The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Genetic variants and abnormal processing of pre-miR-182, a circadian clock modulator, in major depression patients with late insomnia
Abstract
Previous studies in mice have reported five different microRNAs (miRNAs; miR-219-1/132/183/96/182) to be modulators of the endogenous circadian clock and have presented experimental evidence for some of the genes involved in the molecular clock machinery as target sites. Moreover, disruption of circadian rhythms has long been implicated in the pathophysiology of major depression (MD). We investigated these miRNAs and some of their target sites at the sequence and functional levels as possible predisposing factors for susceptibility to MD and related chronobiological subphenotypes. Mutational screening was performed in a sample of 359 MD patients and 341 control individuals. We found a significant association between the T allele of the rs76481776 polymorphism in the pre-miR-182 and late insomnia in MD patients. Previous studies have reported an association between insomnia and CLOCK gene, a predicted miR-182 target site. A significant overexpression of miR-182 was detected by quantitative real-time polymerase chain reaction in cells transfected with the mutated form of the pre-miR-182 when compared with wild-type form. Moreover, a significant reduction in luciferase activity of plasmids with 3' UTR of ADCY6, CLOCK and DSIP genes was shown when transfecting cells with the mutated form of pre-miR-182 compared with cells that did not express miR-182. These data indicate that abnormal processing of pre-miR-182 in patients carrying the T allele of the rs76481776 polymorphism may contribute to the dysregulation of circadian rhythms in MD patients with insomnia, which could influence expression levels of the mature form of miR-182 and might increase downregulation in some of its target genes.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A handful of studies have also identified depression risk variants in precursor miRNA encoding genes, 44 , 45 variants located in or near miRNA target genes 46 , 47 or variants located in genes involved in miRNA processing.”
From Epigenetics and depression (2019) · cites this paper as [44]
Citations
Cites
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
miRBase: tools for microRNA genomics
Griffiths‐Jones, S., Saini, H. K., van Dongen, S., & Enright, A. J. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm952 · Cited by 4,432
Two-Process Model of Sleep Regulation
Binder, M. D., Hirokawa, N., & Windhorst, U. (2008) · Springer eBooks · doi:10.1007/978-3-540-29678-2_6166 · Cited by 3,900
Structured clinical interview for DSM-IV axis I disorders : SCID-I : clinical version : scoresheet
First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (1997) · American Psychiatric Press eBooks · Cited by 3,101
Bushati, N., & Cohen, S. M. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123406 · Cited by 2,750
Information theory as an extension of the maximum likelihood principle
Akaike, H. (1973) · Medical Entomology and Zoology · Cited by 2,357
Molecular analysis of mammalian circadian rhythms
Reppert, S. M., & Weaver, D. R. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.647 · Cited by 1,444
SNPassoc: an R package to perform whole genome association studies
González, J. R., Armengol, L., Solé, X., Guinó, E., Mercader, J. M., Estivill, X., & Moreno, V. R. (2007) · Bioinformatics · doi:10.1093/bioinformatics/btm025 · Cited by 795
Self-citationCircadian genes, rhythms and the biology of mood disorders
McClung, C. A. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.02.003 · Cited by 666
Common vs. rare allele hypotheses for complex diseases
Schork, N. J., Murray, S. S., Frazer, K. A., & Topol, E. J. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.04.010 · Cited by 649
Flagged first, then by citations
Research works printed but not linked: 1
- American Psychiatric Association, 2000, Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), Text Revision.
Cited by
Sorted by citations
Items 101–164 of 164
Sleep in child and adolescent psychiatry: overlooked and underappreciated
Tarokh, L., Hamann, C., & SCHIMMELMANN, B. G. (2014) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-014-0554-7 · Cited by 15
miR-96 Inhibits SV2C to Promote Depression-Like Behavior and Memory Disorders in Mice
Sun, L., Bai, D., Lin, M., Eerdenidalai, Zhang, L., Wang, F., & Jin, S.-W. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.575345 · Cited by 16
Ribonucleoprotein Complexes That Control Circadian Clocks
Wang, D., Liang, X., Chen, X., & Guo, J. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14059018 · Cited by 16
Mithani, S., Yun, S., Leete, J. J., Guedes, V. A., Fink, A. M., Pattinson, C. L., Kim, H., Weljie, A. M., Gill, J., & Gehrman, P. (2021) · Sleep Medicine · doi:10.1016/j.sleep.2021.01.013 · Cited by 17
Role of miR-182 in cardiovascular and cerebrovascular diseases
Pei, G., Chen, L., Wang, Y., He, C., Fu, C., & Wei, Q. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1181515 · Cited by 15
Variations in circadian genes and individual nocturnal symptoms of insomnia. The HUNT study
Bragantini, D., Sivertsen, B., Gehrman, P., Lydersen, S., & Güzey, I. C. (2019) · Chronobiology International · doi:10.1080/07420528.2019.1582540 · Cited by 14
Yang, F., Wang, H., Wang, C., & Chi, G. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28985 · Cited by 13
RetractedGill, J., Lee, H., Baxter, T., Reddy, S. Y., Barr, T. L., Kim, H., Wang, D., & Mysliwiec, V. (2015) · Biological Research For Nursing · doi:10.1177/1099800415575343 · Cited by 13
Biomarkers for primary open-angle glaucoma progression
Zhao, M., Ma, P., Xie, Q., Bui, A. D., Yonamine, S., Hinterwirth, A. J., Zhong, L., Chen, C., Doan, T. A., & Han, Y. (2022) · Experimental Eye Research · doi:10.1016/j.exer.2022.109025 · Cited by 11
Xu, C., Yang, C., Zhang, A., Xu, Y. J., Li, X., Liu, Z., Liu, S., Sun, N., & Zhang, K. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.04.061 · Cited by 11
The role of microRNAs in learning and long-term memory
Grinkevich, L. N. (2020) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vj20.687 · Cited by 14
miRNA Landscape in Pathogenesis and Treatment of Vogt–Koyanagi–Harada Disease
Vega‐Tapia, F., Bustamante, M., Valenzuela, R. A., Urzúa, C. A., & Cuitiño, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.658514 · Cited by 10
Serafini, G., Pompili, M., Hansen, K. F., Obrietan, K. H., Dwivedi, Y., Amore, M., Shomron, N., & Girardi, P. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00208 · Cited by 10
MicroRNA in the molecular mechanism of the circadian clock in mammals
Zhao, Z. (2012) · Frontiers in bioscience · doi:10.2741/4112 · Cited by 9
Noncoding RNAs: Bridging Regulation of Circadian Rhythms and Inflammation
Hardeland, R. (2019) · Advances in Neuroimmune Biology · doi:10.3233/nib-190159 · Cited by 9
Polymorphism analysis of miR182 and CDKN2B genes in Greek patients with primary open angle glaucoma
Moschos, M. M., Dettoraki, M., Karekla, A., Lamprinakis, I., Damaskos, C., Gouliopoulos, N., Tibilis, M., & Gazouli, M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233692 · Cited by 9
Mutation Screening in the miR-183/96/182 Cluster in Patients With Inherited Retinal Dystrophy
Xu, S., Coku, A., Muraleedharan, C. K., Harajli, A., Mishulin, E., Dahabra, C., Choi, J. J., Garcia, W. J., Webb-Jones, K., Birch, D. G., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.619641 · Cited by 8
Identification of putative pathogenic SNPs implied in schizophrenia-associated miRNAs
Sun, X., & Zhang, J. (2014) · BMC Bioinformatics · doi:10.1186/1471-2105-15-194 · Cited by 8
Negative impact of insufficient sleep on the brain
Cao, Q., Xiang, H., Wang, Y., Liu, F., Weng, X., & Xu, F. (2025) · Brain-Apparatus Communication A Journal of Bacomics · doi:10.1080/27706710.2025.2465538 · Cited by 11
Chen, C., Xu, Y.-J., Zhang, S.-R., Wang, X., Hu, Y., Guo, D., Zhou, X., Zhu, W., Wen, A., Tan, Q., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e14265 · Cited by 7
RetractedKarpagavalli, M., Sivagurunathan, S., Panda, T. S., Srikakulam, N., Arora, R., Dohadwala, L., Tiwary, B. K., Sadras, S. R., Arunachalam, J. P., Pandi, G., et al. (2024) · Molecular Omics · doi:10.1039/d3mo00122a · Cited by 8
Genetic and epigenetic control on clock genes in multiple sclerosis
Motawi, T. K., Shaker, O. G., Hassanin, S. O., Ibrahim, S. G., & Senousy, M. A. (2021) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2021.07.016 · Cited by 7
Epigenetics of Sleep Disruption
Gazerani, P. (2020) · OBM Neurobiology · doi:10.21926/obm.neurobiol.2003071 · Cited by 6
Circadian systems biology in Metazoa
Lin, L., Huang, H., Juan, H., & for the 2014 Taida Cancer Systems Biology Study Group (2015) · Briefings in Bioinformatics · doi:10.1093/bib/bbv006 · Cited by 6
Song, H., Sun, X., Niu, W., Zhang, Q., Zhang, L.-Y., & Zhong, A. (2022) · The European Journal of Psychiatry · doi:10.1016/j.ejpsy.2022.09.005 · Cited by 5
Paradigms in miRNA biogenesis pathways
Panda, M., & Prajapati, V. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99661-7.00003-5 · Cited by 5
Sivagurunathan, S., Srikakulam, N., Arunachalam, J. P., Pandi, G., & Chidambaram, S. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/305144 · Cited by 5
Role of chronotype in depression
Zhao, Y., Liao, J., & Huang, Q. (2025) · World Journal of Psychiatry · doi:10.5498/wjp.v15.i10.109087 · Cited by 7
Zhang, M., Du, Y., Chen, L., Tang, Q., Liu, C., Li, N., Zhang, T., Cheng, Y., & Wang, Y. (2025) · SLEEP · doi:10.1093/sleep/zsaf051 · Cited by 5
Human Genomic Variants and Inherited Disease
Antonarakis, S. E., & Cooper, D. N. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812537-3.00006-8 · Cited by 7
Effects of HTR1B 3′ region polymorphisms and functional regions on gene expression regulation
Xia, X., Ding, M., Xuan, J.-F., Xing, J.-X., Pang, H., Yao, J., Wu, X., & Wang, B.-J. (2020) · BMC Genetics · doi:10.1186/s12863-020-00886-8 · Cited by 4
Human Gene Mutation in Inherited Disease
Antonarakis, S. E., & Cooper, D. N. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-383834-6.00007-0 · Cited by 7
MICRORNAS WITH SPECIFIC ROLES IN DIABETES AND PSYCHIATRIC DISEASES
Rădoi, V., Carşote, M., Petriş, R., Păun, D. L., & Poiană, C. (2014) · Medicine and Pharmacy Reports · doi:10.15386/cjmed-288 · Cited by 4
Transcriptomic analysis of MicroRNA expression in enamel-producing cells
Nirvani, M., Khuu, C., Tulek, A., Utheim, T. P., Sand, L. P., Snead, M. L., & Sehic, A. (2018) · Gene · doi:10.1016/j.gene.2018.11.089 · Cited by 4
Sleeping effects in the quality of life of women with insomnia
Tessaro, M., & Navarro-Peternella, F. M. (2015) · Fisioterapia em Movimento · doi:10.1590/0103-5150.028.004.ao06 · Cited by 3
Epigenetic biomarkers in neuropsychiatric disorders
Lin, C.-C., & Huang, T. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800226-1.00003-4 · Cited by 4
Mapping of Nervous System Diseases via MicroRNAs
(2016) · CRC Press eBooks · doi:10.1201/b19229 · Cited by 3
Han, X., Ding, X., Xu, L., Liu, M., & Feng, X. (2016) · PubMed Central · doi:10.7499/j.issn.1008-8830.2016.03.016 · Cited by 2
Emerging role of microRNAs as novel targets of antidepressants
Manoharan, A., & Paul, A. (2021) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2021.102906 · Cited by 2
Li, D., Huang, W., Yang, F., Li, B., & Cai, S. (2020) · European Journal of Inflammation · doi:10.1177/2058739220929159 · Cited by 2
Intestinal Microbiota and Sleep Inversion
Хавкин, А. И., Новикова, В. П., & Trapeznikova, A. Y. (2022) · Педиатрическая фармакология · doi:10.15690/pf.v19i4.2442 · Cited by 1
Li, N., & Zhao, X. (2025) · Nucleosides Nucleotides & Nucleic Acids · doi:10.1080/15257770.2025.2511106 · Cited by 1
Geneticsof sleep and circadian rhythms
Shaw, P. J., Tafti, M., & Thorpy, M. J. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139649469.006 · Cited by 1
Genetics in Chronobiology and Obesity
Garaulet, M., & Ordovás, J. M. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5082-5_8 · Cited by 1
MicroRNA Implications in Neurodegenerative Disorders
Chaudhuri, A. D., & Yelamanchili, S. V. (2016) · Springer eBooks · doi:10.1007/978-3-319-44022-4_21 · Cited by 1
Circadian Rhythm Gene CLOCK Polymorphisms and the Risk of Schizophrenia Among Iranian Patients
Arash, S., & Moridnia, A. (2023) · Trends in Medical Sciences · doi:10.5812/tms-138786 · Cited by 1
Perchance to dream: understanding the complexities of sleep
Greener, M. (2012) · Progress in Neurology and Psychiatry · doi:10.1002/pnp.225
Experimental Methods for Functional Studies of microRNAs in Animal Models of Psychiatric Disorders
Jovasevic, V., & Radulović, J. (2016) · Neuromethods · doi:10.1007/7657_2016_9
Sleep in Child and Adolescent Psychiatry
Hamann, C. (2015) · BORIS (University Library Bern)
Genetics of Post-traumatic Stress Disorder and Sleep Disturbance
Lind, M. J., Berenz, E. C., Nugent, N. R., Trainor, C. D., Koenen, K. C., Vladimirov, V. I., & Amstadter, A. B. (2017) · Springer eBooks · doi:10.1007/978-1-4939-7148-0_9
Metabolic stress and antipsychotic treatment induced gene expression alterations in human cell
Kálmán, S. (2016) · SZTE Repository of Dissertations (University of Szeged) · doi:10.14232/phd.2988
Circadian miR-449c-5p regulates uterine Ca2+ transport during eggshell calcification in chickensPreprint
Cui, Z., Zhang, Z., Amevor, F. K., Du, X., Li, L., Tian, Y., Kang, X., Shu, G., Zhu, Q., Wang, Y., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-213129/v2
(2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-14353a
Circadian miR-449c-5p Regulates Uterine Ca2+ Transport During Eggshell Calcification in ChickensPreprint
Cui, Z., Zhang, Z., Amevor, F. K., Du, X., Li, L., Tian, Y., Kang, X., Shu, G., Zhu, Q., Wang, Y., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-213129/v1
Exosomal MicroRNAs as Brain Memory Devices
Fujii, Y. R. (2023) · Springer eBooks · doi:10.1007/978-981-99-3165-1_5
ANALYSIS OF CLOCK GENE RS1801260 POLYMORPHISM IN IRANIAN PATIENTS WITH INSOMNIA
Gholamalaian, D., & Zare, M. (2023) · Studies in Medical Sciences · doi:10.61186/umj.34.4.223
Cui, Z., Zhang, Z., Amevor, F. K., Du, X., Li, L., Tian, Y., Kang, X., Shu, G., Zhu, Q., Wang, Y., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16879943
Cui, Z., Zhang, Z., Amevor, F. K., Du, X., Li, L., Tian, Y., Kang, X., Shu, G., Zhu, Q., Wang, Y., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16879940
MicroRNA Profile in Menopausal Women with Insomnia: A Pilot Study
Semenova, N. V., Райгородская, М. П., Averinskaya, D. A., Михайловна, М. И., Kolesnikov, S. I., Евгеньевна, Г. Н., & Kolesnikova, L. I. (2025) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-026-06598-w
Perdigoto, S., Cruz, M. G. M. E., Remesal, M., Scala, M., Soltero, M. D. R. G., Azpeleta, C., & de Pedro, M. (2026) · Sleep Medicine X · doi:10.1016/j.sleepx.2026.100184
Sunzeri, F. (2026) · Springer eBooks · doi:10.1007/978-3-032-14465-2_13
Korkutata, M., & Dilsiz, N. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06175-2
Epigenetic basis of circadian rhythms and sleep disorders
Qureshi, I., & Mehler, M. F. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139649469.015
Metadata
- Authors
- Saus, E., Soria, V., Escaramís, G., Vivarelli, F., Crespo, J. M., Kagerbauer, B., Menchón, J. M., Urretavizcaya, M., Gratacòs, M., & Estivill, X.
- Affiliations
- Centre for Genomic Regulation (ES)
- Bellvitge University Hospital (ES)
- Universitat Pompeu Fabra (ES)
- ORCID
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-07-23
- Volume
- 19
- Issue
- 20
- Pages
- 4017-4025
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2151643998
- Cited by
- 163
- References
- 51
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 3 · 2023: 7 · 2022: 9 · 2021: 13 · 2020: 9 · 2019: 11 · 2018: 8 · 2017: 8 · 2016: 19 · 2015: 13 · 2014: 18 · 2013: 19 · 2012: 13
- FWCI
- 5.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Molecular Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Generalitat de Catalunya (2009SGR1554)
- Ministerio de Ciencia e Innovación (SAF2008-00357, 2009SGR1554)
- Instituto de Salud Carlos III (2009SGR1554, PI050960)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- miR-182, major depressive disorder, circadian clock, circadian rhythm disruption, microRNA processing, clock genes, delta sleep-inducing peptide, microRNA binding sites, genetic susceptibility, 3' untranslated region
- MeSH terms
- Circadian Rhythm, Depressive Disorder, Major, Major Depressive Disorder, DNA Mutational Analysis, Gene Expression Regulation, Genetic Vectors, Humans, Sleep Initiation and Maintenance Disorders, Plasmids, Polymorphism, Genetic, RNA Precursors, Transfection, Genetic Variation, Polymerase Chain Reaction, Sequence Alignment, Genetic Predisposition to Disease, MicroRNAs, CLOCK Proteins, Circadian Clocks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
