The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.
The genetics of circadian rhythms, sleep and health
Open accessAbstract
Circadian rhythms are 24-h rhythms in physiology and behaviour generated by molecular clocks, which serve to coordinate internal time with the external world. The circadian system is a master regulator of nearly all physiology and its disruption has major consequences on health. Sleep and circadian rhythm disruption (SCRD) is a ubiquitous feature in today's 24/7 society, and studies on shift-workers have shown that SCRD can lead not only to cognitive impairment, but also metabolic syndrome and psychiatric illness including depression (1,2). Mouse models of clock mutants recapitulate these deficits, implicating mechanistic and causal links between SCRD and disease pathophysiology (3-5). Importantly, treating clock disruption reverses and attenuates these adverse health states in animal models (6,7), thus establishing the circadian system as a novel therapeutic target. Significantly, circadian and clock-controlled gene mutations have recently been identified by Genome-Wide Association Studies (GWAS) in the aetiology of sleep, mental health and metabolic disorders. This review will focus upon the genetics of circadian rhythms in sleep and health.
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Cites
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Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle
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High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice
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Cited by
Genomic Imprinting and Physiological Processes in Mammals
Tucci, V., Isles, A. R., Kelsey, G., Ferguson-Smith, A. C., Tucci, V., Bartolomei, M. S., Benvenisty, N., Bourc’his, D., Charalambous, M., Dulac, C., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.043 · Cited by 544
Chronotype, circadian rhythm, and psychiatric disorders: Recent evidence and potential mechanisms
Zou, H., Zhou, H., Yan, R., Yao, Z., & Lu, Q. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.811771 · Cited by 269
Circadian rhythms in neurodegenerative disorders
Nassan, M., & Videnovic, A. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-021-00577-7 · Cited by 253
Chronotype and Cancer: Emerging Relation Between Chrononutrition and Oncology from Human Studies
Godos, J., Currenti, W., Ferri, R., Lanza, G., Caraci, F., Frias-Toral, E., Guglielmetti, M., Ferraris, C., Lipari, V., Carvajal Altamiranda, S., et al. (2025) · Nutrients · doi:10.3390/nu17030529 · Cited by 22
Metadata
- Authors
- Jagannath, A., Taylor, L., Wakaf, Z., Vasudevan, S. R., & Foster, R. G.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-07-14
- Volume
- 26
- Issue
- R2
- Pages
- R128-R138
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2735309017
- Cited by
- 256
- References
- 106
- FWCI
- 8.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
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