The DOI matches its Crossref record; 190 of the 190 references it cites were found in a registry or an index.
Small regulatory RNAs in mammals
Abstract
Mammalian cells harbor numerous small non-protein-coding RNAs, including small nucleolar RNAs (snoRNAs), microRNAs (miRNAs), short interfering RNAs (siRNAs) and small double-stranded RNAs, which regulate gene expression at many levels including chromatin architecture, RNA editing, RNA stability, translation, and quite possibly transcription and splicing. These RNAs are processed by multistep pathways from the introns and exons of longer primary transcripts, including protein-coding transcripts. Most show distinctive temporal- and tissue-specific expression patterns in different tissues, including embryonal stem cells and the brain, and some are imprinted. Small RNAs control a wide range of developmental and physiological pathways in animals, including hematopoietic differentiation, adipocyte differentiation and insulin secretion in mammals, and have been shown to be perturbed in cancer and other diseases. The extent of transcription of non-coding sequences and the abundance of small RNAs suggests the existence of an extensive regulatory network on the basis of RNA signaling which may underpin the development and much of the phenotypic variation in mammals and other complex organisms and which may have different genetic signatures from sequences encoding proteins.
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Citations
Cites
1 retracted
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Cited by
Miranda, K. C., Huynh, T., Tay, Y., Ang, Y.-S., Tam, W.-L., Thomson, A. M., Lim, B., & Rigoutsos, I. (2006) · Cell · doi:10.1016/j.cell.2006.07.031 · Cited by 2,063
Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters
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Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation
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Self-citationGenome-wide transcription and the implications for genomic organization
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Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs
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Metadata
- Authors
- Mattick, J. S., & Makunin, I. V.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-04-15
- Volume
- 14
- Issue
- suppl_1
- Pages
- R121-R132
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2115441328
- Cited by
- 512
- References
- 190
- FWCI
- 16.85
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
