Assessment of mitochondrial biogenesis and mTORC1 signaling during chronic rapamycin feeding in male and female mice

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In Vivo Measurement of Microtubule Dynamics Using Stable Isotope Labeling with Heavy Water

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Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the Liver Transcriptome

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The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity

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Skeletal muscle mitochondrial protein synthesis and respiration increase with low-load blood flow restricted as well as high-load resistance training

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Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome

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CORP: The use of deuterated water for the measurement of protein synthesis

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Skeletal Muscle Ribosome and Mitochondrial Biogenesis in Response to Different Exercise Training Modalities

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Comparative idiosyncrasies in life extension by reduced mTOR signalling and its distinctiveness from dietary restriction

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Cancer cachexia in a mouse model of oxidative stress

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Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance

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Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice

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Impact of dairy protein during limb immobilization and recovery on muscle size and protein synthesis; a randomized controlled trial.

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Six Weeks of Low-Load Blood Flow Restricted and High-Load Resistance Exercise Training Produce Similar Increases in Cumulative Myofibrillar Protein Synthesis and Ribosomal Biogenesis in Healthy Males

Sieljacks, P., Wang, J., Groennebaek, T., Rindom, E., Jakobsgaard, J. E., Herskind, J., Gravholt, A., Møller, A. B., Musci, R. V., de Paoli, F. V., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00649 · Cited by 50 · see citing works

Long‐lived Snell dwarf mice display increased proteostatic mechanisms that are not dependent on decreased mTORC 1 activity

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The measurement of protein synthesis for assessing proteostasis in studies of slowed aging

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Massage as a mechanotherapy promotes skeletal muscle protein and ribosomal turnover but does not mitigate muscle atrophy during disuse in adult rats

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Molecular changes associated with spinal cord aging

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Chronic metformin treatment decreases cardiac injury during ischemia-reperfusion by attenuating endoplasmic reticulum stress with improved mitochondrial function

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Skeletal Muscle Nuclei in Mice are not Post-mitotic

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Influence of Nrf2 activators on subcellular skeletal muscle protein and DNA synthesis rates after 6 weeks of milk protein feeding in older adults

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Quality control systems in cardiac aging

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Long-lived crowded-litter mice have an age-dependent increase in protein synthesis to DNA synthesis ratio and mTORC1 substrate phosphorylation

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Gene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver

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Lipid hydroperoxides and oxylipins are mediators of denervation induced muscle atrophy

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Long term rapamycin treatment improves mitochondrial DNA quality in aging mice

Bielas, J. H., Herbst, A. J., Widjaja, K., Hui, J., Aiken, J. M., McKenzie, D. I., Miller, R. A., Brooks, S. V., & Wanagat, J. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.02.021 · Cited by 37 · see citing works

Short-term Calorie Restriction and 17α-Estradiol Administration Elicit Divergent Effects on Proteostatic Processes and Protein Content in Metabolically Active Tissues

Miller, B. F., Pharaoh, G. A., Hamilton, K. L., Peelor, F. F., Kirkland, J. L., Freeman, W. M., Mann, S. N., Kinter, M. T., Price, J. C., & Stout, M. B. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz113 · Cited by 37 · see citing works

The Dunkin Hartley Guinea Pig Is a Model of Primary Osteoarthritis That Also Exhibits Early Onset Myofiber Remodeling That Resembles Human Musculoskeletal Aging

Musci, R., Walsh, M., Konopka, A., Wolff, C. A., Peelor, F., Reiser, R., Santangelo, K., & Hamilton, K. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.571372 · Cited by 25 · see citing works

Mitochondrial proteostasis as a shared characteristic of slowed aging: the importance of considering cell proliferation

Hamilton, K. L., & Miller, B. F. (2017) · The Journal of Physiology · doi:10.1113/jp274335 · Cited by 35 · see citing works

Physiologic Responses to Dietary Sulfur Amino Acid Restriction in Mice Are Influenced by Atf4 Status and Biological Sex

Jonsson, W. O., Margolies, N., Mirek, E. T., Zhang, Q., Linden, M. A., Hill, C. M., Link, C., Bithi, N., Zalma, B. A., Levy, J. L., et al. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa396 · Cited by 35 · see citing works

Differential effects of vitamin C or protandim on skeletal muscle adaptation to exercise

Bruns, D. R., Ehrlicher, S. E., Khademi, S., Biela, L. M., Peelor, F. F., Miller, B. F., & Hamilton, K. L. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00277.2018 · Cited by 33 · see citing works

Differential Effects of Rapamycin and Metformin in Combination With Rapamycin on Mechanisms of Proteostasis in Cultured Skeletal Myotubes

Wolff, C. A., Reid, J. J., Musci, R. V., Bruns, D. R., Linden, M. A., Konopka, A. R., Peelor, F. F., Miller, B. F., & Hamilton, K. L. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz058 · Cited by 33 · see citing works

Skeletal muscle mitochondrial protein synthesis and respiration in response to the energetic stress of an ultra-endurance race

Konopka, A. R., Castor, W. M., Wolff, C. A., Musci, R. V., Reid, J. J., Laurin, J. L., Valenti, Z. J., Hamilton, K. L., & Miller, B. F. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00457.2017 · Cited by 32 · see citing works

Serum extracellular vesicle miR-203a-3p content is associated with skeletal muscle mass and protein turnover during disuse atrophy and regrowth

Pelt, D. W. V., Vechetti, I. J., Lawrence, M. M., Pelt, K. L. V., Patel, P., Miller, B. F., Butterfield, T. A., & Dupont‐Versteegden, E. E. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00223.2020 · Cited by 29 · see citing works

Reduced in vivo hepatic proteome replacement rates but not cell proliferation rates predict maximum lifespan extension in mice

Thompson, A. C. S., Bruss, M. D., Price, J. C., Khambatta, C. F., Holmes, W. E., Colangelo, M., Dalidd, M., Roberts, L. S., Astle, C. M., Harrison, D. E., et al. (2015) · Aging Cell · doi:10.1111/acel.12414 · Cited by 28 · see citing works

Chronic rapamycin treatment on the nutrient utilization and metabolism of juvenile turbot (Psetta maxima)

Wang, Q., He, G., Mai, K., Xu, W., Zhou, H., Wang, X., & Mei, L. (2016) · Scientific Reports · doi:10.1038/srep28068 · Cited by 28 · see citing works

The loss of cardiac SIRT3 decreases metabolic flexibility and proteostasis in an age-dependent manner

Li, P., Newhardt, M. F., Matsuzaki, S., Eyster, C. A., Pranay, A., Peelor, F. F., Batushansky, A., Kinter, C. S., Subramani, K., SUBRAHMANIAN, S. M., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00695-0 · Cited by 26 · see citing works

Continuous administration of the mTORC1 inhibitor everolimus induces tolerance and decreases autophagy in mice

Kurdi, A., Doncker, M. D., Leloup, A. J. A., Neels, H. M., Timmermans, J., Lemmens, K., Apers, S., Meyer, G. R. Y. D., & Martinet, W. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13626 · Cited by 25 · see citing works

Sex differences in changes of protein synthesis with rapamycin treatment are minimized when metformin is added to rapamycin

Wolff, C. A., Lawrence, M. M., Porter, H. L., Zhang, Q., Reid, J. J., Laurin, J. L., Musci, R. V., Linden, M. A., Peelor, F. F., Wren, J. D., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00243-8 · Cited by 24 · see citing works

Geroprotector drugs and exercise: friends or foes on healthy longevity?

Elliehausen, C. J., Anderson, R. M., Diffee, G. M., Rhoads, T. W., Lamming, D. W., Hornberger, T. A., & Konopka, A. R. (2023) · BMC Biology · doi:10.1186/s12915-023-01779-9 · Cited by 24 · see citing works

Brain Protein Synthesis Rates in the UM-HET3 Mouse Following Treatment With Rapamycin or Rapamycin With Metformin

Reid, J. J., Linden, M. A., Peelor, F. F., Miller, R. A., Hamilton, K. L., & Miller, B. F. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz069 · Cited by 21 · see citing works

Phytochemical compound PB125 attenuates skeletal muscle mitochondrial dysfunction and impaired proteostasis in a model of musculoskeletal decline

Musci, R. V., Andrie, K. M., Walsh, M., Valenti, Z. J., Linden, M. A., Afzali, M. F., Bork, S. B., Campbell, M. A., Johnson, T., Kail, T. E., et al. (2022) · The Journal of Physiology · doi:10.1113/jp282273 · Cited by 17 · see citing works

Muscle from aged rats is resistant to mechanotherapy during atrophy and reloading

Lawrence, M. M., Pelt, D. W. V., Confides, A. L., Hettinger, Z. R., Hunt, E. R., Reid, J. J., Laurin, J. L., Peelor, F. F., Butterfield, T. A., Miller, B. F., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00215-y · Cited by 17 · see citing works

Mitochondrial integrity in a neonatal bovine model of right ventricular dysfunction

Bruns, D. R., Brown, R. D., Stenmark, K. R., Buttrick, P. M., & Walker, L. A. (2014) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00270.2014 · Cited by 17 · see citing works

Skeletal muscle mitochondrial respiration in a model of age-related osteoarthritis is impaired after dietary rapamycin

Elliehausen, C. J., Minton, D. M., Nichol, A. D., & Konopka, A. R. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111579 · Cited by 15 · see citing works

Assessment of protein synthesis in highly aerobic canine species at the onset and during exercise training

Miller, B. F., Ehrlicher, S. E., Drake, J. C., Peelor, F. F., Biela, L. M., Pratt-Phillips, S. E., Davis, M. S., & Hamilton, K. L. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00982.2014 · Cited by 14 · see citing works

Turnover and replication analysis by isotope labeling (TRAIL) reveals the influence of tissue context on protein and organelle lifetimes

Hasper, J., Welle, K. A., Hryhorenko, J. R., Ghaemmaghami, S., & Buchwalter, A. L. (2023) · Molecular Systems Biology · doi:10.15252/msb.202211393 · Cited by 10 · see citing works

The combination of NRF1 and Nrf2 activators in myoblasts stimulate mechanisms of proteostasis without changes in mitochondrial respiration

Walsh, M., Zhang, Q., Musci, R. V., & Hamilton, K. L. (2022) · Redox in Muscle Physiology Exercise and Sport · doi:10.1016/j.rimpes.2022.100001 · Cited by 11 · see citing works

Homeostatic responses to amino acid insufficiency

Anthony, T. G. (2015) · Animal nutrition · doi:10.1016/j.aninu.2015.10.001 · Cited by 10 · see citing works

Lactobacillus-fermented milk enhances postprandial muscle protein synthesis in Sprague-Dawley rats

Sumi, K., Osada, K., Ashida, K., & Nakazato, K. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103789 · Cited by 9 · see citing works

Short-term repeated human biopsy sampling contributes to changes in muscle morphology and higher outcome variability

Long, D. E., Mantuano, A. J., Confides, A. L., Miller, B. F., Kern, P. A., Butterfield, T. A., & Dupont‐Versteegden, E. E. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00441.2023 · Cited by 9 · see citing works

Turning strains into strengths for understanding psychiatric disorders

Moore, S. J., Murphy, G. G., & Cazares, V. A. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0772-y · Cited by 9 · see citing works

Cognitive function is preserved in aged mice following long-term β-hydroxy β-methylbutyrate supplementation

Munroe, M., Mahmassani, Z. S., Dvoretskiy, S., Reid, J. J., Miller, B. F., Hamilton, K. L., Rhodes, J. S., & Boppart, M. D. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2018.1483101 · Cited by 8 · see citing works

Tumor burden negatively impacts protein turnover as a proteostatic process in noncancerous liver, heart, and muscle, but not brain

Brown, J. L., Lawrence, M. M., Borowik, A., Oliver, L. A., Peelor, F. F., Remmen, H. V., & Miller, B. F. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01026.2020 · Cited by 8 · see citing works

Precision remodeling: how exercise improves mitochondrial quality in myofibers

Drake, J. C., & Yan, Z. (2019) · Current Opinion in Physiology · doi:10.1016/j.cophys.2019.05.005 · Cited by 8 · see citing works

Skeletal and cardiac muscle have different protein turnover responses in a model of right heart failure

Bruns, D. R., McNair, B. D., Peelor, F. F., Borowik, A., Pranay, A., Yusifov, A., & Miller, B. F. (2023) · GeroScience · doi:10.1007/s11357-023-00777-7 · Cited by 7 · see citing works

Short-term changes in diet composition do not affect in vivo hepatic protein synthesis in rats

Estrada, A. L., Hudson, W. M., Kim, P., Stewart, C. M., Peelor, F. F., Wei, Y., Wang, D., Hamilton, K. L., Miller, B. F., & Pagliassotti, M. J. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00209.2017 · Cited by 6 · see citing works

Systemic delivery of a mitochondria targeted antioxidant partially preserves limb muscle mass and grip strength in response to androgen deprivation

Rossetti, M. L., Dunlap, K. R., Salazar, G., Hickner, R. C., Kim, J., Chase, P. B., Miller, B. F., & Gordon, B. S. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111391 · Cited by 6 · see citing works

Antioxidants and Polyphenols Mediate Mitochondrial Mediated Muscle Death Signaling in Sarcopenia

Alway, S. E. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-810422-4.00026-9 · Cited by 6 · see citing works

Deuterium labeling enables proteome-wide turnover kinetics analysis in cell culture

Alamillo, L., Ng, D. C. M., Currie, J., Black, A., Pandi, B., Manda, V., Pavelka, J., Schaal, P., Travers, J. G., McKinsey, T. A., et al. (2025) · Cell Reports Methods · doi:10.1016/j.crmeth.2025.101104 · Cited by 6 · see citing works

The effect of enhanced glycolysis on cardiac aging

Faakye, A., Harold, K. M., Matsuzaki, S., Pranay, A., Garcia, M. F. M., Loveland, B. L., Rigsby, S., Peelor, F. F., Eyster, C. A., Miller, B. F., et al. (2025) · GeroScience · doi:10.1007/s11357-025-01656-z · Cited by 4 · see citing works

Rates of protein synthesis are maintained in brain but reduced in skeletal muscle during dietary sulfur amino acid restriction

Martinez, W., Zhang, Q., Linden, M. A., Schacher, N., Darvish, S., Mirek, E. T., Levy, J. L., Jonsson, W. O., Anthony, T. G., & Hamilton, K. L. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.975129 · Cited by 4 · see citing works

Lifespan Effects of Muscle-Specific Androgen Receptor Overexpression on Body Composition of Male and Female Rats

Barsky, S. T., & Monks, D. A. (2024) · Endocrinology · doi:10.1210/endocr/bqae012 · Cited by 2 · see citing works

Autophagy and Proteostasis in Cardiac Aging

Dai, D., & Rabinovitch, P. S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-805253-2.00015-8 · Cited by 2 · see citing works

Energetic Stress and Proteodynamics in Aging and Longevity

Reid, J. J., Miller, B. F., & Hamilton, K. L. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814253-0.00016-4 · Cited by 1 · see citing works

Linking mitochondrial dysfunction to sarcopenia

Alway, S. E. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822146-4.00004-1 · Cited by 1 · see citing works

Phytochemical Nrf2 activator attenuates skeletal muscle mitochondrial dysfunction and impaired proteostasis in a preclinical model of musculoskeletal agingPreprint

Musci, R. V., Andrie, K. M., Walsh, M., Valenti, Z. J., Afzali, M. F., Johnson, T., Kail, T. E., Martinez, R., Nguyen, T., Sanford, J. L., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.11.448143 · Cited by 1 · see citing works

Mediators and markers of mammalian lifespan extension: Proteomic, proliferative and hormonal adaptations in mouse models of extended lifespan

Thompson, A. C. S. (2014) · ProQuest Demo Repository

Proteome Turnover in Mouse Aging: In Vivo Studies by Stable Isotope Mass Spectrometry

Basisty, N. (2015) · ResearchWorks at the University of Washington (University of Washington)

Molecular Regulation of Muscle Protein Synthesis at Rest and Following Endurance Exercise

Sawan, S. A. (2017) · TSpace (University of Toronto)

Understanding the Importance of Proteostasis in Maximizing Healthspan: Challenges and Connections With the Other Pillars of Aging

Zhang, Q., Walsh, M., Linden, M. A., & Hamilton, K. L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11447-3

Development of a stem cell-based therapy for the recovery of skeletal muscle mass following immobilization

Munroe, M. (2018) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)

Duplexing metabolic deuterated water-labeled samples using dimethyl labeling to estimate protein turnover rates

Deberneh, H. M., Taylor, M. E., Kobak, K. A., Kinter, M. T., Miller, B. F., & Sadygov, R. G. (2025) · Communications Chemistry · doi:10.1038/s42004-025-01762-1

The effect of enhanced glycolysis on cardiac aging - part 2 data

Humphries, K. M., & Pranay, A. (2025) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.15605975

Mitochondrial Biogenesis in Human Skeletal Muscle: High-Intensity Interval Training Versus Moderate-Intensity Continuous Training

Bischof, K. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27219537

Chronic rapamycin administration maintains mitochondrial protein synthesis in heart and skeletal muscle

Drake, J. C., Peelor, F. F., Biela, L. M., Miller, R. A., Hamilton, K. L., & Miller, B. F. (2012) · The FASEB Journal · doi:10.1096/fasebj.26.1_supplement.1075.4

Treatment with rapamycin or rapamycin in combination with metformin contributes to mechanisms of mitochondrial proteostasis in vivo and in vitro

Wolff, C. A., Hamilton, K. L., Miller, B. F., Hickey, M., & Pagliassotti, M. J. (2018) · Digital Collections of Colorado (Colorado State University) · doi:10.25675/3.024313

Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice

Rodriguez, K. A., Dodds, S. G., Strong, R., Galván, V., Sharp, Z. D., & Buffenstein, R. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00083 · Cited by 86 · see citing works

The mTOR Conundrum: Essential for Muscle Function, but Dangerous for Survival

Morley, J. E. (2016) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2016.09.001 · Cited by 9 · see citing works

Rapamycin does not prevent increases in myofibrillar or mitochondrial protein synthesis following endurance exercise

Philp, A., Schenk, S., Pérez‐Schindler, J., Hamilton, D. L., Breen, L., Laverone, E., Jeromson, S., Phillips, S. M., & Baar, K. (2015) · The Journal of Physiology · doi:10.1113/jp271219 · Cited by 69 · see citing works