Lack of Association of P2RX7 Gene rs2230912 Polymorphism with Mood Disorders: A Meta-Analysis
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BACKGROUND: To assess the association of P2RX7 gene rs2230912 polymorphism with mood disorders using a meta-analysis. METHODS: Data were collected from the following electronic databases: PubMed, Excerpta Medica Database, Elsevier Science Direct, Cochrane Library, and Chinese Biomedical Literature Database, with the last report up to April 1, 2013. Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of the association. Dependent on the results of heterogeneity test among individual studies, the fixed effect model (Mantel-Haenszel) or random effect model (DerSimonian-Laird) was selected to summarize the pooled OR. RESULTS: We identified 13 separate studies using search (6,962 cases and 9,262 controls). We detected significant between-study heterogeneity. No significant association of this polymorphism with mood disorders was found (P>0.05). We also performed disease-specific meta-analysis in unipolar depression and bipolar disorder. No significant association of this polymorphism with unipolar depression or bipolar disorder was found (P>0.05). Additionally, we performed subgroup analysis by different types of cases. No significant association of this polymorphism with mood disorders in clinical cohorts or population-based cohorts (P>0.05). A significant association of this polymorphism with mood disorders was found for the allele contrast in family-based cohorts (OR = 1.26, 95%CI = 1.05-1.50, P = 0.01). CONCLUSIONS: Overall, our meta-analysis suggests that P2RX7 gene rs2230912 polymorphism may not contribute to the risk of developing mood disorders using a case-control design. Given the discordance in the subgroup analysis by different types of cases, further studies based on larger sample size are still needed.
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The first meta-analysis reported no association of rs2230912 polymorphism and mood disorder (MDD and BD).
“The first reported no association of rs2230912 polymorphism and mood disorder (MDD and BD) [75], while the”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [75]
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Dunker, C., Gross, S., Vinnenberg, L., Prinz, A., Koch, O., & Junker, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29808-0.00063-7
Extracellular ATP in psychiatric disorders
von Mücke-Heim, I.-A., & Deussing, J. M. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-30250-3.00015-1
ATP and major affective disorders: the involvement of P2X receptors in pathophysiology
Mattova, S., Šimko, P., Colzi, E., Štammová, E., Urbanská, N., Grigoroiu‐Serbânescu, M., Coppi, E., & Kisková, T. (2026) · Purinergic Signalling · doi:10.1007/s11302-026-10147-5
- Authors
- Feng, W.-P., Zhang, B., Li, W., & Liu, J.
- Affiliations
- Shangluo Vocational and Technical College (CN)
- Shangluo Central Hospital (CN)
- Nanjing Medical University (CN)
- Corresponding author
- Liu, Juan
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-02-12
- Volume
- 9
- Issue
- 2
- Pages
- e88575
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3922924
- OpenAlex
- W2071507625
- Cited by
- 48
- References
- 41
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 3 · 2022: 10 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 6 · 2017: 4 · 2016: 5 · 2015: 1 · 2014: 3
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- P2X7 receptor, mood disorders, major depressive disorder, bipolar disorder, genetic association, family-based cohort, population-based cohort
- MeSH terms
- Bipolar Disorder, Genotype, Humans, Polymorphism, Genetic, Reproducibility of Results, Cohort Studies, Linear Models, Odds Ratio, Case-Control Studies, Mood Disorders, Genetic Predisposition to Disease, Receptors, Purinergic P2X7
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