Short telomere length, myocardial infarction, ischemic heart disease, and early death

Weischer, Maren; Bojesen, Stig E.; Cawthon, Richard M.; Freiberg, Jacob J.; Tybjærg-Hansen, Anne; Nordestgaard, Børge G.

doi:10.1161/atvbaha.111.237271

Cited by 197Telomeres, Telomerase, and SenescenceGenetic Associations and EpidemiologyCardiac Health and Mental Health

Short telomere length, myocardial infarction, ischemic heart disease, and early death

Weischer, Maren, Bojesen, Stig E., Cawthon, Richard M., Freiberg, Jacob J., Tybjærg-Hansen, Anne, Nordestgaard, Børge G.·2012·Arteriosclerosis, Thrombosis, and Vascular Biology

DOI 10.1161/atvbaha.111.237271

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Abstract

Objective—: We tested the hypothesis that short telomere length is associated with increased risk of myocardial infarction, ischemic heart disease, and early death. Methods and Results—: We measured leukocyte telomere length in 2 prospective studies of 19 838 Danish general population participants from the Copenhagen City Heart Study and the Copenhagen General Population Study. Participants were followed for up to 19 years for incident myocardial infarction (n=929), ischemic heart disease (n=2038), and death (n=4342). Follow-up was 100% complete. Telomere length decreased linearly with increasing age in women and men in both studies ( P =7×10 −74 to P =3×10 −125 ). Multifactorially adjusted hazard ratios were 1.10 (95% CI 1.01–1.19) for myocardial infarction, 1.06 (1.00–1.11) for ischemic heart disease, and 1.09 (1.05–1.13) for early death per 1000–base pair decrease in telomere length. The multifactorially adjusted hazard ratios for the shortest versus the longest decile of telomere length were 1.49 (1.07–2.07) for myocardial infarction, 1.24 (1.01–1.53) for ischemic heart disease, and 1.25 (1.07–1.46) for early death. Conclusion—: Short telomere length is associated with only modestly increased risk of myocardial infarction, ischemic heart disease, and early death.

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Shorter LTL is linked with premature mortality and a reduction in years of healthy living.
“There are some studies linking shorter LTL with premature mortality (Cawthon et al., 2003; Fitzpatrick et al., 2011; Weischer et al., 2012) and a reduction in years of healthy living (Njajou et al., 2009).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Weischer et al., 2012
Short LTL in humans has been associated with serious medical illnesses including cardiovascular disease, diabetes, and cancer according to meta-analyses.
“Short LTL in humans has been associated with serious medical illnesses with some consistency according to metaanalyses, including cardiovascular disease, diabetes, and cancer (D'Mello et al., 2014; Weischer et al., 2012 Willeit et al, 2014; Wentzensen et al, 2011).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Weischer et al., 2012
Many serious comorbid medical illnesses may also be associated with decreased LTL, presumably independent of the effect of the psychiatric diagnosis.
“In addition to psychiatric and substance-related comorbidities, many serious comorbid medical illnesses may also be associated with decreased LTL (D'Mello et al., 2014; Weischer et al., 2012 Willeit et al, 2014; Wentzensen et al, 2011), and presumably this is independent of the effect of the psychiatric diagnosis.”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Weischer et al., 2012

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Authors: Weischer, M., Bojesen, S. E., Cawthon, R. M., Freiberg, J. J., Tybjærg-Hansen, A., & Nordestgaard, B. G.
Affiliations: University of Copenhagen (DK)
From the Department of Clinical Biochemistry, Herlev Hospital (M.W., S.E.B., J.J.F., B.G.N.), Herlev, Denmark; The Copenhagen General Population Study (M.W., S.E.B., J.J.F., A.T.-H., B.G.N.), Herlev, Denmark; The Copenhagen City Heart Study, Bispebjerg Hospital (S.E.B., A.T.-H., B.G.N.), Copenhagen, Denmark; and Department of Clinical Biochemistry, Rigshospitalet (A.T.-H.), Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark ...
ORCID: Weischer, Maren
Bojesen, Stig E.
Cawthon, Richard M.
Nordestgaard, Børge G.
Venue: Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2012-03
Volume: 32
Issue: 3
Pages: 822-829
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/atvbaha.111.237271
OpenAlex: W2004352690
Cited by: 197
References: 36
Citations by year: 2026: 5 · 2025: 1 · 2024: 14 · 2023: 6 · 2022: 6 · 2021: 12 · 2020: 17 · 2019: 15 · 2018: 18 · 2017: 13 · 2016: 22 · 2015: 19 · 2014: 27 · 2013: 17 · 2012: 5
FWCI: 10.70
Type: journal article
Language: en
Open access: closed
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords: telomere length, leukocyte telomere length, myocardial infarction, ischemic heart disease, early mortality, cardiovascular risk, aging, aging biomarkers
MeSH terms: Adult, Age Factors, Aged, Aging, Denmark, Female, Follow-Up Studies, Humans, Male, Middle Aged, Myocardial Infarction, Phenotype, Prospective Studies, Risk Factors, Time Factors, Proportional Hazards Models, Myocardial Ischemia, Risk Assessment, Genetic Predisposition to Disease, Telomere Shortening, Real-Time Polymerase Chain Reaction

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Short telomere length, myocardial infarction, ischemic heart disease, and early death

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