Short telomere length, myocardial infarction, ischemic heart disease, and early death

Weischer, Maren; Bojesen, Stig E.; Cawthon, Richard M.; Freiberg, Jacob J.; Tybjærg-Hansen, Anne; Nordestgaard, Børge G.

doi:10.1161/atvbaha.111.237271

Cited by 197Telomeres, Telomerase, and SenescenceGenetic Associations and EpidemiologyCardiac Health and Mental Health

Short telomere length, myocardial infarction, ischemic heart disease, and early death

Weischer, Maren, Bojesen, Stig E., Cawthon, Richard M., Freiberg, Jacob J., Tybjærg-Hansen, Anne, Nordestgaard, Børge G.·2012·Arteriosclerosis, Thrombosis, and Vascular Biology

DOI 10.1161/atvbaha.111.237271

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Abstract

Objective—: We tested the hypothesis that short telomere length is associated with increased risk of myocardial infarction, ischemic heart disease, and early death. Methods and Results—: We measured leukocyte telomere length in 2 prospective studies of 19 838 Danish general population participants from the Copenhagen City Heart Study and the Copenhagen General Population Study. Participants were followed for up to 19 years for incident myocardial infarction (n=929), ischemic heart disease (n=2038), and death (n=4342). Follow-up was 100% complete. Telomere length decreased linearly with increasing age in women and men in both studies ( P =7×10 −74 to P =3×10 −125 ). Multifactorially adjusted hazard ratios were 1.10 (95% CI 1.01–1.19) for myocardial infarction, 1.06 (1.00–1.11) for ischemic heart disease, and 1.09 (1.05–1.13) for early death per 1000–base pair decrease in telomere length. The multifactorially adjusted hazard ratios for the shortest versus the longest decile of telomere length were 1.49 (1.07–2.07) for myocardial infarction, 1.24 (1.01–1.53) for ischemic heart disease, and 1.25 (1.07–1.46) for early death. Conclusion—: Short telomere length is associated with only modestly increased risk of myocardial infarction, ischemic heart disease, and early death.

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Shorter LTL is linked with premature mortality and a reduction in years of healthy living.
“There are some studies linking shorter LTL with premature mortality (Cawthon et al., 2003; Fitzpatrick et al., 2011; Weischer et al., 2012) and a reduction in years of healthy living (Njajou et al., 2009).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Weischer et al., 2012
Short LTL in humans has been associated with serious medical illnesses including cardiovascular disease, diabetes, and cancer according to meta-analyses.
“Short LTL in humans has been associated with serious medical illnesses with some consistency according to metaanalyses, including cardiovascular disease, diabetes, and cancer (D'Mello et al., 2014; Weischer et al., 2012 Willeit et al, 2014; Wentzensen et al, 2011).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Weischer et al., 2012
Many serious comorbid medical illnesses may also be associated with decreased LTL, presumably independent of the effect of the psychiatric diagnosis.
“In addition to psychiatric and substance-related comorbidities, many serious comorbid medical illnesses may also be associated with decreased LTL (D'Mello et al., 2014; Weischer et al., 2012 Willeit et al, 2014; Wentzensen et al, 2011), and presumably this is independent of the effect of the psychiatric diagnosis.”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Weischer et al., 2012

Telomere measurement by quantitative PCR
Cawthon, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.10.e47 · Cited by 3,492 · see citing works
Self-citation
Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
Nordestgaard, B. G., Benn, M., Schnohr, P., & Tybjærg-Hansen, A. (2007) · JAMA · doi:10.1001/jama.298.3.299 · Cited by 2,058 · see citing works
Self-citation
Association between telomere length in blood and mortality in people aged 60 years or older
Cawthon, R. M., Smith, K. R., O'Brien, E., Sivatchenko, A., & Kerber, R. A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12384-7 · Cited by 1,761 · see citing works
Self-citation
Telomeres and human disease: ageing, cancer and beyond
Blasco, M. A. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1656 · Cited by 1,690 · see citing works
Telomere length measurement by a novel monochrome multiplex quantitative PCR method
Cawthon, R. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn1027 · Cited by 1,414 · see citing works
Self-citation
Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging
Blackburn, E. H., Greider, C. W., & Szostak, J. W. (2006) · Nature Medicine · doi:10.1038/nm1006-1133 · Cited by 1,030 · see citing works
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
Jaskelioff, M., Muller, F. L., Paik, J.-H., Thomas, E., Jiang, S., Adams, A. C., Sahin, E., Kost-Alimova, M., Protopopov, A., Cadiñanos, J., et al. (2011) · Nature · doi:10.1038/nature09603 · Cited by 857 · cited 2× · see citing works
“Heavy alcohol intake 990 (41) 909 (37) 919 (38) 876 (36) 9 10 5 426 (17) 469 (19) 445 (18) 453 (18) 0.”
Genetically elevated C-reactive protein and ischemic vascular disease
Zacho, J., Tybjærg-Hansen, A., Jensen, J. S., Grande, P., Sillesen, H., & Nordestgaard, B. G. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0707402 · Cited by 839 · see citing works
Self-citation
Leukocyte Telomere Length and Cardiovascular Disease in the Cardiovascular Health Study
Fitzpatrick, A. L., Kronmal, R. A., Gardner, J. P., Psaty, B. M., Jenny, N. S., Tracy, R. P., Walston, J., Kimura, M., & Aviv, A. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj346 · Cited by 773 · see citing works
Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study
Brouilette, S., Moore, J. S., McMahon, A. D., Thompson, J. R., Ford, I., Shepherd, J., Packard, C. J., & Samani, N. J. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60071-3 · Cited by 744 · see citing works
Telomere shortening in atherosclerosis
Samani, N. J., Boultby, R., Butler, R., Thompson, J. R., & Goodall, A. H. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05633-1 · Cited by 609 · see citing works
White Cell Telomere Length and Risk of Premature Myocardial Infarction
Brouilette, S., Singh, R. K., Thompson, J. R., Goodall, A. H., & Samani, N. J. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000067426.96344.32 · Cited by 590 · see citing works
The Association Between Physical Activity in Leisure Time and Leukocyte Telomere Length
Cherkas, L. F. (2008) · Archives of Internal Medicine · doi:10.1001/archinternmed.2007.39 · Cited by 568 · see citing works
Nonfasting triglycerides and risk of ischemic stroke in the general population
Freiberg, J. J. (2008) · JAMA · doi:10.1001/jama.2008.621 · Cited by 542 · see citing works
Self-citation
Telomere Length in the Newborn
Okuda, K., Bardeguez, A., Gardner, J. P., Rodriguez, P., Ganesh, V., Kimura, M., Skurnick, J., Awad, G., & Aviv, A. (2002) · Pediatric Research · doi:10.1203/00006450-200209000-00012 · Cited by 507 · see citing works
Telomere length and risk of incident cancer and cancer mortality
Willeit, P., Willeit, J., Mayr, A., Weger, S., Oberhollenzer, F., Brandstätter, A., Kronenberg, F., & Kiechl, S. (2010) · JAMA · doi:10.1001/jama.2010.897 · Cited by 484 · see citing works
Measurement of telomere length by the Southern blot analysis of terminal restriction fragment lengths
Kimura, M., Stone, R. C., Hunt, S. C., Skurnick, J., Lu, X., Cao, X., Harley, C. B., & Aviv, A. (2010) · Nature Protocols · doi:10.1038/nprot.2010.124 · Cited by 461 · see citing works
Is Telomere Length a Biomarker of Aging? A Review
Mather, K. A., Jorm, A. F., Parslow, R., & Christensen, H. M. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq180 · Cited by 450 · see citing works
Going against the grain: chemotaxis and infection in Vibrio cholerae
Butler, S. M., & Camilli, A. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1207 · Cited by 405 · see citing works
Telomeres as Biomarkers for Ageing and Age-Related Diseases
von Zglinicki, T., & Martin-Ruiz, C. M. (2005) · Current Molecular Medicine · doi:10.2174/1566524053586545 · Cited by 393 · see citing works
Telomere length in different tissues of elderly patients
Friedrich, U., Griese, E.-U., Schwab, M., Fritz, P., Thon, K.-P., & Klotz, U. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00173-1 · Cited by 325 · see citing works
The effects of social status on biological aging as measured by white‐blood‐cell telomere length
Cherkas, L. F., Aviv, A., Valdes, A. M., Hunkin, J., Gardner, J. P., Surdulescu, G. L., Kimura, M., & Spector, T. D. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00222.x · Cited by 306 · see citing works
Cellular Aging Reflected by Leukocyte Telomere Length Predicts Advanced Atherosclerosis and Cardiovascular Disease Risk
Willeit, P., Willeit, J., Kloss‐Brandstätter, A., Ehrlenbach, S., Mayr, A., Gasperi, A., Weger, S., Oberhollenzer, F., Reindl, M., Kronenberg, F., et al. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.205492 · Cited by 289 · see citing works
No Association Between Telomere Length and Survival Among the Elderly and Oldest Old
Bischoff, C., Petersen, H. C., Graakjær, J., Andersen‐Ranberg, K., Vaupel, J. W., Bohr, V. A., Kølvraa, S., & Christensen, K. (2006) · Epidemiology · doi:10.1097/01.ede.0000199436.55248.10 · Cited by 243 · see citing works
Telomere Length Trajectory and Its Determinants in Persons with Coronary Artery Disease: Longitudinal Findings from the Heart and Soul Study
Farzaneh-Far, R., Lin, J., Epel, E., Lapham, K., Blackburn, E., & Whooley, M. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008612 · Cited by 203 · see citing works
Influences on the reduction of relative telomere length over 10 years in the population-based Bruneck Study: introduction of a well-controlled high-throughput assay
Ehrlenbach, S., Willeit, P., Kiechl, S. J., Willeit, J., Reindl, M., Schanda, K., Kronenberg, F., & Kloss‐Brandstätter, A. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyp273 · Cited by 195 · see citing works
Blood leucocyte telomere DNA content predicts vascular telomere DNA content in humans with and without vascular disease
Wilson, W. R. W., Herbert, K. E., Mistry, Y., Stevens, S. E., Patel, H. R., Hastings, R. A., Thompson, M. M., & Williams, B. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn386 · Cited by 185 · see citing works
A Prospective Study of Telomere Length and the Risk of Skin Cancer
Han, J., Qureshi, A. A., Prescott, J., Guo, Q., Ye, L., Hunter, D. J., & Vivo, I. D. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.238 · Cited by 173 · see citing works
Comparison of Chromosome Telomere Integrity in Multiple Tissues from Subjects at Different Ages
Butler, M. G., Tilburt, J. C., DeVries, A., Muralidhar, B., Aue, G., Hedges, L. K., Atkinson, J. T., & Schwartz, H. S. (1998) · Cancer Genetics and Cytogenetics · doi:10.1016/s0165-4608(98)00029-6 · Cited by 124 · see citing works
Telomere Length Dynamics in Vascular Disease: A Review
Butt, H. Z., Atturu, G., London, N. J. M., Sayers, R. D., & Bown, M. J. (2010) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2010.04.012 · Cited by 95 · see citing works
Association of shorter mean telomere length with risk of incident myocardial infarction: A prospective, nested case–control approach
Zee, R. Y. L., Michaud, S. E., Germer, S., & Ridker, P. M. (2009) · Clinica Chimica Acta · doi:10.1016/j.cca.2009.02.004 · Cited by 87 · see citing works
Shared environmental factors associated with telomere length maintenance in elderly male twins
Huda, N., Tanaka, H., Herbert, B., Reed, T., & Gilley, D. P. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00330.x · Cited by 66 · see citing works
Telomeres are shorter in myocardial infarction patients compared to healthy subjects: correlation with environmental risk factors
Maubaret, C. G., Salpea, K. D., Jain, A., Cooper, J. A., Hamsten, A., Sanders, J., Montgomery, H., Neil, A., Nair, D. R., & Humphries, S. E. (2010) · Journal of Molecular Medicine · doi:10.1007/s00109-010-0624-3 · Cited by 46 · see citing works
Substantial variation in qPCR measured mean blood telomere lengths in young men from eleven European countries
Eisenberg, D. T. A., Salpea, K. D., Kuzawa, C. W., Hayes, M. G., & Humphries, S. E. (2011) · American Journal of Human Biology · doi:10.1002/ajhb.21126 · Cited by 44 · see citing works
Techniques in gerontology: Cell lines as standards for telomere length and telomerase activity assessment
Fehrer, C., Grillari‐Voglauer, R., Wieser, M., Pfister, G., Brunauer, R., Cioca, D., Grubeck‐Loebenstein, B., & Lepperdinger, G. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.03.016 · Cited by 27 · see citing works
Effect of ginseng saponin, arsenic trioxide, beta-elemene combined with CTX on telomere-telomerase system in K562 cell line.
Wang, Y., & Fang, M. (2006) · PubMed · Cited by 12 · see citing works

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Haycock, P. C., Heydon, E. E., Kaptoge, S., Butterworth, A. S., Thompson, A., & Willeit, P. (2014) · BMJ · doi:10.1136/bmj.g4227 · Cited by 856 · see citing works
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
Study, A. C., Bojesen, S. E., Study, A. O. C., (GENICA), G. E. I. A. B. C., (SWE-BRCA), S. B. C. S., (EMBRACE), E. S. O. B. &. B. M. C., (GEMO), G. M. O. C. R. I. B. M. C., Pooley, K. A., Johnatty, S. E., Beesley, J., et al. (2013) · Nature Genetics · doi:10.1038/ng.2566 · Cited by 527 · see citing works
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Gardner, M. P., Bann, D., Wiley, L., Cooper, R., Hardy, R., Nitsch, D., Martin-Ruiz, C. M., Shiels, P. G., Sayer, A. A., Barbieri, M., et al. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.12.004 · Cited by 513 · see citing works
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Müezzinler, A., Zaineddin, A. K., & Brenner, H. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.01.003 · Cited by 474 · see citing works
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D’Mello, M. J. J., Ross, S. A., Briel, M., Anand, S. S., Gerstein, H., & Paré, G. (2015) · Circulation: Cardiovascular Genetics · doi:10.1161/circgenetics.113.000485 · Cited by 350 · see citing works
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Liberale, L., Montecucco, F., Tardif, J., Libby, P., & Camici, G. G. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz961 · Cited by 360 · see citing works
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Needham, B. L., Adler, N. E., Gregorich, S. E., Rehkopf, D. H., Lin, J., Blackburn, E. H., & Epel, E. S. (2013) · Social Science & Medicine · doi:10.1016/j.socscimed.2013.02.023 · Cited by 325 · see citing works
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Lu, A. T.-H., Xue, L., Salfati, E., Chen, B. H., Ferrucci, L., Levy, D. A., Joehanes, R., Murabito, J. M., Kiel, D. P., Tsai, P.-C., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02697-5 · Cited by 208 · see citing works
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Kong, C. M., Lee, X. W., & Wang, X. (2013) · The FEBS Journal · doi:10.1111/febs.12326 · Cited by 194 · see citing works
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Vetter, V. M., Meyer, A., Karbasiyan, M., Steinhagen‐Thiessen, E., Hopfenmüller, W., & Demuth, I. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly184 · Cited by 87 · see citing works
Telomere Length, Oxidative Stress, Inflammation and BDNF Levels in Siblings of Patients with Bipolar Disorder: Implications for Accelerated Cellular Aging
Vasconcelos-Moreno, M. P., Fries, G. R., Gubert, C., dos Santos, B. T. M. Q., Fijtman, A., Sartori, J., Ferrari, P., Grün, L. K., Parisi, M. M., Guma, F. T. C. R., et al. (2017) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx001 · Cited by 92 · see citing works
Telomere length and chronological age across the human lifespan: A systematic review and meta-analysis of 414 study samples including 743,019 individuals
Ye, Q., Apsley, A. T., Etzel, L. C., Hastings, W. J., Kozlosky, J. T., Walker, C., Wolf, S. E., & Shalev, I. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102031 · Cited by 89 · see citing works
Telomere length and common disease: study design and analytical challenges
Barrett, J. H., Iles, M. M., Dunning, A. M., & Pooley, K. A. (2015) · Human Genetics · doi:10.1007/s00439-015-1563-4 · Cited by 84 · see citing works
Telomeres and cardiovascular disease risk: an update 2013
Nilsson, P. M., Tufvesson, H., Leósdóttir, M., & Melander, O. (2013) · Translational research · doi:10.1016/j.trsl.2013.05.004 · Cited by 83 · see citing works
Inflammatory Co-morbidities in HIV+ Individuals: Learning Lessons from Healthy Ageing
Hearps, A. C., Martin, G. E., Rajasuriar, R., & Crowe, S. M. (2014) · Current HIV/AIDS Reports · doi:10.1007/s11904-013-0190-8 · Cited by 82 · see citing works
Longitudinal Changes in Leukocyte Telomere Length and Mortality in Humans
Bendix, L., Thinggaard, M., Fenger, M., Kølvraa, S., Avlund, K., Linneberg, A. R., & Osler, M. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt153 · Cited by 82 · see citing works
Shorter leukocyte telomere length is associated with higher risk of infections: a prospective study of 75,309 individuals from the general population
Helby, J., Nordestgaard, B. G., Benfield, T., & Bojesen, S. E. (2017) · Haematologica · doi:10.3324/haematol.2016.161943 · Cited by 80 · see citing works
Self-citation
Leukocyte Telomere Length and Risks of Incident Coronary Heart Disease and Mortality in a Racially Diverse Population of Postmenopausal Women
Carty, C. L., Kooperberg, C. L., Liu, J., Herndon, M., Assimes, T. L., Hou, L., Kroenke, C. H., LaCroix, A. Z., Kimura, M., Aviv, A., et al. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305838 · Cited by 83 · see citing works
Neighborhood characteristics and leukocyte telomere length: The Multi-Ethnic Study of Atherosclerosis
Needham, B. L., Carroll, J., Roux, A. V. D., Fitzpatrick, A. L., Moore, K., & Seeman, T. E. (2014) · Health & Place · doi:10.1016/j.healthplace.2014.04.009 · Cited by 74 · see citing works
Dietary Fiber and Telomere Length in 5674 U.S. Adults: An NHANES Study of Biological Aging
Tucker, L. A. (2018) · Nutrients · doi:10.3390/nu10040400 · Cited by 69 · see citing works
Knee Osteoarthritis, Potential Mediators, and Risk of All‐Cause Mortality: Data From the Osteoarthritis Initiative
Wang, Y., Nguyen, U., Lane, N. E., Lu, N., Wei, J., Lei, G., Zeng, C., & Zhang, Y. (2020) · Arthritis Care & Research · doi:10.1002/acr.24151 · Cited by 70 · see citing works
The role of telomeres and vitamin D in cellular aging and age-related diseases
Pusceddu, I., Farrell, C.-J. L., Pierro, A. M. D., Jani, E., Herrmann, W., & Herrmann, M. (2015) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2014-1184 · Cited by 68 · see citing works
Perinatal Complications and Aging Indicators by Midlife
Shalev, I., Caspi, A., Ambler, A. P., Belsky, D. W., Chapple, S., Cohen, H. J., Israel, S., Poulton, R., Ramrakha, S., Rivera, C. D., et al. (2014) · PEDIATRICS · doi:10.1542/peds.2014-1669 · Cited by 65 · see citing works
Why are there associations between telomere length and behaviour?
Bateson, M., & Nettle, D. (2018) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2016.0438 · Cited by 61 · see citing works
Association between leucocyte telomere length and cardiovascular disease in a large general population in the United States
Xu, C., Wang, Z., Su, X., Da, M., Yang, Z., Duan, W., & Mo, X. (2020) · Scientific Reports · doi:10.1038/s41598-019-57050-1 · Cited by 57 · see citing works
Telomere shortening over 6 years is associated with increased subclinical carotid vascular damage and worse cardiovascular prognosis in the general population
Baragetti, A., Palmen, J., Garlaschelli, K., Grigore, L., Pellegatta, F., Tragni, E., Catapano, A. L., Humphries, S. E., Norata, G. D., & Talmud, P. J. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12282 · Cited by 57 · see citing works
Longitudinal decline of leukocyte telomere length in old age and the association with sex and genetic risk
Berglund, K., Reynolds, C. A., Ploner, A., Gerritsen, L., Hovatta, I., Pedersen, N. L., & Hägg, S. (2016) · Aging · doi:10.18632/aging.100995 · Cited by 56 · see citing works
Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers
Kachuri, L., Saarela, O., Bojesen, S. E., Smith, G. D., Liu, G., Landi, M. T., Caporaso, N. E., Christiani, D. C., Johansson, M., Panico, S., et al. (2018) · International Journal of Epidemiology · doi:10.1093/ije/dyy140 · Cited by 56 · see citing works
Self-citation
Observational and genetic studies of short telomeres and Alzheimer’s disease in 67,000 and 152,000 individuals: a Mendelian randomization study
Madrid, A. S., Rasmussen, K. L., Rode, L., Frikke‐Schmidt, R., Nordestgaard, B. G., & Bojesen, S. E. (2019) · European Journal of Epidemiology · doi:10.1007/s10654-019-00563-w · Cited by 54 · see citing works
Self-citation
Association of TERC and OBFC1 Haplotypes with Mean Leukocyte Telomere Length and Risk for Coronary Heart Disease
Maubaret, C. G., Salpea, K. D., Romanoski, C. E., Folkersen, L., Cooper, J. A., Stephanou, C., Li, K., Palmen, J., Hamsten, A., Neil, A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083122 · Cited by 50 · see citing works
Influence of DNA extraction methods on relative telomere length measurements and its impact on epidemiological studies
Raschenberger, J., Lamina, C., Haun, M., Kollerits, B., Coassin, S., Boes, E., Kedenko, L., Köttgen, A., & Kronenberg, F. (2016) · Scientific Reports · doi:10.1038/srep25398 · Cited by 49 · see citing works
Accelerated leukocyte telomere erosion in schizophrenia: Evidence from the present study and a meta-analysis
Rao, S., Kota, L. N., Li, Z., Yao, Y., Tang, J., Mao, C., Jain, S., Xu, Y. J., & Xu, Q. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.04.010 · Cited by 47 · see citing works
Common mental disorders and association with telomere length (Review)
Vakonaki, E., Tsiminikaki, K., Plaitis, S., Fragkiadaki, P., Tsoukalas, D., Katsikantami, I., Vaki, G., Tzatzarakis, M., Spandidos, D. A., & Tsatsakis, A. M. (2018) · Biomedical Reports · doi:10.3892/br.2018.1040 · Cited by 45 · see citing works
Decline in telomere length by age and effect modification by gender, allostatic load and comorbidities in National Health and Nutrition Examination Survey (1999-2002)
Ghimire, S., Hill, C. V., Sy, F. S., & Rodriguez, R. (2019) · PLoS ONE · doi:10.1371/journal.pone.0221690 · Cited by 44 · see citing works
Telomeres, Aging and Exercise: Guilty by Association?
Chilton, W., O’Brien, B. J., & Charchar, F. J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122573 · Cited by 43 · see citing works
Production of antimicrobial peptides is preserved in aging
Castañeda‐Delgado, J. E., Miranda-Castro, N. Y., González‐Amaro, R., Gonzalez-Curiel, I. E., Montoya-Rosales, A., Rivas-Calderon, B., & Rivas-Santiago, B. T. (2013) · Clinical Immunology · doi:10.1016/j.clim.2013.05.015 · Cited by 42 · see citing works
Low Intake of Vitamin E Accelerates Cellular Aging in Patients With Established Cardiovascular Disease: The CORDIOPREV Study
Corina, A., Rangel-Zúñiga, O. A., Jiménez-Lucena, R., Alcalá-Díaz, J. F., Quintana-Navarro, G., Yubero-Serrano, E. M., López-Moreno, J., Delgado-Lista, J., Tinahones, F., Ordovás, J. M., et al. (2019) · The Journals of Gerontology: Series A · doi:10.1093/gerona/gly195 · Cited by 41 · see citing works
Association of relative telomere length with cardiovascular disease in a large chronic kidney disease cohort: The GCKD study
Raschenberger, J., Kollerits, B., Titze, S. I., Köttgen, A., Bärthlein, B., Ekici, A. B., Forer, L., Schönherr, S., Weißensteiner, H., Haun, M., et al. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.08.020 · Cited by 41 · see citing works
Caffeine consumption and telomere length in men and women of the National Health and Nutrition Examination Survey (NHANES)
Tucker, L. A. (2017) · Nutrition & Metabolism · doi:10.1186/s12986-017-0162-x · Cited by 41 · see citing works
The relationship between neighborhood socioeconomic deprivation and telomere length: The 1999–2002 National Health and Nutrition Examination Survey
Powell‐Wiley, T. M., Gebreab, S. Y., Claudel, S. E., Ayers, C. R., Andrews, M. R., Adu‐Brimpong, J., Berrigan, D. A., & Davis, S. (2019) · SSM - Population Health · doi:10.1016/j.ssmph.2019.100517 · Cited by 41 · see citing works
High tobacco consumption is causally associated with increased all-cause mortality in a general population sample of 55 568 individuals, but not with short telomeres: a Mendelian randomization study
Rode, L., Bojesen, S. E., Weischer, M., & Nordestgaard, B. G. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyu119 · Cited by 42 · see citing works
Self-citation
Telomerase RNA Component Genetic Variants Interact With the Mediterranean Diet Modifying the Inflammatory Status and its Relationship With Aging: CORDIOPREV Study
Gómez-Delgado, F., Delgado‐Lista, J., López-Moreno, J., Rangel-Zúñiga, O. A., Alcala-Diaz, J. F., Leon‐Acuña, A., Corina, A., Yubero‐Serrano, E. M., Torres-Peña, J. D., Camargo, A., et al. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw194 · Cited by 40 · see citing works
Plasma micronutrient levels and telomere length in children
Milne, E., O’Callaghan, N. J., Ramankutty, P., de Klerk, N. H., Greenop, K. R., Armstrong, B. K., Miller, M., & Fenech, M. F. (2014) · Nutrition · doi:10.1016/j.nut.2014.08.005 · Cited by 39 · see citing works
Leukocyte telomere length and cardiovascular disease in African Americans: The Jackson Heart Study
Mwasongwe, S. E., Gao, Y. L., Griswold, M. E., Wilson, J. G., Aviv, A., Reiner, A. P., & Raffield, L. M. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.09.016 · Cited by 39 · see citing works
Visible aging signs as risk markers for ischemic heart disease: Epidemiology, pathogenesis and clinical implications
Christoffersen, M., & Tybjærg‐Hansen, A. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.11.002 · Cited by 39 · see citing works
Self-citation
Telomere length and depression: Prospective cohort study and Mendelian randomisation study in 67 306 individuals
Wium‐Andersen, M. K., Ørsted, D. D., Rode, L., Bojesen, S. E., & Nordestgaard, B. G. (2016) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.115.178798 · Cited by 38 · see citing works
Self-citation
Combined influence of depressive symptoms and systemic inflammation on all-cause and cardiovascular mortality: evidence for differential effects by gender in the English Longitudinal Study of Ageing
Lawes, S., Demakakos, P., Steptoe, A., Lewis, G., & Carvalho, L. A. (2018) · Psychological Medicine · doi:10.1017/s003329171800209x · Cited by 39 · see citing works
Selenium and Coenzyme Q10 Intervention Prevents Telomere Attrition, with Association to Reduced Cardiovascular Mortality—Sub-Study of a Randomized Clinical Trial
Opstad, T. B., Alexander, J., Aaseth, J., Larsson, A. O., Seljeflot, I., & Alehagen, U. (2022) · Nutrients · doi:10.3390/nu14163346 · Cited by 37 · see citing works
Polychlorinated Biphenyls and Leukocyte Telomere Length: An Analysis of NHANES 1999–2002
Scinicariello, F., & Buser, M. C. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.11.028 · Cited by 37 · see citing works
Predicting Survival from Telomere Length versus Conventional Predictors: A Multinational Population-Based Cohort Study
Glei, D. A., Goldman, N., Risques, R. A., Rehkopf, D. H., Dow, W. H., Rosero‐Bixby, L., & Weinstein, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152486 · Cited by 38 · see citing works
Using blood test parameters to define biological age among older adults: association with morbidity and mortality independent of chronological age validated in two separate birth cohorts
Drewelies, J., Hülür, G., Düzel, S., Vetter, V. M., Pawelec, G., Steinhagen‐Thiessen, E., Wagner, G. G., Lindenberger, U., Lill, C. M., Bertram, L., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00662-9 · Cited by 34 · see citing works
Leukocyte telomere length, cancer incidence and all‐cause mortality among Chinese adults: Singapore Chinese Health Study
Samavat, H., Luu, H. N., Beckman, K. B., Jin, A., Wang, R., Koh, W., & Yuan, J. (2020) · International Journal of Cancer · doi:10.1002/ijc.33211 · Cited by 34 · see citing works
Longitudinal changes in leukocyte telomere length and mortality in elderly Swedish men
Yuan, X., Kronström, M., Hellénius, M.-L., Cederholm, T., Xu, D., & Sjögren, P. (2018) · Aging · doi:10.18632/aging.101611 · Cited by 34 · see citing works
Relation Between Leukocyte Telomere Length and Incident Coronary Heart Disease Events (from the 1995 Canadian Nova Scotia Health Survey)
Ye, S., Shaffer, J. A., Kang, M. S., Harlapur, M., Muntner, P., Epel, E. S., Guernsey, D. L., Schwartz, J. E., Davidson, K. W., Kirkland, S., et al. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.12.017 · Cited by 33 · see citing works
Use of Telomere Length as a Biomarker for Aging and Age-Related Disease
Fossel, M. (2012) · Current Translational Geriatrics and Experimental Gerontology Reports · doi:10.1007/s13670-012-0013-6 · Cited by 32 · see citing works
Leucocyte Telomere Length and Risk of Cardiovascular Disease in a Cohort of 1,397 Danish Men and Women
Ellehoj, H., Bendix, L., & Osler, M. (2015) · Cardiology · doi:10.1159/000441819 · Cited by 32 · see citing works
Urinary Phthalates and Leukocyte Telomere Length: An Analysis of NHANES 1999–2002
Scinicariello, F., Feroe, A. G., & Attanasio, R. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.02.027 · Cited by 30 · see citing works
Short Leukocyte Telomere Length Is Associated With Cardioembolic Stroke Risk in Patients With Atrial Fibrillation
Allende, M., Molina, E., González‐Porras, J. R., Toledo, E., Lecumberri, R., & Hermida, J. (2016) · Stroke · doi:10.1161/strokeaha.115.011837 · Cited by 31 · see citing works
Accelerated Biological Aging Secondary to Cardiometabolic Risk Factors Is a Predictor of Cardiovascular Mortality: A Systematic Review and Meta-analysis
Emami, M., Agbaedeng, T. A., Thomas, G., Middeldorp, M. E., Thiyagarajah, A., Wong, C. X. J., Elliott, A. D., Gallagher, C., Hendriks, J., Lau, D. H., et al. (2021) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2021.10.012 · Cited by 31 · see citing works
A Test of Biological and Behavioral Explanations for Gender Differences in Telomere Length: The Multi-Ethnic Study of Atherosclerosis
Needham, B. L., Roux, A. V. D., Bird, C. E., Bradley, R. D., Fitzpatrick, A. L., Jacobs, D. R., Ouyang, P., Seeman, T. E., Thurston, R. C., Vaidya, D. M., et al. (2014) · Biodemography and Social Biology · doi:10.1080/19485565.2014.947471 · Cited by 30 · see citing works
Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
Axelrad, M. D., Budagov, T., & Atzmon, G. (2013) · Journal of Visualized Experiments · doi:10.3791/50246 · Cited by 30 · see citing works
Telomere Length Calibration from qPCR Measurement: Limitations of Current Method
Wang, Y., Savage, S. A., Alsaggaf, R., Aubert, G., Dagnall, C. L., Spellman, S. R., Lee, S. J., Hicks, B. D., Jones, K. M., Katki, H. A., et al. (2018) · Cells · doi:10.3390/cells7110183 · Cited by 29 · see citing works
Leukocyte telomere length correlates with glucose control in adults with recently diagnosed type 2 diabetes
Rosa, E. C. C. C., dos Santos, R. R. C., Fernandes, L. F. A., Neves, F. D. A. R., Coelho, M. S., & Amato, A. A. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.10.020 · Cited by 28 · see citing works
Sequence variation in telomerase reverse transcriptase (TERT) as a determinant of risk of cardiovascular disease: the Atherosclerosis Risk in Communities (ARIC) study
Bressler, J., Franceschini, N., Demerath, E. W., Mosley, T. H., Folsom, A. R., & Boerwinkle, E. (2015) · BMC Medical Genetics · doi:10.1186/s12881-015-0194-x · Cited by 28 · see citing works
In vivo biomarkers of structural and functional brain development and aging in humans
Franke, K., Bublak, P., Hoyer, D., Billiet, T., Gaser, C., Witte, O. W., & Schwab, M. G. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.11.002 · Cited by 28 · see citing works
Relative Telomere Length and Cardiovascular Risk Factors
Koriath, M., Müller, C., Pfeiffer, N., Nickels, S., Beutel, M. E., Schmidtmann, I. M., Rapp, S., Münzel, T. F., Westermann, D., Karakas, M., et al. (2019) · Biomolecules · doi:10.3390/biom9050192 · Cited by 27 · see citing works
Role of Telomeres Shortening in Atherogenesis: An Overview
Yegorov, Y. E., Poznyak, A. V., Nikiforov, N. G., Starodubova, A. V., & Orekhov, A. N. (2021) · Cells · doi:10.3390/cells10020395 · Cited by 26 · see citing works
The Year in Atherothrombosis
Sanz, J., Moreno, P., & Fuster, V. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.06.045 · Cited by 26 · see citing works
The Role of FNDC5/Irisin in Cardiovascular Disease
Grzeszczuk, M., Dzięgiel, P., & Nowińska, K. (2024) · Cells · doi:10.3390/cells13030277 · Cited by 25 · see citing works
Shorter Ends, Faster End? Leukocyte Telomere Length and Mortality Among Older Taiwanese
Glei, D. A., Goldman, N., Weinstein, M., & Risques, R. A. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu191 · Cited by 25 · see citing works
Milk Fat Intake and Telomere Length in U.S. Women and Men: The Role of the Milk Fat Fraction
Tucker, L. A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/1574021 · Cited by 25 · see citing works
Leisure-Time Screen-Based Sedentary Behavior and Leukocyte Telomere Length: Implications for a New Leisure-Time Screen-Based Sedentary Behavior Mechanism
Loprinzi, P. D. (2015) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2015.02.018 · Cited by 24 · see citing works
Expression of telomerase reverse transcriptase positively correlates with duration of lithium treatment in bipolar disorder
Lundberg, M., Biernacka, J. M., Lavebratt, C., Druliner, B. R., Ryu, E., Geske, J. R., Colby, C. L., Boardman, L., Frye, M. A., & Schalling, M. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.112865 · Cited by 24 · see citing works
Telomere Length and Coronary Atherosclerosis in Rheumatoid Arthritis
Ormseth, M. J., Solus, J. F., Oeser, A. M., Bian, A., Gebretsadik, T. S., Shintani, A., Raggi, P., & Stein, C. (2016) · The Journal of Rheumatology · doi:10.3899/jrheum.151115 · Cited by 24 · see citing works
Reduced telomere shortening in lifelong trained male football players compared to age-matched inactive controls
Hagman, M., Werner, C. M., Kamp, K., Fristrup, B., Hornstrup, T., Meyer, T., Böhm, M., Laufs, U., & Krustrup, P. (2020) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2020.05.009 · Cited by 23 · see citing works

Association of shorter mean telomere length with risk of incident myocardial infarction: A prospective, nested case–control approach
Zee, R. Y. L., Michaud, S. E., Germer, S., & Ridker, P. M. (2009) · Clinica Chimica Acta · doi:10.1016/j.cca.2009.02.004 · Cited by 87 · see citing works
Association between telomere length and heart disease in a narrow age cohort of older people
Starr, J., McGurn, B., HARRIS, S., Whalley, L. J., Deary, I. J., & Shiels, P. G. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.12.002 · Cited by 49 · see citing works
Change in Leukocyte Telomere Length Predicts Mortality in Patients with Stable Coronary Heart Disease from the Heart and Soul Study
Goglin, S. E., Farzaneh‐Far, R., Epel, E. S., Lin, J., Blackburn, E. H., & Whooley, M. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160748 · Cited by 68 · see citing works
Association of Telomere Length With Myocardial Infarction: A Prospective Cohort From the Population Based HUNT 2 Study
Østhus, I. B. Ø., Lydersen, S., Dalen, H., Nauman, J., & Wisløff, U. (2017) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2017.04.001 · Cited by 15 · see citing works
Telomere Length: Implications for Atherogenesis
Yin, H. R., & Pickering, J. G. (2023) · Current Atherosclerosis Reports · doi:10.1007/s11883-023-01082-6 · Cited by 24 · see citing works

Authors: Weischer, M., Bojesen, S. E., Cawthon, R. M., Freiberg, J. J., Tybjærg-Hansen, A., & Nordestgaard, B. G.
Affiliations: University of Copenhagen (DK)
From the Department of Clinical Biochemistry, Herlev Hospital (M.W., S.E.B., J.J.F., B.G.N.), Herlev, Denmark; The Copenhagen General Population Study (M.W., S.E.B., J.J.F., A.T.-H., B.G.N.), Herlev, Denmark; The Copenhagen City Heart Study, Bispebjerg Hospital (S.E.B., A.T.-H., B.G.N.), Copenhagen, Denmark; and Department of Clinical Biochemistry, Rigshospitalet (A.T.-H.), Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark ...
ORCID: Weischer, Maren
Bojesen, Stig E.
Cawthon, Richard M.
Nordestgaard, Børge G.
Venue: Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2012-03
Volume: 32
Issue: 3
Pages: 822-829
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/atvbaha.111.237271
OpenAlex: W2004352690
Cited by: 197
References: 36
Citations by year: 2026: 5 · 2025: 1 · 2024: 14 · 2023: 6 · 2022: 6 · 2021: 12 · 2020: 17 · 2019: 15 · 2018: 18 · 2017: 13 · 2016: 22 · 2015: 19 · 2014: 27 · 2013: 17 · 2012: 5
FWCI: 10.70
Type: journal article
Language: en
Open access: closed
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords: telomere length, leukocyte telomere length, myocardial infarction, ischemic heart disease, early mortality, cardiovascular risk, aging, aging biomarkers
MeSH terms: Adult, Age Factors, Aged, Aging, Denmark, Female, Follow-Up Studies, Humans, Male, Middle Aged, Myocardial Infarction, Phenotype, Prospective Studies, Risk Factors, Time Factors, Proportional Hazards Models, Myocardial Ischemia, Risk Assessment, Genetic Predisposition to Disease, Telomere Shortening, Real-Time Polymerase Chain Reaction

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Short telomere length, myocardial infarction, ischemic heart disease, and early death

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