Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells
Open accessAbstract
Variation on chromosome 9p21 is associated with risk of coronary artery disease (CAD). This genomic region contains the CDKN2A and CDKN2B genes which encode the cell cycle regulators p16(INK4a), p14(ARF) and p15(INK4b) and the ANRIL gene which encodes a non-coding RNA. Vascular smooth muscle cell (VSMC) proliferation plays an important role in the pathogenesis of atherosclerosis which causes CAD. We ascertained whether 9p21 genotype had an influence on CDKN2A/CDKN2B/ANRIL expression levels in VSMCs, VSMC proliferation and VSMC content in atherosclerotic plaques. Immunohistochemical examination showed that VSMCs in atherosclerotic lesions expressed p16(INK4a), p14(ARF) and p15(INK4b). Analyses of primary cultures of VSMCs showed that the 9p21 risk genotype was associated with reduced expression of p16(INK4a), p15(INK4b) and ANRIL (P = 1.2 × 10(-5), 1.4 × 10(-2) and 3.1 × 10(-9)) and with increased VSMC proliferation (P = 1.6 × 10(-2)). Immunohistochemical analyses of atherosclerotic plaques revealed an association of the risk genotype with reduced p15(INK4b) levels in VSMCs (P = 3.7 × 10(-2)) and higher VSMC content (P = 5.6 × 10(-4)) in plaques. The results of this study indicate that the 9p21 variation has an impact on CDKN2A and CDKN2B expression in VSMCs and influences VMSC proliferation, which likely represents an important mechanism for the association between this genetic locus and susceptibility to CAD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Chromosome 9p21 encodes the long non-coding RNA ANRIL, which regulates cell proliferation, adhesion, and apoptosis, central mechanisms of atherogenesis and endometriosis.
“Chr9p21 encodes the long non-coding RNA(ncRNA) ANRIL, which has been demonstrated to regulate cell proliferation, adhesion and apoptosis,(43, 44) - central mechanisms of atherogenesis (13, 43) and endometriosis. (2, 3)”
From Endometriosis and Risk of Coronary Heart Disease (2016) · cites this paper as [44]
The Introduction identifies ANRIL as a non-coding RNA gene at 9p21, and the Results and Discussion link ANRIL expression to cell-cycle regulators in vascular smooth muscle cells. The paper also associates 9p21 variation with smooth muscle cell proliferation in atherosclerosis, but it does not demonstrate that ANRIL regulates adhesion or apoptosis. The citing sentence attributes its endometriosis point to other references, not this source. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618 · see citing works
Stary, H. C., Chandler, A. B., Dinsmore, R. E., Fuster, V., Glagov, S. K., Insull, W., Rosenfeld, M. E., Schwartz, C. J., Wagner, W. D., & Wissler, R. W. (1995) · Circulation · doi:10.1161/01.cir.92.5.1355 · Cited by 3,506 · see citing works
Genomewide Association Analysis of Coronary Artery Disease
Samani, N. J., Erdmann, J., Hall, A. S., Hengstenberg, C., Mangino, M., Mayer, B., Dixon, R. J., Meitinger, T., Braund, P., Wichmann, H.-E., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa072366 · Cited by 2,044 · see citing works
Molecular Bases of the Acute Coronary Syndromes
Libby, P. (1995) · Circulation · doi:10.1161/01.cir.91.11.2844 · Cited by 2,029 · see citing works
A Common Variant on Chromosome 9p21 Affects the Risk of Myocardial Infarction
Helgadottir, A., Thorleifsson, G., Manolescu, A., Gretarsdottir, S., Blondal, T., Jonasdottir, A., Jonasdottir, A., Sigurdsson, A., Baker, A., Palsson, A., et al. (2007) · Science · doi:10.1126/science.1142842 · Cited by 1,594 · see citing works
A Common Allele on Chromosome 9 Associated with Coronary Heart Disease
McPherson, R., Pertsemlidis, A., Kavaslar, N., Stewart, A., Roberts, R., Cox, D. R., Hinds, D. A., Pennacchio, L. A., Tybjaerg-Hansen, A., Folsom, A. R., et al. (2007) · Science · doi:10.1126/science.1142447 · Cited by 1,587 · see citing works
Yap, K. L., Li, S., Muñoz-Cabello, A. M., Raguz, S., Zeng, L., Mujtaba, S., Gil, J., Walsh, M. J., & Zhou, M.-M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.021 · Cited by 1,391 · see citing works
Stary, H. C., Chandler, A. B., Glagov, S. K., Guyton, J. R., Insull, W., Rosenfeld, M. E., Schaffer, S. A., Schwartz, C. J., Wagner, W. D., & Wissler, R. W. (1994) · Circulation · doi:10.1161/01.cir.89.5.2462 · Cited by 1,313 · see citing works
Myocardial Infarction Genetics Consortium (2009) · Nature Genetics · doi:10.1038/ng.327 · Cited by 1,088 · see citing works
Burd, C. E., Jeck, W. R., Liu, Y., Sanoff, H. K., Wang, Z., & Sharpless, N. E. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001233 · Cited by 895 · see citing works
Regulation of the INK4b–ARF–INK4a tumour suppressor locus: all for one or one for all
Gil, J., & Peters, G. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1987 · Cited by 843 · see citing works
Stary, H. C., Chandler, A. B., Glagov, S. K., Guyton, J. R., Insull, W., Rosenfeld, M. E., Schaffer, S. A., Schwartz, C. J., Wagner, W. D., & Wissler, R. W. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.5.840 · Cited by 738 · see citing works
Helgadóttir, A., Þorleifsson, G., Magnússon, K. P., Grétarsdóttir, S., Steinthórsdóttir, V., Manolescu, A. R., Jones, G. T., Rinkel, G. J. E., Blankensteijn, J. D., Ronkainen, A., et al. (2008) · Nature Genetics · doi:10.1038/ng.72 · Cited by 724 · see citing works
Genetics and Beyond – The Transcriptome of Human Monocytes and Disease Susceptibility
Zeller, T., Wild, P. S., Szymczak, S., Rotival, M., Schillert, A., Castagné, R., Maouche, S., Germain, M., Lackner, K. J., Rossmann, H., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010693 · Cited by 584 · see citing works
Reilly, M. P., Li, M., He, J., Ferguson, J. F., Stylianou, I. M., Mehta, N. N., Burnett, M. S., Devaney, J. M., Knouff, C. W., Thompson, J. R., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(10)61996-4 · Cited by 539 · see citing works
A Common Allele on Chromosome 9 Associated With Coronary Heart Disease
McPherson, R., Pertsemlidis, A., Kavaslar, N., Stewart, A. F. R., Roberts, R., Cox, D., Hinds, D. A., Pennacchio, L. A., Tybjærg‐Hansen, A., Folsom, A. R., et al. (2007) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000279314.45442.bb · Cited by 524 · see citing works
Broadbent, H. M., Peden, J. F., Stefan Lorkowski, A., Goel, A., Ongen, H., Green, F. R., Clarke, R., Collins, R., Franzosi, M. G., Tognoni, G., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm352 · Cited by 504 · see citing works
p53 and E2f: partners in life and death
Polager, S., & Ginsberg, D. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2718 · Cited by 498 · see citing works
Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice
Visel, A., Zhu, Y., May, D., Afzal, V., Gong, E., Attanasio, C., Blow, M. J., Cohen, J. C., Rubin, E. M., & Pennacchio, L. A. (2010) · Nature · doi:10.1038/nature08801 · Cited by 461 · see citing works
ANRIL Expression Is Associated With Atherosclerosis Risk at Chromosome 9p21
Holdt, L. M., Beutner, F., Scholz, M. R., Gielen, S., Gäbel, G., Bergert, H., Schuler, G. C., Thiery, J., & Teupser, D. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.196832 · Cited by 452 · see citing works
Schunkert, H., Götz, A., Braund, P. S., McGinnis, R. E., Trégouët, D., Mangino, M., Linsel‐Nitschke, P., Cambien, F., Hengstenberg, C., Stark, K. J., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.730614 · Cited by 385 · see citing works
Functional Analysis of the Chromosome 9p21.3 Coronary Artery Disease Risk Locus
Jarinova, O., Stewart, A. F. R., Roberts, R., Wells, G. A., Lau, P., Naing, T., Buerki, C., McLean, B. W., Cook, R., Parker, J. S., et al. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.189522 · Cited by 384 · see citing works
Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression
Cunnington, M. S., Santibanez‐Koref, M., Mayosi, B. M., Burn, J., & Keavney, B. D. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000899 · Cited by 379 · see citing works
Genome-wide association study of intracranial aneurysm identifies three new risk loci
Yasuno, K., Bilgüvar, K., Bijlenga, P., Low, S., Krischek, B., Auburger, G. W. J., Simon, M., Krex, D., Arlıer, Z., Nayak, N. R., et al. (2010) · Nature Genetics · doi:10.1038/ng.563 · Cited by 307 · see citing works
Life and death decisions by the E2F transcription factors
Iaquinta, P. J., & Lees, J. A. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.10.006 · Cited by 304 · see citing works
Susceptibility loci for intracranial aneurysm in European and Japanese populations
Bilgüvar, K., Yasuno, K., Niemela, M. R., Ruigrok, Y. M., zu Fraunberg, M. V. U., van Duijn, C. M., van den Berg, L. H., Mane, S., Mason, C. E., Choi, M., et al. (2008) · Nature Genetics · doi:10.1038/ng.240 · Cited by 274 · see citing works
INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis
Liu, Y., Sanoff, H. K., Cho, H., Burd, C. E., Torrice, C., Mohlke, K. L., Ibrahim, J. G., Thomas, N. E., & Sharpless, N. E. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005027 · Cited by 248 · see citing works
Folkersen, L., Kyriakou, T., Goel, A., Peden, J. F., Mälarstig, A., Paulsson‐Berne, G., Hamsten, A., Watkins, H. C., Franco‐Cereceda, A., Gabrielsen, A., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007677 · Cited by 170 · see citing works
Gizard, F., Amant, C., Barbier, O., Bellosta, S., Robillard, R., Percevault, F., Sevestre, H., Krimpenfort, P., Corsini, A., Rochette, J., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22756 · Cited by 159 · see citing works
Ye, S., Willeit, J., Kronenberg, F., Xu, Q., & Kiechl, S. J. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.11.087 · Cited by 155 · see citing works
Self-citationGene Dosage of the Common Variant 9p21 Predicts Severity of Coronary Artery Disease
Dandona, S., Stewart, A. F. R., Chen, L., Williams, K., So, D. Y. F., O’Brien, E. R., Glover, C. A., Lemay, M., Assogba, O., Vo, L. T. T., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.10.092 · Cited by 154 · see citing works
Expression of Chr9p21 genes CDKN2B (p15), CDKN2A (p16, p14) and MTAP in human atherosclerotic plaque
Holdt, L. M., Sass, K., Gäbel, G., Bergert, H., Thiery, J., & Teupser, D. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.06.029 · Cited by 143 · see citing works
Angelakopoulou, A., Shah, T., Sofat, R., Shah, S. H., Berry, D. J., Cooper, J. A., Palmen, J., Tzoulaki, I., Wong, A., Jefferis, B. J. M. H., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr225 · Cited by 112 · see citing works
Self-citationCluett, C., McDermott, M. M., Guralnik, J. M., Ferrucci, L., Bandinelli, S., Miljkovic, I., Zmuda, J. M., Li, R., Tranah, G. J., Harris, T. B., et al. (2009) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.108.825935 · Cited by 92 · see citing works
Patel, R. S., Su, S., Neeland, I. J., Ahuja, A., Veledar, E., Zhao, J., Helgadóttir, A., Hólm, H., Gulcher, J. R., Stefánsson, K., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq272 · Cited by 88 · see citing works
Chromosome 9p21 in Ischemic Stroke
Anderson, C. D., Biffi, A., Rost, N. S., Cortellini, L., Furie, K. L., & Rosand, J. M. (2010) · Stroke · doi:10.1161/strokeaha.110.580589 · Cited by 82 · see citing works
Gizard, F., Nomiyama, T., Zhao, Y., Findeisen, H. M., Heywood, E. B., Jones, K. L., Staels, B., & Bruemmer, D. (2008) · Circulation Research · doi:10.1161/circresaha.108.186205 · Cited by 62 · see citing works
Segev, A., Nili, N., Qiang, B., Osherov, A. B., Giordano, F. J., Jaffe, R., Gauldie, J., Sparkes, J. D., Fraser, A. R., Ladouceur-Wodzak, M., et al. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.11.007 · Cited by 7 · see citing works
Flagged first, then by citations
1 of the 39 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [5]5. Broadbent, H.M., Peden, J.F., Lorkowski, S., Goel, A., Ongen, H., Green, F., Clarke, R., Collins, R., Franzosi, M.G., Tognoni, G. et al. (2008) Susceptibility to coronary artery disease and diabetes is encoded by 4028 Human Molecular Genetics, 2012, Vol. 21, No. 18
Cited by
Sorted by citations
Molecular Biology of Atherosclerosis
Hopkins, P. N. (2013) · Physiological Reviews · doi:10.1152/physrev.00004.2012 · Cited by 456 · see citing works
Bell, R. D., Long, X., Lin, M., Bergmann, J. H., Nanda, V., Cowan, S. L., Zhou, Q., Han, Y., Spector, D. L., Zheng, D., et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303240 · Cited by 290 · see citing works
Endometriosis and Risk of Coronary Heart Disease
Mu, F., Rich-Edwards, J., Rimm, E. B., Spiegelman, D., & Missmer, S. A. (2016) · Circulation: Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.115.002224 · Cited by 235 · see citing works
“(40-42) Chr9p21 encodes the long non-coding RNA(ncRNA) ANRIL, which has been demonstrated to regulate cell proliferation, adhesion and apoptosis,(43, 44) - central mechanisms of atherogenesis (13, 43) and endometriosis.”
Bochenek, G., Häsler, R., Mokhtari, N. E. E., König, I. R., Loos, B. G., Jepsen, S., Rosenstiel, P. C., Schreiber, S., & Schäefer, A. S. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt299 · Cited by 213 · see citing works
ANRIL: A lncRNA at the CDKN2A/B Locus With Roles in Cancer and Metabolic Disease
Kong, Y., Hsieh, C.-H., & Alonso, L. C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00405 · Cited by 207 · see citing works
Stroke genetics: discovery, biology, and clinical applications
Dichgans, M., Pulit, S. L., & Rosand, J. M. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30043-2 · Cited by 184 · see citing works
Hannou, S. A., Wouters, K., Paumelle, R., & Staels, B. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.01.008 · Cited by 159 · see citing works
Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis
Kojima, Y., Downing, K., Kundu, R., Miller, C., Dewey, F., Lancero, H., Raaz, U., Perisic, L., Hedin, U., Schadt, E., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci70391 · Cited by 148 · see citing works
Genetics of Coronary Artery Disease
Roberts, R. (2014) · Circulation Research · doi:10.1161/circresaha.114.302692 · Cited by 141 · see citing works
Unveiling the Role of the Most Impactful Cardiovascular Risk Locus through Haplotype Editing
Sardo, V. L., Chubukov, P., Ferguson, W. C., Kumar, A., Teng, E. L., Duran, M., Zhang, L., Cost, G. J., Engler, A. J., Urnov, F. D., et al. (2018) · Cell · doi:10.1016/j.cell.2018.11.014 · Cited by 126 · see citing works
Loss of CDKN2B Promotes p53-Dependent Smooth Muscle Cell Apoptosis and Aneurysm Formation
Leeper, N. J., Raiesdana, A., Kojima, Y., Kundu, R. K., Cheng, H. S., Mäegdefessel, L., Toh, R., Ahn, G., Ali, Z. A., Anderson, D. R., et al. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300399 · Cited by 116 · see citing works
Into the Wild: GWAS Exploration of Non-coding RNAs
Giral, H., Landmesser, U., & Kratzer, A. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00181 · Cited by 111 · see citing works
Long non-coding RNAs in the atherosclerotic plaque
Arslan, S., Berkan, Ö., Lalem, T., Şahin, N. Ö., Göksel, S., Korkmaz, Ö., Çetin, N., & Devaux, Y. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.10.012 · Cited by 114 · see citing works
Long Noncoding RNAs in Atherosclerosis
Zhang, Z., Salisbury, D. A., & Sallam, T. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.08.2161 · Cited by 114 · see citing works
Role of flow-sensitive microRNAs and long noncoding RNAs in vascular dysfunction and atherosclerosis
Kumar, S., Williams, D., Sur, S., Wang, J., & Jo, H. (2018) · Vascular Pharmacology · doi:10.1016/j.vph.2018.10.001 · Cited by 113 · see citing works
van Setten, J., Išgum, I., Smolonska, J., Ripke, S., de Jong, P. A., Oudkerk, M., de Koning, H. J., Lammers, J. J., Zanen, P., Groen, H. J. M., et al. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.02.039 · Cited by 109 · see citing works
Holdt, L. M., & Teupser, D. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00145 · Cited by 105 · see citing works
Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells
Aherrahrou, R., Guo, L., Nagraj, V., Aguhob, A., Hinkle, J., Chen, L., Soh, J. Y., Lue, D., Alencar, G. F., Boltjes, A., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.317415 · Cited by 103 · see citing works
Long Noncoding RNA: Recent Updates in Atherosclerosis
Li, H., Zhu, H., & Ge, J. (2016) · International Journal of Biological Sciences · doi:10.7150/ijbs.14430 · Cited by 100 · see citing works
Long noncoding RNAs and atherosclerosis
Zhou, T., Ding, J., Wang, X., & Zheng, X. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.02.025 · Cited by 98 · see citing works
DNA Damage: A Main Determinant of Vascular Aging
Bautista‐Niño, P. K., Portilla-Fernández, E., Vaughan, D. E., Danser, A. H. J., & Roks, A. J. M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17050748 · Cited by 95 · see citing works
Non-coding RNAs: key regulators of smooth muscle cell fate in vascular disease
Leeper, N. J., & Mäegdefessel, L. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx249 · Cited by 86 · see citing works
Sex differences in the genetic and molecular mechanisms of coronary artery disease
Sakkers, T. R., Mokrý, M., Civelek, M., Erdmann, J., Pasterkamp, G., Benavente, E. D., & den Ruijter, H. M. (2023) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2023.117279 · Cited by 79 · see citing works
EphA2 Expression Regulates Inflammation and Fibroproliferative Remodeling in Atherosclerosis
Finney, A. C., Funk, S. D., Green, J. M., Yurdagul, A., Rana, M. A., Pistorius, R., Henry, M., Yurochko, A. D., Pattillo, C. B., Traylor, J. G., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.026644 · Cited by 80 · see citing works
Li, Y., & Mäegdefessel, L. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00429 · Cited by 70 · see citing works
Noncoding RNAs regulate NF-κB signaling to modulate blood vessel inflammation
Cheng, H. S., Njock, M.-S., Khyzha, N., Dang, L. T., & Fish, J. E. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00422 · Cited by 69 · see citing works
Hadri, K. E., Smith, R., Duplus, E., & Amri, C. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010077 · Cited by 70 · see citing works
Association Between the Chromosome 9p21 Locus and Angiographic Coronary Artery Disease Burden
Chan, K., Patel, R. S., Newcombe, P. J., Nelson, C. P., Qasim, A., Epstein, S. E., Burnett, S., Vaccarino, V., Zafari, A. M., Shah, S. H., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.10.051 · Cited by 65 · see citing works
Self-citationLong non-coding RNA ANRIL in gene regulation and its duality in atherosclerosis
Chi, J., Li, J.-Z., Jia, J., Zhang, T., Liu, X.-M., & Yi, L. (2017) · Current Medical Science · doi:10.1007/s11596-017-1812-y · Cited by 64 · see citing works
Epigenetic Reprogramming in Atherosclerosis
Grimaldi, V., Vietri, M. T., Schiano, C., Picascia, A., Pascale, M. R. D., Fiorito, C., Casamassimi, A., & Claudio Napoli, A. (2014) · Current Atherosclerosis Reports · doi:10.1007/s11883-014-0476-3 · Cited by 64 · see citing works
CDKN2B Regulates TGF β Signaling and Smooth Muscle Cell Investment of Hypoxic Neovessels
Nanda, V., Downing, K. P., Ye, J., Xiao, S., Kojima, Y., Spin, J. M., DiRenzo, D. M., Nead, K. T., Connolly, A. J., Dandona, S., et al. (2015) · Circulation Research · doi:10.1161/circresaha.115.307906 · Cited by 60 · see citing works
The role of DNA damage and repair in atherosclerosis: A review
Shah, N. R., & Mahmoudi, M. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.07.005 · Cited by 55 · see citing works
The emerging roles of long noncoding RNAs in common cardiovascular diseases
Jiang, X., & Ning, Q. (2015) · Hypertension Research · doi:10.1038/hr.2015.26 · Cited by 55 · see citing works
Ren, K., Jiang, T., Zheng, X., & Zhao, G.-J. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.04.005 · Cited by 55 · see citing works
Patel, R. S., Asselbergs, F. W., Quyyumi, A. A., Palmer, T., Finan, C., Tragante, V., Deanfield, J. E., Hemingway, H., Hingorani, A. D., & Holmes, M. V. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.01.065 · Cited by 53 · see citing works
Emerging role of long non-coding RNAs in the pathogenesis of periodontitis
Sayad, A., Mirzajani, S., Gholami, L., Razaghi, P., Ghafouri‐Fard, S., & Taheri, M. N. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110362 · Cited by 53 · see citing works
Genetic and epigenetic regulation of abdominal aortic aneurysms
Mangum, K. D., & Farber, M. A. (2020) · Clinical Genetics · doi:10.1111/cge.13705 · Cited by 52 · see citing works
The Role of ANRIL in Atherosclerosis
Razeghian‐Jahromi, I., Akhormeh, A. K., & Zibaeenezhad, M. J. (2022) · Disease Markers · doi:10.1155/2022/8859677 · Cited by 51 · see citing works
Almontashiri, N. A. M., Antoine, D., Zhou, X., Vilmundarson, R. O., Zhang, S. X., Hao, K. N., Chen, H., & Stewart, A. F. R. (2015) · Circulation · doi:10.1161/circulationaha.114.015023 · Cited by 51 · see citing works
Genome-wide association studies of late-onset cardiovascular disease
Smith, J. G., & Newton‐Cheh, C. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.04.004 · Cited by 49 · see citing works
Yang, J., Gu, L., Guo, X., Huang, J., Chen, Z., Huang, G., Kang, Y., Zhang, X., Long, J., & Su, L. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-0593-6 · Cited by 47 · see citing works
Functional Genomics of the 9p21.3 Locus for Atherosclerosis: Clarity or Confusion?
Chen, H.-H., Almontashiri, N. A. M., Antoine, D., & Stewart, A. F. R. (2014) · Current Cardiology Reports · doi:10.1007/s11886-014-0502-7 · Cited by 45 · see citing works
CDKN2B methylation is associated with carotid artery calcification in ischemic stroke patients
Zhou, S., Zhang, Y., Wang, L., Zhang, Z., Cai, B., Liu, K., Zhang, H., Dai, M., Sun, L., Xu, X., et al. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-1093-4 · Cited by 44 · see citing works
Probing the links: Long non-coding RNAs and NF-κB signalling in atherosclerosis
Hussain, M. S., Afzal, O., Gupta, G., Altamimi, A. S. A., Almalki, W. H., Alzarea, S. I., Kazmi, I. A., Kukreti, N., Gupta, S. K., Sulakhiya, K., et al. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154773 · Cited by 43 · see citing works
Variants in ANRIL gene correlated with its expression contribute to myocardial infarction risk
Cheng, J., Cai, M., Chen, Y.-N., Li, Z., Tang, S.-S., Yang, X.-L., Chen, C., Liu, X., & Xiong, X. (2017) · Oncotarget · doi:10.18632/oncotarget.14721 · Cited by 43 · see citing works
SNP rs2071095 in LincRNA H19 is associated with breast cancer risk
Cui, P., Zhao, Y., Chu, X., He, N., Zheng, H., Han, J., Song, F., & Chen, K. (2018) · Breast Cancer Research and Treatment · doi:10.1007/s10549-018-4814-y · Cited by 43 · see citing works
LncRNA HOXA-AS2 represses endothelium inflammation by regulating the activity of NF-κB signaling
Zhu, X., Liu, Y., Yu, J., Du, J., Guo, R., Feng, Y., Zhong, G., Jiang, Y., & Lin, J. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.12.012 · Cited by 43 · see citing works
Long noncoding RNA variations in cardiometabolic diseases
Dechamethakun, S., & Muramatsu, M. (2016) · Journal of Human Genetics · doi:10.1038/jhg.2016.70 · Cited by 42 · see citing works
Kumar, A., Thomas, S., Wong, K. C., Sardo, V. L., Cheah, D. S., Hou, Y., Placone, J. K., Tenerelli, K. P., Ferguson, W. C., Torkamani, A., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0344-5 · Cited by 41 · see citing works
Dechamethakun, S., Ikeda, S., Arai, T., Sato, N., Sawabe, M., & Muramatsu, M. (2014) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.22640 · Cited by 40 · see citing works
Genetics and Genomics of Coronary Artery Disease
Pjanic, M., Miller, C. L., Wirka, R. C., Kim, J. B., DiRenzo, D. M., & Quertermous, T. (2016) · Current Cardiology Reports · doi:10.1007/s11886-016-0777-y · Cited by 40 · see citing works
Multi-Omics Approaches to Study Long Non-coding RNA Function in Atherosclerosis
Turner, A. W., Wong, D., Khan, M. D., Dreisbach, C., Palmore, M., & Miller, C. L. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00009 · Cited by 40 · see citing works
Epigenetic modulation in the treatment of atherosclerotic disease
Byrne, M. M., Murphy, R. T., & Ryan, A. W. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00364 · Cited by 38 · see citing works
Genetic Insights Into Smooth Muscle Cell Contributions to Coronary Artery Disease
Wong, D., Turner, A. W., & Miller, C. L. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312141 · Cited by 34 · see citing works
The contribution of non-coding regulatory elements to cardiovascular disease
Villar, D., Frost, S., Deloukas, P., & Tinker, A. (2020) · Open Biology · doi:10.1098/rsob.200088 · Cited by 34 · see citing works
The short and long of noncoding sequences in the control of vascular cell phenotypes
Miano, J. M., & Long, X. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1936-9 · Cited by 37 · see citing works
Role of noncoding RNA in vascular remodelling
Deng, L., Bradshaw, A. C., & Baker, A. H. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000336 · Cited by 36 · see citing works
Unveiling ncRNA regulatory axes in atherosclerosis progression
Navarro, E., Mallén, A., Cruzado, J. M., Torrás, J., & Hueso, M. (2020) · Clinical and Translational Medicine · doi:10.1186/s40169-020-0256-3 · Cited by 35 · see citing works
Coll-Bonfill, N., de la Cruz-Thea, B., Pisano, M. V., & Musri, M. M. (2016) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-016-1821-x · Cited by 34 · see citing works
Iketani, M., Sekimoto, K., Igarashi, T., Takahashi, M. M., Komatsu, M., Sakane, I., Takahashi, H., Kawaguchi, H., Ohtani‐Kaneko, R., & Ohsawa, I. (2018) · Scientific Reports · doi:10.1038/s41598-018-35239-0 · Cited by 35 · see citing works
Wang, M., Chen, W., Geng, Y., Xu, C., Tao, X., & Zhang, Y. (2019) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.50674 · Cited by 33 · see citing works
Association of endometriosis with cardiovascular disease: Genetic aspects (Review)
Vazgiourakis, V., Zervou, M. I., Papageorgiou, L., Chaniotis, D. I., Spandidos, D. A., Vlachakis, D., Eliopoulos, E., & Goulielmos, G. N. (2023) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2023.5232 · Cited by 32 · see citing works
Srivastava, R., Rolyan, H., Xie, Y., Li, N., Bhat, N., Hong, L., Esteghamat, F., Adeniran, A., Geirsson, A., Zhang, J., et al. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311830 · Cited by 31 · see citing works
Effects of Coronary Artery Disease–Associated Variants on Vascular Smooth Muscle Cells
Solomon, C. U., McVey, D. G., Andreadi, C., Gong, P., Turner, L., Stanczyk, P. J., Khemiri, S., Chamberlain, J. C., Yang, W., Webb, T. R., et al. (2022) · Circulation · doi:10.1161/circulationaha.121.058389 · Cited by 31 · see citing works
Self-citationAlsibai, K. D., Vacher, S., Meseure, D., Nicolas, A., Lae, M. E., Schnitzler, A., Chemlali, W., Cros, J. F., Longchampt, É., Cacheux, W., et al. (2019) · Non-Coding RNA · doi:10.3390/ncrna5030044 · Cited by 30 · see citing works
Genetics meets epigenetics: Genetic variants that modulate noncoding RNA in cardiovascular diseases
Calore, M., Windt, L. J. D., & Rampazzo, A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.10.028 · Cited by 29 · see citing works
What Causes Premature Coronary Artery Disease?
Le, A., Peng, H., Golinsky, D., Scipio, M. D., Lali, R., & Paré, G. (2024) · Current Atherosclerosis Reports · doi:10.1007/s11883-024-01200-y · Cited by 30 · see citing works
Genetic analysis of the 9p21.3 CAD risk locus in Asian Indians
Arvind, P., Jambunathan, S., Nair, J., Kakkar, V. V., & Shanker, J. (2014) · Thrombosis and Haemostasis · doi:10.1160/th13-08-0706 · Cited by 28 · see citing works
The role of non-coding RNA network in atherosclerosis.
Yuan, Y., Xu, L., Geng, Z.-H., Liu, J.-J., Zhang, L.-J., Wu, Y., He, D., & Qu, P. (2020) · Life Science · doi:10.1016/j.lfs.2020.118756 · Cited by 21 · see citing works
Roles of LncRNAs in Regulating Mitochondrial Dysfunction in Septic Cardiomyopathy
Liu, S., & Chong, W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.802085 · Cited by 28 · see citing works
Long noncoding RNAs: emerging roles in pulmonary hypertension
Jin, Q., Zhao, Z., Zhao, Q., Yu, X. L., Yan, L., Zhang, Y., Luo, Q., & Liu, Z. (2019) · Heart Failure Reviews · doi:10.1007/s10741-019-09866-2 · Cited by 27 · see citing works
The Long Non-Coding RNA Landscape of Atherosclerotic Plaques
Kraczkowska, W., & Jagodziński, P. P. (2019) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-019-00427-9 · Cited by 26 · see citing works
Lee, A. M., Ferdjallah, A., Moore, E., Kim, D. C., Nath, A., Greengard, E. G., & Huang, R. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011168 · Cited by 26 · see citing works
CDKN2B Methylation and Aortic Arch Calcification in Patients with Ischemic Stroke
Zhou, S., Cai, B., Zhang, Z., Zhang, Y., Wang, L., Liu, K., Zhang, H., Sun, L., Cai, H., Lu, G., et al. (2016) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.36897 · Cited by 25 · see citing works
Long Noncoding RNA HOXA-AS3 Integrates NF- κ B Signaling To Regulate Endothelium Inflammation
Zhu, X., Chen, D.-C., Liu, Y., Yu, J., Qiao, L., Lin, S., Chen, D., Zhong, G., Lu, X., Wang, Y., et al. (2019) · Molecular and Cellular Biology · doi:10.1128/mcb.00139-19 · Cited by 25 · see citing works
The cis and trans effects of the risk variants of coronary artery disease in the Chr9p21 region
Zhao, W., Smith, J. A., Mao, G., Fornage, M., Peyser, P. A., Sun, Y. V., Turner, S. T., & Kardia, S. L. R. (2015) · BMC Medical Genomics · doi:10.1186/s12920-015-0094-0 · Cited by 25 · see citing works
Aarabi, G., Zeller, T., Heydecke, G., Munz, M., Schäfer, A. S., & Seedorf, U. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00047 · Cited by 24 · see citing works
Antikainen, A. A., Sandholm, N., Trégouët, D., Charmet, R., McKnight, A. J., Ahluwalia, T. S., Syreeni, A., Valo, E., Forsblom, C. M., Gordin, D., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa045 · Cited by 23 · see citing works
Svensson, P., Wahlstrand, B., Olsson, M. M., Froguel, P., Falchi, M., Bergman, R. N., McTernan, P. G., Hedner, T., Carlsson, L. M. S., & Jacobson, P. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.03.075 · Cited by 24 · see citing works
Integrative functional analysis of super enhancer SNPs for coronary artery disease
Gong, J., Qiu, C., Huang, D., Zhang, Y., Yu, S., & Zeng, C. (2018) · Journal of Human Genetics · doi:10.1038/s10038-018-0422-2 · Cited by 24 · see citing works
The protective effects of long non-coding RNA-ANCR on arterial calcification
Zhang, X., Chen, J., Meng, Q., Li, D., Hu, F.-Z., Zhu, Y., Huang, Y., Liu, Y., Sun, L., & Liang, Q.-H. (2020) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-019-01076-y · Cited by 21 · see citing works
Wei, Y., Xiong, J., Zuo, S., Chen, F., Chen, D., Wu, T., Guo, W., & Hu, Y. (2013) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2013.10.095 · Cited by 20 · see citing works
Wang, Z., Gan, X., Qiu, C., Yang, D., Sun, X., & Zeng, Z. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.114747 · Cited by 19 · see citing works
Zhang, L.-W., Li, J., Duan, F., Liu, Z., Zhan, S.-Y., Hu, Y., Jiang, J., Zhang, Y., Huo, Y., & Chen, D. (2014) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-14-170 · Cited by 18 · see citing works
Lusk, C. M., Dyson, G. E., Clark, A. G., Ballantyne, C. M., Frikke‐Schmidt, R., Tybjærg‐Hansen, A., Boerwinkle, E., & Sing, C. F. (2014) · Human Genetics · doi:10.1007/s00439-014-1451-3 · Cited by 17 · see citing works
The Combined Regulation of Long Non-coding RNA and RNA-Binding Proteins in Atherosclerosis
Ding, Y., Yin, R., Zhang, S., Xiao, Q., Zhao, H., Pan, X., & Zhu, X. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.731958 · Cited by 17 · see citing works
Self-citationAssessment and consequences of cell senescence in atherosclerosis
Garrido, A. M., & Bennett, M. R. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000327 · Cited by 17 · see citing works
Interactive effects of CDKN2B‐AS1 gene polymorphism and habitual risk factors on oral cancer
Yeh, J., Chen, Y., Chou, Y., Su, S., Chang, L., Chen, Y., Lin, C., & Yang, S. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17966 · Cited by 16 · see citing works
Marchetti, G., Girelli, D., Zerbinati, C., Lunghi, B., Friso, S., Meneghetti, S., Coen, M., Gagliano, T., Guastella, G., Bochaton-Piallat, M., et al. (2014) · Thrombosis and Haemostasis · doi:10.1160/th14-05-0466 · Cited by 13 · see citing works
Guo, T., Chai, X., Liu, Q., Peng, W., Peng, Z., & Cai, Y. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4468 · Cited by 16 · see citing works
Şakalar, Ç., Gürbüz, E., Kalay, N., & Kaya, M. G. (2013) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.230.171 · Cited by 15 · see citing works
Genetic and Functional Variants Analysis of the GATA6 Gene Promoter in Acute Myocardial Infarction
Sun, Z., Pang, S., Cui, Y., & Yan, B. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.01100 · Cited by 14 · see citing works
Huang, J., Li, M., Li, J., Liang, B., Chen, Z., Yang, J., Guo, X., Huang, S., Gu, L., & Su, L. (2021) · Biochemical Genetics · doi:10.1007/s10528-021-10055-w · Cited by 14 · see citing works
LncRNAs and Cardiovascular Disease
Hennessy, E. J. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-92034-0_5 · Cited by 14 · see citing works
Loinard, C., Basatemur, G., Masters, L. M., Baker, L. L., Harrison, J., Figg, N. L., Vilar, J., Sage, A. P., & Mallat, Z. (2014) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.114.000696 · Cited by 14 · see citing works
The 9p21.3 risk locus for coronary artery disease: A 10-year search for its mechanism
Almontashiri, N. A. M. (2017) · Journal of Taibah University Medical Sciences · doi:10.1016/j.jtumed.2017.03.001 · Cited by 15 · see citing works
Li, X., Zhao, Z., Gao, C., Rao, L., Hao, P., Jian, D., Li, W., Tang, H., & Li, M. (2017) · Cardiology Journal · doi:10.5603/cj.a2017.0133 · Cited by 14 · see citing works
The Genetics of Coronary Artery Disease: A Vascular Perspective
Quaye, L. N. K., Dalzell, C. E., Deloukas, P., & Smith, A. J. P. (2023) · Cells · doi:10.3390/cells12182232 · Cited by 12 · see citing works
Salido, E., Vieira, C. D. M., Mosquera, J. V., Zade, R., Parikh, P., Suryavanshi, S., Miller, C. L., & Sardo, V. L. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.322045 · Cited by 12 · see citing works
Li, P., Li, Y., Chen, L., Ma, X., Yan, X., Yan, M., Qian, B., Wang, F., Xu, J., Yin, J. J., et al. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.4993 · Cited by 12 · see citing works
- Authors
- Motterle, A., Pu, X., Wood, H., Xiao, Q., Gor, S., Liang Ng, F., Chan, K., Cross, F., Shohreh, B., Poston, R. N., Tucker, A. T., Caulfield, M. J., & Ye, S.
- Affiliations
- Queen Mary University of London (GB)
- Barts Health NHS Trust (GB)
- Corresponding author
- Ye, S.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-06-15
- Volume
- 21
- Issue
- 18
- Pages
- 4021-4029
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- PMC
- PMC3428153
- OpenAlex
- W2132038259
- Cited by
- 160
- References
- 39
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 6 · 2023: 10 · 2022: 7 · 2021: 7 · 2020: 12 · 2019: 17 · 2018: 18 · 2017: 14 · 2016: 15 · 2015: 16 · 2014: 18 · 2013: 8 · 2012: 2
- FWCI
- 6.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Molecular Genetics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- British Heart Foundation (FS/12/82/29736, FS/09/044/28007, FS/07/021, FS/11/28/28758)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- chromosome 9p21, coronary artery disease, vascular smooth muscle cells, CDKN2A, CDKN2B, ANRIL, p16INK4a, p14ARF, cell cycle regulators, vascular smooth muscle cell proliferation, atherosclerosis, atherosclerotic plaque, genetic susceptibility
- MeSH terms
- Cells, Cultured, Chromosomes, Human, Pair 9, Coronary Artery Disease, Genotype, Humans, Muscle, Smooth, Vascular, Gene Expression, Cyclin-Dependent Kinase Inhibitor p16, Polymorphism, Single Nucleotide, Myocytes, Smooth Muscle, Cell Proliferation, Atherosclerosis, Cyclin-Dependent Kinase Inhibitor p15, Genetic Association Studies, Plaque, Atherosclerotic, Primary Cell Culture, RNA, Long Noncoding
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
