Comparative Epidemiological Investigation of Alzheimer’s Disease and Colorectal Cancer: The Possible Role of Gastrointestinal Conditions in the Pathogenesis of AD
Open accessAbstract
Alzheimer's disease (AD) is a neurodegenerative disorder that affects approximately 35 million people worldwide, and diet has been reported to influence the prevalence/incidence of AD. Colorectal cancer is among the most common cancers in Western populations, and the correlation between constipation and the occurrence of colorectal cancer has been identified in a number of studies, which show that a Westernized diet is a mutual risk factor. Constipation is a growing health problem, particularly in middle-aged and older adults. As the most common gastrointestinal disorder in adults, constipation affects 2-20% of the world population, and it is associated with several diseases, such as diabetes, Parkinson's disease, and others. Comparing the epidemiological data on colorectal cancer and AD, we find that colorectal cancer and AD have similar epidemiologic feature, which is both disease correlate with high prevalence of constipation. Therefore, we hypothesized that constipation may influence Alzheimer's disease in a similar way that it contributes to colorectal cancer. This review aimed to systemically elucidate the evidence that constipation contributes to Alzheimer's disease progression.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dysbiosis of the gut microbiome causes systemic inflammation, neuroinflammation, and insulin resistance, which are all related to the pathogenesis of Alzheimer's disease.
“Alternatively, dysbiosis of the gut microbiome causes systemic inflammation, neuroinflammation, insulin resistance, which are all related to the pathogenesis of AD [22].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [22]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Vos, T., Allen, C., Arora, M., Barber, R. M., Bhutta, Z. A., Brown, A., Carter, A., Casey, D. C., Charlson, F. J., Chen, A. Z., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31678-6 · Cited by 7,253 · see citing works
Cancer Incidence in Five Continents
(1966) · doi:10.1007/978-3-642-85849-9 · Cited by 5,936 · see citing works
Global prevalence of dementia: a Delphi consensus study
Ferri, C. P., Prince, M. J., Brayne, C., Brodaty, H., Fratiglioni, L., Ganguli, M., Hall, K. S., Hasegawa, K., Hendrie, H. C., Huang, Y., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67889-0 · Cited by 5,336 · cited 1× · see citing works
“First, criteria and time of data collection across studies were different, which might cause some inaccuracy in our research; however, there are several studies that show that AD prevalence is lower in developing countries or lower income areas (Hendrie et al., 1995; Chandra et al., 1998; Prince, 2000; Ferri et al., 2…”
ResultNeuropathological alterations in Alzheimer disease
Serrano-Pozo, A., Frosch, M. P., Masliah, E., & Hyman, B. T. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006189 · Cited by 3,345 · cited 1× · see citing works
“However, the underlying causes of these pathological changes remain unclear, but increasing age and genetic and non-genetic factors may be essential influences (Serrano-Pozo et al., 2011).”
BackgroundColorectal cancer statistics, 2014
Siegel, R. L., Desantis, C. E., & Jemal, A. (2014) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21220 · Cited by 2,558 · see citing works
The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems.
(2015) · PubMed Central · Cited by 2,540 · see citing works
Gut–brain axis: How the microbiome influences anxiety and depression
Foster, J. A., & McVey Neufeld, K.-A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.005 · Cited by 2,460 · cited 1× · see citing works
“Meanwhile, increasing studies showed that the gut microbiota are one essential part influencing anxiety and depression (Foster and Neufeld, 2013; Naseribafrouei et al., 2014).”
BackgroundRAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain
Deane, R., Du Yan, S., Submamaryan, R. K., LaRue, B., Jovanovic, S., Hogg, E., Welch, D., Manness, L., Lin, C., Yu, J., et al. (2003) · Nature Medicine · doi:10.1038/nm890 · Cited by 1,426 · see citing works
Cattaneo, A., Cattane, N., Galluzzi, S., Provasi, S., Lopizzo, N., Festari, C., Ferrari, C., Guerra, U. P., Paghera, B., Muscio, C., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.08.019 · Cited by 1,382 · see citing works
Principles and clinical implications of the brain-gut-enteric microbiota axis
Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342 · see citing works
Worldwide Variations in Colorectal Cancer
Jemal, A., Smith, R. A., & Ward, E. (2009) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20038 · Cited by 1,281 · see citing works
Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination
Berer, K., Mues, M., Koutrolos, M., Rasbi, Z. A., Boziki, M., Johner, C., Wekerle, H., & Krishnamoorthy, G. (2011) · Nature · doi:10.1038/nature10554 · Cited by 1,251 · see citing works
Matthews, F. E., Arthur, A., Barnes, L. E., Bond, J., Jagger, C., Robinson, L., & Brayne, C. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61570-6 · Cited by 1,155 · see citing works
Kimura, I., Inoue, D., Maeda, T., Hara, T., Ichimura, A., Miyauchi, S., Kobayashi, M., Hirasawa, A., & Tsujimoto, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016088108 · Cited by 1,106 · cited 1× · see citing works
“One principle product of gastrointestinal bacteria is shortchain fatty acids, which include butyric acid, propionic acid, and acetic acid, and the enteric nervous system can be affected by these substances; these metabolites can also influence the sympathetic system (Kimura et al., 2011), increase mucosal serotonin re…”
BackgroundEpidemiology of Alzheimer DiseasePreprint
Mayeux, R. P., & Stern, Y. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006239 · Cited by 1,070 · see citing works
Correlation between the human fecal microbiota and depression
Naseribafrouei, A., Hestad, K., Avershina, E., Sekelja, M., Linløkken, A., Wilson, R., & Rudi, K. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12378 · Cited by 1,044 · cited 1× · see citing works
“Meanwhile, increasing studies showed that the gut microbiota are one essential part influencing anxiety and depression (Foster and Neufeld, 2013; Naseribafrouei et al., 2014).”
BackgroundEpidemiology of constipation in children and adults: A systematic review
Mugie, S. M., Benninga, M. A., & Lorenzo, C. D. (2011) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2010.12.010 · Cited by 944 · see citing works
Suares, N. C., & Ford, A. C. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2011.164 · Cited by 906 · cited 1× · see citing works
“, 1999); one study showed the pooled prevalence of chronic idiopathic constipation in diverse countries as follows: South East Asia was 11%, North America was 14%, Northern Europe was 16%, Southern Europe was 16%, and South America was 18% (Suares and Ford, 2011).”
BackgroundVecsey, C. G., Hawk, J. D., Lattal, K. M., Stein, J. M., Fabian, S., Attner, M. A., Cabrera, S. M., McDonough, C. B., Brindle, P. K., Abel, T. G., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0296-07.2007 · Cited by 828 · cited 1× · see citing works
“, 2011), increase mucosal serotonin release and affect learning and memory function (Vecsey et al., 2007; Stefanko et al., 2009).”
BackgroundLRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms
Deane, R., Wu, Z., Sagare, A., Davis, J., Du Yan, S., Hamm, K., Xu, F., Parisi, M., LaRue, B., Hu, H. W., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.017 · Cited by 828 · see citing works
The question of familial meningiomas and schwannomas:
King, A. A., & Gutmann, D. H. (2000) · Neurology · doi:10.1212/wnl.54.1.4 · Cited by 814 · see citing works
Increasing incidence of colorectal cancer in Asia: implications for screening
Sung, J. J. �., Lau, J., Goh, K., & Leung, W. K. (2005) · The Lancet Oncology · doi:10.1016/s1470-2045(05)70422-8 · Cited by 740 · cited 15× · see citing works
“There is one research study that provided dementia data on people aged above 60 years in different places, and the data indicated that the prevalence in North America was 6.3%, Western Europe was 5.3%, Latin American was 4.9%, China was 4.0%, and the Western Pacific area was 4.0% (Ferri et al., 2005); people from Nort…”
BackgroundInfluentialThe Blood-Brain Barrier in Brain Homeostasis and Neurological Diseases
Weiss, N., Miller, F., Cazaubon, S., & Couraud, P.-O. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.10.022 · Cited by 731 · see citing works
Functional bowel disorders in apparently healthy people
Thompson, W., & Heaton, K. W. (1980) · Gastroenterology · doi:10.1016/0016-5085(80)90142-0 · Cited by 665 · see citing works
Asano, Y., Hiramoto, T., Nishino, R., Aiba, Y., Kimura, T., Yoshihara, K., Koga, Y., & Sudo, N. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00341.2012 · Cited by 659 · see citing works
Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis
Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12109 · Cited by 637 · cited 1× · see citing works
“Research on germ-free animals has revealed that the gut microbiota is essential in central nervous system and enteric nervous system development and maturation (Barbara et al., 2005; Stilling et al., 2014).”
Background(2000) · EUR Research Repository (Erasmus University Rotterdam) · Cited by 563 · see citing works
Castellani, R. J., Rolston, R. K., & Smith, M. A. (2010) · Disease-a-Month · doi:10.1016/j.disamonth.2010.06.001 · Cited by 561 · see citing works
Real-Time PCR Quantitation of Clostridia in Feces of Autistic Children
Song, Y., Liu, C., & Finegold, S. M. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.11.6459-6465.2004 · Cited by 556 · see citing works
Systematic review: impact of constipation on quality of life in adults and children
Belsey, J., Greenfield, S., Candy, D., & Geraint, M. (2010) · Alimentary Pharmacology and Therapeutics · doi:10.1111/j.1365-2036.2010.04273.x · Cited by 554 · see citing works
Epidemiology of Dementias and Alzheimer’s Disease
Sosa, A. L., Acosta, I., & Prince, M. J. (2012) · Archives of Medical Research · doi:10.1016/j.arcmed.2012.11.003 · Cited by 553 · see citing works
Epidemiologic Survey of Dementia in a Community-Dwelling Brazilian Population
Herrera, E., Caramelli, P., Silveira, A. S. B., & Nitríni, R. (2002) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200204000-00007 · Cited by 539 · see citing works
Rocca, W. A., Petersen, R. C., Knopman, D. S., Hebert, L. E., Evans, D. A., Hall, K. S., Gao, S., Unverzagt, F. W., Langa, K. M., Larson, E. B., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2010.11.002 · Cited by 498 · see citing works
ABC of colorectal cancer: Epidemiology
Boyle, P. (2000) · BMJ · doi:10.1136/bmj.321.7264.805 · Cited by 494 · see citing works
Stewart, W. F., Liberman, J. N., Sandler, R. S., Woods, M. S., Stemhagen, A., Chee, E. M., Lipton, R. B., & Farup, C. E. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01642.x · Cited by 490 · cited 1× · see citing works
“7% (Stewart et al., 1999); one study showed the pooled prevalence of chronic idiopathic constipation in diverse countries as follows: South East Asia was 11%, North America was 14%, Northern Europe was 16%, Southern Europe was 16%, and South America was 18% (Suares and Ford, 2011).”
BackgroundHendrie, H. C., Osuntokun, B. O., Hall, K. S., Ogunniyi, A. O., Hui, S. L., Unverzagt, F. W., Gureje, O., Rodenberg, C. A., Baiyewu, O., & Musick, B. S. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.10.1485 · Cited by 457 · cited 2× · see citing works
“From these studies, we can infer that the prevalence of dementia and Alzheimer’s disease was lower in developing or low and middle income countries [11, 12, 16, 17]; the difference between the developed and developing countries was very large in some studies (Hendrie et al., 1995; Chandra et al., 1998).”
BackgroundResultComplex interactions among diet, gastrointestinal transit, and gut microbiota in humanized mice
Kashyap, P. C., Marcobal, A., Ursell, L. K., Larauche, M., Duboc, H., Earle, K. A., Sonnenburg, E. D., Ferreyra, J. A., Higginbottom, S. K., Million, M., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.047 · Cited by 451 · cited 1× · see citing works
“An experiment using humanized (ex-germ-free mice transplanted with human fecal microflora) mice described that the change in gastrointestinal motility could lead to the alteration of gut microbiota; furthermore, with the administration of polyethylene glycol or a nonfermentable cellulose-based diet, which affects gast…”
MethodSpecific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice
Verdú, E. F., Bercik, P., Verma-Gandhu, M., Huang, X.-X., Blennerhassett, P., Jackson, W., Mao, Y., Wang, L., Rochat, F., & Collins, S. M. (2006) · Gut · doi:10.1136/gut.2005.066100 · Cited by 448 · cited 1× · see citing works
“Moreover, gut microbiota have shown the ability to activate the gastrointestinal mucosal immune system (Verdu et al., 2006).”
BackgroundParé, P., Ferrazzi, S., Thompson, W., Irvine, E. J., & Rance, L. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.05259.x · Cited by 445 · see citing works
Modulation of long-term memory for object recognition via HDAC inhibition
Stefanko, D. P., Barrett, R. M., Ly, A. R., Reolon, G. K., & Wood, M. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903964106 · Cited by 402 · cited 1× · see citing works
“, 2011), increase mucosal serotonin release and affect learning and memory function (Vecsey et al., 2007; Stefanko et al., 2009).”
BackgroundKHALIF, I., QUIGLEY, E., KONOVITCH, E., & MAXIMOVA, I. (2005) · Digestive and Liver Disease · doi:10.1016/j.dld.2005.06.008 · Cited by 382 · cited 1× · see citing works
“Another study found that Bifidobacterium and Lactobacillus were less abundant in adult patients with constipation (Khalif et al., 2005).”
ResultStructural changes in the gut microbiome of constipated patients
Zhu, L., Liu, W., Alkhouri, R., Baker, R. D., Bard, J. E., Quigley, E. M., & Baker, S. S. (2014) · Physiological Genomics · doi:10.1152/physiolgenomics.00082.2014 · Cited by 381 · see citing works
Kunze, W. A., Mao, Y., Wang, B., Huizinga, J. D., Ma, X., Forsythe, P., & Bienenstock, J. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00686.x · Cited by 328 · cited 1× · see citing works
“There have been reports that Lactobacillus reuteri could increase the excitability of the nerves by suppressing the calciumdependent potassium channels; thus, gut microbiota would be able to influence gut motility and pain perception (Kunze et al., 2009).”
BackgroundInteractions Between Commensal Bacteria and Gut Sensorimotor Function in Health and Disease
Barbara, G., Stanghellini, V., Brandi, G., Cremon, C., Nardo, G. D., De Giorgio, R., & Corinaldesi, R. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.00230.x · Cited by 325 · see citing works
AGA technical review on constipation
Locke, G., Pemberton, J. H., & Phillips, S. F. (2000) · Gastroenterology · doi:10.1053/gast.2000.20392 · Cited by 320 · cited 1× · see citing works
“either self-reported or Rome criteria, constipation occurs in 2– 20% of the population (Locke et al., 2000).”
BackgroundAge-Associated Remodeling of the Intestinal Epithelial Barrier
Tran, L., & Greenwood-Van Meerveld, B. (2013) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glt106 · Cited by 320 · see citing works
Husebye, E., Hellström, P. M., Sundler, F., Chen, J., & Midtvedt, T. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.3.g368 · Cited by 319 · cited 1× · see citing works
“, 2005), and another group demonstrated that intestinal bacteria could influence the migrating myoelectric complex, which are waves of electrical activity that sweep through the intestine in a regular cycle during fasting in a germ-free rat model (Husebye et al., 2001).”
BackgroundTwenty-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden
Qiu, C., Strauss, E. I. V., Bäckman, L., Winblad, B. G., & Fratiglioni, L. (2013) · Neurology · doi:10.1212/wnl.0b013e318292a2f9 · Cited by 307 · see citing works
Altered brain-gut axis in autism: comorbidity or causative mechanisms
Mayer, E. A., Padua, D., & Tillisch, K. (2014) · BioEssays · doi:10.1002/bies.201400075 · Cited by 304 · cited 1× · see citing works
“Moreover, the association between gut bacteria alteration and the severity of symptoms has been observed in autism patients (Song et al., 2004; Mayer et al., 2014).”
BackgroundBlood–brain-barriers in aging and in Alzheimer’s disease
Marques, F., Sousa, J. C., Sousa, N., & Palha, J. A. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-38 · Cited by 273 · cited 2× · see citing works
“Therefore, LPSs, amyloids and other complexes excreted by fungi and bacteria in the gut more easily get through (Marques et al., 2013; Tran and Greenwood-Van Meerveld, 2013; Hill and Lukiw, 2015; Shoemark and Allen, 2015); thus, amyloid formation and dissemination caused by gut microbiota might be more influential in…”
BackgroundFiest, K. M., Roberts, J. I., Maxwell, C. J., Hogan, D. B., Smith, E. E., Frolkis, A. D., Cohen, A., Kirk, A., Pearson, D. M., Pringsheim, T. M., et al. (2016) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2016.36 · Cited by 270 · see citing works
Wald, A. M., Scarpignato, C., Mueller‐Lissner, S., Kamm, M. A., Hinkel, U., HELFRICH, I., Schuijt, C., & Mandel, K. G. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03806.x · Cited by 268 · see citing works
Prevalence of clinically diagnosed Alzheimer's disease and other dementing disorders
Rocca, W. A., Bonaiuto, S., Lippi, A., Luciani, P., Turtù, F., Cavarzeran, F., & Amaducci, L. A. (1990) · Neurology · doi:10.1212/wnl.40.4.626 · Cited by 263 · see citing works
Attaluri, A., Jackson, M., Valestin, J., & Rao, S. S. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2009.655 · Cited by 261 · see citing works
Prevalence of Alzheimer's disease and other dementias in rural India
Chandra, V., Ganguli, M., Pandav, R. S., Johnston, J. M., Belle, S. H., & DeKosky, S. T. (1998) · Neurology · doi:10.1212/wnl.51.4.1000 · Cited by 258 · cited 2× · see citing works
“From these studies, we can infer that the prevalence of dementia and Alzheimer’s disease was lower in developing or low and middle income countries [11, 12, 16, 17]; the difference between the developed and developing countries was very large in some studies (Hendrie et al., 1995; Chandra et al., 1998).”
BackgroundResultShoemark, D. K., & Allen, S. J. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141170 · Cited by 248 · see citing works
Release of mast cell mediators into the jejunum by cold pain stress in humans
Santos, J., Saperas, E., Nogueiras, C., Mourelle, M., Antolín, M., Cadahia, A., & Malagelada, J. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70577-3 · Cited by 237 · see citing works
Prevalence of severe dementia in Finland
Sulkava, R. O., Wikstrom, J., Aromaa, A., Raitasalo, R., Lehtinen, V., Lahtela, K., & Palo, J. (1985) · Neurology · doi:10.1212/wnl.35.7.1025 · Cited by 230 · see citing works
Burns, A. S., & Iliffe, S. (2009) · BMJ · doi:10.1136/bmj.b75 · Cited by 230 · see citing works
Iyer, L. M., Aravind, L., Coon, S. L., Klein, D. C., & Koonin, E. V. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.05.007 · Cited by 219 · cited 2× · see citing works
“By generating substances that can function local transmitters, such as GABA, serotonin, histamine, melatonin, and acetylcholine (Iyer et al., 2004), and creating active state catecholamines in the gastrointestinal lumen, gut microbiota can affect enteric nervous system excitability (Asano et al.”
BackgroundAre Anxiety and Depression Related to Gastrointestinal Symptoms in the General Population?
Haug, T. T., Mykletun, A., & Dahl, A. A. (2002) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655202317284192 · Cited by 218 · see citing works
Trends in dementia prevalence, incidence, and survival rate in a Japanese community
Ohara, T., Hata, J., Yoshida, D., Mukai, N., Nagata, M., Iwaki, T., Kitazono, T., Kanba, S., Kiyohara, Y., & Ninomiya, T. (2017) · Neurology · doi:10.1212/wnl.0000000000003932 · Cited by 214 · cited 1× · see citing works
“01); the increasing trend is apparent, and we chose the most recent AD prevalence data from Japan for the figure for better comparison (Ohara et al., 2017).”
BackgroundSun, S. X., DiBonaventura, M., Waterman, F., Wagner, J.-S., Dabbous, O. H., & Mody, R. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1639-5 · Cited by 207 · cited 1× · see citing works
“Constipation and Gastrointestinal Condition Alteration Constipation is a worldwide disease that affects almost onethird of the general population during their lifetime; its chronic symptoms seriously impair patient life quality and produce heavy economic burden for patients and society (Sun et al., 2011; Guerin et al.…”
BackgroundDescriptive epidemiology of colorectal cancer
Boyle, P., Zaiudze, D. G., & Smans, M. (1985) · International Journal of Cancer · doi:10.1002/ijc.2910360103 · Cited by 198 · see citing works
Worldwide variation in the doubling time of Alzheimer's disease incidence rates
Ziegler‐Graham, K., Brookmeyer, R., Johnson, E. M., & Arrighi, H. M. (2008) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2008.05.2479 · Cited by 195 · see citing works
A Nationwide Survey on the Prevalence of Dementia and Mild Cognitive Impairment in South Korea
Kim, K. W., Park, J. H., Kim, M.-H., Kim, M.-D., Kim, B., Kim, S.-K., Kim, J. L., Moon, S. W., Bae, J. N., Woo, J. I., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101221 · Cited by 194 · see citing works
Luo, J., Wang, T., Liang, S., Hu, X., Li, W., & Jin, F. (2014) · Science China Life Sciences · doi:10.1007/s11427-014-4615-4 · Cited by 187 · see citing works
Garrigues, V. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh072 · Cited by 185 · see citing works
Scazufca, M., Menezes, P., Vallada, H., Crepaldi, A. L., Pastor-Valero, M., Coutinho, L. M. S., Rienzo, V. D. D., & Almeida, O. (2008) · International Psychogeriatrics · doi:10.1017/s1041610207005625 · Cited by 183 · see citing works
Can a Bacterial Endotoxin be a Key Factor in the Kinetics of Amyloid Fibril Formation?
Asti, A., & Gioglio, L. (2014) · Journal of Alzheimer's Disease · doi:10.3233/jad-131394 · Cited by 180 · cited 1× · see citing works
“One study investigated the possible causes of Aβ plaque formation and reported that E. coli endotoxin could potentiate Aβ fibril formation in vitro, which could be part of AD pathogenesis (Asti and Gioglio, 2014).”
BackgroundKim, S.-E., Choi, S. C., Park, K. S., Park, M. I., Shin, J. E., Lee, T. H., Jung, K. W., Koo, H. S., & Myung, S.-J. (2015) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm14048 · Cited by 180 · see citing works
Prevalence and Subtypes of Dementia in Taiwan: A community Survey of 5297 Individuals
Liu, H.-C., Lin, K., Teng, E. L., Wang, S., Fuh, J., Guo, N., Chou, P., Hu, H., & Chiang, B. N. (1995) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1995.tb06379.x · Cited by 175 · see citing works
Microbial-generated amyloids and Alzheimer's disease (AD)
Hill, J. M., & Lukiw, W. J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00009 · Cited by 173 · cited 2× · see citing works
“…and other complexes excreted by fungi and bacteria in the gut more easily get through (Marques et al., 2013; Tran and Greenwood-Van Meerveld, 2013; Hill and Lukiw, 2015; Shoemark and Allen, 2015); thus, amyloid formation and dissemination caused by gut microbiota might be more influential in the…”
BackgroundThe intestinal ecosystem in chronic functional constipation
Zoppi, G., Cinquetti, M., Luciano, A., Benini, A., Muner, A., & Minelli, E. B. (1998) · Acta Paediatrica · doi:10.1111/j.1651-2227.1998.tb01547.x · Cited by 169 · see citing works
Daulatzai, M. A. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1266-6 · Cited by 141 · see citing works
Zloković, B. V. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00310-4 · Cited by 138 · cited 1× · see citing works
“…that the receptor for advanced glycosylation products (RAGE) and apolipoprotein E and J control the amyloid influx through the blood–brain barrier (Zlokovic, 1996; Rashid et al., 2003), while low density lipoprotein receptor-related protein monitors amyloid clearance (Deane et al., 2004), which…”
BackgroundDietary Links to Alzheimer's Disease: 1999 Update
Grant, W. B. (1999) · Journal of Alzheimer s Disease · doi:10.3233/jad-1999-14-501 · Cited by 138 · see citing works
Dong, M., Peng, B., Lin, X., Zhao, J., Zhou, Y.-R., & Wang, R. (2007) · Age and Ageing · doi:10.1093/ageing/afm128 · Cited by 132 · see citing works
Study of constipation in a geriatric hospital, day hospital, dold people’s home and at home
Kinnunen, O. (1991) · Aging Clinical and Experimental Research · doi:10.1007/bf03323997 · Cited by 131 · see citing works
Defecation Disorders: A French Population Survey
Siproudhis, L., Pigot, F., Godeberge, P., Damon, H., Soudan, D., & Bigard, M. A. (2005) · Diseases of the Colon & Rectum · doi:10.1007/s10350-005-0249-8 · Cited by 130 · see citing works
Constipation in Australian Women: Prevalence and Associated Factors
Chiarelli, P., Brown, W. J., & McElduff, P. (2000) · International Urogynecology Journal · doi:10.1007/s001920050073 · Cited by 128 · see citing works
Rosselli, D., Ardila, A., Ardila, G. P., Morillo, L., Lorenzo, L. E. B., Rey, O., & Cuartero, J. M. C. (2000) · Revista de Neurología · doi:10.33588/rn.3005.99125 · Cited by 125 · see citing works
Constipation, laxative use and risk of colorectal cancer: The Miyagi Cohort Study
Watanabe, T., Nakaya, N., Kurashima, K., Kuriyama, S., Tsubono, Y., & Tsuji, I. (2004) · European Journal of Cancer · doi:10.1016/j.ejca.2004.06.014 · Cited by 115 · see citing works
Role of Gut Microbiota in Obesity, Type 2 Diabetes and Alzheimer’s Disease
Naseer, M. I., Bibi, F., Al-Qahtani, M. H., Chaudhary, A., Azhar, E. I., Kamal, M. A., & Yasir, M. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273113126660147 · Cited by 109 · cited 1× · see citing works
“Gut microbiota alteration and the increase in intestinal permeability may cause an overall systemic inflammation, neuroinflammation and dysfunction of particular brain regions, such as the cerebellum and hippocampus (Daulatzai, 2014a,b), and may also cause insulin resistance, which has been shown to be related to AD p…”
BackgroundMicroflora Modulation of Motility
Quigley, E. M. M. (2011) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2011.17.2.140 · Cited by 106 · see citing works
Dietary links to Alzheimer’s disease
Grant, W. B. (1997) · Cited by 104 · see citing works
Trends in the Prevalence of Dementia in Japan
Dodge, H. H., Buracchio, T., Fisher, G. G., Kiyohara, Y., Meguro, K., Tanizaki, Y., & Kaye, J. A. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/956354 · Cited by 103 · cited 1× · see citing works
“Westernized diets tend to include meat, sweets, and high-fat dairy products, which are found to be risk factors for AD (Grant, 1997); for instance, when Japan made a nutritional transition from the traditional Japanese diet to a Western-pattern diet, AD rates rose from 1% in 1985 to 7% in 2008 (Dodge et al., 2012).”
BackgroundLPS-induced neuroinflammatory effects do not recover with time
Hauss‐Wegrzyniak, B., Vraniak, P., & Wenk, G. L. (2000) · Neuroreport · doi:10.1097/00001756-200006050-00032 · Cited by 99 · see citing works
Toumi, R., Soufli, I., Rafa, H., Belkhelfa, M., Biad, A., & Touil–Boukoffa, C. (2014) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201402700418 · Cited by 96 · cited 2× · see citing works
“…that removing gut microbiota in the animal models of multiple sclerosis could hold back the progression of repalsing-remitting demyelination (Berer et al., 2011), and other studies described that oral ingestion of probiotics could relieve neuroinflammation (Luo et al., 2014; Toumi et al., 2014).”
BackgroundThe prevalence of dementia in a sample of elderly norwegians
Engedal, K., & Haugen, P. K. (1993) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.930080706 · Cited by 96 · see citing works
Hammer, N. D., Wang, X., McGuffie, B. A., & Chapman, M. R. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-13406 · Cited by 93 · see citing works
The enteric microbiota in the pathogenesis and management of constipation
Quigley, E. M. M. (2011) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2011.01.003 · Cited by 86 · cited 2× · see citing works
“Some studies showed that gut microbiota could affect gut immune response system to release mediators, which are bacterial fermentation end-products and intestinal neuroendocrine factors, to influence gastrointestinal motor ability (Barbara et al., 2005; Quigley, 2011a; Wu et al., 2013).”
BackgroundWu, R., Pasyk, M., Wang, B., Forsythe, P., Bienenstock, J., Mao, Y., Sharma, P., Stanisz, A. M., & Kunze, W. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12072 · Cited by 84 · see citing works
Prevalence and Subtypes of Dementia in a Rural Chinese Population
Liu, H.-C., Fuh, J., Wang, S., Liu, C.-Y., Larson, E. B., Lin, K.-N., Wang, H.-C., Chou, P., Wu, Z., Lin, C.-H., et al. (1998) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199809000-00002 · Cited by 82 · see citing works
Grant, W. B. (2016) · Journal of the American College of Nutrition · doi:10.1080/07315724.2016.1161566 · Cited by 79 · cited 2× · see citing works
“Keywords: Alzheimer, colorectal cancer, constipation, gut-brain axis, gut microbiota alteration INTRODUCTION Alzheimer’s disease (AD) is a chronic neurodegenerative disease which was first described by Alois Alzheimer (Grant, 2016).”
BackgroundBekkering, P., Jafri, I., van Overveld, F. J., & Rijkers, G. T. (2013) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2013.848793 · Cited by 77 · see citing works
Identification of Dementia Cases in the Community: A Brazilian Experience
Ramos‐Cerqueira, A. T. D. A., Torres, A. R., Crepaldi, A., de Oliveira, N. I. L., Scazufca, M., Menezes, P. R., & Prince, M. J. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53553.x · Cited by 74 · see citing works
Wald, A., Mueller-Lissner, S., Kamm, M., Hinkel, U., Richter, E., Schuijt, C., & Mandel, K. (2009) · Alimentary Pharmacology and Therapeutics · doi:10.1111/j.1365-2036.2009.04169.x · Cited by 71 · see citing works
Guerin, A., Carson, R. T., Lewis, B., Yin, D., Kaminsky, M., & Wu, E. (2014) · Journal of Medical Economics · doi:10.3111/13696998.2014.919926 · Cited by 71 · cited 1× · see citing works
“Constipation and Gastrointestinal Condition Alteration Constipation is a worldwide disease that affects almost onethird of the general population during their lifetime; its chronic symptoms seriously impair patient life quality and produce heavy economic burden for patients and society (Sun et al., 2011; Guerin et al.…”
BackgroundPrevalence of dementia and associated risk factors in Middle Anatolia, Turkey
Arslantaş, D., Özbabalık, D., Metintaş, S., Özkan, S., Kalyoncu, C., Özdemır, G., & Arslantaş, A. (2009) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2009.03.033 · Cited by 67 · see citing works
A Community-Based Study of Dementia: The Rotterdam Elderly Study
Breteler, M. M. B., Ouweland, F. A. V. D., Grobbee, D. E., & Albert Hofman, D. (1992) · Neuroepidemiology · doi:10.1159/000110957 · Cited by 61 · see citing works
Prevalence of Alzheimer Disease in US States
Weuve, J., Hebert, L. E., Scherr, P. A., & Evans, D. A. (2014) · Epidemiology · doi:10.1097/ede.0000000000000199 · Cited by 61 · see citing works
Treatment of Chronic Hepatic Encephalopathy
Morgan, M. Y. (1970) · The Lancet · doi:10.1016/s0140-6736(70)90060-7 · Cited by 51 · see citing works
Pamuk, Ö. N., Pamuk, G. E., & Çelık, A. F. (2003) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2003.03155.x · Cited by 47 · see citing works
Alam, M., Alam, Q., Kamal, M., Abuzenadah, A., & Haque, A. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273113126660151 · Cited by 47 · see citing works
Functional gut disorders and health care seeking behavior in an Italian non-patient population.
Gaburri, M., Bassotti, G., Bacci, G., Cinti, A., Bosso, R., Ceccarelli, P., Paolocci, N., Pelli, M. A., & Morelli, A. (1989) · PubMed · Cited by 43 · see citing works
Prevalence of constipation in the German population – a representative survey (GECCO)
Enck, P., Leinert, J., Smid, M., Köhler, T., & Schwille‐Kiuntke, J. (2015) · United European Gastroenterology Journal · doi:10.1177/2050640615603009 · Cited by 43 · cited 1× · see citing works
“5%, which was much higher than their previously reported prevalence and similar to data in other European countries (Enck et al., 2015).”
ResultRole of Stress, Depression, and Aging in Cognitive Decline and Alzheimer’s Disease
Daulatzai, M. A. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_350 · Cited by 42 · cited 1× · see citing works
“…may cause an overall systemic inflammation, neuroinflammation and dysfunction of particular brain regions, such as the cerebellum and hippocampus (Daulatzai, 2014a,b), and may also cause insulin resistance, which has been shown to be related to AD pathogenesis (Bekkering et al., 2013; Alam et…”
BackgroundGastrointestinal symptoms are still common in a general Western population.
van Kerkhoven, L. A. S., Eikendal, T., Laheij, R. J. F., van Oijen, M. G. H., & Jansen, J. B. �. �. (2008) · PubMed · Cited by 42 · see citing works
Obadia, Y., Rotily, M., Degrand-Guillaud, A., Guélain, J., Ceccaldi, M. P., Severo, C., Poncet, M., & Alpérovitch, A. (1997) · European Journal of Epidemiology · doi:10.1023/a:1007300305507 · Cited by 41 · see citing works
A Greek survey of community prevalence and characteristics of constipation
Papatheodoridis, G., Vlachogiannakos, J., Karaïtianos, I., & Karamanolis, D. G. (2010) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e32832bfdf0 · Cited by 41 · see citing works
Lu, C., Chang, F. ‐., CHEN, C. ‐., LUO, J. ‐., & Lee, S. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02949.x · Cited by 41 · see citing works
Prevalence and incidence of Alzheimers disease and other dementing disorders in Pylea, Greece
Tsolaki, M., Fountoulakis, C., Pavlopoulos, I., Chatzi, E., & Kazis, A. (1999) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/153331759901400308 · Cited by 33 · see citing works
Neuroepidemiología en el Oriente colombiano
Ardila, G. P., Vesga, B., Leon‐Sarmiento, F. E., Lorenzo, L. E. B., López, L. C. N., Torres, E. V., & Toloza, N. R. G. (2002) · Revista de Neurología · doi:10.33588/rn.3411.2001486 · Cited by 32 · see citing works
Gastrointestinal Symptoms in Type 1 Diabetic Patients, as Compared to a General Population
Mjörnheim, A.-C., Finizia, C. A., Blohmé, G., Attvall, S., Lundell, L. R., & Ruth, M. (2003) · Digestion · doi:10.1159/000074523 · Cited by 30 · see citing works
Potter, J. D., & Lindor, N. M. (2009) · Springer eBooks · doi:10.1007/978-0-387-09568-4 · Cited by 29 · cited 4× · see citing works
“Moreover, the majority of the case-control studies showed that meals with more vegetables and fruit are correlated with lower risk of colorectal cancer (Potter and Lindor, 2009).”
BackgroundInfluentialThe Prevalences of Gastrointestinal Symptoms in a Rural Community in Korea.
Choo, K. Y., Choi, M., Choi, H., Lee, D. S., Kim, J. I., Kim, S. S., Bhang, C. S., Park, S., Kim, J. K., Han, S. W., et al. (2000) · Cited by 27 · see citing works
Hofman, M., Seifritz, E., Kräuchi, K., Höck, C., Hampel, H. J., Neugebauer, A., & Müller-Spahn, F. (2000) · International Journal of Geriatric Psychiatry · doi:10.1002/(sici)1099-1166(200001)15:1 · Cited by 20 · see citing works
Gains and losses on the road to understanding Alzheimer’s disease
Konietzko, U. (2015) · Swiss Medical Weekly · doi:10.4414/smw.2015.14233 · Cited by 6 · cited 2× · see citing works
“…the Aβ peptide and intracellular tangles of tau protein accompanied with reactive microgliosis, dystrophic neurites, and loss of neurons and synapses (Konietzko, 2015), and alteration in the production and processing of amyloid β-protein has been hypothesized as the major initiating factor.”
BackgroundTominaga (1997) · doi:10.1002/(sici)1097-0215(1997)10+
Flagged first, then by citations
1 of the 121 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Ferri C. P. Prince M. Brayne C. Brodaty H. Fratiglioni L. Ganguli M. (2006). Global prevalence of dementia: a Delphi consensus study. Lancet 366 2112– 2117. 10.1016/S0140-6736(05)67889-0 PMC2850264 16360788 · DOI
- Pradilla G. Vesga B. E. Leon-Sarmiento F. E. Bautista L. E. Núñez L. C. Vesga E. (2002). Neuroepidemiology in the eastern region of Colombia. Rev. Neurol. 34 1035– 1043. 12134301
- Rosselli D. Ardila A. Pradilla G. Morillo L. Bautista L. Rey O. (2000). The mini-mental state examination as a selected diagnostic test for dementia: a Colombian population study. GENECO. Rev. Neurol. 30 428– 432. 10775968
- Stewart B. W. Kleihues P. (2003). World Cancer Report Lyon. Lyon: IARC press.
Cited by
Sorted by citations
Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease
Khan, S., Barve, K. H., & Kumar, M. S. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200528142429 · Cited by 820 · see citing works
Griñán-Ferré, C., Bellver-Sanchis, A., Izquierdo, V., Corpas, R., Roig-Soriano, J., Chillón, M., Andres-Lacueva, C., Somogyvári, M., Sőti, C., Sanfeliu, C., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101271 · Cited by 208 · see citing works
“Furthermore, various studies link gut microbiota dysbiosis and development of psychiatric disorders such as depression, autism, anxiety, as well as neurodegenerative diseases such as AD (Sampson et al., 2016; Zhang et al., 2018).”
BackgroundTeixeira, M. I., Lopes, C. M., Amaral, M. H., & Costa, P. C. (2020) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2020.01.005 · Cited by 132 · see citing works
The Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review
Ambrosini, Y. M., Borcherding, D. C., Kanthasamy, A., Kim, H. J., Willette, A., Jergens, A., Allenspach, K., & Mochel, J. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00130 · Cited by 116 · see citing works
He, X., Li, L., Xian, W., Li, M., Zhang, L., Xu, J., Pei, Z., Zheng, H., & Hu, X. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02199-8 · Cited by 116 · see citing works
Candido, S., Lupo, G., Pennisi, M., Basile, M. S., Anfuso, C. D., Petralia, M. C., Gattuso, G., Vivarelli, S., Spandidos, D. A., Libra, M., et al. (2019) · Oncology Reports · doi:10.3892/or.2019.7215 · Cited by 86 · see citing works
Cause of death among patients with colorectal cancer: a population-based study in the United States
Chen, J., Zheng, Y., Wang, H., Zhang, D., Zhao, L., Yu, D., Lin, Z., & Zhang, T. (2020) · Aging · doi:10.18632/aging.104022 · Cited by 51 · see citing works
“In recent years, some researchers have found that diet and constipation might influence the progression of AD [52].”
BackgroundSelf-citationWang, F., Fei, M., Hu, W., Wang, X., Liu, S., Zeng, Y., Zhang, J., Lv, Y., Niu, J., Meng, X., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.821654 · Cited by 47 · see citing works
Paley, E. L. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190873 · Cited by 41 · see citing works
Impact of constipation on progression of Alzheimer's disease: A retrospective study
Nakase, T., Tatewaki, Y., Thyreau, B., Mutoh, T., Tomita, N., Yamamoto, S., Takano, Y., Muranaka, M., & Taki, Y. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13940 · Cited by 37 · see citing works
Sannemann, L., Schild, A., Altenstein, S., Bartels, C., Brosseron, F., Büerger, K., Cosma, N. C., Fließbach, K., Freiesleben, S. D., Glanz, W., et al. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00701-7 · Cited by 36 · see citing works
Salvo, C. D., D’Antongiovanni, V., Benvenuti, L., d’Amati, A., Ippolito, C., Segnani, C., Pierucci, C., Bellini, G., Annese, T., Virgintino, D., et al. (2024) · Food & Function · doi:10.1039/d4fo02075h · Cited by 34 · see citing works
Aran, K. R., Gupta, G. D., & Singh, S. (2021) · Inflammopharmacology · doi:10.1007/s10787-021-00883-y · Cited by 33 · see citing works
“8 million people worldwide are associated with AD (Zhang et al. 2018).”
BackgroundConstipation and Its Associated Factors among Patients with Dementia
Chen, C., Liang, T.-M., Chen, H.-H., Lee, Y.-Y., Chuang, Y., & Chen, N.-C. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17239006 · Cited by 32 · see citing works
“Based on the similarity of the prevalence distributions of these two diseases, it can be speculated that Alzheimer’s disease may be correlated with constipation, which means that either disease may share a common factor, such as a low fiber intake or decreased exercise, or one disease could contribute to the occurrenc…”
BackgroundNeuroprotective expression of turmeric and curcumin
Abbas, S., Latif, M. S., Shafie, N. S., Ghazali, M. I., & Kormin, F. B. (2020) · Food Research · doi:10.26656/fr.2017.4(6).363 · Cited by 25 · see citing works
“Although the origin of turmeric is uncertain, it is thought to be originated from the tropical part of Southeast Asia, most probably India.”
BackgroundInfluentialKang, J., Lee, M., Park, M.-C., Lee, J., Lee, S., Park, J., Koyanagi, A., Smith, L., Nehs, C. J., Yon, D. K., et al. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.12.010 · Cited by 27 · see citing works
“The etiologies of constipation and AD remain unknown; however, according to a comparative epidemiological investigation, they share common risk factors such as sex, age, economic status, and dietary habits [15].”
BackgroundXia, Y., Prokop, S., Bell, B. M., Gorion, K.-M. M., Croft, C. L., Nasif, L. H., Xu, G. M., Riffe, C. J., Manaois, A. N., Strang, K. H., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03373-1 · Cited by 23 · see citing works
MicroRNA-Target Interaction Regulatory Network in Alzheimer’s Disease
Turk, A., Kunej, T., & Peterlin, B. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11121275 · Cited by 19 · see citing works
Xu, W., Yu, P., Shao, S., Xie, Z., Wu, Y., Liu, J., Xu, T., Cai, G., & Yang, H. (2024) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.13394 · Cited by 12 · see citing works
Yelleswarapu, N. K., Masino, M., Henderson, S., Fernandes, R., Swain, G. M., Galligan, J. J., & Xu, H. (2022) · Neurogastroenterology & Motility · doi:10.1111/nmo.14439 · Cited by 8 · see citing works
Huang, K., Tang, X., Li, Y., Zhang, Z., Ye, K. X., Shen, Q.-F., Wang, X., Zhu, X., Huang, X., Lu, G., et al. (2020) · Aging · doi:10.18632/aging.103674 · Cited by 8 · see citing works
“Alterations of gut microbiota may mechanically promote neurological inflammation, insulin resistance [7, 13], and consequent neurological pathogenesis [14].”
BackgroundSmach, M. A., Zarrouk, A., Hafsa, J., Gaffrej, H., Abdallah, J. B., Charfeddine, B., & Limem, K. (2020) · Journal of Medicinal Food · doi:10.1089/jmf.2020.0028 · Cited by 7 · see citing works
Review Current and Emerging Treatment Options for Alzheimer's Disease
Vats, D. K., Biswas, N., Pandian, P., & Kamalakannan, A. (2023) · Neurology Letters · doi:10.52547/nl.2.1.1 · Cited by 6 · see citing works
“Engaging in activities that individuals find enjoyable and meaningful can help improve mood, reduce stress, and promote social interaction (3, 20, 25).”
BackgroundAbdelaziz, A. I., Gad, A. M., & Azab, S. S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823304-7.00012-x · Cited by 4 · see citing works
Du, W., Xia, X., Gou, Q., & Qiu, Y. (2024) · Translational Oncology · doi:10.1016/j.tranon.2024.102169 · Cited by 3 · see citing works
“Immune regulation has been identified as a potential link between these conditions; however, the current body of evidence is insufficient to fully elucidate the precise nature of this relationship [8 – 11].”
Shen, M., Yu, X., Wu, S., Qiu, J., Wang, R., Li, K., & Zhang, Q. (2025) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2025.105182 · Cited by 2 · see citing works
Sennoside A alleviating cognitive impairment in APP/PS1 mice via balancing microbiome metabolism
Shi, Y., Ma, H., Li, H., Wang, Y., Wang, C., Zhang, N., Luo, G., Wang, Y., & Gao, X. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251389922 · Cited by 2 · see citing works
“10 In addition, previous studies have proved that laxatives, the mainstay of constipation management, could improve cognitive memory.”
Suo, J., Shen, X., He, J., Sun, H., Shi, Y., He, R., Zhang, X., Wang, X., Xi, Y., & Liang, W. (2023) · Epidemiology and Health · doi:10.4178/epih.e2023064 · Cited by 2 · see citing works
“We utilized group-based trajectory modeling to identify distinct trajectory groups of cognitive function as they relate to age [27].”
BackgroundMethodEditorial: Probiotics and constipation
Song, J., Zhao, X., Park, K.-Y., & Suo, H. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1114149 · Cited by 2 · see citing works
Fernandes, R., Masino, M., Flood, E. D., Lansdell, T. A., Srikrishna, N., Mui, R. K., Dorrance, A. M., Galligan, J. J., & Xu, H. (2025) · Neurogastroenterology & Motility · doi:10.1111/nmo.70056 · Cited by 1 · see citing works
Aspectos clínicos e moleculares do Alzheimer – revisão de literatura
Mota, W. Q., Lobão, I. D. S., da Cunha, J. V. L., Ferreira, L. A. A., Ramos, G. L., da Silva, S. M. F., de Sousa, I. S., & Moreira, H. N. S. (2024) · Brazilian Journal of Health Review · doi:10.34119/bjhrv7n2-465 · Cited by 1 · see citing works
Causal associations and shared genetic etiology between neurodegenerative diseases and constipation
Sun, W., Zhu, A., Chang, H., Xia, J., Gao, J., Zhang, Z., Chi, F., Zhu, Y., & Bao, X. (2025) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823251362469 · Cited by 1 · see citing works
“53 The brain can also affect the function and composition of gastrointestinal bacteria by altering intestinal permeability, which can result in the migration of these bacteria across the gut epithelium and trigger an immune reaction in the gastrointestinal mucosa.”
(2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823485-3.00040-3
A Preliminary Study on the Mechanism of Alcohol Abuse in Alzheimer’s Disease
徐, 加. (2023) · Open Journal of Natural Science · doi:10.12677/ojns.2023.112017
Molecular pathway of neurodegenerative diseases: Allopathic and herbal approaches
Kombo, H. Z., Yesmin, S., Parnholia, M., & Singh, G. (2025) · AIP conference proceedings · doi:10.1063/5.0272895
Bowel Health, Laxative Use, and Cognitive Function in Older Puerto Rican Adults
Dinesh, D., Lee, J. S., Scott, T. M., Tucker, K. L., & Palacios, N. (2025) · Journal of Aging Research · doi:10.1155/jare/2674457 · Cited by 1 · see citing works
“…among those with constipation [44], low cognitive scores among participants with constipation [45], Journal of Aging Research increased prevalence of AD among those with constipation [15], and a positive correlation between the prevalence and progression of dementia and constipation [18, 46].”
Constipation symptoms are associated with worse cognitive outcomes in older adults without dementia
Liu, X., Zhou, J. H., Xie, X., Zheng, W., Liu, D., Cheng, G., Hu, F., Wang, J., Cai, C., Liu, J., et al. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1578181
Self-citationLi, Z., Wang, X., Li, M., Zhang, G., Ye, Z., Wang, X., & Zhang, C. (2026) · Discover Oncology · doi:10.1007/s12672-025-04136-0
“The gut-brain axis further supports this link: gut microbiota alterations correlate directly or indirectly with amyloidosis [26].”
- Authors
- Zhang, T., Han, Y., Wang, J., Hou, D., Deng, H., Deng, Y. L., & Song, Z.
- Affiliations
- Third Xiangya Hospital (CN)
- Corresponding author
- Song, Zhi
- Venue
- Frontiers in Aging Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2018-09-28
- Volume
- 10
- Pages
- 176-176
- ISSN
- 1663-4365 (ISSN-L)
- PMC
- PMC6172982
- OpenAlex
- W2803118356
- Cited by
- 38
- References
- 121
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 6 · 2020: 8 · 2019: 3
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Aging Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81671296)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, colorectal cancer, constipation, gastrointestinal diseases, Western diet, pathogenesis, neurodegeneration, Parkinson's disease, diabetes mellitus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
