The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
Subjective Cognitive Impairment and Affective Symptoms: A Systematic Review
Open accessAbstract
PURPOSE OF STUDY: Subjective cognitive impairment (SCI) has been argued to reflect affective symptoms (i.e., depression and anxiety) rather than actual cognitive issues. Although a number of studies exist that look at the associations between SCI and affective symptoms, no review is available to aggregate this disparate literature. We addressed this gap by conducting a systematic review to better understand the relationships among SCI and affective symptoms among older adults in both community and clinical settings. DESIGN AND METHODS: We reviewed available literature per the criteria of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Weight of evidence (WoE) ratings and narrative synthesis were completed for 58 articles. RESULTS: A majority of studies focused on community-based samples (n = 40). Approximately half (53%) of the articles reviewed met high WoE criteria for the current review. Cross-sectional findings consistently identified a positive relationship among SCI and affective symptoms. Findings from available longitudinal studies (n = 9) were mixed but suggested a possible reciprocal relationship among SCI and depression. The relationship between SCI and anxiety appeared to be driven by fears over loss of function. Following consultation with health professionals, the association between SCI and anxiety was diminished or eliminated. IMPLICATIONS: Although SCI is consistently related to affective symptoms in older adults cross-sectionally, more longitudinal work is needed to understand their temporal relationship. Improved measurement of SCI would support a deeper understanding of the impact of SCI on psychological well-being.
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Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000097 · Cited by 64,042
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
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“It is important to note that individuals with MCI also have SCI (self- or informant-reported) as part of MCI’s diagnostic criteria (Albert et al., 2011).”
BackgroundSperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155
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Cited by
Sorted by citations
The characterisation of subjective cognitive decline
Jessen, F., Amariglio, R. E., Buckley, R. F., van der Flier, W. M., Han, Y., Molinuevo, J. L., Rabin, L., Rentz, D. M., Rodriguez-Gomez, O., Saykin, A. J., et al. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30368-0 · Cited by 1,389
Subjective cognitive decline and risk of MCI
van Harten, A. C., Mielke, M. M., Swenson-Dravis, D. M., Hagen, C. E., Edwards, K. K., Roberts, R. O., Geda, Y. E., Knopman, D. S., & Petersen, R. C. (2018) · Neurology · doi:10.1212/wnl.0000000000005863 · Cited by 323
“SCD has been shown to be associated with depressive symptoms, certain personality traits, anxiety, and physical complaints.(9) However, even after adjusting for these factors in our analyses, the association between SCD and risk of MCI remained.”
Functional cognitive disorders: a systematic review
McWhirter, L., Ritchie, C., Stone, J., & Carson, A. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(19)30405-5 · Cited by 240
Subjective cognitive impairment and quality of life: a systematic review
Hill, N. L., Madrigal, C. B., Mogle, J. A., Muñoz, E., DePasquale, N., Wion, R. K., & Bratlee‐Whitaker, E. (2017) · International Psychogeriatrics · doi:10.1017/s1041610217001636 · Cited by 192
Self-citationBuckley, R. F., Hanseeuw, B., Schultz, A. P., Vannini, P., Aghjayan, S. L., Properzi, M. J., Jackson, J. D., Mormino, E. C., Rentz, D. M., Sperling, R. A., et al. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2017.2216 · Cited by 173
“Our hypothesis was that associations between SCD and tau-specific anatomy (ie, with one or both of the entorhinal or inferior temporal FTP-PET regions) could inform the earliest appearance of SCD.”
Influential
Metadata
- Authors
- Hill, N. L., Mogle, J., Wion, R., Munoz, E., DePasquale, N., Yevchak, A. M., & Parisi, J. M.
- Affiliations
- Pennsylvania State University (US)
- Johns Hopkins University (US)
- Corresponding author
- Hill, Nikki L.
- Venue
- The Gerontologist
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-06-23
- Volume
- 56
- Issue
- 6
- Pages
- e109-e127
- ISSN
- 0016-9013 (ISSN-L)
- 1758-5341
- PMC
- PMC5181393
- OpenAlex
- W2461875054
- Cited by
- 277
- References
- 103
- Citations by year
- 2026: 28 · 2025: 44 · 2024: 37 · 2023: 22 · 2022: 40 · 2021: 33 · 2020: 27 · 2019: 21 · 2018: 15 · 2017: 8
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Gerontologist (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (F31AG050385)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Keywords
- subjective cognitive impairment, affective symptoms, depression, anxiety, older adults, bidirectional relationship, psychological well-being
- MeSH terms
- Affective Symptoms, Aged, Aged, 80 and over, Anxiety, Depression, Humans, Independent Living, Diagnostic Self Evaluation, Cognitive Dysfunction
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