The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
The Relevance of Mouse Models for Investigating Age-Related Bone Loss in Humans
Open accessAbstract
Mice are increasingly used for investigation of the pathophysiology of osteoporosis because their genome is easily manipulated, and their skeleton is similar to that of humans. Unlike the human skeleton, however, the murine skeleton continues to grow slowly after puberty and lacks osteonal remodeling of cortical bone. Yet, like humans, mice exhibit loss of cancellous bone, thinning of cortical bone, and increased cortical porosity with advancing age. Histologic evidence in mice and humans alike indicates that inadequate osteoblast-mediated refilling of resorption cavities created during bone remodeling is responsible. Mouse models of progeria also show bone loss and skeletal defects associated with senescence of early osteoblast progenitors. Additionally, mouse models of atherosclerosis, which often occurs in osteoporotic participants, also suffer bone loss, suggesting that common diseases of aging share pathophysiological pathways. Knowledge of the causes of skeletal fragility in mice should therefore be applicable to humans if inherent limitations are recognized.
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Gut microbiota induce IGF-1 and promote bone formation and growth
Yan, J., Herzog, J. W., Tsang, K., Brennan, C. A., Bower, M. A., Garrett, W. S., Sartor, B. R., Aliprantis, A. O., & Charles, J. F. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607235113 · Cited by 750
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EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimerʼns disease
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Metadata
- Authors
- Jilka, R. L.
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-05-20
- Volume
- 68
- Issue
- 10
- Pages
- 1209-1217
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2098095516
- Cited by
- 329
- References
- 95
- FWCI
- 14.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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