The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Large non-coding RNAs: missing links in cancer?
Open accessAbstract
Cellular homeostasis is achieved by the proper balance of regulatory networks that if disrupted can lead to cellular transformation. These cell circuits are fine-tuned and maintained by the coordinated function of proteins and non-coding RNAs (ncRNAs). In addition to the well-characterized protein coding and microRNAs constituents, large ncRNAs are also emerging as important regulatory molecules in tumor-suppressor and oncogenic pathways. Recent studies have revealed mechanistic insight of large ncRNAs regulating key cancer pathways at a transcriptional, post-transcriptional and epigenetic level. Here we synthesize these latest advances within the context of their mechanistic roles in regulating and maintaining cellular equilibrium. We posit that similar to protein-coding genes, large ncRNAs are a newly emerging class of oncogenic and tumor-suppressor genes. Our growing knowledge of the role of large ncRNAs in cellular transformation is pointing towards their potential use as biomarkers and targets for novel therapeutic approaches in the future.
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Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
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Self-citationLong Noncoding RNA as Modular Scaffold of Histone Modification Complexes
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Cited by
The emerging role of lncRNAs in cancer
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microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer
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Metadata
- Authors
- Huarte, M., & Rinn, J. L.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-08-20
- Volume
- 19
- Issue
- R2
- Pages
- R152-R161
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2153826038
- Cited by
- 484
- References
- 13
- FWCI
- 9.94
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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