Weight Loss Strategies in the Elderly: A Clinical Conundrum
Open accessAbstract
The age‐related concomitant loss of skeletal muscle and accumulation of excess adipose tissue have been commonly referred to as sarcopenic obesity. While weight loss may help mitigate the metabolic abnormalities linked to obesity, low fitness levels and muscle atrophy complicate the effectiveness of lifestyle interventions. Because of low levels of compliance, suboptimal economic efficiency, and low functional capacity, there has been no consensus on optimal therapy. This includes the use of high‐protein diets that do not ensure muscle preservation during weight loss in this segment of the population. The primary objectives of this review are to discuss the relevance of sarcopenic obesity, examine the feasibility of weight loss in the elderly, and highlight new approaches to the problem.
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Adherence to prolonged dietary restriction in humans is poor.
“Adherence to prolonged dietary restriction in humans is also poor [141]”
From Targeting Intramyocellular Lipids to Improve Aging Muscle Function (2025) · cites this paper as [141]
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Sarcopenia: European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601 · see citing works
Cost-Effectiveness in Health and Medicine
(1996) · doi:10.1093/oso/9780195108248.001.0001 · Cited by 7,193 · see citing works
Ford, E. S., Giles, W. H., & Dietz, W. H. (2002) · JAMA · doi:10.1001/jama.287.3.356 · Cited by 6,698 · see citing works
Grundy, S. M., Brewer, H. B., Cleeman, J. I., Smith, S. C., & Lenfant, C. (2004) · Circulation · doi:10.1161/01.cir.0000111245.75752.c6 · Cited by 5,982 · see citing works
Exercise and Physical Activity for Older Adults
Chodzko-Zajko, W. J., Proctor, D. N., Fiatarone Singh, M. A., Minson, C. T., Nigg, C. R., Salem, G. J., & Skinner, J. S. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181a0c95c · Cited by 5,153 · see citing works
Epidemiology of Sarcopenia among the Elderly in New Mexico
Baumgartner, R. N., Koehler, K. M., Gallagher, D., Romero, L., Heymsfield, S. B., Ross, R. R., Garry, P. J., & Lindeman, R. D. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009520 · Cited by 4,004 · see citing works
Flegal, K. M., Kit, B. K., Orpana, H., & Graubard, B. I. (2013) · JAMA · doi:10.1001/jama.2012.113905 · Cited by 3,998 · see citing works
Bauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft, A. J., Morley, J. E., Phillips, S., Sieber, C., Stehle, P., Teta, D., et al. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.021 · Cited by 2,553 · cited 3× · see citing works
“Convincing data from these and other studies highlight the importance of increased dietary protein in older individuals that may delay or dramatically reduce the risk of sarcopenia (79,86-88).”
BackgroundStudenski, S. A., Peters, K. W., Alley, D. E., Cawthon, P. M., McLean, R. R., Harris, T. B., Ferrucci, L., Guralnik, J. M., Fragala, M. S., Kenny, A. M., et al. (2014) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glu010 · Cited by 2,545 · see citing works
Comparison of Weight-Loss Diets with Different Compositions of Fat, Protein, and Carbohydrates
Sacks, F. M., Bray, G. A., Carey, V. J., Smith, S. R., Ryan, D. H., Anton, S. D., McManus, K., Champagne, C. M., Bishop, L. M., Laranjo, N., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0804748 · Cited by 1,966 · cited 1× · see citing works
“A recent review of 19 clinical trials employing caloric restrictioninduced weight loss in younger individuals (>914 participants) demonstrated similar efficacy with respect to total weight loss regardless of protein intake (89).”
BackgroundCruz-Jentoft, A. J., Landi, F., Schneider, S. M., Zuniga, C., Arai, H., Boirie, Y., Chen, L.-K., Fielding, R. A., Martin, F. C., Michel, J.-P., et al. (2014) · Age and Ageing · doi:10.1093/ageing/afu115 · Cited by 1,963 · see citing works
Ogden, C. L., Yanovski, S. Z., Carroll, M. D., & Flegal, K. M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.052 · Cited by 1,561 · see citing works
Pahor, M., Guralnik, J. M., Ambrosius, W. T., Blair, S., Bonds, D. E., Church, T. S., Espeland, M. A., Fielding, R. A., Gill, T. M., Groessl, E. J., et al. (2014) · JAMA · doi:10.1001/jama.2014.5616 · Cited by 1,427 · see citing works
Hazards of Hospitalization of the Elderly
Creditor, M. C. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-118-3-199302010-00011 · Cited by 1,409 · see citing works
Weight loss, exercise, or both and physical function in obese older adults
Villareal, D. T., Chode, S., Parimi, N., Sinacore, D. R., Hilton, T., Armamento-Villareal, R., Napoli, N., Qualls, C., & Shah, K. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1008234 · Cited by 1,096 · see citing works
Katsanos, C. S., Kobayashi, H., Sheffield-Moore, M., Aarsland, A., & Wolfe, R. R. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00488.2005 · Cited by 923 · see citing works
Self-citationKitzman, D. W., Brubaker, P., Morgan, T., Haykowsky, M., Hundley, G., Kraus, W. E., Eggebeen, J., & Nicklas, B. J. (2016) · JAMA · doi:10.1001/jama.2015.17346 · Cited by 921 · see citing works
Long-Term Calorie Restriction Is Highly Effective in Reducing the Risk for Atherosclerosis in Humans
Fontana, L., Meyer, T. E., Klein, S., & Holloszy, J. O. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308291101 · Cited by 902 · see citing works
Protein and energy supplementation in elderly people at risk from malnutrition
Milne, A. C., Potter, J., Vivanti, A., & Avenell, A. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003288.pub3 · Cited by 849 · see citing works
The Critical Role of Metabolic Pathways in Aging
Barzilai, N., Huffman, D. M., Muzumdar, R. H., & Bartke, A. (2012) · Diabetes · doi:10.2337/db11-1300 · Cited by 803 · see citing works
Skeletal muscle loss: cachexia, sarcopenia, and inactivity
Evans, W. J. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.28608a · Cited by 724 · see citing works
Kalantar‐Zadeh, K., Block, G., Horwich, T. B., & Fonarow, G. C. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.11.039 · Cited by 689 · see citing works
Cardiorespiratory Fitness and Adiposity as Mortality Predictors in Older Adults
Sui, X., LaMonte, M. J., Laditka, J. N., Hardin, J. W., Chase, N., Hooker, S. P., & Blair, S. N. (2007) · JAMA · doi:10.1001/jama.298.21.2507 · Cited by 640 · see citing works
Tanaka, H., & Seals, D. R. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.141879 · Cited by 555 · see citing works
Functional Impact of 10 Days of Bed Rest in Healthy Older Adults
Kortebein, P., Symons, T. B., Ferrando, A., Paddon-Jones, D., Ronsen, O., Protas, E., Conger, S., Lombeida, J., Wolfe, R., & Evans, W. J. (2008) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/63.10.1076 · Cited by 550 · see citing works
Self-citationA Conceptual Framework of Frailty: A Review
Bortz, W. M. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.5.m283 · Cited by 550 · see citing works
Balagopal, P., Rooyackers, O., Adey, D., Ades, P. A., & Nair, K. S. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.4.e790 · Cited by 541 · see citing works
Strength and muscle mass loss with aging process. Age and strength loss
Keller, K., & Engelhardt, M. M. (2019) · Muscles Ligaments and Tendons Journal · doi:10.32098/mltj.04.2013.17 · Cited by 499 · see citing works
Prolonged bed rest decreases skeletal muscle and whole body protein synthesis
Ferrando, A. A., Lane, H. W., Stuart, C. A., Davis-Street, J. E., & Wolfe, R. R. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.4.e627 · Cited by 498 · see citing works
Self-citationSarcopenia: burden and challenges for public health
Beaudart, C., Rizzoli, R., Bruyère, O., Reginster, J., & Biver, E. (2014) · Archives of Public Health · doi:10.1186/2049-3258-72-45 · Cited by 498 · see citing works
Bohé, J., Low, A., Wolfe, R. R., & Rennie, M. J. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.050674 · Cited by 496 · see citing works
Self-citationNutrition, frailty, and sarcopenia
Cruz-Jentoft, A. J., Kiesswetter, E., Drey, M., & Sieber, C. C. (2017) · Aging Clinical and Experimental Research · doi:10.1007/s40520-016-0709-0 · Cited by 488 · see citing works
Noakes, M., Keogh, J. B., Foster, P. R., & Clifton, P. M. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.6.1298 · Cited by 483 · see citing works
Amino acid ingestion improves muscle protein synthesis in the young and elderly
Paddon-Jones, D., Sheffield-Moore, M., Zhang, X.-J., Volpi, E., Wolf, S. E., Aarsland, A., Ferrando, A. A., & Wolfe, R. R. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00368.2003 · Cited by 467 · see citing works
Self-citationWeight stability masks sarcopenia in elderly men and women
Gallagher, D., Ruts, E., Visser, M., Heshka, S., Baumgartner, R. N., Wang, J., Pierson, R. N., Pi-Sunyer, F. X., & Heymsfield, S. B. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.2.e366 · Cited by 466 · see citing works
Optimal protein intake in the elderly
Wolfe, R. R., Miller, S. L., & Miller, K. B. (2008) · Clinical Nutrition · doi:10.1016/j.clnu.2008.06.008 · Cited by 456 · see citing works
Self-citationNicklas, B. J., Ambrosius, W., Messier, S. P., Miller, G. D., Penninx, B. W., Loeser, R. F., Palla, S., Bleecker, E., & Pahor, M. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.4.544 · Cited by 443 · see citing works
on behalf of the SPRINTT Consortium, Marzetti, E., Calvani, R., Tosato, M., Cesari, M., Di Bari, M., Cherubini, A., Collamati, A., D’Angelo, E., Pahor, M., et al. (2017) · Aging Clinical and Experimental Research · doi:10.1007/s40520-016-0704-5 · Cited by 438 · see citing works
Bahat, G., Tufan, A., Tufan, F., Kılıç, C., Akpınar, T. S., Köse, M., Erten, N., Karan, M. A., & Cruz-Jentoft, A. J. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.02.002 · Cited by 428 · see citing works
Basal Muscle Amino Acid Kinetics and Protein Synthesis in Healthy Young and Older Men
Volpi, E. (2001) · JAMA · doi:10.1001/jama.286.10.1206 · Cited by 416 · see citing works
Skeletal muscle atrophy during short-term disuse: Implications for age-related sarcopenia
Wall, B. T., Dirks, M. L., & van Loon, L. J. C. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.07.003 · Cited by 400 · see citing works
The danger of weight loss in the elderly
Miller, S. L., & Wolfe, R. R. (2008) · The Journal of nutrition, health and aging · doi:10.1007/bf02982710 · Cited by 384 · see citing works
Self-citationStrength and muscle mass loss with aging process. Age and strength loss.
Keller, K., & Engelhardt, M. (2013) · Europe PMC (PubMed Central) · Cited by 340 · see citing works
The Obesity Paradox in the Elderly: Potential Mechanisms and Clinical Implications
Oreopoulos, A., Kalantar-Zadeh, K., Sharma, A. M., & Fonarow, G. C. (2009) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2009.07.005 · Cited by 323 · see citing works
Rey-López, J. P., Rezende, L. F. M., Pastor‐Valero, M., & Tess, B. H. (2014) · Obesity Reviews · doi:10.1111/obr.12198 · Cited by 311 · see citing works
Lifestyle change and mobility in obese adults with type 2 diabetes
Rejeski, W. J., Ip, E. H., Bertoni, A. G., Bray, G. A., Evans, G., Gregg, E. W., & Zhang, Q. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1110294 · Cited by 301 · see citing works
Davidson, L. E., Hudson, R., Kilpatrick, K., Kuk, J. L., McMillan, K., Janiszewski, P. M., Lee, S., Lam, M., & Ross, R. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2008.558 · Cited by 297 · see citing works
Physical Activity, Health Benefits, and Mortality Risk
Kokkinos, P. F. (2012) · ISRN Cardiology · doi:10.5402/2012/718789 · Cited by 294 · see citing works
Human muscle protein synthesis and breakdown during and after exercise
Kumar, V., Atherton, P. J., Smith, K., & Rennie, M. J. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91481.2008 · Cited by 285 · see citing works
Whole-body leucine and lysine metabolism: response to dietary protein intake in young men
Motil, K. J., Matthews, D. E., Bier, D. M., Burke, J. F., Munro, H. N., & Young, V. R. (1981) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1981.240.6.e712 · Cited by 250 · see citing works
Kim, J. E., O’Connor, L. E., Sands, L. P., Slebodnik, M. B., & Campbell, W. W. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuv065 · Cited by 238 · see citing works
Ferrando, A. A., Paddon-Jones, D., Hays, N. P., Kortebein, P., Ronsen, O., Williams, R. H., McComb, A., Symons, T. B., Wolfe, R. R., & Evans, W. (2010) · Clinical Nutrition · doi:10.1016/j.clnu.2009.03.009 · Cited by 237 · see citing works
Self-citationDrummond, M. J., Dickinson, J. M., Fry, C. S., Walker, D. K., Gundermann, D. M., Reidy, P. T., Timmerman, K. L., Markofski, M. M., Paddon‐Jones, D., Rasmussen, B. B., et al. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00603.2011 · Cited by 224 · see citing works
Tanner, R. E., Brunker, L. B., Agergaard, J., Barrows, K. M., Briggs, R. A., Kwon, O. S., Young, L. M., Hopkins, P. N., Volpi, E., Marcus, R. L., et al. (2015) · The Journal of Physiology · doi:10.1113/jp270699 · Cited by 223 · see citing works
Paddon-Jones, D., Sheffield-Moore, M., Katsanos, C. S., Zhang, X.-J., & Wolfe, R. R. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2005.10.006 · Cited by 223 · cited 1× · see citing works
“elderly, would only represent 295 kcal (almost one-third of the calories contained in 40 g of whey protein) and 33% of total caloric intake (95).”
BackgroundSelf-citationTowards a multidisciplinary approach to understand and manage obesity and related diseases
Bischoff, S. C., Boirie, Y., Cederholm, T., Chourdakis, M., Cuerda, C., Delzenne, N. M., Deutz, N. E. P., Fouque, D. P., Genton, L., Gil, C., et al. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.11.007 · Cited by 211 · see citing works
Intentional Weight Loss and All-Cause Mortality: A Meta-Analysis of Randomized Clinical Trials
Kritchevsky, S. B., Beavers, K. M., Miller, M. E., Shea, M. K., Houston, D. K., Kitzman, D. W., & Nicklas, B. J. (2015) · PLOS ONE · doi:10.1371/journal.pone.0121993 · Cited by 207 · see citing works
Body composition changes in stable-weight elderly subjects: The effect of sex
Zamboni, M. M., Zoico, E., Scartezzini, T., Mazzali, G., Tosoni, P., Zivelonghi, A., Gallagher, D., Pergola, G. D., Francesco, V. D., & Bosello, O. (2003) · Aging Clinical and Experimental Research · doi:10.1007/bf03324517 · Cited by 207 · see citing works
Batsis, J. A., Mackenzie, T. A., Lopez-Jimenez, F., & Bartels, S. J. (2015) · Nutrition Research · doi:10.1016/j.nutres.2015.09.003 · Cited by 203 · see citing works
Wolfe, R. R. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512002590 · Cited by 187 · see citing works
Self-citationVeronese, N., Cereda, E., Solmi, M., Fowler, S. A., Manzato, E., Maggi, S., Manu, P., Abe, E., Hayashi, K., Allard, J. P., et al. (2015) · Obesity Reviews · doi:10.1111/obr.12309 · Cited by 187 · see citing works
Health benefits of aerobic training programs in adults aged 70 and over: a systematic review
Bouaziz, W., Vogel, T., Schmitt, E., Kaltenbach, G., Gény, B., & Lang, P. O. (2016) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2016.10.012 · Cited by 175 · see citing works
Myopenia—a new universal term for muscle wasting
Fearon, K. C. H., Evans, W. J., & Anker, S. D. (2011) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-011-0025-7 · Cited by 174 · see citing works
Coker, R. H., Hays, N. P., Williams, R. H., Wolfe, R. R., & Evans, W. J. (2015) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu123 · Cited by 174 · see citing works
Self-citationEspeland, M. A., Glick, H. A., Bertoni, A., Brancati, F. L., Bray, G. A., Clark, J. M., Curtis, J. M., Egan, C., Evans, M., Foreyt, J. P., et al. (2014) · Diabetes Care · doi:10.2337/dc14-0093 · Cited by 174 · see citing works
Weight-Control Practices Among U.S. Adults, 2001–2002
Weiss, E. C., Galuska, D. A., Khan, L. K., & Serdula, M. K. (2006) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2006.03.016 · Cited by 170 · see citing works
Body mass index and mortality in chronic obstructive pulmonary disease
Guo, Y., Zhang, T., Wang, Z., Yu, F., Qin, X., Guo, W. P., Wu, C., & He, J. (2016) · Medicine · doi:10.1097/md.0000000000004225 · Cited by 170 · see citing works
Atherton, P. J., Greenhaff, P. L., Phillips, S. M., Bodine, S. C., Adams, C. M., & Lang, C. H. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00257.2016 · Cited by 166 · see citing works
Bouchonville, M., Armamento-Villareal, R., Shah, K., Napoli, N., Sinacore, D. R., Qualls, C., & Villareal, D. T. (2014) · International Journal of Obesity · doi:10.1038/ijo.2013.122 · Cited by 163 · see citing works
Midlife Physical Activity and Mobility in Older Age
Patel, K. V., Coppin, A. K., Manini, T. M., Lauretani, F., Bandinelli, S., Ferrucci, L., & Guralnik, J. M. (2006) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2006.05.005 · Cited by 155 · see citing works
Nordby, P., Saltin, B., & Helge, J. W. (2006) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/j.1600-0838.2005.00480.x · Cited by 148 · see citing works
Association of Physical Activity History With Physical Function and Mortality in Old Age
Stenholm, S., Koster, A., Valkeinen, H., Patel, K. V., Bandinelli, S., Guralnik, J. M., & Ferrucci, L. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv111 · Cited by 138 · see citing works
Chomentowski, P., Dube, J. J., Amati, F., Stefanovic-Racic, M., Zhu, S., Toledo, F. G. S., & Goodpaster, B. H. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glp007 · Cited by 137 · see citing works
The Pathophysiology of Wasting in the Elderly
Roubenoff, R. (1999) · Journal of Nutrition · doi:10.1093/jn/129.1.256s · Cited by 126 · see citing works
Shad, B. J., Thompson, J. L., & Breen, L. (2016) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00213.2016 · Cited by 125 · see citing works
Hays, N. P., Galassetti, P. R., & Coker, R. H. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.02.003 · Cited by 122 · see citing works
Self-citationMurphy, R. A., Patel, K. V., Kritchevsky, S. B., Houston, D. K., Newman, A. B., Koster, A., Simonsick, E. M., Tylvasky, F. A., Cawthon, P. M., Harris, T. B., et al. (2014) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12954 · Cited by 109 · see citing works
Kim, I.-Y., Schutzler, S., Schrader, A., Spencer, H. J., Azhar, G., Ferrando, A. A., & Wolfe, R. R. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00365.2015 · Cited by 109 · see citing works
Self-citationLee, J. S., Visser, M., Tylavsky, F. A., Kritchevsky, S. B., Schwartz, A. V., Sahyoun, N., Harris, T. B., Newman, A. B., & Study, F. T. H. A. (2010) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glp042 · Cited by 108 · see citing works
Coker, R. H., Williams, R. H., Yeo, S. E., KORTEBEIN, P. M., Bodenner, D. L., Kern, P. A., & Evans, W. J. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2033 · Cited by 102 · see citing works
Self-citationBarberi, L., Scicchitano, B. M., & Musarò, A. (2015) · European Journal of Translational Myology · doi:10.4081/ejtm.2015.5227 · Cited by 95 · see citing works
Coker, R. H., Miller, S., Schutzler, S., Deutz, N., & Wolfe, R. R. (2012) · Nutrition Journal · doi:10.1186/1475-2891-11-105 · Cited by 92 · see citing works
Self-citationNutrition and physical activity for the prevention and treatment of age-related sarcopenia
Bosaeus, I. G., & Rothenberg, E. M. (2015) · Proceedings of The Nutrition Society · doi:10.1017/s002966511500422x · Cited by 92 · see citing works
Weight loss with high and low carbohydrate 1200 kcal diets in free living women
Lean, M., Han, T. S., Prvan, T., Richmond, P., & Avenell, A. (1997) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600391 · Cited by 86 · see citing works
Sánchez‐Rodríguez, D., Marco, E., Ronquillo-Moreno, N., Miralles, R., Vázquez‐Ibar, O., Escalada, F., & Muniesa, J. M. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.08.024 · Cited by 82 · see citing works
Jankovic, N., Geelen, A., Streppel, M. T., de Groot, C. P. G. M., Jong, J. C. K., Orfanos, P., Bamia, C., Trichopoulou, A., Boffetta, P., Bobák, M., et al. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.095117 · Cited by 77 · see citing works
Heianza, Y., Arase, Y., Tsuji, H., Fujihara, K., Saito, K., Hsieh, S. D., Tanaka, S., Kodama, S., Hara, S., & Sone, H. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4427 · Cited by 72 · see citing works
Human soleus and vastus lateralis muscle protein metabolism with an amino acid infusion
Carroll, C. C., Fluckey, J. D., Williams, R. H., Sullivan, D. H., & Trappe, T. A. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00393.2004 · Cited by 69 · see citing works
Protein and energy supplementation in elderly people at risk from malnutrition
Milne, A., Potter, J., & Avenell, A. (2002) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003288 · Cited by 68 · see citing works
Backx, E. M. P., Tieland, M., Borgonjen-van den Berg, K. J., Claessen, P. R., van Loon, L. J. C., & de Groot, L. C. P. G. M. (2016) · International Journal of Obesity · doi:10.1038/ijo.2015.182 · Cited by 66 · see citing works
Jankowski, C. M., Gozansky, W. S., Pelt, R. E. V., Schenkman, M. L., Wolfe, P., Schwartz, R. S., & Kohrt, W. M. (2008) · Obesity · doi:10.1038/oby.2007.84 · Cited by 64 · see citing works
Community Weight Loss to Combat Obesity and Disability in At-Risk Older Adults
Rejeski, W. J., Ambrosius, W. T., Burdette, J. H., Walkup, M. P., & Marsh, A. P. (2017) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glw252 · Cited by 58 · see citing works
Coker, R. H., & Wolfe, R. R. (2011) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32834da629 · Cited by 55 · see citing works
Self-citationAlagiakrishnan, K., Banach, M., Ahmed, A., & Aronow, W. S. (2016) · Annals of Medicine · doi:10.1080/07853890.2016.1197415 · Cited by 46 · see citing works
Nutrition in the critically ill patient
Koekkoek, K. W. A. C., & van Zanten, A. R. H. (2017) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000441 · Cited by 45 · see citing works
Keadle, S. K., Arem, H. E., Moore, S. C., Sampson, J. N., & Matthews, C. E. (2015) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-015-0315-0 · Cited by 44 · see citing works
Graber, T. G., Borack, M. S., Reidy, P. T., Volpi, E., & Rasmussen, B. B. (2017) · Nutrition & Metabolism · doi:10.1186/s12986-017-0187-1 · Cited by 34 · see citing works
Bed Rest Worsens Impairments in Fat and Glucose Metabolism in Older, Overweight Adults
Coker, R. H., Hays, N. P., Williams, R. H., Xu, L., Wolfe, R. R., & Evans, W. J. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt100 · Cited by 33 · see citing works
Self-citationHolst, M., Beermann, T., Mortensen, M. N., Skadhauge, L. B., Køhler, M., Lindorff‐Larsen, K., & Rasmussen, H. H. (2016) · Nutrition · doi:10.1016/j.nut.2016.05.011 · Cited by 26 · see citing works
Cost-Effectiveness of Obesity Prevention and Treatment
Bray, G., & Bouchard, C. (2014) · CRC Press eBooks · doi:10.1201/b16472-40 · Cited by 3 · see citing works
Government’s Evolving Role: Nutrition, Education, Regulation, Monitoring, and Research
Bray, G., & Bouchard, C. (2014) · CRC Press eBooks · doi:10.1201/b16472-41 · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 102 references couldn’t be matched to a known paper.
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Frailty and Cardiovascular Health
James, K., Jamil, Y., Kumar, M., Kwak, M. J., Nanna, M. G., Qazi, S., Troy, A. L., Butt, J. H., Damluji, A. A., Forman, D. E., et al. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.031736 · Cited by 135 · see citing works
INTERDISCIPLINARY CLINICAL PRACTICE GUIDELINES "MANAGEMENT OF OBESITY AND ITS COMORBIDITIES"
Dedov, I. I., Shestakova, M. V., Mel'nichenko, G. A., Mazurina, N. V., Andreeva, E. N., Bondarenko, I. Z., Руслановна, Г. З., Dzgoeva, F. K., Елисеев, М. С., Ershova, E. V., et al. (2021) · Obesity and metabolism · doi:10.14341/omet12714 · Cited by 162 · see citing works
Rossi, A. P., Rubele, S., Calugi, S., Caliari, C., Pedelini, F., Soave, F., Chignola, E., Vittoria Bazzani, P., Mazzali, G., Dalle Grave, R., et al. (2019) · Obesity · doi:10.1002/oby.22493 · Cited by 90 · see citing works
Espeland, M. A., Justice, J. N., Bahnson, J. L., Evans, J. K., Munshi, M. N., Hayden, K. M., Simpson, F. R., Johnson, K., Johnston, C. A., & Kritchevsky, S. B. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab342 · Cited by 39 · see citing works
Elderly Obesity: Is It Harmful or Beneficial?
Kim, T. N. (2018) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes.2018.27.2.84 · Cited by 33 · see citing works
Chen, F., Xu, S., Cao, L., Wang, Y., Chen, F., Tian, H., Hu, J., Wang, Z., & Wang, D. (2021) · Nutrition · doi:10.1016/j.nut.2021.111386 · Cited by 27 · see citing works
Addressing Obesity to Promote Healthy Aging
Roderka, M. N., Puri, S., & Batsis, J. A. (2020) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2020.06.006 · Cited by 24 · see citing works
The weight-loss paradox in older adults: balancing fat loss with muscle preservation
Arslan, S., & Aydın, A. (2025) · Bulletin of the National Research Centre/Bulletin of the National Research Center · doi:10.1186/s42269-025-01374-8 · Cited by 19 · see citing works
Simpson, F. R., Pajewski, N. M., Beavers, K. M., Kritchevsky, S. B., McCaffery, J. M., Nicklas, B. J., Wing, R. R., Bertoni, A. G., Ingram, F., Ojeranti, D., et al. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa153 · Cited by 19 · see citing works
Krzymińska-Siemaszko, R., Deskur-Śmielecka, E., Styszyński, A., & Wieczorowska–Tobis, K. (2021) · Nutrients · doi:10.3390/nu13041061 · Cited by 19 · see citing works
Coker, R. H., Shin, K. J., Scholten, K., Johannsen, M., Tsigonis, J., Kim, I., Schutzler, S. E., & Wolfe, R. R. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.12.013 · Cited by 19 · see citing works
Self-citationCoker, M. S., Barati, Z., Murphy, C. J., Bateman, T., Newcomer, B. R., Wolfe, R. R., & Coker, R. H. (2022) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2022.07.004 · Cited by 16 · see citing works
Self-citationKvedaras, M., Minderis, P., Krusnauskas, R., & Ratkevičius, A. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111320 · Cited by 15 · see citing works
Targeting Intramyocellular Lipids to Improve Aging Muscle Function
Russ, D. W., Manickam, R., & Tipparaju, S. M. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02622-6 · Cited by 15 · see citing works
Scott, D. S., Seibel, M. J., Cumming, R. G., Naganathan, V., Blyth, F., Couteur, D. G. L., Handelsman, D. J., Hsu, B., Waite, L. M., & Hirani, V. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz184 · Cited by 13 · see citing works
Polonsky, T. S., Tian, L., Zhang, D., Bazzano, L., Criqui, M. H., Ferrucci, L., Guralnik, J. M., Kibbe, M. R., Leeuwenburgh, C., Sufit, R. L., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.118.010890 · Cited by 12 · see citing works
Long-term weight patterns and physical activity in gallstones
Kim, H. J., Kang, T., Kim, M. J., Swan, H., & Park, S. M. (2024) · Scientific Reports · doi:10.1038/s41598-024-77218-8 · Cited by 11 · see citing works
Loss of body weight is dose-dependently associated with reductions in symptoms of hip osteoarthritis
Salis, Z., Gallagher, R., Lawler, L., & Sainsbury, A. (2024) · International Journal of Obesity · doi:10.1038/s41366-024-01653-w · Cited by 10 · see citing works
The need for an integrative musculoskeletal approach in sarcopenia: the ISarcoPRM Kickstart
Özçakar, L., Kara, M., Quittan, M., Ata, A. M., Michail, X., & Kaymak, B. (2020) · European Journal of Physical and Rehabilitation Medicine · doi:10.23736/s1973-9087.20.06255-3 · Cited by 10 · see citing works
Pre-diabetes in the elderly and the see-saw model of paternalism
Burch, P., & Holm, S. (2020) · Journal of Medical Ethics · doi:10.1136/medethics-2020-106573 · Cited by 10 · see citing works
Sahu, B., Pani, S., Swalsingh, G., Senapati, U., Pani, P., Pati, B., Rout, S., Trivedi, R., Raj, R., Dey, S., et al. (2023) · Molecular Omics · doi:10.1039/d3mo00127j · Cited by 8 · see citing works
Coker, M. S., Ladd, K., Murphy, C. J., Ruby, B. C., Shriver, T. C., Schoeller, D. A., Newcomer, B. R., Bateman, T., Bartlett, L., & Coker, R. H. (2020) · Physiological Reports · doi:10.14814/phy2.14682 · Cited by 8 · see citing works
Self-citationThe older, the less potential benefit for type 2 diabetes from weight control
Zhou, Q., Sun, J., Wu, Z., Wu, W., Zhang, X., Pan, Q., Qi, H., Yuan, H., Shi, H., Cao, S., et al. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-02979-8 · Cited by 8 · see citing works
Liao, Y.-N., Chen, H.-Y., Yang, C.-W., Lee, P.-W., Hsu, C.-Y., Huang, Y.-T., & Yang, T.-H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.978814 · Cited by 7 · see citing works
Effects of fasting on skeletal muscles and body fat of adult and old C57BL/6J mice
Kvedaras, M., Minderis, P., Cesanelli, L., Čekanauskaitė, A., & Ratkevičius, A. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111474 · Cited by 7 · see citing works
Salis, Z., & Sainsbury, A. (2022) · Arthritis Care & Research · doi:10.1002/acr.25057 · Cited by 5 · see citing works
Thompson, J., Parkinson, M., & Collery, R. (2020) · International Journal of Older People Nursing · doi:10.1111/opn.12343 · Cited by 4 · see citing works
Salis, Z., Lui, L., Lane, N. E., Ensrud, K. E., & Sainsbury, A. (2023) · Journal of the American Geriatrics Society · doi:10.1111/jgs.18371 · Cited by 4 · see citing works
Lee, I. (2023) · Exercise Science · doi:10.15857/ksep.2023.00332 · Cited by 3 · see citing works
The evolving continuum of dysglycaemia: Non‐diabetic hyperglycaemia in older adults
Golding, J. A., Hope, S. V., Chakera, A. J., & Puttanna, A. (2023) · Diabetic Medicine · doi:10.1111/dme.15177 · Cited by 2 · see citing works
Obesity in Older Adults: Pathophysiology and Clinical Implications
Vuittonet, C. L., Sbharwal, A., & Pitchumoni, C. S. (2020) · Springer eBooks · doi:10.1007/978-3-319-90761-1_98-1 · Cited by 2 · see citing works
Lapinskas, E., Krusnauskas, R., Čekanauskaitė, A., & Ratkevičius, A. (2020) · Growth Factors · doi:10.1080/08977194.2021.1960831 · Cited by 2 · see citing works
Obesity in Older Adults: Pathophysiology and Clinical Implications
Vuittonet, C. L., Sbharwal, A., & Pitchumoni, C. S. (2021) · Springer eBooks · doi:10.1007/978-3-030-30192-7_98 · Cited by 2 · see citing works
Iftikhar, M., Jamal, A., Shah, M. M., & Khan, S. J. (2023) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-6684-2354-7.ch003 · Cited by 2 · see citing works
Nutrition for Older Adults: Perspectives on Dietary Guidance for Healthy Aging
Booth, S. L., Campbell, W. W., Volpi, E., Ferrucci, L., Starke-Reed, P. E., Bailey, R. L., Bales, C. W., Barbey, A. K., Choi, I., Houston, D. K., et al. (2026) · Current Developments in Nutrition · doi:10.1016/j.cdnut.2026.107658 · Cited by 3 · see citing works
Vuelta, Ó. G., & Armada, X. (2022) · Archivo Español de Arqueología · doi:10.3989/aespa.095.022.15 · Cited by 1 · see citing works
Hulme, A., Sangelaji, B., Walker, C., Fallon, T., Denham, J., Martin, P., Woodruffe, S., Bell, K., Aniftos, M., Kirkpatrick, J., et al. (2024) · Journal of Interprofessional Care · doi:10.1080/13561820.2024.2380436 · Cited by 1 · see citing works
Sabour, H. (2019) · Springer eBooks · doi:10.1007/978-3-030-16073-9_18
Coker, M. S., Ladd, K., Barati, Z., Murphy, C. J., Bateman, T., Newcomer, B. R., Wolfe, R. R., & Coker, R. H. (2021) · Preprints.org · doi:10.20944/preprints202101.0432.v1
Self-citationBagrowski, B., & Roś, K. (2021) · Journal of Kinesiology and Exercise Sciences · doi:10.5604/01.3001.0015.7064
Effect of Nursing Intervention on Weight Loss of Obese Older Adults
Elmawla, D. A., Boughdady, A. M., & Radwan, E. (2019) · Alexandria Scientific Nursing Journal · doi:10.21608/asalexu.2019.206574
Weight Loss in Older Overweight Persons – Effects on Body Composition and Physical Function
Nilsen, K. L., & Rosendahl-Riise, H. (2022) · Norsk tidsskrift for ernæring · doi:10.18261/ntfe.20.4.2
A Sled Dog Model for Positive Health Effects of Weight Management and Exercise
Falkenstein, L. K., Jerome, S., Jerome, S., Jerome, E., Reynolds, A. J., Duffy, L. K., Duffy, L. K., Dunlap, K. L., & Dunlap, K. L. (2023) · American journal of biochemistry & biotechnology/American journal of biochemistry and biotechnology · doi:10.3844/ajbbsp.2023.47.54
Additional file 1 of The older, the less potential benefit for type 2 diabetes from weight control
Zhou, Q., Sun, J., Wu, Z., Wu, W., Zhang, X., Pan, Q., Qi, H., Yuan, H., Shi, H., Cao, S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19625444
Madden, A. M., Soepnel, L. M., Africa, C., Rhoda, J. L., Morar, Z., Lambert, E. V., Gutterman, S., Millard, F., Bolnick, H. J., Davies, J. C., et al. (2026) · BMC Geriatrics · doi:10.1186/s12877-026-07541-4
Miao, J., Wang, X., Huang, K., Wang, Y., & Zang, S. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1839686
- Authors
- Coker, R. H., & Wolfe, R. R.
- Affiliations
- University of Alaska Fairbanks (US)
- Alaska Division of Geological and Geophysical Surveys (US)
- Corresponding author
- Coker, Robert H.
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2017-12-20
- Volume
- 26
- Issue
- 1
- Pages
- 22-28
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- PMC
- PMC5744894
- OpenAlex
- W2779398127
- Cited by
- 47
- References
- 102
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 7 · 2021: 9 · 2020: 9 · 2019: 5 · 2018: 2
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (5 U54 GM104944)
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- sarcopenic obesity, weight loss, older adults, muscle atrophy, sarcopenia, high-protein diet, lifestyle intervention, metabolic abnormalities, functional capacity
- MeSH terms
- Adult, Aged, Aged, 80 and over, Humans, Middle Aged, Obesity, Weight Loss, Muscle, Skeletal, Sarcopenia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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