Weight Loss and Regain and Effects on Body Composition: The Health, Aging, and Body Composition Study
Open accessAbstract
BACKGROUND: Older adults are less able to conserve lean mass relative to fat mass with weight change. A cycle of weight loss and regain in an older individual could accelerate sarcopenia. We examined whether older adults experiencing weight loss and regain would show a greater loss of lean mass during a weight-loss period than gain in lean mass during the weight-regain period, thus have overall a greater net loss of lean mass compared with those who maintained weight in the Health, Aging, and Body Composition Study. METHODS: We compared the body composition change in 147 older weight changers (54% women, 38% black) with the gender- and race-matched weight-stable individuals over the weight-cycling period. A weight cycle was defined as weight loss of 3% or more with regain of within +/-3% of baseline weight for a period of 2 years. RESULTS: Both men and women showed significantly lower total body mass after the weight loss and regain. Proportionally, more lean mass was lost during the weight-loss period than was gained during the weight-regain period, especially in men. After weight regain, men showed only a slightly lower lean mass than the stable group, and this was not statistically significant, although the failure to fully regain total weight explained most of the deficit in lean mass after the weight cycle. CONCLUSION: These data suggest that weight loss even with regain may contribute to a net loss of lean mass in older men but warrant further studies.
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Observational cohort data in older adults examining body composition changes with weight loss and subsequent regain suggest that weight cycling may accelerate loss of lean mass with aging.
“Observational cohort data in older adults examining body composition changes with weight loss and subsequent regain suggest that weight cycling may accelerate loss of lean mass with aging.18, 19”
From Legacy effects of short-term intentional weight loss on total body and thigh composition in overweight and obese older adults (2016) · cites this paper as [19]
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Cites
International Journal of Obesity
(2019) · International Journal of Obesity · doi:10.1038/41366.1476-5497 · Cited by 2,092 · see citing works
Weight Change in Old Age and its Association with Mortality
Newman, A. B., Yanez, D., Harris, T., Duxbury, A., Enright, P. L., Fried, L. P., & for the Cardiovascular Study Research Group (2001) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2001.49258.x · Cited by 566 · see citing works
Self-citationThe definition of weight maintenance
Stevens, J., Truesdale, K. P., McClain, J. E., & Cai, J. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803175 · Cited by 462 · see citing works
Newman, A. B., Lee, J. S., Visser, M., Goodpaster, B. H., Kritchevsky, S. B., Tylavsky, F. A., Nevitt, M., & Harris, T. B. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.4.872 · Cited by 445 · see citing works
Self-citationVisser, M., Fuerst, T. P., Lang, T., Salamone, L. M., Harris, T. B., Health, F. T., Study, B. C., & Body Composition Working Group (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.4.1513 · Cited by 422 · see citing works
Self-citationSchoeller, D. A., Tylavsky, F. A., Baer, D. J., Chumlea, W. C., Earthman, C. P., Fuerst, T., Harris, T. B., Heymsfield, S. B., Horlick, M., Lohman, T. G., et al. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.5.1018 · Cited by 253 · see citing works
Self-citationMeasurement of fat mass using DEXA: a validation study in elderly adults
Salamone, L. M., Fuerst, T. P., Visser, M., Kern, M., Lang, T., Dockrell, M., Cauley, J. A., Nevitt, M. C., Tylavsky, F., & Lohman, T. G. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.1.345 · Cited by 234 · see citing works
Self-citationVisser, M., Pahor, M., Tylavsky, F. A., Kritchevsky, S. B., Cauley, J. A., Newman, A. B., Blunt, B. A., & Harris, T. B. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00124.2002 · Cited by 216 · see citing works
Self-citationLongitudinal changes in adult fat-free mass: influence of body weight
Forbes, G. B. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.6.1025 · Cited by 183 · see citing works
Effects of birth cohort and age on body composition in a sample of community-based elderly
Ding, J., Kritchevsky, S. B., Newman, A. B., Taaffe, D. R., Nicklas, B. J., Visser, M., Lee, J. S., Nevitt, M. C., Tylavsky, F. A., Rubin, S. M., et al. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.2.405 · Cited by 148 · see citing works
Self-citationWeight cycling and fat distribution.
Rodin, J., Sharpe, N. R., Rebuffé-Scrive, M., & Greenwood, M. R. C. (1990) · PubMed · Cited by 144 · see citing works
Atkinson, R. L. (1994) · JAMA · doi:10.1001/jama.1994.03520150064038 · Cited by 134 · see citing works
Involuntary Weight Loss in Elderly Outpatients: Recognition, Etiologies, and Treatment
Wallace, J. I., & Schwartz, R. S. (1997) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(18)30146-0 · Cited by 106 · see citing works
Weight Cycling and the Risk of Developing Type 2 Diabetes among Adult Women in the United States
Field, A. E., Manson, J. E., Laird, N. M., Williamson, D. F., Willett, W. C., & Colditz, G. A. (2004) · Obesity Research · doi:10.1038/oby.2004.34 · Cited by 98 · see citing works
Unintentional Weight Loss in the United States
Meltzer, A. A., & Everhart, J. E. (1995) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117557 · Cited by 93 · see citing works
Weight Cycling in Humans: A Review of the Literature
Wing, R. R. (1992) · Annals of Behavioral Medicine · doi:10.1093/abm/14.2.113 · Cited by 93 · see citing works
Effects of weight cycling on body composition
Prentice, A. M., Jebb, S. A., Goldberg, G., Coward, W. A., Murgatroyd, P. R., Poppitt, S., & Cole, T. (1992) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/56.1.209s · Cited by 87 · see citing works
Body fat distribution of overweight females with a history of weight cycling
Wallner, S. J., Luschnigg, N., Schnedl, W. J., Lahousen, T., Sudi, K. M., Crailsheim, K., Möller, R., Tafeit, E., & Horejsi, R. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802736 · Cited by 73 · see citing works
QDR 4500A DXA overestimates fat-free mass compared with criterion methods
Tylavsky, F. A., Lohman, T. G., Blunt, B. A., Schoeller, D. A., Fuerst, T. P., Cauley, J. A., Nevitt, M. C., Visser, M., & Harris, T. B. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00732.2002 · Cited by 68 · see citing works
Self-citationComposition (lean and fat tissue) of weight changes in adult Danes
Heitmann, B. L., & Garby, L. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/75.5.840 · Cited by 65 · see citing works
Tylavsky, F. A., Lohman, T. G., Dockrell, M., Lang, T., Schoeller, D. A., Wan, J. Y., Fuerst, T. P., Cauley, J. A., Nevitt, M. C., & Harris, T. B. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.2.356 · Cited by 63 · see citing works
Self-citationFactors Associated with Impaired Appetite in Well-Functioning Community-Dwelling Older Adults
Lee, J. S., Kritchevsky, S. B., Tylavsky, F. A., Harris, T. B., Ayonayon, H. N., & Newman, A. B. (2006) · Journal of Nutrition for the Elderly · doi:10.1300/j052v26n01_02 · Cited by 62 · see citing works
Self-citationEffects of intentional weight cycling on non-obese young women
Kajioka, T., Tsuzuku, S., Shimokata, H., & Sato, Y. (2002) · Metabolism · doi:10.1053/meta.2002.29976 · Cited by 60 · see citing works
Is weight cycling detrimental to health? A review of the literature in humans.
Muls, E., Kempen, K. P., Vansant, G. A. A. M., & Saris, W. H. M. (1995) · PubMed · Cited by 53 · see citing works
Lee, J. S., Kritchevsky, S. B., Tylavsky, F. A., Harris, T. B., Everhart, J. E., Simonsick, E. M., Rubin, S. M., & Newman, A. B. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.2.466 · Cited by 33 · see citing works
Self-citationLee, J. S., Kritchevsky, S. B., Harris, T. B., Tylavsky, F. A., Rubin, S. M., & Newman, A. B. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.3.644 · Cited by 29 · see citing works
Self-citationJen, K. ‐. C., Lu, H., Savona, L., Watkins, A., & Shaw, M. (1995) · PubMed · Cited by 24 · see citing works
Roberts, S. B., & Williamson, D. F. (2002) · Journal of Nutrition · doi:10.1093/jn/132.12.3824s · Cited by 23 · see citing works
Impact of Weight‐Cycling History on Bone Density in Obese Women
Gallagher, K. I., Jakicic, J. M., Kiel, D. P., et al. (2002) · Obesity Research · doi:10.1038/oby.2002.123 · Cited by 19 · see citing works
Tylavsky, F. A., Fuerst, T. P., Nevitt, M. C., et al. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06426.x · Cited by 16 · see citing works
Self-citation
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Cited by
Sorted by citations
Beavers, K. M., Lyles, M. F., Davis, C. C., Wang, X., Beavers, D. P., & Nicklas, B. J. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.004895 · Cited by 126 · see citing works
Rossi, A. P., Rubele, S., Calugi, S., Caliari, C., Pedelini, F., Soave, F., Chignola, E., Vittoria Bazzani, P., Mazzali, G., Dalle Grave, R., et al. (2019) · Obesity · doi:10.1002/oby.22493 · Cited by 90 · see citing works
Sammarco, R., Marra, M., Di Guglielmo, M. L., Naccarato, M., Contaldo, F., Poggiogalle, E., Donini, L. M., & Pasanisi, F. (2017) · Obesity Facts · doi:10.1159/000468153 · Cited by 75 · see citing works
Poggiogalle, E., Migliaccio, S., Lenzi, A., & Donini, L. M. (2014) · Endocrine · doi:10.1007/s12020-014-0315-x · Cited by 67 · see citing works
Impact of body-composition methodology on the composition of weight loss and weight gain
Pourhassan, M., Schautz, B., Braun, W., Gluer, C.-C., Bosy-Westphal, A., & Müller, M. J. (2013) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2013.35 · Cited by 43 · see citing works
Weight Loss Strategies in the Elderly: A Clinical Conundrum
Coker, R. H., & Wolfe, R. R. (2018) · Obesity · doi:10.1002/oby.21961 · Cited by 47 · see citing works
Is Weight Loss Harmful for Skeletal Health in Obese Older Adults?
Papageorgiou, M., Kerschan-Schindl, K., Sathyapalan, T., & Pietschmann, P. (2020) · Gerontology · doi:10.1159/000500779 · Cited by 45 · see citing works
Measuring the impact of weight cycling on body composition: a methodological challenge
Bosy-Westphal, A., & Müller, M. J. (2014) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0000000000000092 · Cited by 33 · see citing works
The physiological effects of weight-cycling: A review of current evidence
Sanaya, N., Janusaite, M., Dalamaga, M., & Magkos, F. (2024) · Current Obesity Reports · doi:10.1007/s13679-023-00539-8 · Cited by 31 · see citing works
Weight cycling and its effects on muscle mass, sarcopenia and sarcopenic obesity
Zamboni, M., Giani, A., Fantin, F., Rossi, A. P., Mazzali, G., & Zoico, E. (2025) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-025-09963-8 · Cited by 24 · see citing works
Chmelo, E. A., Beavers, D. P., Lyles, M. F., Marsh, A. P., Nicklas, B. J., & Beavers, K. M. (2016) · Nutrition & Diabetes · doi:10.1038/nutd.2016.8 · Cited by 15 · see citing works
Swift, D. L., Ross, L. M., Laddu, D. R., Conroy, M. B., German, C. A., Evangelista, L. S., Marvel, F. A., Jerome, G. J., on behalf the American Heart Association Council on Lifestyle and Cardiometabolic Health, Council on Cardiovascular and Stroke Nursing, et al. (2026) · Circulation · doi:10.1161/cir.0000000000001441 · Cited by 13 · see citing works
- Authors
- Lee, J. S., Visser, M., Tylavsky, F. A., Kritchevsky, S. B., Schwartz, A. V., Sahyoun, N., Harris, T. B., Newman, A. B., & Study, F. T. H. A.
- Affiliations
- University of Georgia (US)
- Vrije Universiteit Amsterdam (NL)
- University of Tennessee Health Science Center (US)
- Wake Forest University Health Sciences (US)
- University of California, San Francisco (US)
- University of Maryland, College Park (US)
- National Institutes of Health (US)
- University of Pittsburgh (US)
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-04-14
- Volume
- 65A
- Issue
- 1
- Pages
- 78-83
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC2796877
- OpenAlex
- W2155575267
- Cited by
- 108
- References
- 30
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 5 · 2023: 3 · 2022: 10 · 2021: 7 · 2020: 8 · 2019: 6 · 2018: 9 · 2017: 6 · 2016: 4 · 2015: 8 · 2014: 9 · 2013: 10 · 2012: 5
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- VU Research Portal (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Hologic
- National Institutes of Health
- National Institute on Aging (N01‐AG‐6–2101, N01AG62106, N01-AG-62103, P30AG021332)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- weight loss, weight regain, weight cycling, body composition, lean body mass, fat mass, sarcopenia, older adults, aging, sex differences
- MeSH terms
- Aged, Aging, Body Composition, Female, Follow-Up Studies, Health Status, Humans, Male, Obesity, United States, Weight Gain, Weight Loss, Absorptiometry, Photon, Prevalence, Muscle, Skeletal
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