A randomized single-blind controlled trial of letrozole as a low-cost IVF protocol in women with poor ovarian response: a preliminary report
Abstract
BACKGROUND: Use of letrozole, a selective inhibitor of aromatase, reduces the gonadotrophin dose required to induce follicular maturation. We evaluated whether incorporation of letrozole could be an effective low-cost IVF protocol for poor responders. METHODS: A randomized, controlled, single-blind trial was conducted in the Assisted Reproduction Unit, Institute of Reproductive Medicine, Kolkata, India. Thirty-eight women with a history of poor ovarian response to gonadotrophins were recruited. Thirteen women (Let-FSH group) received letrozole 2.5 mg daily from day 3-7, and recombinant FSH (rFSH) 75 IU/day on days 3 and 8; and 25 women (GnRH-ag-FSH group) underwent long GnRH agonist protocol and stimulated with rFSH (300-450 IU/day). Ovulation was triggered by 10,000 IU of HCG followed by IVF-embryo transfer. The main outcome measures were total dose of rFSH (IU/cycle), terminal estradiol (E2) (pg/ml), numbers of follicles, oocytes retrieved and transferable embryo, endometrial thickness (mm), and pregnancy rate. RESULTS: Compared with the GnRH-ag-FSH group (2865 +/- 228 IU), the Let-FSH group (150 +/- 0 IU) received a significantly (P < 0.001) lower total dose of FSH. Except for terminal E2, which was significantly higher (P < 0.001) in the GnRH-ag-FSH group (380 +/- 46 pg/ml) than the Let-FSH group (227 +/- 45 pg/ml), the treatment outcomes in all other respects, including pregnancy rate, were statistically comparable. CONCLUSIONS: Adjunctive use of letrozole may form an effective means of low-cost IVF protocol in poorly responding women.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In a randomized trial of 38 women with poor ovarian response, combined letrozole and FSH required a significantly lower total dose of FSH compared with the GnRH-a and FSH group.
“The combined letrozole and FSH group required a significantly lower total dose of FSH as compared with the GnRH-a and FSH group.”
From A new era in ovulation induction (2006) · cites this paper as [69]
In that trial, treatment outcomes including pregnancy rates were statistically comparable between combined letrozole and FSH and GnRH-a and FSH.
“Except for the E 2 levels in late follicular phase, which were significantly higher in the GnRH-a and FSH group, the treatment outcomes in all respects, including the pregnancy rates, were statistically comparable.”
From A new era in ovulation induction (2006) · cites this paper as [69]
Cites
Mitwally, M. F. M., & Casper, R. F. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(00)01705-2 · Cited by 801 · cited 7× · see citing works
“Letrozole, a highly selective, non-steroidal aromatase inhibitor, could successfully induce ovulation in women with polycystic ovary syndrome (PCOS) (Mitwally and Casper, 2000), including even those who were resistant to clomiphene citrate (Mitwally and Casper, 2001).”
BackgroundInfluentialLabrie, F., Bélanger, A., Cusan, L., Gomez, J.-L., & Candas, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4160 · Cited by 713 · see citing works
Androgen and follicle stimulating hormone interactions in primate ovarian follicle development
Weil, S., Vendola, K., Zhou, J., & Bondy, C. A. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.8.5929 · Cited by 592 · see citing works
Navot, D., Bergh, R. A., Williams, M. C., Garrisi, G. J., Guzman, I., Sandler, B., & Grunfeld, L. (1991) · The Lancet · doi:10.1016/0140-6736(91)93060-m · Cited by 523 · see citing works
Insulin-Like Growth Factors and Ovarian Follicular Development*
Giudice, L. C. (1992) · Endocrine Reviews · doi:10.1210/edrv-13-4-641 · Cited by 521 · see citing works
Toner, J. P., Philput, C. B., Jones, G. S., & Muasher, S. J. (1991) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54249-6 · Cited by 495 · see citing works
Aromatase inhibition improves ovarian response to follicle-stimulating hormone in poor responders
Mitwally, M. F. M., & Casper, R. F. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)03280-0 · Cited by 407 · see citing works
Clinical management of low ovarian response to stimulation for IVF: a systematic review
Tarlatzis, B. C. (2003) · Human Reproduction Update · doi:10.1093/humupd/dmg007 · Cited by 364 · see citing works
Mitwally, M. F. M. (2003) · Human Reproduction · doi:10.1093/humrep/deg311 · Cited by 344 · see citing works
The role of local estrogen Biosynthesis in males and females
Simpson, E., Rubin, G., Clyne, C., Robertson, K., O’Donnell, L., Jones, M., & Davis, S. (2000) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(00)00254-x · Cited by 249 · see citing works
Land, J. A., Yarmolinskaya, M. I., Dumoulin, J. C. M., & Evers, J. L. H. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58269-7 · Cited by 224 · see citing works
A Preliminary Report on Oocyte Donation Extending Reproductive Potential to Women over 40
Sauer, M. V., Paulson, R. J., & Løbo, R. A. (1990) · New England Journal of Medicine · doi:10.1056/nejm199010253231702 · Cited by 214 · see citing works
Are Estrogens of Import to Primate/Human Ovarian Folliculogenesis?
Palter, S. F., Tavares, A. B., Hourvitz, A., Veldhuis, J. D., & Adashi, E. Y. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.3.0433 · Cited by 189 · see citing works
Vendola, K., Zhou, J., Wang, J., & Bondy, C. A. (1999) · Human Reproduction · doi:10.1093/humrep/14.9.2328 · Cited by 185 · see citing works
Wardle, P. G., McLaughlin, E. A., McDermott, A., Mitchell, J. D., Ray, B. D., & Hull, M. G. R. (1985) · The Lancet · doi:10.1016/s0140-6736(85)90289-2 · Cited by 165 · see citing works
Scott, R. T., & Navot, D. (1994) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56700-4 · Cited by 156 · see citing works
OOCYTE DONATION IN 61 PATIENTS
Serhal, P. F., & Craft, I. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92762-1 · Cited by 150 · see citing works
Insulin-like growth factors and ovarian follicular development
Giudice, L. C. (1992) · Endocrine Reviews · doi:10.1210/er.13.4.641 · Cited by 150 · see citing works
van Hooff, M. H. A., Alberda, A. T., Huisman, G. J., Zeilmaker, G. H., & Leerentveld, R. A. (1993) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a138053 · Cited by 147 · see citing works
Kupesic, S. P., Kurjak, A., Bjeloš, D., & Vujisić, S. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(02)04567-3 · Cited by 137 · see citing works
Healey, S., Tan, S. L., Tulandi, T., & Biljan, M. M. (2003) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.03.001 · Cited by 132 · see citing works
Aromatase inhibitors for the treatment of infertility
Mitwally, M. F., & Casper, R. F. (2003) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.12.3.353 · Cited by 120 · see citing works
Karande, V. C., Gs, J., Ll, V., & Muasher, S. (1991) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(91)90566-n · Cited by 110 · see citing works
Rombauts, L. J. F., Suikkari, A., MacLachlan, V. B., Trounson, A. O., & Healy, D. L. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00018-1 · Cited by 90 · see citing works
Ben‐Rafael, Z., Strauss, J. F., Mastroianni, L., & Flickinger, G. L. (1986) · Fertility and Sterility · doi:10.1016/s0015-0282(16)49632-9 · Cited by 78 · see citing works
Aromatase inhibition for ovarian stimulation: future avenues for infertility management
Mitwally, M. F., & Casper, R. F. (2002) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/00001703-200206000-00003 · Cited by 71 · see citing works
Toth, T. L., Awwad, J. T., Veeck, L. L., Jones, H. W., & Muasher, S. J. (1996) · PubMed · Cited by 40 · see citing works
Toner, J., Philput, C., Gs, J., & Muasher, S. (1992) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(92)90345-j · Cited by 39 · see citing works
Navot, D., Bergh, P., Williams, M., Garrisi, G. J., Guzmán, L., Sandler, B., & Grunfeld, L. (1992) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(92)90759-c · Cited by 34 · see citing works
Could ovarian infection impair ovarian response to gonadotrophin stimulation?
Keay, S. D., Liversedge, N., & Jenkins, J. M. (1998) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1998.tb10082.x · Cited by 33 · see citing works
Natural-cyclein vitrofertilization in women aged over 44 years
Bar‐Hava, I., Ferber, A., Ashkenazi, J., Dicker, D., Ben‐Rafael, Z., & Orvieto, R. (2000) · Gynecological Endocrinology · doi:10.3109/09513590009167689 · Cited by 13 · see citing works
A preliminary report on oocyte donation extending reproductive potential to women over 40
Sauer, M. V., Paulson, R., & Ra, L. (1991) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(91)90302-l · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ferraretti, A. P., Marca, A. L., Fauser, B. C. J. M., Tarlatzis, B. C., Nargund, G., Gianaroli, L., & on behalf of the ESHRE working group on Poor Ovarian Response Definition (2011) · Human Reproduction · doi:10.1093/humrep/der092 · Cited by 1,884 · see citing works
Aromatase Inhibitors for Ovulation Induction
Casper, R. F., & Mitwally, M. F. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1923 · Cited by 272 · see citing works
Pandian, Z., McTavish, A. R., Aucott, L. S., Hamilton, M. P. R., & Bhattacharya, S. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004379.pub3 · Cited by 241 · see citing works
Kyrou, D., Kolibianakis, E. M., Venetis, C. A., Papanikolaou, E. G. E., Bontis, J. N., & Tarlatzis, B. C. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.12.077 · Cited by 239 · see citing works
Zhang, Y., Zhang, C., Shu, J., Guo, J., Chang, H., Leung, P. C. K., Sheng, J., & Huang, H. (2019) · Human Reproduction Update · doi:10.1093/humupd/dmz046 · Cited by 232 · see citing works
Polyzos, N. P., & Devroey, P. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.09.048 · Cited by 227 · see citing works
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF
Barad, D. H., & Gleicher, N. (2006) · Human Reproduction · doi:10.1093/humrep/del254 · Cited by 224 · see citing works
Twins born after transplantation of ovarian cortical tissue and oocyte vitrification
Sánchez-Serrano, M., Crespo, J., Mirabet, V., Cobo, A. C., Escribá, M.-J., Simón, C., & Pellicer, A. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.09.046 · Cited by 223 · see citing works
Barad, D., Brill, H., & Gleicher, N. (2007) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-007-9178-x · Cited by 207 · see citing works
Use of letrozole in assisted reproduction: a systematic review and meta-analysis
Requena, A., Herrero, J. C., Landeras, J., Navarro, E., Neyro, J. L., Salvador, C., Tur, R., Callejo, J., Checa, M. Á., Farré, M., et al. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn033 · Cited by 197 · see citing works
A new era in ovulation induction
Holzer, H., Casper, R., & Tulandi, T. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.05.078 · Cited by 194 · see citing works
Mild ovarian stimulation for IVF
Verberg, M. F. G., Macklon, N., Nargund, G., Frydman, R., Devroey, P., Broekmans, F. J., & Fauser, B. C. J. M. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn056 · Cited by 193 · see citing works
Aromatase inhibitors: the next generation of therapeutics for endometriosis?
Attar, E., & Bulun, S. E. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.09.064 · Cited by 184 · see citing works
Esteves, S. C., Roque, M., Bedoschi, G., Conforti, A., Humaidan, P., & Alviggi, C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00461 · Cited by 153 · see citing works
Bosdou, J. K., Venetis, C. A., Kolibianakis, E. M., Toulis, K. A., Goulis, D. G., Zepiridis, L., & Tarlatzis, B. C. (2012) · Human Reproduction Update · doi:10.1093/humupd/dmr051 · Cited by 141 · see citing works
Endometrial receptivity defects during IVF cycles with and without letrozole
Miller, P. B. W., Parnell, B. A., Bushnell, G., Tallman, N., Forstein, D. A., Higdon, H. L., Kitawaki, J., & Lessey, B. A. (2012) · Human Reproduction · doi:10.1093/humrep/der452 · Cited by 128 · see citing works
Androgens and ovarian function: translation from basic discovery research to clinical impact
Walters, K. A., Rodriguez Paris, V, Aflatounian, A., & Handelsman, D. J. (2019) · Journal of Endocrinology · doi:10.1530/joe-19-0096 · Cited by 104 · see citing works
Datta, A. K., Maheshwari, A., Felix, N., Campbell, S. C., & Nargund, G. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa035 · Cited by 105 · see citing works
Youssef, M. A. F. M., van Wely, M., Al-Inany, H. G., Madani, T., Jahangiri, N., Khodabakhshi, S., Alhalabi, M., Akhondi, M. M., Ansaripour, S., Tokhmechy, R., et al. (2016) · Human Reproduction · doi:10.1093/humrep/dew282 · Cited by 101 · see citing works
Regimen of ovarian stimulation affects oocyte and therefore embryo quality
Bosch, E., Labarta, E., Kolibianakis, E. M., Rosen, M. P., & Meldrum, D. R. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.01.022 · Cited by 97 · see citing works
Yaralı́, H., Esinler, İ., Polat, M., Bozdağ, G., & Tıraş, B. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.04.057 · Cited by 86 · see citing works
A randomized trial of superovulation with two different doses of letrozole
Al-Fadhli, R., Sylvestre, C. V., Buckett, W. M., Tan, S. L., & Tulandi, T. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.07.1283 · Cited by 84 · see citing works
Use of aromatase inhibitors in poor-responder patients receiving GnRH antagonist protocols
Özmen, B., Sönmezer, M., Atabekoğlu, C. S., & Olmuş, H. (2009) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2009.05.007 · Cited by 82 · see citing works
Ganesh, A., Goswami, S. K., Chattopadhyay, R., Chaudhury, K., & Chakravarty, B. (2009) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-008-9284-4 · Cited by 79 · see citing works
Self-citationBaştu, E., Buyru, F., Özsürmeli, M., Demiral, İ., Doğan, M., & Yeh, J. (2016) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2016.05.027 · Cited by 79 · see citing works
(2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.03.019 · Cited by 77 · see citing works
Kamath, M. S., Maheshwari, A., Bhattacharya, S., Lor, K. Y., & Gibreel, A. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008528.pub3 · Cited by 75 · see citing works
Li, Y., Li, X., Yang, X., Cai, S., Lu, G., Lin, G., Humaidan, P., & Gong, F. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00642 · Cited by 73 · see citing works
Treatment strategies for endometriosis
Rodgers, A. K., & Falcone, T. (2008) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.9.2.243 · Cited by 72 · see citing works
Effective treatment protocol for poor ovarian response: A systematic review and meta-analysis
Jeve, Y. B., & Bhandari, H. M. (2016) · Journal of Human Reproductive Sciences · doi:10.4103/0974-1208.183515 · Cited by 70 · see citing works
Sunkara, S. K., Pundir, J., & Khalaf, Y. (2011) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2011.01.015 · Cited by 66 · see citing works
Esencan, E., Beroukhim, G., & Seifer, D. B. (2022) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-022-01033-x · Cited by 69 · see citing works
Qin, Y., Zhao, Z., Sun, M., Geng, L., Che, L., & Chen, Z.-J. (2011) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-9-9 · Cited by 63 · see citing works
Biomaterials for Dental Implants: An Overview
Amarnath, G. S., Muddugangadhar, B. C., Tripathi, S., Suchismita, D., & Divya, M. S. (2011) · International Journal of Oral Implantology and Clinical Research · doi:10.5005/jp-journals-10012-1030 · Cited by 61 · see citing works
Mohsen, I. A., & Din, R. E. E. (2012) · Gynecological Endocrinology · doi:10.3109/09513590.2012.730569 · Cited by 59 · see citing works
Aromatase inhibitors for female infertility: a systematic review of the literature
Polyzos, N. P., Tzioras, S., Badawy, A., Valachis, A., Dritsas, C., & Mauri, D. N. (2009) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2009.06.008 · Cited by 57 · see citing works
Evidence‐based management of poor ovarian response
Venetis, C. A., Kolibianakis, E. M., Tarlatzi, T. B., & Tarlatzis, B. C. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05665.x · Cited by 55 · see citing works
Mitwally, M. F., Casper, R. F., & Diamond, M. P. (2005) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-3-54 · Cited by 55 · see citing works
Current evidence supporting "letrozole" for ovulation induction
Kar, S. (2013) · Journal of Human Reproductive Sciences · doi:10.4103/0974-1208.117166 · Cited by 56 · see citing works
Detti, L., Williams, D. B., Robins, J. C., Maxwell, R. A., & Thomas, M. A. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.04.053 · Cited by 53 · see citing works
Conforti, A., Carbone, L., Girolamo, R. D., Iorio, G. G., Guida, M., Campitiello, M. R., Ubaldi, F. M., Rienzi, L. F., Vaiarelli, A., Cimadomo, D., et al. (2024) · Fertility and Sterility · doi:10.1016/j.fertnstert.2024.09.038 · Cited by 52 · see citing works
The effects of letrozole on ovarian stimulation for fertility preservation in cancer-affected women
Checa, M. Á., Corchado, A. R., Cuadri, M. E. S., González-Comadran, M., Brassesco, M., & Carreras, R. (2012) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2012.02.020 · Cited by 52 · see citing works
Lee, T., Lin, Y., Seow, K., Hwang, J., Tzeng, C., & Yang, Y. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.06.029 · Cited by 51 · see citing works
Letrozole or clomiphene citrate as first line for anovulatory infertility: a debate
Kamath, M. S., & George, K. (2011) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-9-86 · Cited by 50 · see citing works
Bechtejew, T. N., de Nadai, M. N., Nastri, C. O., & Martins, W. P. (2017) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.17442 · Cited by 50 · see citing works
Shanbhag, S., Aucott, L. S., Bhattacharya, S., Hamilton, M. A., & McTavish, A. R. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004379.pub2 · Cited by 50 · see citing works
Kooshesh, L., Bahmanpour, S., Zeighami, S., & Nasr‐Esfahani, M. H. (2020) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-020-00591-2 · Cited by 48 · see citing works
Aromatase inhibitors in stimulated IVF cycles
Papanikolaou, E. G. E., Polyzos, N. P., Humaidan, P., Pados, G., Bosch, E., Tournaye, H. J., & Tarlatzis, B. C. (2011) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-9-85 · Cited by 45 · see citing works
Lee, V. C. Y., Chan, C. C. W., Ng, E. H. Y., Yeung, W. S. B., & Ho, P. C. (2011) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2011.05.012 · Cited by 44 · see citing works
Aromatase inhibitors for ovulation induction and ovarian stimulation
Lee, V. C. Y., & Ledger, W. J. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04006.x · Cited by 42 · see citing works
Youssef, M. A. F. M., van Wely, M., Mochtar, M. H., Fouda, U. M., ElDaly, A. A., Abidin, E. Z. E., Elhalwagy, A., Abdallah, A. A. M., Zaki, S. S., Ghafar, M. S. A., et al. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.10.033 · Cited by 42 · see citing works
Different ovarian stimulation protocols for women with diminished ovarian reserve
Loutradis, D., Drakakis, P., Vomvolaki, E., & Antsaklis, A. (2007) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-007-9181-2 · Cited by 42 · see citing works
Liu, X., Li, T., Wang, B., Xiao, X., Liang, X., & Huang, R. (2020) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-020-05513-6 · Cited by 41 · see citing works
Misoprostol With or Without Letrozole Pretreatment for Termination of Pregnancy
Lee, V. C. Y., Ng, E. H. Y., Yeung, W. S. B., & Ho, P. C. (2011) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e3182073fbf · Cited by 41 · see citing works
Use of aromatase inhibitors in practice of gynecology
Usluoğullari, B., Duvan, C. Z., & Usluoğulları, C. A. (2015) · Journal of Ovarian Research · doi:10.1186/s13048-015-0131-9 · Cited by 40 · see citing works
Eruption Chronology in Children: A Cross-sectional Study
Verma, N., Bansal, A. V., Tyagi, P., Jain, A., Tiwari, U., & Gupta, R. (2017) · International Journal of Clinical Pediatric Dentistry · doi:10.5005/jp-journals-10005-1450 · Cited by 40 · see citing works
Low-cost in vitro fertilization: current insights
Maheshwari, A., & Teoh, P. J. (2014) · International Journal of Women s Health · doi:10.2147/ijwh.s51288 · Cited by 38 · see citing works
Surface Modifications for Endosseous Dental Implants
Shetty, O. K., Parekh, R., & Tabassum, R. (2012) · International Journal of Oral Implantology and Clinical Research · doi:10.5005/jp-journals-10012-1078 · Cited by 38 · see citing works
Comparison of mild and microdose GnRH agonist flare protocols on IVF outcome in poor responders
Karimzadeh, M., Mashayekhy, M., Mohammadian, F., & Moghaddam, F. M. (2011) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-010-1828-z · Cited by 36 · see citing works
Ebrahimi, M., Akbari-Asbagh, F., & Ghalandar-Attar, M. (2017) · International Journal of Reproductive BioMedicine (IJRM) · doi:10.29252/ijrm.15.2.101 · Cited by 35 · see citing works
Montoya-Botero, P., Drakopoulos, P., González-Foruria, I., & Polyzos, N. P. (2020) · Human Reproduction Open · doi:10.1093/hropen/hoaa066 · Cited by 35 · see citing works
What can the clinician do to improve implantation?
Boomsma, C. M., & Macklon, N. (2006) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)61034-6 · Cited by 35 · see citing works
Bülow, N. S., Holt, M. D., Skouby, S. O., Petersen, K. B., Englund, A. L. M., Pinborg, A. B., & Macklon, N. S. (2021) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2021.12.006 · Cited by 34 · see citing works
Mukherjee, S., Sharma, S., & Chakravarty, B. (2012) · Journal of Human Reproductive Sciences · doi:10.4103/0974-1208.101014 · Cited by 34 · see citing works
Thakur, S., & Habib, R. (2017) · International Journal of Clinical Pediatric Dentistry · doi:10.5005/jp-journals-10005-1442 · Cited by 33 · see citing works
Dehbashi, S., Dehbashi, S., Kazerooni, T., Robati, M., Alborzi, S., & Shadman, A. (2009) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 32 · see citing works
Current Therapeutic Options for Controlled Ovarian Stimulation in Assisted Reproductive Technology
Racca, A., Drakopoulos, P., Neves, A. R., & Polyzos, N. P. (2020) · Drugs · doi:10.1007/s40265-020-01324-w · Cited by 33 · see citing works
The use of aromatase inhibitors in in vitro fertilization
García-Velasco, J. A. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.09.042 · Cited by 32 · see citing works
What should be the maximum FSH dose in IVF/ICSI in poor responders?
Siristatidis, C. S., & Hamilton, M. (2007) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443610701327420 · Cited by 30 · see citing works
Datta, A. K., Maheshwari, A., Felix, N., Campbell, S. C., & Nargund, G. (2020) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2020.03.005 · Cited by 30 · see citing works
Potential of Aromatase Inhibitors for Ovulation and Superovulation Induction in Infertile Women
Mitwally, M. F., & Casper, R. F. (2006) · Drugs · doi:10.2165/00003495-200666170-00001 · Cited by 29 · see citing works
Poor responders in IVF: an update in therapy
Giovanale, V., Pulcinelli, F. M., Ralli, E., Primiero, F. M., & Caserta, D. (2014) · Gynecological Endocrinology · doi:10.3109/09513590.2014.987228 · Cited by 28 · see citing works
Yang, X., Lin, G., Lu, G., & Gong, F. (2019) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-019-0483-x · Cited by 27 · see citing works
Shapira, M., Orvieto, R., Lebovitz, O., Nahum, R., Aizer, A., Segev-Zahav, A., & Haas, J. (2020) · Journal of Ovarian Research · doi:10.1186/s13048-020-00666-z · Cited by 27 · see citing works
Therapeutic strategies for ovulation induction in infertile women with polycystic ovary syndrome
Cristello, F., Cela, V., Artini, P. G., & Genazzani, A. R. (2005) · Gynecological Endocrinology · doi:10.1080/09513590500463360 · Cited by 27 · see citing works
Jovanovic, V. P., Kort, D. H., Guarnaccia, M. M., Sauer, M. V., & Løbo, R. A. (2011) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-011-9643-4 · Cited by 27 · see citing works
Evolution of External and Internal Implant to Abutment Connection
Prithviraj, D., & Muley, N. (2012) · International Journal of Oral Implantology and Clinical Research · doi:10.5005/jp-journals-10012-1079 · Cited by 27 · see citing works
Prajapati, D., Nayak, R., Pai, D., Upadhya, N., Bhaskar, V., & Kamath, P. (2017) · International Journal of Clinical Pediatric Dentistry · doi:10.5005/jp-journals-10005-1445 · Cited by 27 · see citing works
Suma, N. (2017) · International Journal of Clinical Pediatric Dentistry · doi:10.5005/jp-journals-10005-1440 · Cited by 25 · see citing works
Nabati, A., Peivandi, S., Khalilian, A., Mirzaeirad, S., & Hashemi, S. A. (2015) · Global Journal of Health Science · doi:10.5539/gjhs.v8n4p166 · Cited by 23 · see citing works
Lee, K., Kim, C., Suk, H.-J., Lee, Y., Kwon, S.-K., Kim, S.-H., Chae, H., & Kang, B. (2014) · Obstetrics & Gynecology Science · doi:10.5468/ogs.2014.57.3.216 · Cited by 20 · see citing works
Moini, A., Lavasani, Z., Kashani, L., Mojtahedi, M. F., & Yamini, N. (2019) · International Journal of Reproductive BioMedicine (IJRM) · doi:10.18502/ijrm.v17i9.5101 · Cited by 22 · see citing works
Noriega-Portella, L., Noriega-Hoces, L., Delgado, A., Rubio, J., Gonzales‐Castañeda, C., & Gonzales, G. F. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.08.060 · Cited by 22 · see citing works
Role of androgens in the treatment of patients with low ovarian response
Feigenberg, T., Simon, A., Ben‐Meir, A., Gielchinsky, Y., & Laufer, N. (2009) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2009.09.012 · Cited by 21 · see citing works
Das, D., Samir, P. V., Verma, R. K., & Singh, N. (2017) · International Journal of Clinical Pediatric Dentistry · doi:10.5005/jp-journals-10005-1448 · Cited by 21 · see citing works
Controlled ovarian hyperstimulation with sequential letrozole co-treatment in normo/high responders
Ecemiş, T., Taşçı, Y., & Çağlar, G. S. (2015) · Gynecological Endocrinology · doi:10.3109/09513590.2015.1110133 · Cited by 20 · see citing works
Ezoe, K., Fukuda, J., Takeshima, K., Shinohara, K., & Kato, K. (2022) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-022-05174-0 · Cited by 19 · see citing works
Anatomical Considerations in Implant Selection and Positioning
Shetty, M., Prasad, K., & Mehra, D. (2013) · International Journal of Oral Implantology and Clinical Research · doi:10.5005/jp-journals-10012-1088 · Cited by 19 · see citing works
Aromatase inhibitors: A new approach for controlling ovarian function in cattle
Yapura, J., Zwiefelhofer, E. M., Pierson, R. A., & Adams, G. P. (2017) · Theriogenology · doi:10.1016/j.theriogenology.2017.08.025 · Cited by 20 · see citing works
Elassar, A. A., Engmann, L., NULSEN, J. C., & Benadiva, C. A. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.03.103 · Cited by 19 · see citing works
Bülow, N. S., Warzecha, A. K., Nielsen, M. V., Andersen, C. Y., Holt, M. D., Petersen, M. R., Sopa, N., Zedeler, A., Englund, A. L. M., Pinborg, A. B., et al. (2023) · Human Reproduction · doi:10.1093/humrep/dead182 · Cited by 18 · see citing works
Polyetheretherketone (PEEK) Dental Implants: A Case for Immediate Loading
Marya, K., Dua, J., Chawla, S., Sonoo, P. R., Aggarwal, A., & Singh, V. (2011) · International Journal of Oral Implantology and Clinical Research · doi:10.5005/jp-journals-10012-1043 · Cited by 18 · see citing works
Lin, H.-T., Wu, M., Tsai, L.-C., Chen, T.-S., & Ou, H. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.780392 · Cited by 17 · see citing works
Çelik, S., Turgut, N. E., Yağmur, E., Boynukalin, K., Çelik, D. C., Fındıklı, N., Purısa, S., & Bahçeci, M. (2015) · Journal of Turkish Society of Obstetric and Gynecology · doi:10.4274/tjod.76402 · Cited by 17 · see citing works
Ghaffari, F., Jahangiri, N., Madani, T., Khodabakhshi, S., & Chehrazi, M. (2019) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.12988 · Cited by 17 · see citing works
Yoldemir, T. (2016) · Climacteric · doi:10.3109/13697137.2016.1164133 · Cited by 17 · see citing works
Ovarian Stimulation for IVF: Mild Approaches
Hamdine, O., Broekmans, F. J., & Fauser, B. C. J. M. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0659-8_14 · Cited by 16 · see citing works
Olgan, Ş., & Humaidan, P. (2017) · Reproductive Biology · doi:10.1016/j.repbio.2017.01.006 · Cited by 16 · see citing works
Kotsakis, G. A., Chrepa, V., & Katta, S. (2011) · International Journal of Oral Implantology and Clinical Research · doi:10.5005/jp-journals-10012-1051 · Cited by 15 · see citing works
Infections Resulting from Bone Grafting Biomaterials
Singh, R., Mahesh, L., & Shukla, S. (2013) · International Journal of Oral Implantology and Clinical Research · doi:10.5005/jp-journals-10012-1095 · Cited by 15 · see citing works
- Authors
- Goswami, S. K.
- Affiliations
- Institute of Reproductive Medicine (IN)
- Corresponding author
- Goswami, S.K.
- ORCID
- Goswami, S.K.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-06-24
- Volume
- 19
- Issue
- 9
- Pages
- 2031-2035
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2105251513
- Cited by
- 372
- References
- 31
- Citations by year
- 2025: 5 · 2024: 3 · 2023: 6 · 2022: 8 · 2021: 12 · 2020: 14 · 2019: 10 · 2018: 5 · 2017: 40 · 2016: 12 · 2015: 44 · 2014: 37 · 2013: 33 · 2012: 36
- FWCI
- 8.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- letrozole, poor ovarian response, aromatase inhibitors, recombinant FSH, GnRH agonist protocol, oocyte retrieval, pregnancy rate
- MeSH terms
- Letrozole, Adult, Cost Control, Dose-Response Relationship, Drug, Drug Resistance, Embryo Transfer, Estradiol, Female, Fertilization in Vitro, Follicle Stimulating Hormone, Gonadotropins, Chorionic Gonadotropin, Humans, Gonadotropin-Releasing Hormone, Nitriles, Ovary, Pregnancy, Recombinant Proteins, Triazoles, Single-Blind Method, Treatment Outcome, Pregnancy Rate, Aromatase Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
