance and hyperglycaemia in cardiovascular disease development
Laakso, M., & Kuusisto, J. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.29 · Cited by 862 · see citing works
Weindruch, R. H., & Walford, R. L. (1982) · Science · doi:10.1126/science.7063854 · Cited by 766 · see citing works
Self-citationCaloric restriction reduces age-related and all-cause mortality in rhesus monkeys
Colman, R. J., Beasley, T. M., Kemnitz, J. W., Johnson, S. C., Weindruch, R., & Anderson, R. M. (2014) · Nature Communications · doi:10.1038/ncomms4557 · Cited by 711 · see citing works
Self-citationMultiple Comparison Procedures: The Practical Solution
Saville, D. J. (1990) · The American Statistician · doi:10.1080/00031305.1990.10475712 · Cited by 638 · see citing works
Aging and Survival: The Genetics of Life Span Extension by Dietary Restriction
Mair, W. B., & Dillin, A. G. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061206.171059 · Cited by 600 · see citing works
Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts
Gems, D., & Partridge, L. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183712 · Cited by 545 · see citing works
Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?
Guarente, L. (2008) · Cell · doi:10.1016/j.cell.2008.01.007 · Cited by 513 · see citing works
Weiss, E. P., Racette, S. B., Villareal, D. T., Fontana, L., Steger-May, K., Schechtman, K. B., Klein, S., & Holloszy, J. O. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.5.1033 · Cited by 353 · see citing works
Effect of Calorie Restriction with or without Exercise on Body Composition and Fat Distribution
Redman, L. M., Heilbronn, L. K., Martin, C. K., Alfonso, A., Smith, S. R., Ravussin, E., & for the Pennington CALERIE Team (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2184 · Cited by 293 · see citing works
Fontana, L., Villareal, D. T., Weiss, E. P., Racette, S. B., Steger-May, K., Klein, S. B., & Holloszy, J. O. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00102.2007 · Cited by 263 · see citing works
Bodkin, N. L., Alexander, T. M., Ortmeyer, H. K., Johnson, E., & Hansen, B. C. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.3.b212 · Cited by 250 · see citing works
Action of food restriction in delaying the aging process
Masoro, E. J., Yu, B. P., & Bertrand, H. A. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.13.4239 · Cited by 247 · see citing works
Racette, S. B., Weiss, E. P., Villareal, D. T., Arif, H., Steger-May, K., Schechtman, K. B., Fontana, L., Klein, S., & Holloszy, J. O. (2006) · The Journals of Gerontology: Series A · doi:10.1093/gerona/61.9.943 · Cited by 237 · see citing works
Kemnitz, J. W., Weindruch, R. H., Roecker, E. B., Crawford, K. S., Kaufman, P. L. P., & Ershler, W. B. (1993) · Journal of Gerontology · doi:10.1093/geronj/48.1.b17 · Cited by 224 · see citing works
Self-citationCaloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals
Lefevre, M., Redman, L. M., Heilbronn, L. K., Smith, J. V., Martin, C. K., Rood, J. C., Greenway, F. L., Williamson, D. A., Smith, S. R., & Ravussin, E. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.05.036 · Cited by 217 · see citing works
A microarray analysis of sexual dimorphism of adipose tissues in high-fat-diet-induced obese mice
Grove, K. L., Fried, S. K., Greenberg, A. S., Xiao, X. Q., & Clegg, D. J. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.12 · Cited by 208 · see citing works
HANSEN, B. C., & Bodkin, N. L. (1986) · Diabetologia · doi:10.1007/bf00870281 · Cited by 204 · see citing works
A new rhesus macaque assembly and annotation for next-generation sequencing analyses
Zimin, A. V., Cornish, A. S., Maudhoo, M. D., Gibbs, R. M., Zhang, X., Pandey, S., Meehan, D. T., Wipfler, K., Bosinger, S. E., Johnson, Z. P., et al. (2014) · Biology Direct · doi:10.1186/1745-6150-9-20 · Cited by 177 · see citing works
Ruminations on dietary restriction and aging
Kennedy, B. K., Steffen, K. K., & Kaeberlein, M. R. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6470-y · Cited by 157 · see citing works
Response of fecal cortisol to stress in captive chimpanzees (Pan troglodytes)
Whitten, P. L., Stavisky, R. C., Aureli, F., & Russell, E. (1998) · American Journal of Primatology · doi:10.1002/(sici)1098-2345(1998)44:1 · Cited by 138 · see citing works
Self-citationAge-related pathology and biosenescent markers in captive rhesus macaques
Uno, H. (1997) · AGE · doi:10.1007/s11357-997-0001-5 · Cited by 105 · see citing works
Calorie Restriction and Aging in Nonhuman Primates
Kemnitz, J. W. (2011) · ILAR Journal · doi:10.1093/ilar.52.1.66 · Cited by 105 · see citing works
Self-citationHealthspan, Translation, and New Outcomes for Animal Studies of Aging
Kirkland, J. L., & Peterson, C. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/gln063 · Cited by 98 · see citing works
Dietary restriction and glucose regulation in aging rhesus monkeys: a follow-up report at 8.5 yr
Gresl, T. A., Colman, R. J., Roecker, E. B., Havighurst, T. C., Huang, Z., Allison, D. B., Bergman, R. N., & Kemnitz, J. W. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.4.e757 · Cited by 93 · see citing works
Self-citationNgwenya, L. B., Heyworth, N. C., Shwe, Y., Moore, T. L., & Rosene, D. L. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00102 · Cited by 90 · see citing works
Risk factors for endometriosis in the rhesus monkey (Macaca mulatta): a case-control study
Hadfield, R. (1997) · Human Reproduction Update · doi:10.1093/humupd/3.2.109 · Cited by 86 · see citing works
Metabolic shifts due to long-term caloric restriction revealed in nonhuman primates
Rezzi, S., Martin, F., Shanmuganayagam, D., Colman, R. J., Nicholson, J. K., & Weindruch, R. H. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.02.008 · Cited by 77 · see citing works
Self-citationPandya, J. D., Grondin, R., Yonutas, H. M., Haghnazar, H., Gash, D. M., Zhang, Z., & Sullivan, P. G. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.01.018 · Cited by 70 · see citing works
Nonhuman Primate Calorie Restriction
Colman, R. J., & Anderson, R. M. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3224 · Cited by 68 · see citing works
Self-citationDietary Restriction in Nonhuman Primates: Progress Report on the NIA Study
Lane, M. A., Ingram, D. K., Cutler, R. G., Knapka, J. J., Barnard, D. E., & Roth, G. S. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb27434.x · Cited by 66 · see citing works
Self-citationMorphometric comparison of Chinese-origin and Indian-derived rhesus monkeys (Macaca mulatta)
Clarke, M. R., & O'Neil, J. A. S. (1999) · American Journal of Primatology · doi:10.1002/(sici)1098-2345(1999)47:4 · Cited by 62 · see citing works
Yamada, Y., Colman, R. J., Kemnitz, J. W., Baum, S. T., Anderson, R. M., Weindruch, R. H., & Schoeller, D. A. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.08.002 · Cited by 61 · see citing works
Self-citationRamsey, J. J., Laatsch, J. L., & Kemnitz, J. W. (2000) · Journal of Medical Primatology · doi:10.1034/j.1600-0684.2000.290102.x · Cited by 53 · see citing works
Self-citationAge and sex differences in body size and composition during Rhesus monkey adulthood
Hudson, J. C., Baum, S. T., Frye, D. M. D., Roecker, E. B., & Kemnitz, J. W. (1996) · Aging Clinical and Experimental Research · doi:10.1007/bf03339677 · Cited by 39 · see citing works
Self-citationNew strategies for basal insulin treatment in type 2 diabetes mellitus
DAILEY, G. E. (2004) · Clinical Therapeutics · doi:10.1016/s0149-2918(04)90132-4 · Cited by 38 · see citing works
Public and private mechanisms of life extension in Caenorhabditis elegans
Houthoofd, K., & Vanfleteren, J. R. (2007) · Molecular Genetics and Genomics · doi:10.1007/s00438-007-0225-1 · Cited by 35 · see citing works
Caloric restriction lowers plasma lipoprotein (a) in male but not female rhesus monkeys
Edwards, I. J., Rudel, L. L., Terry, J. G., Kemnitz, J. W., Weindruch, R. H., Zaccaro, D. J., & Cefalu, W. T. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00107-3 · Cited by 31 · see citing works
Self-citationBowden, D. M., & Williams, D. D. (1984) · Advances in veterinary science and comparative medicine · doi:10.1016/b978-0-12-039228-5.50015-2 · Cited by 28 · see citing works
Plasma diacylglycerol composition is a biomarker of metabolic syndrome onset in rhesus monkeys
Polewski, M. A., Burhans, M. S., Zhao, M., Colman, R. J., Shanmuganayagam, D., Lindstrom, M. J., Ntambi, J. M., & Anderson, R. M. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m057562 · Cited by 25 · see citing works
Self-citationRodriguez, N. A., Garcia, K. D., Fortman, J. D., Hewett, T. A., Bunte, R. M., & Bennett, B. T. (2002) · Journal of Medical Primatology · doi:10.1034/j.1600-0684.2002.01001.x · Cited by 23 · see citing works
Kanthaswamy, S., Johnson, Z. P., Trask, J. S., Smith, D. G., Ramakrishnan, R., Bahk, J., Ng, J., Wiseman, R. W., Kubisch, H. M., Vallender, E. J., et al. (2014) · American Journal of Primatology · doi:10.1002/ajp.22290 · Cited by 23 · see citing works
Endometriosis: clinical monitoring and treatment procedures in Rhesus Monkeys
Mattison, J. A., Ottinger, M. A., Powell, D., Longo, D. L., & Ingram, D. K. (2007) · Journal of Medical Primatology · doi:10.1111/j.1600-0684.2006.00208.x · Cited by 20 · see citing works
Self-citationMasoro, E. J. (1998) · PubMed · Cited by 6 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Rhesus Macaque Genome S.. Evolutionary and biomedical insights from the rhesus macaque genome. Science 316, 222– 234 (2007). 17431167
Cited by
Sorted by citations
Hallmarks of aging: An expanding universe
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell · doi:10.1016/j.cell.2022.11.001 · Cited by 6,549 · see citing works
Effects of intermittent fasting on health, aging, and disease
de Cabo, R., & Mattson, M. P. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1905136 · Cited by 1,605 · see citing works
From discoveries in ageing research to therapeutics for healthy ageing
Campisi, J., Kapahi, P., Lithgow, G. J., Melov, S., Newman, J. C., & Verdin, E. (2019) · Nature · doi:10.1038/s41586-019-1365-2 · Cited by 1,389 · see citing works
Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States
Mattson, M. P., & Arumugam, T. V. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.05.011 · Cited by 1,242 · see citing works
Animal models of obesity and diabetes mellitus
Kleinert, M., Clemmensen, C., Hofmann, S. M., Moore, M. C., Renner, S., Woods, S. C., Huypens, P., Beckers, J., de Angelis, M. H., Schürmann, A., et al. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.161 · Cited by 853 · see citing works
Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease
Smith, R. L., Soeters, M. R., Wüst, R. C. I., & Houtkooper, R. H. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00211 · Cited by 787 · see citing works
Molecular mechanisms of dietary restriction promoting health and longevity
Green, C. L., Lamming, D. W., & Fontana, L. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00411-4 · Cited by 714 · see citing works
Madeo, F., Carmona-Gutierrez, D., Hofer, S. J., & Kroemer, G. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.018 · Cited by 630 · see citing works
mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review
Weichhart, T. (2018) · Gerontology · doi:10.1159/000484629 · Cited by 596 · see citing works
Meta-hallmarks of aging and cancer
López-Otín, C., Pietrocola, F., Roiz-Valle, D., Galluzzi, L., & Kroemer, G. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2022.11.001 · Cited by 529 · see citing works
Immunosenescence: a key player in cancer development
Lian, J., Yue, Y., Yu, W., & Zhang, Y. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00986-z · Cited by 510 · see citing works
Francesco, A. D., Germanio, C. D., Bernier, M., & de Cabo, R. (2018) · Science · doi:10.1126/science.aau2095 · Cited by 497 · see citing works
The quest to slow ageing through drug discovery
Partridge, L., Fuentealba, M., & Kennedy, B. K. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0067-7 · Cited by 468 · see citing works
Redman, L. M., Smith, S. R., Burton, J. H., Martin, C. K., Il'yasova, D., & Ravussin, E. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.019 · Cited by 472 · see citing works
“…remaining colonies of CR primates (Colman et al., 2009; Mattison et al., 2012), despite differences in study designs, current data support the observation that sustained CR extends life without chronic disease and promotes amore youthful physical andmental func- tionality (Mattison et al., 2017).”
ResultThe ageing epigenome and its rejuvenation
Zhang, W., Qu, J. T., Liu, G., & Belmonte, J. C. I. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0204-5 · Cited by 472 · see citing works
The role of lipid metabolism in aging, lifespan regulation, and age‐related disease
Johnson, A. A., & Stolzing, A. (2019) · Aging Cell · doi:10.1111/acel.13048 · Cited by 452 · see citing works
“With the exception of research showing that caloric restriction improves health and sur‐ vival in rhesus monkeys (Mattison et al., 2017), little aging work has been done in longer‐lived organisms.”
BackgroundmTOR as a central regulator of lifespan and aging
Papadopoli, D. J., Boulay, K., Kazak, L., Pollak, M., Mallette, F. A., Topisirović, I., & Hulea, L. (2019) · F1000Research · doi:10.12688/f1000research.17196.1 · Cited by 431 · see citing works
Autophagy and the cell biology of age-related disease
Leidal, A. M., Levine, B., & Debnath, J. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0235-8 · Cited by 424 · see citing works
Stekovic, S., Hofer, S. J., Tripolt, N., Aon, M. A., Royer, P., Pein, L., Stadler, J. T., Pendl, T., Prietl, B., Url, J., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.07.016 · Cited by 412 · see citing works
“, 2018), caloric restriction (CR) is known to extend healthspan and lifespan in model organisms, including rhesus monkeys (Anton and Leeuwenburgh, 2013; Mattison et al., 2017).”
BackgroundKraus, W. E., Bhapkar, M., Huffman, K. M., Pieper, C. F., Krupa Das, S., Redman, L. M., Villareal, D. T., Rochon, J., Roberts, S. B., Ravussin, E., et al. (2019) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(19)30151-2 · Cited by 407 · see citing works
Melzer, D. R., Pilling, L. C., & Ferrucci, L. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0183-6 · Cited by 371 · see citing works
Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice
Acosta-Rodríguez, V. A., Rijo‐Ferreira, F., Izumo, M., Xu, P., Wight‐Carter, M., Green, C. B., & Takahashi, J. S. (2022) · Science · doi:10.1126/science.abk0297 · Cited by 361 · see citing works
Quantifying resilience of humans and other animals
Scheffer, M., Bolhuis, J. E., Borsboom, D., Buchman, T. G., Gijzel, S. M. W., Goulson, D., Kammenga, J. E., Kemp, B., van de Leemput, I. A., Levin, S. A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1810630115 · Cited by 357 · see citing works
Nutrition, longevity and disease: From molecular mechanisms to interventions
Longo, V. D., & Anderson, R. M. (2022) · Cell · doi:10.1016/j.cell.2022.04.002 · Cited by 342 · see citing works
Self-citationDaily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories
Mitchell, S. J., Bernier, M., Mattison, J. A., Aon, M. A., Kaiser, T. A., Anson, R. M., Ikeno, Y., Anderson, R. M., Ingram, D. K., & de Cabo, R. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.08.011 · Cited by 305 · see citing works
“Even though the original NHP studies were designed to investigate CR and not patterns of feeding behavior (Mattison et al., 2017), the differences in diet composition and feeding regimens between the two studies have been a point of interest.”
Self-citationInterconnections between Inflammageing and Immunosenescence during Ageing
Teissier, T., Boulanger, É., & Cox, L. S. (2022) · Cells · doi:10.3390/cells11030359 · Cited by 310 · see citing works
The carbohydrate-insulin model: A physiological perspective on the obesity pandemic
Ludwig, D. S., Aronne, L. J., Astrup, A., de Cabo, R., Cantley, L. C., Friedman, M. I., Heymsfield, S. B., Johnson, J. D., King, J. C., Krauss, R. M., et al. (2021) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab270 · Cited by 292 · see citing works
Drosophila as a model for ageing
Piper, M. D. W., & Partridge, L. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.09.016 · Cited by 273 · see citing works
Braidy, N., Berg, J., Clement, J., Khorshidi, F., Poljak, A., Jayasena, T., Grant, R., & Sachdev, P. S. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7269 · Cited by 286 · see citing works
“CR has been investigated in rhesus monkeys, which are the closest experimental model organism to human in a controlled environment (226).”
BackgroundOxidative stress and the role of redox signalling in chronic kidney disease
Kishi, S., Nagasu, H., Kidokoro, K., & Kashihara, N. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00775-0 · Cited by 283 · see citing works
Acosta-Rodríguez, V. A., de Groot, M. H. M., Rijo‐Ferreira, F., Green, C. B., & Takahashi, J. S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.007 · Cited by 252 · see citing works
Importance of circadian timing for aging and longevity
Acosta-Rodríguez, V. A., Rijo‐Ferreira, F., Green, C. B., & Takahashi, J. S. (2021) · Nature Communications · doi:10.1038/s41467-021-22922-6 · Cited by 249 · see citing works
Caenorhabditis elegans as a Useful Model for Studying Aging Mutations
Zhang, S., Li, F., Zhou, T., Wang, G., & Li, Z. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.554994 · Cited by 245 · see citing works
Calorie Restriction and Aging in Humans
Flanagan, E. W., Most, J., Mey, J. T., & Redman, L. M. (2020) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-122319-034601 · Cited by 239 · see citing works
“, feeding protocols, treatment of age-related diseases) (81).”
ResultHealthful aging mediated by inhibition of oxidative stress
Vatner, S. F., Zhang, J., Oydanich, M. K., Berkman, T., Naftalovich, R., & Vatner, D. E. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101194 · Cited by 239 · see citing works
Mitochondria as Potential Targets in Alzheimer Disease Therapy: An Update
Cenini, G., & Voos, W. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00902 · Cited by 257 · see citing works
Diet strategies for promoting healthy aging and longevity: An epidemiological perspective
Hu, F. B. (2023) · Journal of Internal Medicine · doi:10.1111/joim.13728 · Cited by 220 · see citing works
“Calorie restriction has been widely considered a promising approach to fostering long-term health and longevity [12].”
BackgroundMitochondria, energy, and metabolism in neuronal health and disease
Trigo, D., Avelar, C., Fernandes, M., Sá, J., & Silva, O. A. B. D. C. E. (2022) · FEBS Letters · doi:10.1002/1873-3468.14298 · Cited by 218 · see citing works
Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?
van Beek, A. A., Van den Bossche, J., Mastroberardino, P. G., de Winther, M. P. J., & Leenen, P. J. M. (2019) · Trends in Immunology · doi:10.1016/j.it.2018.12.007 · Cited by 207 · see citing works
The ups and downs of caloric restriction and fasting: from molecular effects to clinical application
Hofer, S. J., Carmona‐Gutiérrez, D., Mueller, M. I., & Madeo, F. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202114418 · Cited by 207 · see citing works
Che, T., Cheng, Y. Z., Tian, D., Zhang, X., Liu, X., & Wu, Z. (2021) · Nutrition & Metabolism · doi:10.1186/s12986-021-00613-9 · Cited by 213 · see citing works
Autophagy in aging and longevity
Wong, S. Q., Kumar, A. V., Mills, J., & Lapierre, L. R. (2019) · Human Genetics · doi:10.1007/s00439-019-02031-7 · Cited by 204 · see citing works
When less may be more: calorie restriction and response to cancer therapy
O’Flanagan, C. H., Smith, L. A., McDonell, S. B., & Hursting, S. D. (2017) · BMC Medicine · doi:10.1186/s12916-017-0873-x · Cited by 201 · see citing works
“Longitudinal studies at the National Institute of Ageing and the University of Wisconsin showed a significant reduction in the incidence of cancers in rhesus monkeys fed a CR diet compared to a control diet [7].”
BackgroundThe Effects of Intermittent Fasting on Brain and Cognitive Function
Gudden, J., Vásquez, A. A., & Bloemendaal, M. (2021) · Nutrients · doi:10.3390/nu13093166 · Cited by 204 · see citing works
Ageing of the gut microbiome: Potential influences on immune senescence and inflammageing
Conway, J., & Duggal, N. A. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101323 · Cited by 194 · see citing works
Metabolism and Colorectal Cancer
Sedlak, J. C., Yilmaz, Ö. H., & Roper, J. (2022) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-031521-041113 · Cited by 201 · see citing works
Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders
Salvadores, N., Sanhueza, M., Manque, P., & Court, F. A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00451 · Cited by 182 · see citing works
“, 2017), monkeys (Mattison et al., 2017), and humans (Prehn et al.”
BackgroundIs Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases?
Díaz‐Vegas, A., Sánchez-Aguilera, P., Krycer, J. R., Morales, P. E., Monsalves‐Álvarez, M., Cifuentes, M., Rothermel, B. A., & Lavandero, S. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa005 · Cited by 174 · see citing works
Pak, H. H., Haws, S. A., Green, C. L., Koller, M., Lavarias, M. T., Richardson, N. E., Yang, S. E., Dumas, S. N., Sonsalla, M., Bray, L., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00466-9 · Cited by 171 · see citing works
Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies
Lucas, V., Cavadas, C., & Aveleira, C. A. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000622 · Cited by 169 · see citing works
Mitochondrial dysfunction in the regulation of aging and aging-related diseases
Zhang, X., Gao, Y., Zhang, S., Wang, Y., Pei, X., Chen, Y., Zhang, J., Zhang, Y., Du, Y., Hao, S., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02308-7 · Cited by 175 · see citing works
“Subsequent studies in primates also demonstrated that aging is a plastic process [2].”
Mechanisms of Lifespan Regulation by Calorie Restriction and Intermittent Fasting in Model Organisms
Hwangbo, D., Lee, H., Abozaid, L. S., & Min, K. (2020) · Nutrients · doi:10.3390/nu12041194 · Cited by 164 · see citing works
“Thus, if all variables were controlled, it was suggested that CR can robustly increase lifespan in monkeys and also suggest applications in humans [93].”
BackgroundNew insight into dyslipidemia‐induced cellular senescence in atherosclerosis
Xiang, Q., Tian, F., Xu, J. R., Du, X., Zhang, S., & Liu, L. (2022) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12866 · Cited by 164 · see citing works
“Since then, accumulating evidence has suggested that CR not only increases the lifespan but also protects against age-associated disorders in several species (Mattison et al., 2017; Pifferi et al., 2018).”
BackgroundNon-human primates as a model for aging
Colman, R. J. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.07.008 · Cited by 154 · see citing works
“Although of differing design, both trials indicate that long-term CR can be carried out safely and is associated with evidence of improved health [92].”
BackgroundSelf-citationCaloric restriction increases lifespan but affects brain integrity in grey mouse lemur primates
Pifferi, F., Terrien, J., Marchal, J., Dal‐Pan, A., Djelti, F., Hardy, I., Chahory, S., Cordonnier, N., Desquilbet, L., Hurion, M., et al. (2018) · Communications Biology · doi:10.1038/s42003-018-0024-8 · Cited by 151 · see citing works
Aging and Caloric Restriction Research: A Biological Perspective with Translational Potential
Balasubramanian, P., Howell, P. R., & Anderson, R. M. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.06.015 · Cited by 148 · see citing works
“This turned out to be the case (Mattison et al., 2017).”
BackgroundSelf-citationUntangling Determinants of Enhanced Health and Lifespan through a Multi-omics Approach in Mice
Aon, M. A., Bernier, M., Mitchell, S. J., Germanio, C. D., Mattison, J. A., Ehrlich, M. R., Colman, R. J., Anderson, R. M., & de Cabo, R. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.018 · Cited by 146 · see citing works
“Subsequent analysis conducted across the two studies brought to light methodological considerations such as diet, feeding regimen, age of onset, and genetic differences (Mattison et al., 2017).”
BackgroundSelf-citationGut Microbiota during Dietary Restrictions: New Insights in Non-Communicable Diseases
Rinninella, E., Cintoni, M., Raoul, P. C., Ianiro, G., Laterza, L., Lopetuso, L. R., Ponziani, F. R., Gasbarrini, A., & Mele, M. C. (2020) · Microorganisms · doi:10.3390/microorganisms8081140 · Cited by 151 · see citing works
“Several animal studies have shown that CR and fasting interventions reduce the occurrence of tumors during normal aging [31,40,41].”
BackgroundAmino Acid Sensing in Metabolic Homeostasis and Health.
Hu, X.-M., & Guo, F. (2020) · Endocrine reviews · doi:10.1210/endrev/bnaa026 · Cited by 123 · see citing works
<scp>TOR</scp>‐mediated regulation of metabolism in aging
Antikainen, H., Driscoll, M., Haspel, G., & Dobrowolski, R. (2017) · Aging Cell · doi:10.1111/acel.12689 · Cited by 122 · see citing works
“primates, in which a recent re-examination of two previous parallel studies in rhesus monkeys reconciled their seemingly contradictory data, and demonstrated the effectiveness of dietary restriction in extending lifespan and maintaining health (Mattison et al., 2017).”
ResultThe neurovascular unit and systemic biology in stroke — implications for translation and treatment
Tiedt, S., Buchan, A. M., Dichgans, M., Lizasoaín, I., Moro, M. Á., & Lo, E. H. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00703-z · Cited by 132 · see citing works
Rhesus macaques as a tractable physiological model of human ageing
Chiou, K. L., Montague, M. J., Goldman, E. A., Watowich, M. M., Sams, S. N., Song, J., Horvath, J. E., Sterner, K. N., Ruiz-Lambides, A. V., Martínez, M. I., et al. (2020) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0612 · Cited by 127 · see citing works
Autophagy in health and disease: From molecular mechanisms to therapeutic target
Lu, G. X., Wang, Y., Shi, Y. P., Zhang, Z., Huang, C., He, W., Wang, C., & Shen, H. (2022) · MedComm · doi:10.1002/mco2.150 · Cited by 127 · see citing works
Intermittent fasting: from calories to time restriction
Duregon, E., Pomatto, L. C. D., Bernier, M., Price, N. L., & de Cabo, R. (2021) · GeroScience · doi:10.1007/s11357-021-00335-z · Cited by 128 · see citing works
Shobin, E., Bowley, M. P., Estrada, L. I., Heyworth, N. C., Orczykowski, M. E., Eldridge, S. A., Calderazzo, S. M., Mortazavi, F., Moore, T. L., & Rosene, D. L. (2017) · GeroScience · doi:10.1007/s11357-017-9965-y · Cited by 121 · see citing works
Calorie restriction in rodents: Caveats to consider
Ingram, D. K., & de Cabo, R. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.05.008 · Cited by 122 · see citing works
Self-citationPetr, M. A., Tulika, T., Carmona-Marin, L. M., & Scheibye‐Knudsen, M. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.12.001 · Cited by 119 · see citing works
NAD+ flux is maintained in aged mice despite lower tissue concentrations
McReynolds, M. R., Chellappa, K., Chiles, E., Jankowski, C., Shen, Y., Chen, L., Descamps, H. C., Mukherjee, S., Bhat, Y. R., Lingala, S. R., et al. (2021) · Cell Systems · doi:10.1016/j.cels.2021.09.001 · Cited by 112 · see citing works
Pomatto, L. C. D., Bodogai, M., Bosompra, O., Kato, J. I., Wong, S., Carpenter, M., Duregon, E., Chowdhury, D., Krishna, P., Ng, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26431-4 · Cited by 119 · see citing works
The road ahead for health and lifespan interventions
Gonzalez-Freire, M., Diaz-Ruiz, A., Hauser, D., Martinez-Romero, J., Ferrucci, L., Bernier, M., & de Cabo, R. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101037 · Cited by 118 · see citing works
Most, J., Gilmore, L. A., Smith, S. R., Han, H., Ravussin, E., & Redman, L. M. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00261.2017 · Cited by 117 · see citing works
Brigger, D., Riether, C., van Brummelen, R., Mosher, K. I., Shiu, A., Ding, Z., Bachmeier‐Zbären, N., Gasser, P., Guntern, P., Yousef, H., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0228-3 · Cited by 113 · see citing works
Dorling, J. L., Martin, C. K., & Redman, L. M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101038 · Cited by 118 · see citing works
“Despite the widespread promotion of CR, some show its beneficial effects vary substantially (de Cabo and Mattson, 2019; Mattison et al., 2017).”
BackgroundTowards natural mimetics of metformin and rapamycin
Aliper, A. M., Jellen, L. C., Cortese, F., Artemov, A. V., Karpinsky‐Semper, D., Moskalev, A., Swick, A. G., & Zhavoronkov, A. A. (2017) · Aging · doi:10.18632/aging.101319 · Cited by 111 · see citing works
“Caloric restriction is a well-known intervention for extending lifespan across species [13], but has limited practical value in humans [14].”
BackgroundEffects of anti-aging interventions on intestinal microbiota
Du, Y., Gao, Y., Zeng, B., Fan, X., Yang, D., & Yang, M. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1994835 · Cited by 115 · see citing works
“For a long time, CR has been recognized as one of the most effective nongenetic dietary interventions that can increase lifespan and prevent age-related diseases.(32,33) CR/DR can also result in changes in the intestinal microbiota and metabolome.”
BackgroundWahl, D., Coogan, S. C. P., Solon‐Biet, S. M., de Cabo, R., Haran, J. B., Raubenheimer, D., Cogger, V. C., Mattson, M. P., Simpson, S. J., & Couteur, D. G. L. (2017) · Clinical Interventions in Aging · doi:10.2147/cia.s145247 · Cited by 111 · see citing works
Aspirin Recapitulates Features of Caloric Restriction
Pietrocola, F., Castoldi, F., Markaki, M., Lachkar, S., Chen, G., Enot, D. P., Durand, S., Bossut, N., Tong, M., Malik, S. A., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.024 · Cited by 112 · see citing works
“…restriction-based strategies or periodic fasting have a favorable impact on health and longevity, both in non-human primates (Colman et al., 2009; Mattison et al., 2017) and in human studies (Longo and Mattson, 2014), although studies carried out in different research centers yielded…”
ResultVerkhratsky, A., Augusto‐Oliveira, M., Pivoriūnas, A., Popov, A., Brazhe, A., & Semyanov, A. V. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02465-3 · Cited by 108 · see citing works
Intestinal alkaline phosphatase targets the gut barrier to prevent aging
Kühn, F., Adiliaghdam, F., Cavallaro, P. M., Hamarneh, S. R., Tsurumi, A., Hoda, R. S., Munoz, A. R., Dhole, Y., Ramirez, J. M., Liu, E., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.134049 · Cited by 107 · see citing works
“Regarding the prevention of chronic inflammation and metabolic syndrome, IAP shows effects similar to caloric restriction (47).”
BackgroundWhy and how are we living longer?
Kirkwood, T. B. L. (2017) · Experimental Physiology · doi:10.1113/ep086205 · Cited by 107 · see citing works
“It is notable that the evidence for dietary restriction delaying intrinsic ageing in non-human primates is at best equivocal, although it is clear that a reduced-calorie diet can be protective against some chronic diseases (Mattison et al. 2017).”
BackgroundQuiescence: Good and Bad of Stem Cell Aging
Tümpel, S., & Rudolph, K. L. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.05.002 · Cited by 108 · see citing works
Antiaging agents: safe interventions to slow aging and healthy life span extension
Liu, J. (2022) · Natural Products and Bioprospecting · doi:10.1007/s13659-022-00339-y · Cited by 107 · see citing works
“Because these studies did not use the same dietary conditions, it is difficult to directly compare these results [218].”
ResultAdipose tissue as a linchpin of organismal ageing
Nguyen, T., & Corvera, S. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01046-3 · Cited by 106 · see citing works
“Caloric restriction consists of a decrease in total calorie consumption to the point of avoiding malnutrition, and extends lifespan across numerous species ranging from yeast to primates 168,169 .”
Caloric restriction and cellular senescence
Fontana, L., Nehme, J., & Demaria, M. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.10.005 · Cited by 104 · see citing works
“Accumulating data indicate that CR extends lifespan also in non-human primates 38 .”
BackgroundLongevity: Lesson from Model Organisms
Taormina, G., Ferrante, F., Vieni, S., Grassi, N., Russo, A. G., & Mirisola, M. G. (2019) · Genes · doi:10.3390/genes10070518 · Cited by 103 · see citing works
“However, data from both studies suggest that many of the beneficial effects of CR reported in rodents also occur in primate models, thus suggesting a possible role also in human aging [131].”
BackgroundThe obesity-breast cancer link: a multidisciplinary perspective
Devericks, E. N., Carson, M. S., McCullough, L. E., Coleman, M. F., & Hursting, S. D. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10043-5 · Cited by 109 · see citing works
Principles of the Molecular and Cellular Mechanisms of Aging
da Silva, P. F. L., & Schumacher, B. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.11.018 · Cited by 99 · see citing works
Mitochondrial Dysfunction: A Key Player in Brain Aging and Diseases
Bartman, S., Coppotelli, G., & Ross, J. M. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46030130 · Cited by 101 · see citing works
“To further investigate the ability of CR to improve the human lifespan, several studies have been conducted, specifically in non-human primates, such as the rhesus monkeys [265].”
BackgroundMihalas, B. P., Redgrove, K. A., McLaughlin, E. A., & Nixon, B. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/4015874 · Cited by 100 · see citing works
“While translation into nonhuman primates has been controversial, there is evidence to suggest that CR also delays the onset of age-related disorders in rhesus monkeys [239].”
Focusing on mitochondria in the brain: from biology to therapeutics
Song, N., Mei, S., Wang, X.-X., Hu, G., & Lu, M. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00409-w · Cited by 102 · see citing works
Novel treatment strategies for chronic kidney disease: insights from the animal kingdom
Stenvinkel, P., Painer, J., Kuro‐o, M., Lanaspa, M. A., Arnold, W., Ruf, T., Shiels, P. G., & Johnson, R. J. (2018) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.169 · Cited by 99 · see citing works
Astroglia in Alzheimer’s Disease
Verkhratsky, A., Parpura, V., Rodriguez, J. J., & Zorec, R. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-9913-8_11 · Cited by 94 · see citing works
Hever, J., & Cronise, R. J. (2017) · Europe PMC (PubMed Central) · doi:10.11909/j.issn.1671-5411.2017.05.012 · Cited by 94 · see citing works
Interventions to promote cardiometabolic health and slow cardiovascular ageing
Fontana, L. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0026-8 · Cited by 94 · see citing works
Regan, J. C., Froy, H., Walling, C. A., Moatt, J. P., & Nussey, D. H. (2019) · Functional Ecology · doi:10.1111/1365-2435.13418 · Cited by 93 · see citing works
Current nutritional and pharmacological anti-aging interventions
Ros, M., & Carrascosa, J. M. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165612 · Cited by 95 · see citing works
Perspectives on Precision Medicine Approaches to NAFLD Diagnosis and Management
Lonardo, A., Arab, J. P., & Arrese, M. A. (2021) · Advances in Therapy · doi:10.1007/s12325-021-01690-1 · Cited by 93 · see citing works
“Therefore, while female mice respond better to caloric restriction in terms of longevity [129], non-human primates show a male-specific reduction in body weight and increase in insulin sensitivity when subjected to this dietary limitation [130].”
BackgroundBloemberg, D., & Quadrilatero, J. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00261.2018 · Cited by 93 · see citing works
The Molecular Link from Diet to Cancer Cell Metabolism
Bose, S., Allen, A. E., & Locasale, J. W. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.05.018 · Cited by 93 · see citing works
Regulation of metabolic health by essential dietary amino acids
Green, C. L., & Lamming, D. W. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.07.004 · Cited by 89 · see citing works
“Differences in diet and baseline intake of calories likely explains the disparities between the two studies, and analysis of the combined data from both studies suggest that CR promotes both health span and lifespan relative to ad libitum fed non-human primates (Mattison et al., 2017).”
Result
- Authors
- Mattison, J. A., Colman, R. J., Beasley, T. M., Allison, D. B., Kemnitz, J. W., Roth, G. S., Ingram, D. K., Weindruch, R., de Cabo, R., & Anderson, R. M.
- Affiliations
- National Institute on Aging (US)
- University of Wisconsin–Madison (US)
- University of Alabama at Birmingham (US)
- Pennington Biomedical Research Center (US)
- Corresponding author
- Anderson, Rozalyn M.
- ORCID
- Venue
- Nature Communications
- Published
- 2017-01-17
- Volume
- 8
- Issue
- 1
- Pages
- 14063-14063
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC5247583
- OpenAlex
- W2577597748
- Cited by
- 838
- References
- 51
- Citations by year
- 2026: 52 · 2025: 86 · 2024: 75 · 2023: 85 · 2022: 96 · 2021: 97 · 2020: 111 · 2019: 92 · 2018: 87 · 2017: 56
- FWCI
- 40.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- University of Wisconsin-Madison (P51OD011106)
- National Institutes of Health (P51RR000167/P51OD011106, P51OD011106)
- National Institute on Aging (R56AG047358, R01AG037000, R01AG040178, P01AG011915)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK056336)
- National Center for Research Resources (P51RR000167/P51OD011106, P51RR000167)
- Office of Research Infrastructure Programs, National Institutes of Health (P51 OD011106, P51RR000167)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- caloric restriction, rhesus monkeys, lifespan extension, survival, age-related morbidity, fasting blood glucose, body weight, dietary intake, study design comparison, species specificity, non-human primates, aging
- MeSH terms
- Animals, Body Weight, Energy Intake, Diet, Female, Longevity, Longitudinal Studies, Macaca mulatta, Male, Caloric Restriction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
