The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Predictive chromatin signatures in the mammalian genome
Open accessAbstract
The DNA sequence of an organism is a blueprint of life: it harbors not only the information about proteins and other molecules produced in each cell, but also instructions on when and where such molecules are made. Chromatin, the structure of histone and DNA that has co-evolved with eukaryotic genome, also contains information that indicates the function and activity of the underlying DNA sequences. Such information exists in the form of covalent modifications to the histone proteins that comprise the nucleosome. Thanks to the development of high throughput technologies such as DNA microarrays and next generation DNA sequencing, we have begun to associate the various combinations of chromatin modification patterns with functional sequences in the human genome. Here, we review the rapid progress from descriptive observations of histone modification profiles to highly predictive models enabling use of chromatin signatures to enumerate novel functional sequences in mammalian genomes that have escaped previous detection.
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Citations
Cites
High-Resolution Profiling of Histone Methylations in the Human Genome
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“Chromatin modifications associated with genes and geneproximal elements have been extensively investigated, either through closed experimental systems that exclusively survey genic regions (14,34,35) or through exclusively analyzing only these regions even when using open experimental systems that survey the entire ge…”
BackgroundMethodA bivalent chromatin structure marks key developmental genes in embryonic stem cells
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“Given that RNAPI and RNAPIII generally transcribe ubiquitously expressed elements such as rRNAs and tRNAs, less regulation of this process is required, which may require fewer chromatin modifications.”
BackgroundResultInfluentialSelf-citationHistone modifications at human enhancers reflect global cell-type-specific gene expression
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Transcriptional Regulatory Elements in the Human Genome
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Cited by
An integrated encyclopedia of DNA elements in the human genome
The ENCODE Project Consortium (2012) · Nature · doi:10.1038/nature11247 · Cited by 18,072
Regulation of chromatin by histone modifications
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Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact
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Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
Cheng, Y., He, C., Wang, M., Ma, X., Mo, F., Yang, S., Han, J., & Wei, X. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0095-0 · Cited by 1,097
“H3K9ac and H3K9me3 are two common modifications at promoters.(160,161) Appropriate histone modifications are important in gene expression and human biology; otherwise, alterations in PTMs may be associated with tumorigenesis.”
BackgroundRegulation of nucleosome dynamics by histone modifications
Zentner, G. E., & Henikoff, S. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2470 · Cited by 923
Metadata
- Authors
- Hon, G. C., Hawkins, R. D., & Ren, B.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-10-06
- Volume
- 18
- Issue
- R2
- Pages
- R195-R201
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2163775594
- Cited by
- 222
- References
- 11
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- green
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