The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Overexpression of Mn Superoxide Dismutase Does Not Increase Life Span in Mice
Open accessAbstract
Genetic manipulations of Mn superoxide dismutase (MnSOD), SOD2 expression have demonstrated that altering the level of MnSOD activity is critical for cellular function and life span in invertebrates. In mammals, Sod2 homozygous knockout mice die shortly after birth, and alterations of MnSOD levels are correlated with changes in oxidative damage and in the generation of mitochondrial reactive oxygen species. In this study, we directly tested the effects of overexpressing MnSOD in young (4-6 months) and old (26-28 months) mice on mitochondrial function, levels of oxidative damage or stress, life span, and end-of-life pathology. Our data show that an approximately twofold overexpression of MnSOD throughout life in mice resulted in decreased lipid peroxidation, increased resistance against paraquat-induced oxidative stress, and decreased age-related decline in mitochondrial ATP production. However, this change in MnSOD expression did not alter either life span or age-related pathology.
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Cites
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Self-citationComplex iii releases superoxide to both sides of the inner mitochondrial membrane
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Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis
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Extending Healthy Life Span—From Yeast to Humans
Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023
Signal transduction by reactive oxygen species
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Oxidative Stress in Aging Human Skin
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The Critical Role of Metabolic Pathways in Aging
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Metadata
- Authors
- Jang, Y. C., Perez, V. I., Song, W., Lustgarten, M. S., Salmon, A. B., Mele, J., Qi, W., Liu, Y., Liang, H., Chaudhuri, A., Ikeno, Y., Epstein, C. J., Van Remmen, H., & Richardson, A.
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-07-24
- Volume
- 64A
- Issue
- 11
- Pages
- 1114-1125
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2154674926
- Cited by
- 202
- References
- 12
- FWCI
- 7.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Jang, Y. C., Perez, V. I., Song, W., Lustgarten, M. S., Salmon, A. B., Mele, J., Qi, W., Liu, Y., Liang, H., Chaudhuri, A., Ikeno, Y., Epstein, C. J., Van Remmen, H., & Richardson, A. (2009). Overexpression of Mn Superoxide Dismutase Does Not Increase Life Span in Mice. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. https://doi.org/10.1093/gerona/glp100
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